2024/04/18 更新

写真a

モリナガ　ユウコ
森永　裕子
所属
医歯学域医学系 医歯学総合研究科 健康科学専攻 人間環境学講座 特任研究員
職名
特任研究員

学位

  • 学士(保健学） （ 1994年4月   九州大学 ）

経歴

  • 鹿児島大学   特任研究員

    2003年4月 - 現在

 

論文

  • Kanmura S, Morinaga Y, Tanaka A, Komaki Y, Iwaya H, Kumagai K, Mawatari S, Sasaki F, Tanoue S, Hashimoto S, Sameshima Y, Ono Y, Ohi H, Ido A .  Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis. .  Clinical and translational gastroenterology12 ( 4 ) e00331   2021年4月

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  • Hidehito Maeda 1 , Fumisato Sasaki 2 , Yuko Morinaga 1 , Masayuki Kabayama 1 , Hiromichi Iwaya 1 , Yuga Komaki 1 , Shiho Arima 1 , Yuichiro Nasu 1 , Shiroh Tanoue 1 , Shinichi Hashimoto 1 , Shuji Kanmura 1 , Akihiro Nishiguchi 3 , Tetsushi Taguchi 3 , Akio Ido .  Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis .  national library medicine22 ( 3 ) 1 - 13   2020年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Hexanoyl (Hx:C6) group-modified alkaline-treated gelatin porous film (HAG) is a newly developed degradable hydrogel characterized by strong adhesiveness and high affinity for vascular endothelial growth factor (VEGF). The aim of this study was to clarify the effect of HAG sheets on the healing process of post-endoscopic submucosal dissection (ESD) porcine gastric artificial ulcers.

    DOI： 10.1159/000509056

    PubMed

  • Nishikoba N, Kumagai K, Kanmura S, Nakamura Y, Ono M, Eguchi H, Kamibayashiyama T, Oda K, Mawatari S, Tanoue S, Hashimoto S, Tsubouchi H, Ido A .  HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression. .  Frontiers in immunology11   2135   2020年

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  • Nishikoba N, Kumagai K, Kanmura S, Nakamura Y, Ono M, Eguchi H, Kamibayashiyama T, Oda K, Mawatari S, Tanoue S, Hashimoto S, Tsubouchi H, Ido A .  HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression. .  Frontiers in immunology11   2135   2020年

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  • Akihito Tanaka 1 , Shuji Kanmura 1 , Yuko Morinaga 1 , Katsuto Kawabata 1 , Shiho Arima 1 , Fumisato Sasaki 1 , Yuichirou Nasu 1 , Shiroh Tanoue 1 , Shinichi Hashimoto 1 , Masahiko Takeshita 2 , Shiro Takeda 3 , Akio Ido 1 .  Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response .  molecular medicine reports21 ( 21 ) 1181 - 1191   2019年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated the beneficial effect of Lactobacillus plantarum 06CC2 in experimental colitis in mice. An experimental colitis model in C57BL6 mice was induced using dextran sulfate sodium. Mice were orally administered 06CC2 (06CC2 group) or PBS only (control group) by gavage. The disease activity index (DAI), histological grading, and colon tissue and colonic lamina propria mononuclear cells (LPMCs) were examined macroscopically and histopathologically, and the expression levels of inflammation‑associated cytokines (IL‑6, IL‑12, TNF‑α and IL‑10) in these samples were determined. Compared with the control group, the 06CC2 group exhibited a significantly lower DAI (1.5±0.8 vs. 0.2±0.3, respectively; P<0.05) and pathology score (6.3±1.5 vs. 3.8±1.3, respectively; P<0.05). IL‑10 expression in colonic LPMCs was higher in the 06CC2 group than in the control group, although there was no significant difference in IFN‑γ, IL‑6 or IL‑12 expression in colonic LPMCs between the two groups. In addition, 06CC2 stimulated the production of IL‑10 from CD11b‑positive cells and CD11c‑positive cells in the colon. The 06CC2 strain induced IL‑10 production in the colon and attenuated colon inflammation.

    DOI： 10.3892/mmr.2020.10925

    PubMed

  • Kawabata K, Kanmura S, Morinaga Y, Tanaka A, Makino T, Fujita T, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Ido A .  A high‑fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium‑induced colitis. .  International journal of molecular medicine43 ( 3 ) 1487 - 1496   2019年3月

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  • Yohei Ono 1 , Shuji Kanmura 2 , Yuko Morinaga 1 , Kohei Oda 1 , Katsuto Kawabata 1 , Shiho Arima 1 , Fumisato Sasaki 1 , Yuichirou Nasu 1 , Shiroh Tanoue 1 , Shinichi Hashimoto 1 , Hiroki Taguchi 1 , Hirofumi Uto 1 3 , Hirohito Tsubouchi 4 , Akio Ido 1 .  The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn's disease. .  BMC Gastroenterol17 ( 1 ) 40   2017年3月

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    記述言語：日本語   掲載種別：研究論文（大学，研究機関等紀要）  

    Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages may contribute to the pathogenesis of inflammatory bowel diseases (IBDs). However, there have been no reports on the kinetics of AIM in IBD and the impact of AIM on the pathogenesis of IBD. In this study, we aimed to investigate the diagnostic utility of levels of AIM and their correlation with the activity of Crohn's disease (CD) and IBD.

    DOI： 10.1186/s12876-017-0591-z

    PubMed

  • Kanmura S, Hamamoto H, Morinaga Y, Oda K, Fujita T, Arima S, Nasu Y, Sasaki F, Hashimoto S, Taguchi H, Setoyama H, Ido A .  Fecal Human Neutrophil Peptide Levels Correlate with Intestinal Inflammation in Ulcerative Colitis. .  Digestion93 ( 4 ) 300 - 8   2016年

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  • Kumagai K, Tabu K, Sasaki F, Takami Y, Morinaga Y, Mawatari S, Hashimoto S, Tanoue S, Kanmura S, Tamai T, Moriuchi A, Uto H, Tsubouchi H, Ido A .  Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice. .  PloS one10 ( 11 ) e0143413   2015年

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  • Kumagai K, Tabu K, Sasaki F, Takami Y, Morinaga Y, Mawatari S, Hashimoto S, Tanoue S, Kanmura S, Tamai T, Moriuchi A, Uto H, Tsubouchi H, Ido A .  Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice. .  PloS one10 ( 11 ) e0143413   2015年

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