Faculty Profiles - ENDO Yasuyuki

Papers - ENDO Yasuyuki

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Fujimoto M., Takahashi M., Hifumi T., Yabuki A., Furusawa Y., Hatai H., Endo Y. . Cabot rings in a cat with myeloproliferative disease . Veterinary Clinical Pathology53 ( 2 ) 196 - 201 2024.6

Language：Japanese Publisher：Veterinary Clinical Pathology

A 6-year-old spayed female Scottish Fold cat presented with lethargy and anorexia. A complete blood cell count indicated severe anemia and mild thrombocytopenia. Examination of peripheral blood smears revealed marked changes in the erythroid lineage, including the presence of basophilic stippling and Howell-Jolly bodies as well as an increase in nucleated erythrocytes, polychromatophils, ovalocytes, and schistocytes. Additionally, some erythrocytes contained a ring or figure-eight shaped structure known as a Cabot ring, which were especially observed in polychromatophilic erythrocytes. Hemolytic diseases (Mycoplasma infection and IMHA) were diagnostically excluded, and the cat was treated through prednisolone administration, whole blood transfusion, and administration of vitamins (K2 and B12); however, the anemia progressively worsened. Cabot rings were observed until Day 22 and subsequently disappeared as the number of nucleated RBCs increased, and the erythrocyte lineage shifted to immature population. On Day 42, peripheral blood examination revealed further left shifting and appearance of many rubriblasts. The patient died at home on Day 43. Necropsy revealed neoplastic cells infiltrating the bone marrow and other organs, which were immunopositive to CD71 which is an erythroid lineage marker. In humans, Cabot rings have been observed in megaloblastic anemia, lead poisoning, myelodysplastic syndrome, and myelofibrosis; further, they are thought to be related to stressed bone marrow and dyserythropoiesis. This is the first case report of a cat with Cabot rings, which are suggestive of defects in erythroid lineage production.

DOI： 10.1111/vcp.13340

Scopus

PubMed

Shirozu T., Kayano M., Hirose F., Oshiro S., Nagamine T., Endo Y., Izawa M., Xuan X., Fukumoto S. . Serological survey of Toxoplasma gondii infection in endangered Iriomote cat (Prionailurus bengalensis iriomotensis) and simulation of the effect on population dynamics . European Journal of Wildlife Research69 ( 4 ) 2023.8

Language：Japanese Publisher：European Journal of Wildlife Research

The Iriomote cat (Prionailurus bengalensis iriomotensis) is an endangered leopard cat that inhabits only Iriomotejima Island, Japan. The number of Iriomote cats is estimated to be approximately 100–110 and has been almost stable but slightly decreased in the coastal lowland. Infectious diseases are one of the major concerns in the conservation of Iriomote cats. Toxoplasma gondii is a protozoan parasite that causes toxoplasmosis. Toxoplasmosis is fatal in immunocompromised hosts, especially kittens and cat fetuses. We investigated the seroprevalence of T. gondii in Iriomote cats. Based on seroprevalence data, we simulated the effect of T. gondii infection on the population dynamics of Iriomote cats. The seroprevalence of T. gondii in Iriomote cats was significantly higher than that in domestic cats and dogs. Furthermore, the seroprevalence of T. gondii in domestic cats was significantly higher on Iriomotejima Island than on Okinawajima Island. Our simulation demonstrated that T. gondii eradication may help increase the population of Iriomote cats by an average of 11.5 (23.1%) cats in 2120. Therefore, controlling T. gondii may be an effective strategy for the conservation of Iriomote cats.

DOI： 10.1007/s10344-023-01702-1

Scopus

Matsuu A., Hatai H., Hifumi T., Hamakubo E., Take M., Tanaka T., Momoi Y., Endo Y., Koyoshi A., Kamikubo Y., Kamatsuki R., Kurusu N., Tabata H., Matsuyama H., Yanaidani M., Kawabata M., Kawabata T. . Clinical and Pathological Findings in Fatal Cases of Severe Fever With Thrombocytopenia Syndrome With High Viremia in Cats . Topics in Companion Animal Medicine52 100756 2023.1

Language：Japanese Publisher：Topics in Companion Animal Medicine

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease caused by the SFTS virus (SFTSV). SFTSV causes severe symptoms both in humans and cats. In this study, we report the clinical and pathological findings of 4 fatal cases of cats with high SFTS viremia levels. These cats showed an acute onset of fever, leukopenia, thrombocytopenia, and increased serum amyloid A and pro-inflammatory cytokine levels. A high viral copy number was detected in the blood, oral swabs, rectal swabs, conjunctiva swabs, and urine. Histopathologically, necrotizing lymphadenitis, splenitis with lymphoblastoid cell proliferation, and hemophagocytosis were observed in all 4 cats. Immunohistochemistry revealed the presence of SFTSV antigen on lymphoblastoid B cells. SFTSV-RNA was detected in systemic tissues, including the brain. The present findings provide useful information for understanding the features of fatal SFTS in cats. To elucidate the mechanisms of severe progress of SFTS cats, as well as its role as a source of human infection, further research is needed.

DOI： 10.1016/j.tcam.2022.100756

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PubMed

Ichizawa S., Uenoyama R., Nakanishi N., Endo Y., Suka A., Izawa M., Miyazaki M. . A comparative profile of urinary scent signals of two endangered Japanese populations of leopard cat . Frontiers in Ecology and Evolution11 2023

Language：Japanese Publisher：Frontiers in Ecology and Evolution

Two subspecies of mainland leopard cats (Prionailurus bengalensis), Iriomote cats (Prionailurus bengalensis iriomotensis), and Tsushima leopard cats (Prionailurus bengalensis euptilurus), are small, endangered felids that are endemic to the Japanese islands, Iriomote-jima and Tsushima, respectively. Both subspecies have an estimated population size of only about 100 individuals each. Therefore, it is crucial to expand our understanding of these subspecies to successfully conserve them. While their morphology, anatomy, ecology, pathology, and genetics are well studied, little is known about their physiology regulated in subspecies-specific manners. This study characterized their urinary volatile and nonvolatile organic compounds, with which individuals express their physiological status and territorial ownership. We found significantly higher levels of 3-mercapto-3-methyl-1-butanol and its structural analogs, which are scent signals of domestic cats, in the urinary headspace of Iriomote cats than in that of Tsushima leopard cats. There were no differences in the urinary levels of felinine, an amino acid that acts as a precursor of 3-mercapto-3-methyl-1-butanol, suggesting the variation of catalytic activities for decomposing felinine to 3-mercapto-3-methyl-1-butanol between subspecies. Both subspecies exhibited physiological proteinuria due to the secretion of carboxylesterase 5A, also known as cauxin, for the production of felinine. In conclusion, while the two endangered Japanese subspecies of mainland leopard cats share similar genetic backgrounds, urinary contents of metabolites vary between the subspecies. We suggest that after the separation into two subspecies, the regulation of the metabolic pathway for 3-mercapto-3-methyl-1-butanol production likely evolved differently in each subspecies in response to their specific environments.

DOI： 10.3389/fevo.2023.1194611

Scopus

Takahashi K., Nango H., Ushijima M., Takashima M., Nakamoto M., Matsutomo T., Jikihara H., Arakawa N., Maki S., Yabuki A., Endo Y., Yamato O. . Therapeutic effect of aged garlic extract on gingivitis in dogs . Frontiers in Veterinary Science10 1277272 2023

Language：Japanese Publisher：Frontiers in Veterinary Science

Periodontal disease is one of the most common dental health problems in dogs. Clinical studies in humans have shown that aged garlic extract (AGE), which contains stable and water-soluble sulfur-containing bioactive compounds, improves the symptoms of periodontal diseases. Our previous study demonstrated that oral administration of AGE in healthy Beagle dogs at 90 mg/kg/day for 12 weeks had no adverse effects such as hemolytic anemia, which is well known to occur as a result of ingestion of Allium species, including onions and garlic, in dogs. However, the therapeutic potential of AGE in canine periodontal disease remains unclear. Accordingly, we investigated the therapeutic effects of AGE in Beagle dogs with mild gingivitis. Feeding 18 mg/kg/day of AGE for 8 weeks resulted in the improvement of gingival index score, level of volatile sulfur compounds in exhaled air, and enzyme activity of periodontal pathogens without any adverse effects on clinical signs and hematological and serum biochemical parameters. Moreover, AGE increased the concentration of salivary cathelicidin, an antimicrobial peptide that contributes to the oral innate immune response. These results suggest that AGE could be a potential therapeutic agent for canine gingivitis.

DOI： 10.3389/fvets.2023.1277272

Scopus

PubMed

Furusawa Y, Takahashi M, Iwanaga T, Yabuki A, Kano R, Hatai H, Sueno W, Endo Y, Momoi Y. . Systemic Inonotus sp. infection in a dog. . J Vet Med Sci 2020.5Systemic Inonotus sp. infection in a dog. Reviewed

Identification of Felis catus Gammaherpesvirus 1 in Tsushima Leopard Cats (Prionailurus bengalensis euptilurus) on Tsushima Island, Japan. . 10 ( 7 ) E378 2018.7Identification of Felis catus Gammaherpesvirus 1 in Tsushima Leopard Cats (Prionailurus bengalensis euptilurus) on Tsushima Island, Japan.Reviewed

Lai YC, Ushio N, Rahman MM, Katanoda Y, Ogihara K, Naya Y, Moriyama A, Iwanaga T, Saitoh Y, Sogawa T, Sunaga T, Momoi Y, Izumi H, Miyoshi N, Endo Y, Fujiki M, Kawaguchi H, Miura N. . Aberrant expression of microRNAs and the miR-1/MET pathway in canine hepatocellular carcinoma. . Veterinary Comparative Oncology 2018.1Aberrant expression of microRNAs and the miR-1/MET pathway in canine hepatocellular carcinoma.Reviewed

Tateno, M., Takahashi, M., Miyake, E., Nishigaki, K., Tsujimoto, H. and Endo, Y. . Molecular epidemiological study of gammaherpesvirus in domestic cats in Japan . Journal of Veterinary Medical Science 2017.8Molecular epidemiological study of gammaherpesvirus in domestic cats in JapanReviewed

Sato, S., Kabeya, H., Negishi, A., Tsujimoto, H., Nishigaki, K., Endo, Y. and Maruyama, S. . Molecular survey of Bartonella henselae and Bartonella clarridgeiae in pet cats across Japan by species-specific nested-PCR. . Epidemiology and Infection145 ( 13 ) 2694 - 2700 2017.8Molecular survey of Bartonella henselae and Bartonella clarridgeiae in pet cats across Japan by species-specific nested-PCR.

Yamazaki H, Miura N, Lai YC, Takahashi M, Goto-Koshino Y, Yasuyuki M, Nakaichi M, Tsujimoto H, Setoguchi A, Endo Y. . Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs. . J Vet Med Sci79 ( 7 ) 1225 - 1229 2017.7Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs.Reviewed

Lai, Y. C., Fujikawa, T., Maemura, T., Ando, T., Kitahara, G., Endo, Y., Yamato, O., Koiwa, M., Kubota, C. and Miura, N. . Inflammation-related microRNA expression level in the bovine milk is affected by mastitis . PLoS One12 ( 5 ) e0177182 2017.5Inflammation-related microRNA expression level in the bovine milk is affected by mastitisReviewed

Yamazaki H, Lai YC, Tateno M, Setoguchi A, Goto-Koshino Y, Endo Y, Nakaichi M, Tsujimoto H, Miura N. . Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic condition. . PLoS One12 ( 5 ) e0177305 2017.5Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic condition.Reviewed

Jikuya, M., Tateno, M., Takahashi, M. and Endo, Y. . The presence of tick-borne diseases in domestic dogs and cats living on Iriomote-jima and Tsushima islands . Journal of Veterinary Medical Science79 ( 6 ) 1086 - 1090 2017.5The presence of tick-borne diseases in domestic dogs and cats living on Iriomote-jima and Tsushima islandsReviewed

Masatani, T., Hayashi, K., Andoh, M., Tateno, T., Endo, Y., Asada, M., Kusakisako, K., Tanaka, T., Gokuden, M., Hozumi, N., Nakadohzono, F. and Matsuo, T. . Detection and molecular characterization of Babesia, Theileria, and Hepatozoon species in hard ticks collected from Kagoshima, the southern region in Japan . Ticks and Tick Borne Diseases8 ( 4 ) 581 - 587 2017.3Detection and molecular characterization of Babesia, Theileria, and Hepatozoon species in hard ticks collected from Kagoshima, the southern region in JapanReviewed

Miyake A, Watanabe S, Hiratsuka T, Ito J, Ngo MH, Makundi I, Kawasaki J, Endo Y, Tsujimoto H, Nishigaki K. . Novel feline leukemia virus interference group based on the env gene . Jounal of Virology90 ( 9 ) 4832 - 4837 2016.4Novel feline leukemia virus interference group based on the env geneReviewed

Masatani T, Yoshihara S, Matsubara A, Gotoh T, Takahashi H, Tanaka T, Andoh M, Endo Y, Matsuo T. . Dynamics of Theileria orientalis genotype population in cattle in a year-round grazing system . Acta Parasitologica 2016.3Dynamics of Theileria orientalis genotype population in cattle in a year-round grazing systemReviewed

Kawamura, M., Watanabe, S., Odahara, Y., Nakagawa, S., Endo, Y., Tsujimoto, H. and Nishigaki, K. . Genetic diversity in the feline leukemia virus gag gene . Virus Research2204 74 - 81 2015.6Genetic diversity in the feline leukemia virus gag geneReviewed

Tateno, M., Sunahara, A., Nakanishi, N., Izawa, M., Matsuo, T., Setoguchi, A. and Endo, Y. . Molecular survey of arthropod-borne pathogens in ticks obtained from Japanese wildcats . Ticks Tick Borne Dis6 281 - 289 2015.4Molecular survey of arthropod-borne pathogens in ticks obtained from Japanese wildcatsReviewed

Kubo, S., Tateno, M., Ichikawa, Y. and Endo, Y. . A molecular epidemiological survey of Babesia, Hepatozoon, Ehrlichia and Anaplasma infections of dogs in Japan . J Vet Med SciIn press 2015A molecular epidemiological survey of Babesia, Hepatozoon, Ehrlichia and Anaplasma infections of dogs in JapanReviewed

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Papers - ENDO Yasuyuki