Updated on 2021/03/23

写真a

 
HARAGUCHI Misako
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Functional Biology and Pharmacology Associate Professor
Title
Associate Professor

Degree

  • 博士(医学) ( 1992.3   鹿児島大学 )

Research Interests

  • CRISPR/Cas9システムを用いた誘導性遺伝子欠失マウス作製

Research Areas

  • Life Science / Molecular biology

  • Life Science / Cell biology

Education

  • Kagoshima University

    1989.4 - 1992.3

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    Country: Japan

Research History

  • Kagoshima University   Associate Professor

    2003.4

Professional Memberships

  • 日本分子生物学会

    2005.10

  • 日本癌学会

    1990.4

  • 日本生化学会

    1985.10

Studying abroad experiences

  • 1997.4 - 2000.3   Sanford Burnham Prebys medical discovery institute  

 

Papers

  • Haraguchi M, Fukushige T, Kanekura T, Ozawa M .  E-cadherin loss in RMG-1 cells inhibits cell migration and its regulation by Rho GTPases. .  Biochem Biophys Rep18   100650   2019.5E-cadherin loss in RMG-1 cells inhibits cell migration and its regulation by Rho GTPases.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrep.2019.100650.

  • Haraguchi M, Sato M, Ozawa M. .  1. CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells .  PLoS One   2015.71. CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) CellsReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0132260

  • Haraguchi M, Indo HP, Iwasaki Y, Iwashita Y, Fukushige T, Majima HJ, Izumo K, Horiuchi M, Kanekura T, Furukawa T, Ozawa M. .  Snail modulates cell metabolism in MDCK cells. .  Biochem Biophys Res Commun.432 ( 4 ) 618 - 625   2013.3Snail modulates cell metabolism in MDCK cells. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Kume K, Haraguchi M, Hijioka H, Ishida T, Miyawaki A, Nakamura N, Ozawa M. .  The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells. .  Biochem Biophys Res Commun.430 ( 3 ) 889 - 894   2013.1The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells. Reviewed

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  • Shimokawa M, Haraguchi M, Kobayashi W, Higashi Y, Matsushita S, Kawai K, Kanekura T, Ozawa M. .  The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. .  Biochem Biophys Res Commun.430 ( 3 ) 1078 - 1082   2013.1The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2.Reviewed

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  • Zhao HY, Ooyama A, Yamamoto M, Ikeda R. Haraguchi M, Tabata S, Furukawa T, Che XF, Iwashita K, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M, Akiyama S. .  Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells. .  Cancer Lett. 270 ( 1 ) 156 - 163   2008.10Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.Reviewed

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  • Zhao HY, Ooyama A, Yamamoto M, Ikeda R, Haraguchi M, Tabata S, Furukawa T, Che XF, Zhang S, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M, Akiyama S. .  Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. .  Cancer Res. 68 ( 17 ) 7035 - 7041   2008.9Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil.Reviewed

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  • Haraguchi M, Okubo T, Miyashita Y, Miyamoto Y, Hayashi M, Crotti TN, McHugh KP, Ozawa M 2008;283(35):23514-23 .  Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. .  J Biol Chem.283 ( 35 ) 23514 - 23523   2008.8Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. Reviewed

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  • Tachiwada T, Chen ZS, Che XF, Matsumoto M, Haraguchi M, Gotanda T, Sumizawa T, Furukawa T, Nishiyama K, Seki N, Yamamoto M, Nakagawa M, Akiyama S. .  Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells. .  Oncol Rep. 18 ( 3 ) 721 - 727   2007.9Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells. Reviewed

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  • Uto T.,Wang X.,Sato K.,Haraguchi M., Akagi T.,Akashi M.,馬場昌範(BABAMASANORI) .  Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity .  The Journal of Immunology178 ( 5 ) 2979 - 2986   2007.3Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunityReviewed

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  • Nakajima Y, Haraguchi M, Furukawa T, Yamamoto M, Nakanishi H, Tatematsu M, Akiyama S. .  2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9. .  Int J Cancer.119 ( 7 ) 1710 - 1716   2006.102-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9.Reviewed

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  • Zhang Y, Yasumoto Y, Ikeda T, Takenouchi S, Sogabe A, Nosaki T, Che X, Zheng C, Haraguchi M, Akiyama S, Tsubouchi H. .  Apolipoprotein E regulates primary cultured human mesangial cell proliferation. 2 .  Nephron Exp Nephrol102 ( 2 ) 62 - 70   2006.9Apolipoprotein E regulates primary cultured human mesangial cell proliferation. 2Reviewed

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  • Che XF, Zheng CL, Owatari S, Mutoh M, Gotanda T, Jeung HC, Furukawa T, Ikeda R, Yamamoto M, Haraguchi M, Arima N, Akiyama S. .  Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines. .  Blood105 ( 12 ) 4880 - 4887   2006.6Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines.Reviewed

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  • Gotanda T, *Haraguchi M, Tachiwada T, Shinkura R, Koriyama C, Akiba S, Kawahara M, Nishiyama K, Sumizawa T, Furukawa T, Mimata H, Nomura Y, Akiyama S, Nakagawa M. .  Molecular basis for the involvement of thymidine phosphorylase in cancer invasion. .  Int J Mol Med. 17 ( 6 ) 1085 - 1091   2006.6Molecular basis for the involvement of thymidine phosphorylase in cancer invasion. Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Shimamoto Y, Sumizawa T, Haraguchi M, Gotanda T, Jueng HC, Furukawa T, Sakata R, Akiyama S. .  Direct activation of the human major vault protein gene by DNA-damaging agents. 2006 15(3):645-52有り .  Oncol Rep. 15 ( 3 ) 645 - 652   2006.3Direct activation of the human major vault protein gene by DNA-damaging agents. 2006 15(3):645-52有りReviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Ikeda R, Che XF, Ushiyama M, Yamaguchi T, Okumura H, Nakajima Y, Takeda Y, Shibayama Y, Furukawa T, Yamamoto M, Haraguchi M, Sumizawa T, Yamada K, Akiyama S. .  2-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK. .  Biochem Biophys Res Commun.342 ( 1 ) 280 - 285   2006.32-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK. Reviewed

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  • Jeung HC, Che XF, Haraguchi M*, Zhao HY, Furukawa T, Gotanda T, Zheng CL, Tsuneyoshi K, Sumizawa T, Roh JK, Akiyama S. .  Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase .  FEBS Lett.580 ( 5 ) 1294 - 1302   2006.2Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase Reviewed

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  • Tsuneyoshi K, *Haraguchi M, Hongye Z, Gotanda T, Tachiwada T, Sumizawa T, Furukawa T, Baba M, Akiyama SI, Nakagawa M. .  Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity. .  Cancer Lett. 244 ( 2 ) 239 - 246   2006.2Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity. Reviewed

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  • Noguchi T, Ren XQ, Aoki S, Igarashi Y, Che XF, Nakajima Y, Takahashi H, Mitsuo R, Tsujikawa K, Sumizawa T, Haraguchi M, Kobayashi M, Goto S, Kanehisa M, Aikou T, Akiyama S, Furukawa T. .  MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 o .  Biochem.Pharmacol.70 ( 7 ) 1056 - 1065   2005.10MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 oReviewed

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  • Jeung HC, Che XF, Haraguchi M, Furukawa T, Zheng CL, Sumizawa T, Rha SY, Roh JK, Akiyama S. .  Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents. .  Biochem Pharmacol.70 ( 1 ) 13 - 21   2005.7Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents.Reviewed

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  • Ikeda R, Che XF, Yamaguchi T, Ushiyama M, Zheng CL, Okumura H, Takeda Y, Shibayama Y, Nakamura K, Jeung HC, Furukawa T, Sumizawa T, Haraguchi M, Akiyama S, Yamada K. .  Cepharanthine has potent enhancement of the sensitivity of anticancer agents in K562 cells. .  Cancer Sci.96 ( 6 ) 372 - 376   2005.6Cepharanthine has potent enhancement of the sensitivity of anticancer agents in K562 cells.Reviewed

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  • GSH inhibits trypsinization of the C-terminal half of human MRP1.Ren XQ, Furukawa T, Nakajima Y, Takahashi H, Aoki S, Sumizawa T, Haraguchi M, Kobayashi M, Chijiiwa K, Akiyama S. .  GSH suppresses a tryptic site in the C-terminal half human MRP1. .  J. Biol. Chem280 ( 7 ) 6231 - 6237   2005.2GSH suppresses a tryptic site in the C-terminal half human MRP1.Reviewed

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  • Zheng CL, Sumizawa T, Che XF, Tsuyama S, Furukawa T, Haraguchi M, Gao H, Gotanda T, Jueng HC, Murata F, Akiyama S. .  Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes. .  Biochem. Biophys. Res. Commun. 326 ( 1 ) 100 - 107   2005.1Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes.Reviewed

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  • Ren X.Q., Furukawa T., Haraguchi M., Sumizawa T., Aoki S., Kobayashi M., Akiyama S. .  Function of the ABC signature sequences in the human multidrug resistance protein 1. .  Mol. Pharmacol65 ( 6 ) 1536 - 1542   2004.6Function of the ABC signature sequences in the human multidrug resistance protein 1.Reviewed

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  • Mitsuo M, NoguchiT, Nakajima Y, Aoki S, Ren XO, Sumizawa T, Haraguchi M, Kobayashi M, Baba M, Nagata Y, Akiyama S, Furukawa T .  P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A. .  Oncol Res14   39 - 48   2003P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A.

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  • Ichikawa M, Yoshimura A, Sumizawa T, Shudo N, Kuwazuru Y, Furukawa T, Akiyama S. .  Interaction of organic chemicals with P-glycoprotein in the adrenal gland, kidney, and a multidrug-resistant KB cell. .  JOurnal of Biological Chemistry992 ( 3 ) 307 - 314   1992.3 Interaction of organic chemicals with P-glycoprotein in the adrenal gland, kidney, and a multidrug-resistant KB cell. Reviewed

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    Language:English   Publishing type:Doctoral thesis  

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MISC

  • The role of the transcriptional regulator snail in cell detachment, reattachment and migration. Reviewed

    Haraguchi,M

    Cell Adh Migr.   3 ( 3 )   259 - 263   2009.7

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • αカテニンとカドヘリン 細胞骨格と接着

    原口みさ子、小沢政之

    蛋白質核酸酵素   51 ( 6 )   636 - 641   2006.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • チミジンホスホリラーゼ がん分子標的治療 2005, 3(2), 32-39

    原口みさ子、中島融一、池田龍二、古川龍彦、住澤知之、秋山伸一

    メデイカルビュー社   3 ( 2 )   32 - 39   2005.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. Reviewed

    Akiyama S, Furukawa T, Sumizawa T, Takebayashi Y, Nakajima Y, Shimaoka S, Haraguchi M.

    Cancer Sci.   95 ( 11 )   851 - 857   2004.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Presentations

  • 原口みさ子、小沢政之   CRISPR/Cas9システムを用いたsnail欠失細胞の作製、および細胞内代謝における変化解析  

    日本生化学会  日本生化学会

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    Event date: 2014.12

    Language:Japanese  

    Venue:京都  

    国内学会

  • 原口みさ子、小澤政之   Snail, slug発現誘導による細胞内代謝変化  

    日本分子生物学会  日本分子生物学会

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    Event date: 2013.12

    Language:Japanese  

    Venue:神戸市  

    国内学会

  • 原口 みさ子、小澤政之   2012  

    日本生化学会  日本生化学会

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    Event date: 2012.12

    Language:Japanese  

    Venue:福岡市  

    国内学会

  • Misako Haraguchi, Masayuki Ozawa   Snail reduces oxydative phosphorylation in MDCK cells   International conference

    Keystone symposium  Keystone symposium

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    Event date: 2012.2

    Language:English  

    Venue:Banff Canada  

    国際学会

  • 原口みさ子 小沢政之   snailによる細胞内代謝調節機構  

    日本生化学会  日本生化学会

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    Event date: 2011.9

    Language:Japanese  

    Venue:京都  

    国内学会

  • 原口みさ子 小沢政之   Snail regulates cell Metabolism  

    日本生化学会  日本生化学会

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    Event date: 2010.12

    Language:Japanese  

    Venue:神戸市  

    国内学会

  • 原口みさ子 小沢政之   Snail modulates cell metabolism in MDCK cells  

    日本癌学会  日本癌学会

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    Event date: 2010.9

    Language:Japanese  

    Venue:大阪市  

    国内学会

  • 原口みさ子 小沢政之   Regulation of MDCK cell metabolism by transcription factor snail  

    日本生化学会  日本生化学会

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    Event date: 2009.10

    Language:Japanese  

    Venue:神戸市  

    国内学会

  • 原口みさ子 小沢政之   Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins  

    日本癌学会  日本癌学会

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    Event date: 2008.9

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • 原口みさ子、大久保議、宮下矢誉衣、小澤政之   転写因子スネイルはインテグリンや細胞外マトリックスタンパクの発現を調節することにより細胞と基質間の接着を制御する。  

    日本生化学会  日本生化学会

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    Event date: 2007.12

    Language:Japanese  

    Venue:横浜市  

    国内学会

  • 原口みさ子   チミジンホスホリラーゼ遺伝子の一塩基多型 (SNPs)とその酵素活性との関連日本癌学会総会  

    日本癌学会総会  日本癌学会総会

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    Event date: 2005.9

    Language:Japanese  

    Venue:札幌市  

    国内学会

  • 原口みさ子   チミジンホスホリラーゼの血管新生活性機構  

    がん分子標的治療研究会  がん分子標的治療研究会

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    Event date: 2004.5

    Language:Japanese  

    Venue:鹿児島市  

    国内学会

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