研究者詳細 - 三好　宣彰

論文 - 三好　宣彰

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Ishikawa T., Hifumi T., Kuramoto T., Kouzuma C., Kouzuma M., Sakanoue S., Hirano K., Moriwaki E., Miyoshi N., Miura N., Yamato O., Takahashi M. . Pancreatic lymphangioma and concurrent intestinal lymphangiectasia in a dog . Journal of Veterinary Internal Medicine40 ( 1 ) aalaf033 2026年1月査読

Ayami Yutsudo, Natsume Kurahara, Shigeki Yamano, Osamu Yamato, Noriaki Miyoshi, Tatsuro Hifumi, Akira Yabuki . High prevalence of renal amyloidosis in cats in an overcrowded colony. . J Vet Med Sci87 ( 11 ) 1216 - 1220 2025年11月査読

Yuki Uchimura, Juin Jia Sim, Shinji Hirano, Tatsuro Hifumi, Noriaki Miyoshi, Masashi Takahashi, Yasuyuki Endo . Detection of Felis catus papillomavirus-derived genes in squamous cell carcinoma tissues in cats in Japan . J Vet Med Sci87 ( 6 ) 626 - 633 2025年6月査読

Rashid MHO, Ezzikouri S, Soliman AM, Akter L, Momohara K, Hifumi T, Miyoshi N, Hishiki T, Abdel-Moneim AS, Kohara M, Tsukiyama-Kohara K . Drug repositioning: Identification of potent inhibitors of NS3 protease and NS5 RdRp for control of DENV infection. . Biomedicine & Pharmacotherapy187 118104 2025年4月査読国際共著

Apoptosis in kidney tissue of senior and geriatric cats with chronic kidney disease . J Vet Med Sci87 ( 3 ) 248 - 256 2025年3月査読

Md Haroon Or Rashid, Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Tatsuro Hifumi, Shintaro Ogawa, Noriaki Miyoshi, Yasuhito Tanaka, Kyoko Tsukiyama-Kohara . Adeno-associated virus 2 CRISPR/Cas9-mediated targeting of hepatitis B virus in tree shrews . Virus Research354 199550 2025年2月査読国際共著

Tatsuro HIFUMI, Yuki TANAKA, Kyoko TSUKIYAMA-KOHARA , Noriaki MIYOSHI . Phyllodes tumor in the mammary gland of a northern tree shrew (Tupaia belangeri) . J Vet Med Sci87 ( 4 ) 384 - 388 2025年2月査読

Shinji Hirano, Tatsuro Hifumi, Noriaki Miyoshi . Epidemiological analysis of mammary tumors in female dogs in Japan: A study based on Kyushu–Okinawa region . The Veterinary Journal310 2025年1月査読

Hiroyuki Tani, Tatsuro Hifumi, Keita Ito, Tomohide Kuramoto, Noriaki Miyoshi, Makoto Fujiki, Tomohiro Nakayama . A case report of feline mast cell tumour with intertumoral heterogeneity: Identification of secondary mutations c.998G>C and c.2383G>C in KIT after resistance to toceranib . Veterinary Medicine and Science10 ( 5 ) e70003 2024年8月査読

Tatsuro Hifumi, Yoshinori Inokuchi, Masashi Tsujio, Shogo Tanaka, Shinji Hirano, Noriaki Miyoshi . Bilateral hibernomas in the femoral regions of a dog. . Canadian Veterinary Journal 2024年4月査読

Natsume Kurahara, Ayami Yutsudo, Yu Furusawa, Osamu Yamato, Noriaki Miyoshi, Tatsuro Hifumi, Akira Yabuki . Immunohistochemical analysis of renal oxidative damage in senior and geriatric cats with chronic kidney disease. . Journal of Comparative Pathology207 14 - 17 2023年11月査読

Lipi Akter, Md Abul Hashem, Tofazzal Md Rakib, Md Haroon Or Rashid, Kazi Anowar Hossain, Rupaly Akhter, Masashi Utsunomiya, Bouchra Kitab, Tatsuro Hifumi, Noriaki Miyoshi, Fumie Maetani, Kyoko Tsukiyama‐Kohara . Investigation of koala retrovirus in captive koalas with pneumonia and comparative analysis of subtype distribution. . Archives of Virology168 298 2023年10月査読国際共著

Hui-Wen Chen, Yu-Chang Lai, Md Mahfuzur Rahman, Al Asmaul Husna, Md Nazmul Hasan, Hitoshi Hatai, Noriaki Miyoshi , Osamu Yamato, Naoki Miura. . NGS-identified miRNAs in canine mammary gland tumors show unexpected expression alterations in qPCR analysis. . in vivo36 ( 4 ) 1628 - 1636 2022年7月査読

Yoneshige R, Wada M, Honkawa Y, Miura N, Miyoshi N, Ando T . A clinical case of a subepiglottic cyst in a Japanese Black calf. . Journal of Veterinary Medical Science84 ( 7 ) 978 - 981 2022年7月査読

Hifumi T, Akioka K, Tanaka T, Miyoshi N. . Development of a loop-mediated isothermal amplification (LAMP) assay targeting the mitochondrial cytochrome b gene for the rapid detection of alveolar echinococcosis in hepatic nodules of horses. . Vet Parasitol299 109573 2021年11月査読

Furusawa Y, Takahashi M, Shima-Sawa M, Hatai H, Miyoshi N, Yamato O, Yabuki A . Immunocytochemical evaluation of epithelial–mesenchymal transition in epithelial tumors of dogs and cats. . Journal of Veterinary Medical Science83 ( 9 ) 1363 - 1368 2021年9月査読

YABUKI Akira, FURUSAWA Yu, MIYOSHI Noriaki, TANIGUCHI Kazuyuki, YAMATO Osamu . Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs . The Jounal of Veterinary Medical Science 2021年4月査読

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：公益社団法人日本獣医学会

<p>Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal nitric oxide synthase in the dysplastic kidneys of three young dogs. Renin-immunoreactivity, which occurs in the juxtaglomerular and tubular cells of dysplastic kidneys, did not differ from that in the normal kidneys of young dogs. Macula densa cells in the normal kidneys showed neuronal nitric oxide synthase -immunoreactivity, but those in the dysplastic kidneys showed no apparent signals. This observation may be correlated with the pathological mechanisms of renal failure in young dogs.</p>

DOI： 10.1292/jvms.21-0074

PubMed

CiNii Research

Tatsuro Hifumi, Tetsuya Tanaka, Emmanuel Pacia Hernandez, Kohei Akioka, Kaori Yamada, Yasutaka Imamura, Hitoshi Hatai, Noriaki Miyoshi . Relationship between hepatic grayish-white solid nodules in horses imported from Canada and larval Echinococcus multilocularis infection . The Canadian Veterinary Journal62 ( 3 ) 285 - 288 2021年3月査読

Hitoshi Hatai, Takashi Hatazoe, Haruka Seo, Teruaki Tozaki, Shingo Ishikawa, Noriaki Miyoshi, Kazuhiro Misumi, Seiji Hobo . Primary sinonasal malignant melanoma with systemic metastasis in a non-gray horse . Journal of Veterinary Diagnostic Investigation33 ( 2 ) 379 - 383 2021年3月査読

Mohammad Enamul Hoque Kayesh, Yutaka Amako, Md Abul Hashem, Shuko Murakami, Shintaro Ogawa, Naoki Yamamoto, Tatsuro Hifumi, Noriaki Miyoshi, Masaya Sugiyama, Yasuhito Tanaka, Masashi Mizokami, Michinori Kohara, Kyoko Tsukiyama-Kohara . Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA . Virus Research290 198191 2020年12月査読

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Virus Research

Chronic hepatitis B virus (HBV) infection constitutes a global health issue with limited current therapeutic efficacy owing to the persistence of viral episomal DNA (cccDNA). The CRISPR/Cas9 system, a newly developed, powerful tool for genome editing and potential gene therapy, requires efficient delivery of CRISPR components for successful therapeutic application. Here, we investigated the effects of lentiviral- or adeno-associated virus 2 (AAV2) vector-mediated delivery of 3 guide (g)RNAs/Cas9 selected from 16 gRNAs. These significantly suppressed HBV replication in cells, with WJ11/Cas9 exhibiting highest efficacy and chosen for in vivo study. AAV2/WJ11-Cas9 also significantly inhibited HBV replication and significantly reduced cccDNA in the tested cells. Moreover, AAV2/WJ11-Cas9 enhanced entecavir effects when used in combination, indicative of different modes of action. Notably, in humanized chimeric mice, AAV2/WJ11-Cas9 significantly suppressed HBcAg, HBsAg, and HBV DNA along with cccDNA in the liver tissues without significant cytotoxicity; accordingly, next generation sequencing data showed no significant genomic mutations. To our knowledge, this represents the first evaluation of the CRISPR/Cas9 system using an HBV natural infection mode. Therefore, WJ11/Cas9 delivered by comparatively safer AAV2 vectors may provide a new therapeutic strategy for eliminating HBV infection and serve as an effective platform for curing chronic HBV infection.

DOI： 10.1016/j.virusres.2020.198191

Scopus

PubMed

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