Nagata R, Matsuura E, Nozuma S, Dozono M, Noguchi Y, Ando M, Hiramatsu Y, Kodama D, Tanaka M, Kubota R, Yamakuchi M, Higuchi Y, Sakiyama Y, Arata H, Higashi K, Hashiguchi T, Nakane S, Takashima H .  Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder. .  Frontiers in neurology14   1137958   2023Reviewed International journal

Satoshi Nozuma, Matsuura E, Tashiro Y, Nagata R, Ando M, Hiramatsu Y, Higuchi Y, Sakiyama Y, Hashiguchi A, Michizono K, Higashi K, Matsuzaki T, Kodama D, Tanaka M, Yamano Y, Moritoyo T, Kubota R, Takashima H .  Efficacy of l-Arginine treatment in patients with HTLV-1-associated neurological disease. .  Annals of clinical and translational neurology10 ( 2 ) 237 - 245   2022.12Reviewed International journal

Tashiro, Y., Matsuura, E., Sagara, Y., Nozuma, S., Kodama, D., Tanaka, M., Koriyama, C., Kubota, R., Takashima, H. .  High Prevalence of HTLV-1 Carriers among the Elderly Population in Kagoshima, a Highly Endemic Area in Japan .  AIDS Research and Human Retroviruses38 ( 5 ) 363 - 369   2022.5Reviewed International journal

Kodama D, Tanaka M, Matsuzaki T, Nozuma S, Matsuura E, Takashima H, Izumo S, Kubota R .  Anti-Human T-Cell Leukemia Virus Type 1 (HTLV-1) Antibody Assays in Cerebrospinal Fluid for the Diagnosis of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. .  Journal of Clinical Microbiology59 ( 5 )   2021.4Reviewed International journal

Satoshi Nozuma, Ryuji Kubota, Steven Jacobson .  Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis .  Journal of NeuroVirology26 ( 5 ) 652 - 663   2020.10Reviewed International coauthorship International journal

Kazu Okuma, Madoka Kuramitsu, Toshihiro Niwa, Tomokuni Taniguchi, Yumiko Masaki, Gohzoh Ueda, Chieko Matsumoto, Rieko Sobata, Yasuko Sagara, Hitomi Nakamura, Masahiro Satake, Kiyonori Miura, Naoki Fuchi, Hideaki Masuzaki, Akihiko Okayama, Kazumi Umeki, Yoshihisa Yamano, Tomoo Sato, Masako Iwanaga, Kaoru Uchimaru, Makoto Nakashima, Atae Utsunomiya, Ryuji Kubota, Kenji Ishitsuka, Hiroo Hasegawa, Daisuke Sasaki, Ki-Ryang Koh, Mai Taki, Kisato Nosaka, Masao Ogata, Isao Naruse, Noriaki Kaneko, Sara Okajima, Kenta Tezuka, Emi Ikebe, Sahoko Matsuoka, Kazuo Itabashi, Shigeru Saito, Toshiki Watanabe, Isao Hamaguchi .  Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan. .  Retrovirology17 ( 1 ) 26 - 26   2020.8Reviewed International journal

Daisuke Kodama, Masakazu Tanaka, Toshio Matsuzaki, Kimiko Izumo, Nobuaki Nakano, Eiji Matsuura, Mineki Saito, Masahiro Nagai, Masahisa Horiuchi, Atae Utsunomiya, Hiroshi Takashima, Ryuji Kubota, Shuji Izumo .  Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. .  PLoS neglected tropical diseases14 ( 7 ) e0008361 - 21   2020.7Reviewed International journal

Norihiro Takenouchi, Masakazu Tanaka, Teruaki Sato, Jinchun Yao, Jun ichi Fujisawa, Shuji Izumo, Ryuji Kubota, Eiji Matsuura .  Expression of TSLC1 in patients with HAM/TSP .  Journal of NeuroVirology26 ( 3 ) 404 - 414   2020.4Reviewed International journal

Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh KR, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Okayama A, Miura K, Satake M, Saito S, Itabashi K, Yamaguchi K, Kuroda M, Watanabe T, Okuma K, Hamaguchi I. .  Development of reference material with assigned value for human T-cell leukemia virus type 1 quantitative PCR in Japan .  Microbiology and Immunology62 ( 10 ) 673 - 676   2018.10Reviewed International journal

Gao H, Ye X, Cai R, Xu Q, Liang L, Izumo S, Xing HQ, Kubota R .  Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis. .  International Journal of Infectious Diseases8   1 - 3   2018.1Reviewed International coauthorship International journal

Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh KR, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Okayama A, Miura K, Satake M, Saito S, Itabashi K, Yamaguchi K, Kuroda M, Watanabe T, Okuma K, Hamaguchi I .  Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot analysis results. .  Journal of Clinical Microbiology55 ( 9 ) 2838 - 2849   2017.7Reviewed International journal

Kubota R. .  Pathogenesis of human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis .  Clinical and Experimental Neuroimmunology8 ( 2 ) 117 - 128   2017.5Invited Reviewed International journal

Nozuma S, Matsuura E､Kodama D, Tashiro Y, Matsuzaki T, Kubota R, Izumo S, Takashima H. .  Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis .  Retrovirology14 ( 1 ) 26   2017.4Reviewed International journal

Xing HQ, Zhang Y, Izumo K, Arishima S, Kubota R, Ye X, Xu Q, Mori K, Izumo S. .  Decrease of aquaporin-4 and excitatory amino acid transporter-2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV-associated neurocognitive disorders .  Neuropathology37 ( 1 ) 25 - 34   2017.2Reviewed International coauthorship International journal

Wang J, Zhang Y, Xu Q, Zheng H, Yin Y, Ye X, Qiu J, Zhang Z, Liu Y, Hao Y, Wang W, Mori K, Izumo S, Kubota R, Shao Y. .  Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells .  Oncotarget8 ( 11 ) 18082 - 18094   2017Reviewed International coauthorship International journal

Matsuura E, Nozuma S, Tashiro Y, Kubota R, Izumo S, Takashima H. .  HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression .  Journal of the Neurological Sciences371   112 - 116   2016.12Reviewed International journal

Kuramitsu M, Okuma K, Yamochi T, Sato T, Sasaki D, Hasegawa H, Umeki K, Kubota R, Sobata R, Matsumoto C, Kaneko N, Naruse I, Yamagishi M, Nakashima M, Momose H, Araki K, Mizukami T, Mizusawa S, Okada Y, Ochiai M, Utsunomiya A, Koh KR, Ogata M, Nosaka K, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Satake M, Okayama A, Mochizuki M, Izumo S, Saito S, Itabashi K, Kamihira S, Yamaguchi K, Watanabe T, Hamaguchi I. .  Standardization of quantitative PCR for human T-Cell leukemia virus type 1 in Japan: A collaborative study .  Journal of Clinical Microbiology53 ( 11 ) 3485 - 3491   2015.11Reviewed International journal

Kuramitsu M, Okuma K, Yamochi T, Sato T, Sasaki D, Hasegawa H, Umeki K, Kubota R, Sobata R, Matsumoto C, Kaneko N, Naruse I, Yamagishi M, Nakashima M, Momose H, Araki K, Mizukami T, Mizusawa S, Okada Y, Ochiai M, Utsunomiya A, Koh KR, Ogata M, Nosaka K .  Standardization of Quantitative PCR for Human T-cell Leukemia Virus Type 1 in Japan: A Collaborative Study. .  Journal of Clinical Microbiology.53 ( 11 ) 3485 - 3491   2015.11Standardization of Quantitative PCR for Human T-cell Leukemia Virus Type 1 in Japan: A Collaborative Study.Reviewed International journal

Matsuura E, Yoshimura A, Nozuma S, Higuchi I, Kubota R, Takashima H. .  Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP) .  BMC Neurology15 ( 1 ) 18   2015.2Reviewed International journal

Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S. .  Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis .  Journal of Neuropathology and Experimental Neurology74 ( 1 ) 2 - 14   2015.1Reviewed International journal

Nozuma S, Matsuura E, Matsuzaki T, Watanabe O, Kubota R, Izumo S, Takashima H. .  Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis .  PLoS ONE9 ( 5 ) e86144   2014.5Reviewed International journal

Kawabata T, Higashimoto I, Takashima H, Izumo S, Kubota R. .  Human T-lymphotropic virus type I (HTLV-I)-specific CD8+ cells accumulate in the lungs of patients infected with HTLV-I with pulmonary involvement .  Journal of Medical Virology84 ( 7 ) 1120 - 1127   2012.7Reviewed International journal

久保田龍二 .  HAMスペクトラム .  臨床神経学51 ( 11 ) 1044 - 1046   2011.12Invited

Kozako T, Yoshimitsu M, Akimoto M, White Y, Matsushita K, Soeda S, Shimeno H, Kubota R, Izumo S, Arima N. .  Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers with autoimmune disorders .  Human Immunology72 ( 11 ) 1001 - 1006   2011.11Reviewed International journal

Abdelbary NH, Abdullah HM, Matsuzaki T, Hayashi D, Tanaka Y, Takashima H, Izumo S, Kubota R. .  Reduced Tim-3 expression on human T-lymphotropic virus type I (HTLV-I) tax-specific cytotoxic T lymphocytes in HTLV-I infection .  Journal of Infectious Diseases203 ( 7 ) 948 - 959   2011.4Reviewed International journal

Kozako T, Akimoto M, Toji S, White Y, Suzuki S, Arima T, Suruga Y, Matsushita K, Shimeno H, Soeda S, Kubota R, Izumo S, Uozumi K, Arima N .  Target epitopes of HTLV-1 recognized by class I MHC-restricted cytotoxic T lymphocytes in patients with myelopathy and spastic paraparesis and infected patients with autoimmune disorders .  Journal of Medical Virology83 ( 3 ) 501 - 509   2011.3Reviewed International journal

Hazem M. Abdullah, Itsuro Higuchi, Ryuji Kubota, Eiji Matsuura, Akihiro Hashiguchi, Nashwa H. Abdelbary, Yukie Inamori, Hiroshi Takashima, Shuji Izumo .  Histopathological differences between human T-lymphotropic virus type 1-positive and human T-lymphotropic virus type 1-negative polymyositis .  Clinical and Experimental Neuroimmunology2 ( 1 ) 12 - 24   2011.1Reviewed International journal

Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T. .  Intra- and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays: A multi-center study .  Cancer Science101 ( 11 ) 2361 - 2367   2010.11Reviewed International journal

Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, Hasegawa D, Izumi T, Fujita H, Aratani S, Fujii R, Yagishita N, Kamijuku H, Kanekura T, Seino KI, Nishioka K, Nakajima T, Yamano Y. .  Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders .  Blood114 ( 15 ) 3208 - 3215   2009.11Reviewed International journal

Xing HQ, Hayakawa H, Izumo K, Kubota R, Gelpi E, Budka H, Izumo S. .  In vivo expression of proinflammatory cytokines in HIV encephalitis: An analysis of 11 autopsy cases: Original Article .  Neuropathology29 ( 4 ) 433 - 442   2009.8Reviewed International coauthorship International journal

Xing HQ, Hayakawa H, Gelpi E, Kubota R, Budka H, Izumo S. .  Reduced expression of excitatory amino acid transporter 2 and diffuse microglial activation in the cerebral cortex in AIDS cases with or without HIV encephalitis .  Journal of Neuropathology and Experimental Neurology68 ( 2 ) 199 - 209   2009.2Reviewed International coauthorship International journal

Hayashi D, Kubota R, Takenouchi N, Nakamura T, Umehara F, Arimura K, Izumo S, Osame M. .  Accumulation of human T-lymphotropic virus type I (HTLV-I)-infected cells in the cerebrospinal fluid during the exacerbation of HTLV-I - Associated myelopathy .  Journal of NeuroVirology14 ( 5 ) 459 - 463   2008.12Reviewed International journal

Hayashi D, Kubota R, Takenouchi N, Tanaka Y, Hirano R, Takashima H, Osame M, Izumo S, Arimura K. .  Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy .  Journal of Neuroimmunology200 ( 1-2 ) 115 - 124   2008.8Reviewed International journal

Xing HQ, Mori K, Sugimoto C, Ono F, Izumo K, Kubota R, Izumo S .  Impaired astrocytes and diffuse activation of microglia in the cerebral cortex in simian immunodeficiency virus-infected macaque without simian immunodeficiency virus encephalitis. .  Journal of Neuropathology and Experimental Neurology 67 ( 6 ) 600 - 611   2008.6Reviewed

Matsuura E, Umehara F, Nose H, Higuchi I, Matsuoka E, Izumi K, Kubota R, Saito M, Izumo S, Arimura K, Osame M. .  Inclusion body myositis associated with human T-lymphotropic virus-type I infection: Eleven patients from an endemic area in Japan .  Journal of Neuropathology and Experimental Neurology67 ( 1 ) 41 - 49   2008.1Reviewed International journal

Nose H, Kubota R, Seth NP, Goon PK, Tanaka Y, Izumo S, Usuku K, Ohara Y, Wucherpfennig KW, Bangham CRM, Osame M. Saito M. .  Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide .  Journal of Infectious Diseases196 ( 12 ) 1761 - 1772   2007.12Reviewed International coauthorship International journal

Obama K, Kubota R, Tara M, Furukawa Y. Osame M, Arimura K. .  Killer cell immunoglobulin-like receptor/3DL2 expression in adult T-cell leukaemia .  British Journal of Haematology138 ( 5 ) 666 - 667   2007.9Reviewed International journal

Kubota R, Hanada K, Furukawa Y, Arimura K, Osame M, Gojobori T, Izumo S. .  Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs .  Journal of Immunology178 ( 9 ) 5966 - 5972   2007.5Reviewed International journal

出雲周二、久保田龍二、Hui Qin Xing .  レトロウイルス感染と神経疾患 .  脳と神経58 ( 7 ) 595 - 604   2006.7レトロウイルス感染と神経疾患Invited

Izumo S., Kubota R., Xing H.Q. .  Retrovirus infection and neurological disorders .  No to shinkei. Brain and nerve58 ( 7 ) 595 - 604   2006.7Reviewed

Nose H, Saito M, Usuku K, Sabouri AH, Matsuzaki T, Kubota R, Eiraku N, Furukawa Y, Izumo S, Arimura K, Osame M. .  Clinical symptoms and the odds of human T-cell lymphotropic virus type 1- associated myelopathy/tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: Application of best-fit logistic regression equation based on host genotype, age, and provirus load .  Journal of NeuroVirology12 ( 3 ) 171 - 177   2006.6Reviewed International journal

Saito M, Nakagawa M, Kaseda S, Matsuzaki T, Jonosono M, Eiraku N, Kubota R, Takenouchi N, Nagai M, Furukawa Y, Usuku K, Izumo S, Osame M. .  Decreased Human T Lymphotropic Virus Type I (HTLV-I) Provirus Load and Alteration in T Cell Phenotype after Interferon-α Therapy for HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis .  Journal of Infectious Diseases189 ( 1 ) 29 - 40   2004.1Reviewed International journal

納光弘、宇宿功市郎、梅原藤雄、斉藤峰輝、古川良尚、久保田龍二、永井将弘、樋口逸郎、中川正法、有村公良、出雲周二 .  HAMの病態と治療 .  日本内科学会雑誌92 ( 9 ) 1673 - 82   2003.9HAMの病態と治療

Report on a pending question 5. Disease state and treatment of HAM. .  Nihon Naika Gakkai Kaishi92 ( 9 ) 1673 - 1682   2003.9International journal

Kubota R, Furukawa Y, Izumo S, Usuku K, Osame M. .  Degenerate specificity of HTLV-1-specific CD8+ T cells during viral replication in patients with HTLV-1-associated myelopathy (HAM/TSP) .  Blood101 ( 8 ) 3074 - 3081   2003.4Reviewed International journal

Furukawa Y, Kubota R, Eiraku N, Nakagawa M, Usuku K, Izumo S, Osame M. .  Human T-cell lymphotropic virus type I (HTLV-I)-related clinical and laboratory findings for HTLV-I-infected blood donors .  Journal of Acquired Immune Deficiency Syndromes32 ( 3 ) 328 - 334   2003.3Reviewed International journal

Matsuyama W, Kubota R, Hashiguchi T, Momi H, Kawabata M, Nakagawa M, Arimura K, Osame M. .  Purified protein derivative of tuberculin upregulates the expression of vascular endothelial growth factor in T lymphocytes in vitro .  Immunology106 ( 1 ) 96 - 101   2002.5Reviewed International journal

上原 明子 , 岡本 裕嗣 , 西垂水 和隆 , 宇都 正 , 久保田 龍二 , 城之園 学 , 榮樂 信隆 , 有村 公良 , 納 光弘 .  メチルプレドニゾロン超大量療法で中枢・末梢の伝導ブロックが改善したADEMの1例 .  臨床神経学42 ( 3 ) 237 - 9   2002.3メチルプレドニゾロン超大量療法で中枢・末梢の伝導ブロックが改善したADEMの1例Reviewed International journal

Kubota R, Soldan SS, Martin R, Jacobson S. .  Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient. .  Journal of NeuroVirology8 ( 1 ) 53 - 7   2002.2Reviewed International journal

Matsuyama W, Kubota R, Hamasaki T, Mizoguchi A, Iwami F, Wakimoto J, Kawabata M, Osame M. .  Enhanced inhibition of lymphocyte activation by Mycobacterium avium complex in human T lymphotrophic virus type I carriers .  Thorax56 ( 5 ) 394 - 397   2001.5Reviewed International journal

Furukawa Y, Kubota R, Tara M, Izumo S, Osame M. .  Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia .  Blood97 ( 4 ) 987 - 993   2001.2Reviewed International journal

Nagai M, Kubota R, Greten TF, Schneck JP, Leist TP, Jacobson S .  Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. .  Journal of Infectious Diseases183 ( 2 ) 197 - 205   2001.1Reviewed International journal

Kubota R, Nagai M, Kawanishi T, Osame S, Jacobson S .  Increased HTLV type 1 tax-specific CD8+ cells in HTLV type 1-associated myelopathy/tropical spastic paraparesis: Correlation with HTLV type 1 proviral load .  AIDS Research and Human Retroviruses16 ( 16 ) 1705 - 1709   2000.11Reviewed International journal

Kubota R, Soldan SS, Martin R, Jacobson S .  An altered peptide ligand antagonizes antigen-specific T cells of patients with human T lymphotropic virus type I-associated neurological disease .  Journal of Immunology164 ( 10 ) 5192 - 5198   2000.5Reviewed International journal

Miley WJ, Suryanarayana K, Manns A, Kubota R, Jacobson S, Lifson JD, Waters D .  Real-time polymerase chain reaction assay for HTLV type I DNA viral load cell-associated .  AIDS Research and Human Retroviruses16 ( 7 ) 665 - 675   2000.5Reviewed International journal

Kubota R, Kawanishi T, Matsubara H, Manns A, Jacobson S .  HTLV-I specific IFN-γ+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals .  Journal of Neuroimmunology102 ( 2 ) 208 - 215   2000.1Reviewed International journal

Abe M, Umehara F, Kubota R, Moritoyo T, Izumo S, Osame M .  Activation of macrophages/microglia with the calcium-binding proteins MRP14 and MRP8 is related to the lesional activities in the spinal cord of HTLV-I associated myelopathy .  Journal of Neurology246 ( 5 ) 358 - 364   1999.6Reviewed International journal

Lehky TJ, Levin MC, Kubota R, Bamford RN, Flerlage AN, Soldan SS, Leist TP, Xavier A, White JD, Brown M, Fleisher TA, Top LE, Light S, McFarland HF, Waldman TA, Jacobson S .  Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac .  Annals of Neurology44 ( 6 ) 942 - 947   1998.12Reviewed International journal

Shields MJ, Kubota R, Hodgson W, Jacobson S, Biddison WE, Ribaudo RK .  The effect of human β2-microglobulin on major histocompatibility complex I peptide loading and the engineering of a high affinity variant: Implications for peptide-based vaccines .  Journal of Biological Chemistry273 ( 43 ) 28010 - 28018   1998.10Reviewed International journal

Kubota R, Kawanishi T, Matsubara H, Manns A, Jacobson S .  Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection. .  Journal of immunology (Baltimore, Md. : 1950)161 ( 1 ) 482 - 8   1998.7Reviewed International journal

Greten TF, Slansky JE, Kubota R, Soldan SS, Jaffee EM, Leist TP, Pardoll DM, Jacobson S, Schneck JP .  Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19-specific CD8+ T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients .  Proceedings of the National Academy of Sciences of the United States of America95 ( 13 ) 7568 - 7573   1998.6Reviewed International journal

Biddison WE, Kubota R, Kawanishi T, Taub DD, Cruikshank WW, Center DM, Connor EW, Utz U, Jacobson S .  Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. .  Journal of immunology (Baltimore, Md. : 1950)159 ( 4 ) 2018 - 25   1997.8Reviewed International journal

Saiga A, Orita S, Ninoura-Tada N, Maeda M, Aono Y, Asakawa M, Nakahara K, Kubota R, Osame M, Igarashi H. .  cis-Acting inhibitory elements within the pol-env region of human T- cell leukemia virus type 1 possibly involved in viral persistence .  Journal of Virology71 ( 6 ) 4485 - 4494   1997.6Reviewed International journal

Izumo S, Umehara F, Kashio N, Kubota R, Sato E, Osame M .  Neuropathology of HTLV-1-associated myelopathy (HAM/TSP). .  Leukemia11 Suppl 3   82 - 4   1997.4Neuropathology of HTLV-1-associated myelopathy (HAM/TSP).Reviewed International journal

Umehara F, Kore-eda Y, Arime T, Kubota R, Arimura K, Osame M .  Chronic sensory ataxic neuropathy and ophthalmoplegia with oculomotor nerve hypertrophy associated with IgM antibodies against gangliosides containing disialosyl groups .  Journal of Neurology Neurosurgery and Psychiatry62 ( 6 ) 673 - 674   1997Reviewed International journal

Kubota R., Jacobson S. .  Immunopathogenesis of HAM/TSP: Involvement of HTLV-I specific CD8+ lymphocytes .  Journal of NeuroVirology3 ( SUPPL. 1 )   1997Reviewed International coauthorship International journal

Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M. .  Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence .  Journal of NeuroVirology2 ( 5 ) 330 - 335   1996.10Reviewed International journal

Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M .  Frequent mutation in pX region of HTLV-1 is observed in HAM/TSP patients, but is not specifically associated with the central nervous system lesions. .  Journal of NeuroVirology 1 ( 3-4 ) 286 - 294   1995.9Reviewed International journal

Furukawa Y, Osame M, Kubota R, Tara M, Yoshida M .  Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells. .  Blood85 ( 7 ) 1865 - 70   1995.4Reviewed International journal

Maroushek SR, Osame M, Izumo S, Kubota R, Sato E, Bartholomew C, Haase AT .  Sequence analysis of human T cell lymphotropic virus type I (HTLV-I) Env genes amplified from central nervous system tissues of patients with HTLV-I-associated myelopathy or leukemia .  Microbial Pathogenesis19 ( 5 ) 317 - 333   1995Reviewed International coauthorship International journal

Umehara F, Nakamura A, Izumo S, Kubota R, Ijichi S, Kashio N, Hashimoto K, Usuku K, Sato E, Osame M. .  Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I-associated myelopathy: A possible mechanism to control viral infection in the central nervous system .  Journal of Neuropathology and Experimental Neurology53 ( 6 ) 617 - 624   1994.11Reviewed International journal

Kubota R, Umehara F, Izumo S, Ijichi S, Matsumuro K, Yashiki S, Fujiyoshi T, Sonoda S, Osame M .  HTLV-I proviral DNA amount correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy .  Journal of Neuroimmunology53 ( 1 ) 23 - 29   1994.8Reviewed International journal

Yamagata H, Miki T, Sakoda S, Yamanaka N, Davies J, Shelbourne P, Nakagawa M, Takenaga S, Kubota R, Ogihara T, Johnson K. .  Detection of a premutation in Japanese myotonic dystrophy .  Human Molecular Genetics3 ( 5 ) 819 - 820   1994.5Reviewed

Orita S, Kobayashi H, Saiga A, Kubota R, Osame M, Igarashi H. .  A Spontaneous Point Mutation in the Human T-Cell Leukemia Virus Type 1 pX Gene Leads to Expression of a Novel Doubly Spliced pX-mRNA That Encodes a 25-kD, Amino-Terminal Deleted rex Protein .  DNA and Cell Biology13 ( 4 ) 353 - 364   1994.4Reviewed International journal

Ijichi S, Yuasa Y, Kubota R, Yoshiie K, Niina K, Oda H, Osame M. .  Lack of anti-coxiella burnetii seropositivity in patients with HTLV-I-associated myelopathy .  Neurology44 ( 3 )   1994.3Reviewed International journal

Ijichi S, Izumo S, Eiraku N, Machigashira K, Kubota R, Nagai M, Ikegami I, Kashio N, Umehara F, Maruyama I, Osame M. .  An autoaggressive process against bystander tissues in HTLV-I-infected individuals: A possible pathomechanism of HAM TSP .  Medical Hypotheses41 ( 6 ) 542 - 547   1993.12Reviewed International journal

Kuriyama M, Fujiyama J, Kubota R, Nakagawa M, Osame M .  Osteoporosis and increased bone fracture in cerebrotendinous xanthomatosis .  Metabolism42 ( 11 ) 1497 - 1498   1993.11Osteoporosis and increased bone fracture in cerebrotendinous xanthomatosisReviewed

Hashimoto K, Lalkaka JA, Fujisawa J, Singhal BS, Machigashira K, Kubota R, Suehara M, Osame M, Yoshida M. .  Limited Sequence Divergence of HTLV-I of Indian HAM/TSP Patients from a Prototype Japanese Isolate .  AIDS Research and Human Retroviruses9 ( 6 ) 495 - 498   1993.6Reviewed International coauthorship International journal

Ijichi S, Hall WW, Kubota R, Osame M. .  Lack of Evidence for HTLV-II Infection in Patients with HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in an Endemic Area .  AIDS Research and Human Retroviruses9 ( 5 ) 379 - 380   1993.5Reviewed International coauthorship

Kubota R, Fujiyoshi T, Izumo S, Yashiki S, Maruyama I, Osame M, Sonoda S. .  Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy .  Journal of Neuroimmunology42 ( 2 ) 147 - 154   1993.2Reviewed International journal

Singhal BS, Lalkaka JA, Sonoda S, Hashimoto K, Nomoto M, Kubota R, Osame M .  Human T-lymphotropic virus type I infections in Western India .  AIDS7 ( 1 ) 138 - 139   1993Reviewed International coauthorship International journal

久保田龍二、中川正法、中村昭範、納光弘. .  HAMに対するlymphocytapheresisの治療効果 .  臨床神経学32 ( 9 ) 984 - 988   1992.12Reviewed

Furukawa Y, Fujisawa J, Osame M, Toita M, Sonoda S, Kubota R, Ijichi S, Yoshida M .  Frequent clonal proliferation of human T-cell leukemia virus type 1 (HTLV-1)-infected T cells in HTLV-1-associated myelopathy (HAM-TSP). .  Blood80 ( 4 ) 1012 - 6   1992.8Reviewed International journal

Hokezu Y, Kuriyama M, Kubota R, Nakagawa M, Hujiyama J, Osame M. .  Cerebrotendinous xanthomatosis: cranial CT and MRI studies in eight patients .  Neuroradiology34 ( 4 ) 308 - 312   1992.7Reviewed International journal

久保田龍二、中川正法、中村昭範、栗山勝、納光弘 .  Cerebrotendinous xanthomatosisの1症例：頭部MRI異常および骨粗鬆症について .  臨床神経学32 ( 5 ) 488 - 93   1992.5Cerebrotendinous xanthomatosisの1症例：頭部MRI異常および骨粗鬆症についてReviewed

Kubota R., Nakagawa M., Nakamura A., Kuriyama M., Osame M. .  Cerebrotendinous xanthomatosis - A case with brain MRI abnormality and osteoporosis .  Clinical Neurology32 ( 5 ) 488 - 493   1992Reviewed

中川正法、久保田龍二、中村昭範、藤山二郎、末原雅人 .  著名な呼吸不全を呈したrigid spine症候群の一例 .  臨床神経学31 ( 9 ) 997 - 1001   1991.12Reviewed

M. Nakagawa, R. Kubota, S. Takenaga, A. Nakamura, M. Osame .  Nationwide survey of necrotizing myelopathy associated with malignancy, in Japan .  Clinical Neurology31 ( 5 ) 512 - 5   1991.5Nationwide survey of necrotizing myelopathy associated with malignancy, in JapanReviewed

Nakagawa M, Nakamura A, Kubota R, Kakazu T, Kuba M, Nakasone K, Iwamasa T. .  Necrotizing Myelopathy Associated with Malignancy Caused by Herpes Simplex Virus Type 2: Clinical Report of Two Cases and Literature Review. .  Japanese Journal of Medicine30 ( 2 ) 182 - 188   1991Reviewed International journal

Nakagawa M, Nakahara K, Yoshidome H, Suehara M, Higuchi I, Fujiyama J, Nakamura A, Kubota R, Takenaga S, Arahata K, Asano J, Osame M .  Epidemiology of progressive muscular dystrophy in okinawa, Japan: Classification with molecular biological techniques .  Neuroepidemiology10 ( 4 ) 185 - 191   1991Reviewed International journal

Nakagawa M., Kubota R., Takenaga S., Nakamura A., Osame M. .  Nationwide survey of necrotizing myelopathy associated with malignancy, in Japan .  Clinical Neurology31 ( 5 ) 512 - 515   1991Reviewed International journal

Ijichi S, Eiraku N, Osame M, Izumo S, Kubota R, Maruyama I, Matsumoto M, Niimura T, Sonoda S. .  Activated T lymphocytes in cerebrospinal fluid of patients with HTLV-I-associated myelopathy (HAM/TSP) .  Journal of Neuroimmunology25 ( 2-3 ) 251 - 254   1989.12Reviewed International journal

Ijichi S, Eiraku N, Osame M, Izumo S, Kubota R, Maruyama I, Matsumoto M, Sonoda S. .  In vitro modulation of lymphocyte proliferation by prednisolone and interferon-α in patients with HTLV-I-associated myelopathy (HAM) .  Journal of Neuroimmunology23 ( 2 ) 175 - 178   1989.7Reviewed International journal

Iwamasa T, Utsumi Y, Sakuda H, Yoshitake H, Kakazu T, Kubota R, Nakagawa M .  Two cases of necrotizing myelopathy associated with malignancy caused by herpes simplex virus type 2 .  Acta Neuropathologica78 ( 3 ) 252 - 257   1989.5Reviewed International journal

Kitajima I, Amitani H, Fukunaga H, Iwata S, Kubota R, Izumo S, Osame M. .  Two cases of male hypogonadal osteoporosis .  Journal of Bone and Mineral Metabolism7 ( 1 ) 42 - 48   1989.3Reviewed International journal

HTLV-1

久保田龍二（ Role： Sole author）

神経症候群I、日本臨床社  2013.1 

HAM

久保田龍二、納光弘（ Role： Joint author）

今日の診断基準,南江堂  2007.1 

HTLV-I

久保田龍二、納光弘（ Role： Joint author）

今日の診断基準,南江堂  2007.1 

HAM

久保田龍二,出雲周二（ Role： Joint author）

内科疾患診療マニュアル,中外医学社  2005 

Chapter 22 Retrovirus: HTLV-I associated diseases and immune dysfunction. In Effects of Microbes on the Immune System. International journal

Kubota R, Osame M, Jacobson S.（ Role： Joint author）

Lippincott Williams & Wilkins  2000 

Hypothetical pathogenesis of HAM/TSP: Occurrence of proliferative response of lymphocytes in the central nervous system. In HTLV-I and the Nervous System

Ijichi S, Eiraku N, Osame M, Izumo S, Kubota R, Maruyama I, Sonoda S（ Role： Joint author）

Alan R. Liss, Inc  1989 

Skin manifestations in HTLV-I-associated myelopathy (HAM): Xerosis and erythema. In HTLV-I and the Nervous System

Hashiguchi T, Osame M, Arimura K, Fujiyama J, Furukawa Y, Kubota R, Koreeda Y, Maruyama I, Matsumoto M, Tashiro M, Sato E（ Role： Joint author）

Alan R. Liss, Inc  1989 

HTLV-1関連脊髄症の初発症状と疾患進行速度に関する検討

眞弓芳子, 古園麻衣, 松元陸, 田代雄一, 山野嘉久, 児玉大介, 田中正和, 久保田龍二, 野妻智嗣, 松浦英治, 高嶋博

日本神経学会学術大会プログラム・抄録集   61st   2020

HTLV-1関連脊髄症における疾患特異的TCRレパトアの同定

野妻智嗣, 松浦英治, 田中正和, 久保田龍二, 高嶋博

Neuroimmunology   25 ( 1 )   2020

HPVワクチン関連疾患の臨床経過とワクチン接種後血液サイトカイン・自己抗体の検討

松浦英治, 荒田仁, 東桂子, 田中正和, 安藤匡宏, 平松有, 野妻智嗣, 田代雄一, 崎山佑介, 久保田龍二, 高嶋博

Neuroimmunology   25 ( 1 )   2020

HTLV-1関連脊髄症の初発症状は疾患進行の予測因子である。

松元陸, 眞弓芳子, 古園麻衣, 田代雄一, 松浦英治, 荒田仁, 山野嘉久, 田中正和, 久保田龍二, 高嶋博

Neuroinfection   24 ( 2 )   2019

HAM患者HTLV-1感染細胞のマイクロアレイ解析による治療標的分子の探索

久保田龍二, 田中正和, 春口志門, 児玉大介, 松浦英治, 高嶋博

日本HTLV-1学会学術集会   6th   2019

【HTLV-1関連脊髄症-病態解明と治療の最新情報】HAMの臨床像と発症病理

久保田 龍二

医学のあゆみ   267 ( 10 )   737 - 740   2018.12

HTLV-1関連細胞株と成人T細胞白血病ないしリンパ腫(ATL)に於けるサバイビンの抗原回復免疫組織化学

蓮井 和久, 佐藤 榮一, 宇都宮 與, 木脇 祐俊, 満田 稔, 斉藤 稔, 原 博満, 久保田 龍二, 出雲 周二

日本組織細胞化学会総会・学術集会講演プログラム・予稿集   59回   62 - 62   2018.9

成人T細胞白血病(ATL)の末梢血組織標本のSurvivinの抗原回復免疫組織化学による解析

蓮井 和久, 宇都宮 與, 佐藤 榮一, 原 博満, 木脇 祐俊, 満田 稔, 斉藤 稔, 久保田 龍二, 出雲 周二

日本病理学会会誌   107 ( 1 )   307 - 307   2018.4

HAMに対するアミノ酸内服治療の効果

松浦英治, 田代雄一, 荒田仁, 橋口昭大, 中村友紀, 野妻智嗣, 松崎敏男, 田中正和, 久保田龍二, 久保田龍二, 高嶋博

Neuroimmunology   23 ( 1 )   2018

HTLV-1関連脊髄症(HAM)患者の臨床経過における排尿障害の意義について

古園麻衣, 眞弓芳子, 樋口雄二郎, 野妻智嗣, 田代雄一, 中村友紀, 橋口昭大, 松浦英治, 兒玉大介, 田中正和, 久保田龍二, 高嶋博

日本神経学会学術大会プログラム・抄録集   59th   2018

HAM患者由来HTLV-1感染細胞のウイルス活性化によるToll様受容体の発現低下

久保田龍二, 児玉大介, 田中正和, 松浦英治, 高嶋博

日本HTLV-1学会学術集会   5th   2018

HAM患者に対するL-アルギニン内服治療の試み

田代雄一, 松浦英治, 橋口昭大, 中村友紀, 野妻智嗣, 松崎敏男, 兒玉大介, 田中正和, 久保田龍二, 高嶋博

日本神経学会学術大会プログラム・抄録集   59th   2018

HTLV‐1定量PCRの標準化のための参照品の作製

倉光球, 大隈和, 内丸薫, 山野嘉久, 長谷川寛雄, 野坂生郷, 岡山昭彦, 久保田龍二, 佐竹正博, 金子紀章, 渡邉俊樹, 浜口功

日本HTLV‐1学会学術集会   5th   56   2018

アルギニン塩酸塩を用いたHAM患者治療の試み

松浦英治, 田代雄一, 荒田仁, 崎山祐介, 中村友紀, 野妻智嗣, 松崎敏男, 兒玉大介, 橋口昭大, 岡本裕嗣, 田中正和, 久保田龍二, 高嶋博

Neuroinfection   23 ( 2 )   2018

神経疾患治療ノート　HTLV-1関連脊髄症(HAM)

松浦 英治, 久保田 龍二

Clinical Neuroscience   35 ( 12 )   1474 - 1475   2017.12

成人T細胞白血病(ATL)細胞のリンパ節での動態のSurvivinの抗原回復免疫組織化学による解析

蓮井 和久, 佐藤 榮一, 原 博満, 木脇 祐俊, 満田 稔, 斉藤 稔, 久保田 龍二, 出雲 周二

日本病理学会会誌   106 ( 1 )   355 - 355   2017.3

HTLV-1 complete genome analysis identified a risk subtype for HTLV-1-associated myelopathy/tropical spastic paraparesis and subtype-specific amino acid changes International journal

S. Nozuma, E. Matsuura, T. Matsuzaki, O. Watanabe, D. Kodama, R. Kubota, S. Izumo, H. Takashima

JOURNAL OF THE NEUROLOGICAL SCIENCES   357   E114 - E114   2015.10

Analysis of the association between the sex and disease courses of 132 consequent patients with HTLV-1-associated myelopathy/Tropic spastic paraparesis (HAM/TSP) International journal

Eiji Matsuura, Satoshi Nozuma, Ryuji Kubota, Shuji Izumo, Hiroshi Takashima

RETROVIROLOGY   12   2015.8

HTLV-1 infected CD4+T cells of HAM/TSP patients are susceptible to tunicamycin-induced endoplasmic reticulum stress International journal

Daisuke Kodama, Ryuji Kubota, Toshio Matsuzaki, Hiroshi Takashima, Shuji Izumo

RETROVIROLOGY   12   2015.8

HTLV‐1核酸検査の標準化および検出感度の検討:多施設共同研究

倉光球, 大隈和, 矢持忠徳, 山野嘉久, 長谷川寛雄, 上平憲, 岡山昭彦, 久保田龍二, 出雲周二, 成瀬功, 相良康子, 佐竹正博, 渡邉俊樹, 山口一成, 浜口功

日本HTLV‐1学会学術集会   2nd   28   2015

エクソーム解析によるHAM疾患感受性遺伝子の探索

野妻智嗣, 松浦英治, 久保田龍二, 児玉大介, 松崎敏男, 渡邊修, 三井純, 石浦浩之, 高橋祐二, 山野嘉久, 森下真一, 辻省次, 出雲周二, 高嶋博

日本神経学会学術大会プログラム・抄録集   54 ( Suppl. )   S153 - S153   2014.12

次世代シークエンサーを用いたHAM疾患感受性遺伝子の探索

野妻智嗣, 松浦英治, 久保田龍二, 児玉大介, 松崎敏男, 渡邊修, 三井純, 石浦浩之, 高橋祐二, 山野嘉久, 森下真一, 辻省次, 出雲周二, 高嶋博

Neuroinfection   19 ( 2 )   204 - 204   2014.8

HAMスペクトラム

久保田龍二

神経内科   77 ( 3 )   283 - 288   2012.9

HTLV-Iと筋炎

松浦英治、久保田龍二、樋口逸郎

Clinical Neuroscience   30 ( 3 )   322 - 323   2012.3

HAMスペクトラム

久保田龍二

臨床神経学   51   1044 - 1046   2011.11

Neural Bystander Damage by Infiltrating Virus-Infected T Cells and the Cytotoxic T Lymphocytes in HTLV-I-Associated Neurological Disease International journal

Eiji Matsuura, Ryuji Kubota, Yuetsu Tanaka, Hiroshi Takashima, Shuji Izumo

NEUROLOGY   76 ( 9 )   A433 - A433   2011.3

A role of astrocyte dysfunction in pathogenesis of AIDS encephalopathy International coauthorship International journal

S. Izumo, H. Xing, H. Hayakawa, K. Mori, S. Arishima, R. Kubota, E. Gelpi, H. Budka

BRAIN PATHOLOGY   20   80 - 80   2010.9

HTLV-1 associated polymyositis: a trial to unfold the story International journal

H. M. Abdullah, Higuchi, I, R. Kubota, E. Matsuura, A. Hashiguchi, N. H. Abdelbary, Y. Inamori, S. Izumo

BRAIN PATHOLOGY   20   93 - 94   2010.9

Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic T lymphocytes in HTLV-I-associated neurological disease International journal

R. Kubota, E. Matsuura, S. Izumo

BRAIN PATHOLOGY   20   79 - 79   2010.9

Invariant NKT Cells have Anti-Human T-Lymphotropic Virus Type-1 (HTLV-1) Activity and the Frequency is Significantly Decreased in Patients with HTLV-1 Associated Disorders International journal

Y. Yamano, A. Utsunomiya, K. Takahashi, K. Azakami, K. Seino, K. Nishioka, N. Araya, R. Kubota, T. Sato, T. Nakajima

AIDS RESEARCH AND HUMAN RETROVIRUSES   25 ( 11 )   1202 - 1202   2009.11

Target Epitopes of Human T Lymphotropic Virus 1 Recognized by Class I MHC-Restricted Cytotoxic T Lymphocytes in HAM/TSP Patients and Infected Patients with Autoimmune Disorders International journal

Tomohiro Kozako, Masaki Akimoto, Yohann White, Shingo Toji, Kakushi Matsushita, Ryuji Kubota, Shuji Izumo, Shinsuke Suzuki, Kimiharu Uozumi, Hiroshi Shimeno, Shinji Soeda, Naomichi Arima

BLOOD   114 ( 22 )   1043 - 1043   2009.11

Bystander damage of the central nervous system by HTLV-I-specific CTL with target cell infiltration in HAM/TSP International journal

Eiji Matsuura, Ryuji Kubota, Mineki Saito, Masato Suehara, Toshio Matsuzaki, Kimiyoshi Arimura, Mitsuhiro Osame, Shuji Izumo

AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   596 - 596   2007.4

HLA-A*2402 determines a risk of HAM/TSP independently from the HTLV-I proviral load International journal

Norihiro Takenouchi, Ryuji Kubota, Toshio Matsuzaki, Yoshitaka Furukawa, Shuji Izumo, Kimiyoshi Arimura, Mitsuhiro Osame

AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   644 - 644   2007.4

High expression of CD28 costimulatory molecule and low expression of CTLA4 inhibitory molecule on CD4(+) CD25(+) T cells in HTLV-I-associated myelopathy (HAM/TSP) International journal

Yoshihisa Yamano, Ryuji Kubota, Kimiyoshi Arimura, Shuji Izumo, Shoichi Ozaki, Kusuki Nishioka, Mitsuhiro Osame, Toshihiro Nakajima

AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   611 - 611   2007.4

Genetic stability of HTLV-I despite antiviral pressures by cytotoxic T lymphocytes

Ryuji Kubota, Yoshitaka Furukawa, Kimiyoshi Arimura, Mitsuhiro Osame, Shuji Izumo

AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   612 - 613   2007.4

In vivo selection of human T cell lymphotropic virus type-1-specific CD4(+) cells by disease susceptive class II allele and immunodominant peptide complex in HTLV-1-associated neurological disease International coauthorship International journal

Hirohisa Nose, Koichiro Usuku, Ryuji Kubota, Shuji Izumo, Kimiyoshi Arimura, Charles Bangham, Mitsuhiro Osame, Mineki Saito

AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   634 - 634   2007.4

Role of glial cells in central nervous system injury of human retroviral infection International journal

HuiQin Xing, Ryuji Kubota, Hitoshi Hayakawa, Shuji Izumo

AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   648 - 648   2007.4

Increased CMV-specific CTL associated with decreased expression of Foxp3 in HAM/TSP International journal

Daisuke Hayashi, Ryuji Kubota, Hirohisa Nose, Kimiyoshi Arimura, Shuji Izumo, Mitsuhiro Osame

AIDS RESEARCH AND HUMAN RETROVIRUSES   23 ( 4 )   615 - 615   2007.4

HTLV-I-specific CTL with high TCR degeneracy efficiently recognize naturally occurring mutant viruses in patients with HAM TSP International journal

R. Kubota, K. Arimura, M. Osame, S. Izumo

JOURNAL OF NEUROIMMUNOLOGY   178   256 - 256   2006.9

In vivo selection of T-cell receptor junctional region sequences by HLA-DRB1*0101 human T-cell lymphotropic virus type 1 (HTLV-1) envelope gp21 peptide complexes in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) International journal

H. Nose, M. Saito, A. H. Sabouri, K. Usuku, R. Kubota, S. Izumo, K. Arimura, M. Osame

JOURNAL OF NEUROIMMUNOLOGY   178   72 - 72   2006.9

Visualization of HTLV-I Tax-specific cytotoxic T lymphocytes in the central nervous system of HTLV-I-associated myelopathy International journal

E. Matsuura, R. Kubota, M. Saito, M. Suehara, T. Matsuzaki, K. Arimura, M. Osame, S. Izumo

JOURNAL OF NEUROIMMUNOLOGY   178   257 - 257   2006.9

Increased CTL responses to CMV in HAM/TSP patients: A relation of FOXP3(+) regulatory T cells

D. Hayashi, R. Kubota, H. Nose, K. Arimura, S. Izumo, M. Osame

JOURNAL OF NEUROIMMUNOLOGY   178   256 - 257   2006.9

レトロウイルス感染と神経疾患

出雲周二、久保田龍二、Hui Qin Xing

脳と神経   58   595 - 604   2006.1

ウイルスおよび細菌感染症の多発性硬化症への関わり

久保田龍二,出雲周二

神経研究の進歩,医学書院   50 ( 4 )   503 - 515   2006

Comparison of clinical symptoms and the odds for predicting Htlv-1 associated myelopathy/tropical spastic paraparesis (Ham/Tsp) in healthy virus carriers: Application of best-fit logistic regression equation based on the genotype, age, and provirus load. International journal

H Nose, M Saito, K Usuku, T Matsuzaki, S Izumo, R Kubota, Y Furukawa, K Arimura, M Osame

AIDS RESEARCH AND HUMAN RETROVIRUSES   21 ( 5 )   464 - 464   2005.5

Degeneracy of HTLV-I-specific Ctl inversely correlates with proviral load in patients with Ham/Tsp International journal

R Kubota, M Osame, S Izumo

AIDS RESEARCH AND HUMAN RETROVIRUSES   21 ( 5 )   451 - 452   2005.5

多発性硬化症の診断基準

久保田龍二,納光弘

Clinical Neuroscience,中外医学社   22 ( 7 )   804 - 805   2004.1

Mutations in HTLV-I Tax 11-19 epitope and mutant virus-specific T cells in patients with HAM/TSP. International journal

R Kubota, Y Furukawa, S Izumo, M Osame

AIDS RESEARCH AND HUMAN RETROVIRUSES   19   S42 - S42   2003

A patient of ADEM with central and peripheral conduction block improved with ultra-high-dose methylprednisolone

UEHARA Akiko, OKAMOTO Yuhji, NISHITARUMIZU Kazutaka, UTO Tadashi, KUBOTA Ryuhji, JOHNOSONO Manabu, EIRAKU Nobutaka, ARIMURA Kimiyoshi, OSAME Mitsuhiro

42 ( 3 )   237 - 239   2002.3

Diversity of HTLV-I-specific CTL and proviral load in patients with HAM International coauthorship International journal

R Kubota, Y Furukawa, S Izumo, K Usuku, S Jacobson, M Osame

AIDS RESEARCH AND HUMAN RETROVIRUSES   17   S61 - S61   2001

Existence of escape mutant in HTLV-1 Tax during the development of adult T-cell leukemia International journal

Y Furukawa, R Kubota, M Tara, S Izumo, M Osame

AIDS RESEARCH AND HUMAN RETROVIRUSES   17   S61 - S61   2001

Pathogenesis of HTLV-1-associated inflammatory disorders International journal

S Izumo, N Takenouchi, T Moritoyo, R Kubota, M Osame

AIDS RESEARCH AND HUMAN RETROVIRUSES   17   S18 - S18   2001

Differentiated HTLV-I Tax-specific CD8+cells correlate with the proviral load in HAM/TSP patients International coauthorship International journal

R Kubota, M Nagai, M Osame, S Jacobson

LEUKEMIA   14 ( 3 )   546 - 546   2000.3

Immunopathogenesis of HAM/TSP: Involvement of HTLV-I specific CD8+ lymphocytes Invited International coauthorship International journal

Kubota R, Jacobson S

3 ( SUPPL. 1 )   1997

HIGHLY FREQUENT AND RANDOM MUTATIONS OF HTLV-1 PROVIRAL GENOME WITHIN INDIVIDUALS OF HAM/TSP PATIENTS AND ASYMPTOMATIC CARRIERS International journal

M SAITOL, Y FURUKAWA, R KUBOTA, K USUKU, S SONODA, S IZUMO, M OSAME, M YOSHIDA

AIDS RESEARCH AND HUMAN RETROVIRUSES   11   S141 - S141   1995

Tanaka M, Kodama D, Matsuura E, Takashima H, Izumo S, Kubota R.   Effect of neuraminidase inhibitors on HTLV-1 infection and lymphocyte chemotaxis in HAM/TSP.   International conference

19th International Conference on Human Retrovirology: HTLV & Related Viruses 

Kubota R   HAM: the intractable neurological disease caused by HTLV-1.   Invited International conference

3rd Precision Medicine Conference in Fujian 

久保田龍二   HTLV-1で起こる神経難病：HAM  

日本学術会議九州・沖縄地区会議学術講演会 

久保田龍二、児玉大介、田中正和、松浦英治、高嶋　博   HAM患者由来HTLV-1感染細胞のウイルス活性化によるToll様受容体の発現低下  

第5回日本HTLV-1学会学術集会 

Kubota R:   What is HTLV-1? Seminar in Taipei Blood Center, TBSF, Tapiei, Taiwan   Invited

Seminar in Taipei Blood Center, TBSF, Tapiei, Taiwan 

久保田龍二、児玉大介、田中正和、高嶋　博   HTLV-1 reduces the expression of Toll-like receptor genes in HAM/TSP patients.  

第59回日本神経学会学術大会 

Kubota R   HTLV-1-specific inflammation in the spinal cord of HAM.   Invited International conference

Recent Advances in HTLV-1 Research 

Kodama D, Matsuzaki T, Takashima H, Kubota R, IzumoS   Comparison of anti-HTLV-1 antibody screening tests of CLIA, CLEIA, and PA by ROC analysis using titers and logistic regression models for diagnosis of HAM/TSP.   International conference

XXIII World Congress of Neurology 

Kubota R, Kodama D, Takashima H   Differential Expression of Nucleosome-Related Genes in Activated HTLV-1-Infected Cells of HAM/TSP Patients.   International conference

XXIII World Congress of Neurology 

Kubota R   HAM/TSP: clinical features and pathogenesis.   Invited International conference

2nd Precision Medicine Conference in Fujian 

Kubota R, Kodama D, Takashima H   Gene Expression Profile of Activated HTLV-1-Infected Cells from HAM/TSP Patients.   International conference

18th International Conference on Human Retrovirology: HTLV & Related Viruses, 

久保田龍二、高嶋　博   HAM患者HTLV-1感染細胞のウイルス活性化時の遺伝子変動  

第3回日本HTLV-1学会学術集会 

Kubota R   HAM/TSP: clinical features and pathogenesis   Invited International conference

Precision Medicine Conference in Fujian 

久保田龍二、高嶋　博、出雲周二   Gene expression profile of activated HTLV-1-infected cells from HAM patients  

第57回日本神経学会学術大会 

Kubota R   HAM/TSP: clinical features and pathogenesis.   Invited International conference

4th Cross-Strait Neurology Forum. Xiamen 

久保田龍二、高嶋　博、出雲周二   HAM患者末梢血中HTLV-1感染細胞特異的細胞表面分子の探索  

第27回日本神経免疫学会学術集会 

久保田龍二、高嶋　博、出雲周二   マイクロアレイ解析によるHAM末梢血HTLV-1感染細胞特異的細胞表面分子の探索  

第56回日本神経学会学術大会 

松浦英治、野妻智嗣、松﨑敏男、渡邊修、久保田龍二、出雲周二、高嶋 博   過去10年間に当科に入院した連続HAM患者の筋力低下パターン  

第19回日本神経感染症学会学術集会 

児玉大介、久保田龍二、松﨑敏男、高嶋 博、出雲周二   HAM患者CD4+T細胞表面のN-アセチルラクトサミン－ガレクチン-3格子は細胞外ウイルス会合体かもしれない  

第19回日本神経感染症学会学術集会 

野妻智嗣、松浦英治、久保田龍二、児玉大介、松﨑敏男、渡邊修、三井 純、石浦浩之、高橋祐二、山野嘉久、森下真一、辻省次、出雲周二、高嶋 博   次世代シークエンサーを用いたHAM疾患感受性遺伝子の探索  

第19回日本神経感染症学会学術集会 

久保田龍二、松﨑敏男、高嶋 博、出雲周二   HTLV-1 HBZ特異的CTLのエピトープ同定とHAMにおける検出  

第19回日本神経感染症学会学術集会 

久保田龍二、齊藤峰輝、高嶋 博、出雲周二   HAMにおけるHTLV-1抗原遺伝子変異とCTL認識  

第1回日本HTLV-1学会学術集会 

野妻智嗣、松浦英治、松﨑敏男、渡邊修、久保田龍二、出雲周二、高嶋 博   エクソーム解析によるHAM疾患感受性遺伝子の探索  

第55回日本神経学会総会 

久保田龍二、松﨑敏男、高嶋 博、出雲周二   HAMにおけるHTLV-1 HBZ特異的CTLの検出  

第55回日本神経学会総会 

児玉大介、出雲公子、久保田龍二、松﨑敏男、高嶋 博、出雲周二   HAM/TSPのCD4+T細胞における特異的糖鎖の探索  

第18回日本神経感染症学会総会 

野妻智嗣、松浦英治、松﨑敏男、渡邊修、久保田龍二、出雲周二、高嶋 博   家族性HAMの臨床的解析  

第6回HTLV-I研究会 

松崎敏男、久保田龍二、斉藤峰輝、高嶋 博、出雲周二   神経内科における13年間のHTLV-1キャリア外来の実態  

第6回HTLV-I研究会 

児玉大介、出雲公子、久保田龍二、松﨑敏男、高嶋 博、出雲周二   HAM/TSPのCD4+T細胞における糖鎖の特徴  

第6回HTLV-I研究会 

久保田龍二、高嶋 博、出雲周二   HTLV-1 HBZ特異的CTLエピトープの探索  

第6回HTLV-I研究会 

Matsuzaki T, Kubota R, Takashima H, Izumo S   Early diagnosis of HTLV-1-associated myelopathy (HAM/TSP) in HTLV-1 carrier clinic.   International conference

16th International Conference on Human Retrovirology: HTLV & Related Viruses 

Matsuura E, Nozuma S, Matsuzaki T, Watanabe O, Kubota R, Izumo S, Takashima H   Inflammation with HTLV-1-specific CTLs occurs in the spinal cord of HTLV-1 carriers and the brain of the patients with HAM/TSP.   International conference

16th International Conference on Human Retrovirology: HTLV & Related Viruses 

Nozuma S, Matsuura E, Matsuzaki T , Watanabe O, Kubota R, Izumo S, Takashima H   Clinical features of familial HTLV-I-associated myelopathy/tropical spastic paraparesis.   International conference

16th International Conference on Human Retrovirology: HTLV & Related Viruses 

Kodama D, Izumo K, Kubota R, Matsuzaki T, Takashima H, Izumo S   Characterization of glycans of CD4+T cells in HAM/TSP.   International conference

16th International Conference on Human Retrovirology: HTLV & Related Viruses 

Kubota R, Takashima H, Izumo S   Impaired T cell receptor signaling in HTLV-1-infected CD4+ cells from HAM/TSP patients.   International conference

16th International Conference on Human Retrovirology: HTLV & Related Viruses 

久保田龍二、高嶋 博、出雲周二   HAM患者HTLV-1感染CD4+T細胞における免疫能低下  

第54回日本神経学会学術大会 

久保田龍二、高嶋 博、出雲周二   HAM患者HTLV-1感染細胞における免疫反応低下  

第17回日本神経感染症学会総会 

児玉大介、久保田龍二、出雲周二   オミクス解析手法を用いたHAM病態の検討と治療標的候補遺伝子の探索  

第17回日本神経感染症学会総会 

松浦英治、久保田龍二、出雲周二、高嶋 博   HAM/TSP患者脊髄・大脳およびHTLV-1キャリア脊髄におけるHLTV-1ウイルス特異的細胞障害性T細胞の検出  

第17回日本神経感染症学会総会 

久保田龍二、有島志保、松崎敏男、高嶋 博、出雲周二   HTLV-I特異的CTL機能はHAMとキャリアで異なるのか？  

第24回日本神経免疫学会 

久保田龍二、竹之内徳博、松崎敏男、高嶋 博、出雲周二   HLA-A*24拘束性HTLV-I特異的CTLはHAM発症リスクを下げるか？  

第21回日本組織適合性学会大会 

松浦英治、久保田龍二、高嶋 博   HTLV-1特異的細胞障害性T細胞が関与する病態に関する検討（HAM患者の大脳・HTLV-1 carrierの脊髄の検討）  

第24回日本神経免疫学会 

久保田龍二、有島志保、松崎敏男、高嶋 博、出雲周二   HAMとキャリアにおけるHTLV-I特異的CTL機能の比較  

第5回HTLV-I研究会 

松崎敏男、久保田龍二、斎藤峰輝、吉村 玲、高嶋 博、出雲周二   HAMからみたATLの臨床  

第5回HTLV-I研究会 

松浦英治、久保田龍二、高嶋 博   HAMおよびHTLV-1キャリアの中枢神経におけるHTLV-1特異的細胞障害性T細胞の分布  

第5回HTLV-I研究会 

久保田龍二、有島志保、松崎敏男、高嶋 博、出雲周二   HAMとキャリアにおけるHTLV-I特異的CTL機能の比較検討  

第53回日本神経学会総会 

松崎敏男、久保田龍二、斎藤峰輝、高嶋 博、出雲周二   早期HAMの診断基準提唱と臨床  

第53回日本神経学会総会 

松浦英治、久保田龍二、高嶋 博   HTLV-1キャリアーの脊髄にHTLV-1特異的細胞障害性T細胞は浸潤している  

第53回日本神経学会総会 

Matsuura E, Watanabe O, Takashima H, Kubota R, Izumo S   HTLV-1-specific cytotoxic T cell migration in the cerebrum of the patients with HAM/TSP.   International conference

13th Asian Oceanian Congress of Neurology 

久保田龍二、Abdelbary NH、松崎敏男、林 大輔、高嶋 博、出雲周二   HAMにおけるT細胞疲労関連分子Tim-3発現の低下  

第16回日本神経感染症学会 

久保田龍二   HTLV-I撲滅に向けての最新情報と今後の展望   Invited

第44回中国四国医学検査学会 

児玉大介、久保田龍二、出雲 周二   HTLV-1関連脊髄症（HAM/TSP）のパスウェイ解析  

第4回HTLV-I研究会 

久保田龍二、竹之内徳博、松崎敏男、高嶋 博、出雲周二   HLA-A24拘束性CTLはウイルス量を減少させるがHAM発症リスクを上げる  

第4回HTLV-I研究会 

久保田龍二、竹之内徳博、松崎敏男、高嶋 博、出雲周二   HLA-A*24拘束性HTLV-I特異的CTLはHAM発症リスクを下げるか？  

第23回日本神経免疫学会 

Kodama D, Kubota R, Izumo S   Pathway analysis of HAM/TSP.   International conference

25th Symposium of the International Association for Comparative Reseach on Leukemia and Related Diseases 

Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S   Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic lymphocytes in HTLV-I-associated neurological disease.   International conference

15th International Conference on Human Retrovirology: HTLV & Related Viruses 

Kodama D, Kubota R, Izumo S   Gene expression and glycan profiling of CD4+ T cells in HAM/TSP.   International conference

15th International Conference on Human Retrovirology: HTLV & Related Viruses 

Abdullah HM, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Abdelbary NH, Inamori Y, Takashima H, Izumo S   Histopathologic differences between human T-lymphotropic virus type 1 (HTLV-1)-positive and HTLV-1-negative polymyositis.   International conference

15th International Conference on Human Retrovirology: HTLV & Related Viruses 

Matsuzaki T, Kodama T, Kubota R, Izumo S   Recent epidemiologic trends of HAM/TSP in Japan.   International conference

15th International Conference on Human Retrovirology: HTLV & Related Viruses 

Kubota R. Takenouchi N, Matsuzaki T, Takashima H, Izumo S   HLA-A24-restricted HTLV-I-specific CTL response reduces the HTLV-I proviral load but the HLA increases the risk of HAM/TSP.   International conference

15th International Conference on Human Retrovirology: HTLV & Related Viruses 

Abdelbary NH, Abdullah HM, Matsuzaki T, Hayashi D, Tanaka Y, Takashima H, Izumo S, Kubota R   Reduced Tim-3 expression on HTLV-I Tax-specific cytotoxic T lymphocytes in HTLV-I infection.   International conference

15th International Conference on Human Retrovirology: HTLV & Related Viruses 

Kubota R   Neural bystander damage in HTLV-I-associated myelopathy: an in situ tetramer staining study of HTLV-I-specific CD8+ T cells.  

Departmental Seminar in Neuroimmunology, Max Planck Institute of Neurobiology 

松崎敏男、久保田龍二、出雲周二   HAM患者の全国疫学調査  

第52回日本神経学会総会 

児玉大介、久保田龍二、出雲周二   HTLV-I関連脊髄症(HAM)における糖鎖グライコミクス解析  

第52回日本神経学会総会 

久保田龍二、Abdelbary NH、松崎敏男、林 大輔、高嶋 博、出雲周二   HAMのHTLV-I特異的CTLにおけるT細胞疲労関連分子の検討  

第52回日本神経学会総会  第52回日本神経学会総会

久保田龍二   HAMスペクトラム  

第52回日本神経学会総会 

久保田龍二   HTLV-I関連脊髄症における感染リンパ球とCTLの浸潤によるneural bystander damage  

新潟大学脳研セミナー 

Izumo S, Xing H, Hayakawa H, Mori K, Arishima S, Kubota R, Gelpi E, Budka H   A role of astrocyte dysfunction in pathogenesis of AIDS encephalopathy.   International conference

17th International Congress of Neuropathology 

Abdullah HM, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Abdelbary NH, Inamori Y, Izumo S   HTLV-I associated polymyositis: a trial to unfold the story.   International conference

17th International Congress of Neuropathology 

Kubota R, Matsuura E, Izumo S   Neural bystander damage by infiltrating virus-infected T cells and the cytotoxic lymphocytes in HTLV-I-associated neurological disease.   International conference

17th International Congress of Neuropathology 

小迫知弘、吉満誠、秋元正樹、久保田龍二、出雲周二、添田泰司、占野廣司、松下格司、魚住公治、有馬直道   HTLV-I感染者におけるHTLV-I特異的CTLの発現の多様性  

第3回HTLV-I研究会 

松崎敏男、久保田龍二、出雲周二   HAM患者の全国疫学調査  

第3回HTLV-I研究会 

児玉大介、久保田龍二、出雲周二   HAMのCD4+T細胞における遺伝子発現解析と糖鎖解析による感染細胞の特徴  

第3回HTLV-I研究会 

川端隆史、東元一晃、高嶋博、出雲周二、久保田龍二   HTLV-I関連肺疾患における肺胞洗浄液・肺生検組織でのHTLV-I特異的CTLの集積  

第3回HTLV-I研究会 

Abdelbary N 、Abdullah H 、松崎敏男、林大輔、田中勇悦、高嶋博、出雲周二、久保田龍二   Reduced Tim-3 expression on HTLV-I Tax-specific CTL in HTLV-I infection.  

第3回HTLV-I研究会 

久保田龍二、松浦英治、田中勇悦、高嶋博、出雲周二   HTLV-I感染リンパ球とCTLの浸潤によるneural bystander damage  

第3回HTLV-I研究会 

児玉大介、久保田龍二、有村公良、出雲周二   HTLV-I関連脊髄症(HAM/TSP)患者末梢血CD4＋T細胞のトランスクリプトームの検討  

第51回日本神経学会総会 

久保田龍二、松浦英治、出雲周二   HAM脊髄におけるHTLV-I特異的CTLの集積   International conference

第51回日本神経学会総会 

Abdelbary N、久保田龍二、臼杵扶佐子、山下暁朗、Abdulah H、出雲周二   HTLV-I roles in hUPF1 expression and phosphorylation.  

第22回日本神経免疫学会 

久保田龍二、林大輔、出雲周二   HAM患者末梢血HTLV-I感染細胞におけるケモカインおよびFoxP3の発現  

第22回日本神経免疫学会 

Abdulah H, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Adbelbary N, Izumo S   HTLV-I associated polymyositis: a traial to unfold the story.  

第2回HTLV-I研究会 

Abdelbary N, Kubota R, Usuki F, Abdulah H, Izumo S   Possible effect of HTLV-I on hUPF1 expression and phosphorylation.  

第2回HTLV-I研究会 

児玉大介、久保田龍二、出雲周二   HTLV-I関連脊髄症(HAM/TSP)におけるRNAマイクロアレイ解析による検討  

第2回HTLV-I研究会 

佐藤知雄、阿座上和子、新谷奈津美、高橋克典、宇都宮與、久保田龍二、山野嘉久   HTLV-I関連疾患におけるinvariant NKT細胞の量的・機能的異常  

第2回HTLV-I研究会 

吉満誠、小迫知弘、鈴木伸介、松下格司、魚住公治、久保田龍二、出雲周二、有馬直道   HTLV-I感染者における免疫抑制性受容体の発現  

第2回HTLV-I研究会 

松崎敏男、久保田龍二、有村公良、出雲周二   HTLV-Iキャリア外来の現状とHAM患者の動向について  

第50回日本神経学会総会 

久保田龍二、松浦英治、有村公良、出雲周二   抗原認識特異度の低いHTLV-I特異的CTLはウイルス淘汰圧が高い  

第50回日本神経学会総会 

児玉大介、久保田龍二、出雲周二   HTLV-I関連脊髄症（HAM/TSP）患者末梢血単核球を用いた合胞体形成の検討  

第50回日本神経学会総会 

久保田龍二、松浦英治、有村公良、出雲周二   HAM脊髄におけるHTLV-I特異的CTLとアポトーシス細胞の同定  

第21回日本神経免疫学会 

White Y, Yoshimitsu M, Kozako T, Akimoto M, Toji S, Matsushita K, Kubota R, Izumo S, Uozumi K, Shimeno S, Soeda S, Arima N   Increased frequency of HTLV-I Tax specific CD8+ regulatory T-cells in HTLV-I infected individuals.   International conference

51th American Society of Hematorogy Annual Meeting 

Kubota R   Impact of degenerate TCR recognition of HTLV-I-specific CTL on the viral load in patients with HAM/TSP.  

Summer Seminar in Neuroimmunology Branch, NIH 

久保田龍二、竹之内徳博、松崎敏男、古川良尚、有村公良、出雲周二   HLA-A24はHTLV-Iウイルス量減少に関与するがHAM発症のリスクを上げる  

第1回HTLV-I研究会 

久保田龍二、竹之内徳博、出雲周二   HTLV-I関連脊髄症のウイルス制御におけるCTLの役割  

第12回神経ウイルス学会 

久保田龍二   HTLV-I関連脊髄症におけるCTLの動態  

第29回日本炎症・再生医学会 

久保田龍二、竹之内徳博、松崎敏男、古川良尚、有村公良、出雲周二   HLA-A24はHAMでは頻度が高いがウイルス量は低い  

第49回日本神経学会総会 

久保田龍二、松浦英治、出雲周二   HAMにおけるHTLV-I特異的CTL  

第12回日本神経感染症学会 

久保田龍二、有村公良、納光弘、出雲周二   HAM患者HTLV-I感染細胞でのTCR/CD3発現とTCRシグナルの低下  

第48回日本神経学会総会 

Xing HQ, Kubota R, Hayakawa H, Izumo S   Role of glial cells in central nervous system injury of human retroviral infection.   International conference

13th International Conference on Human Retrovirology: HTLV 

Nose H, Usuku K, Kubota R, Izumo S, Arimura K, Bangham C, Osame M, Saito M   In vivo selection of human T cell lymphotropic virus type-1-specific CD4+ cells by disease susceptive class II allele and immunodominant peptide complex in HTLV-I-associated neurological disease.   International conference

13th International Conference on Human Retrovirology: HTLV 

Matsuura E, Kubota R, Saito M, Suehara T, Matsuzaki K, Arimura K, Osame M, Izumo S   Bystander damage of the central nervous system by HTLV-I specific CTL with target cell infiltration in HAM/TSP.   International conference

13th International Conference on Human Retrovirology: HTLV 

Yamano Y, Kubota R, Arimura K, Ozaki S, Izumo S, Nishioka K, Osame M, Nakajima T   High expression of CD28 costimulatory molecule and low expression of CTLA4 inhibitory molecule on CD4+CD25+ T cells in HTLV-I associated myelopathy (HAM/TSP).   International conference

13th International Conference on Human Retrovirology: HTLV 

Hayashi D, Kubota R, Nose H, Arimura K, Izumo S, Osame M   Increased CMV-specific CTL associated with decreased expression of Foxp3 in HAM/TSP.   International conference

13th International Conference on Human Retrovirology: HTLV 

Kubota R, Furukawa Y, Arimura K, Osame M, Izumo S   Genetic stability of HTLV-I despite antiviral pressures by cytotoxic T lymphocytes.   International conference

13th International Conference on Human Retrovirology: HTLV 

Takenouchi N, Kubota R, Matsuzaki T, Furukawa Y, Izumo S, Arimura K, Osame M   HLA-A*2402 determines a risk of HAM/TSP independently from the HTLV-I proviral load.   International conference

13th International Conference on Human Retrovirology: HTLV 

久保田龍二、有村公良、納光弘、出雲周二   HAM患者患者末梢血CD4+細胞におけるTCR/CD3発現とTCRシグナルの低下  

第19回日本神経免疫学会 

林大輔、久保田龍二、竹之内徳博、中村友紀、梅原藤雄、有村公良、出雲周二、納光弘   CSF HTLV-Iプロウイルス量の増加を伴った急性進行性HTLV-I-associated myelopathy (HAM)の1例  

第19回日本神経免疫学会 

竹之内徳博、Jacobson Steven、久保田龍二、有村公良、出雲周二、納光弘   HTLV-I Receptorの新たな候補  

第19回日本神経免疫学会 

松浦英治、久保田龍二、齊藤峰輝、松崎敏男、末原雅人、有村公良、出雲周二、納光弘   HTLV-I特異的CTLの浸潤によるHAM脊髄のbystander damage  

第19回日本神経免疫学会 

梅原藤雄、松浦英治、能勢裕久、樋口逸郎、泉浩太郎、松岡英二、齊藤峰輝、久保田龍二、出雲周二、納光弘   HTLV-I感染に伴うInclusion Body Myositisが存在する  

第19回日本神経免疫学会 

Nose H, Saito M, Sabouri AH, Usuku K, Kubota R, Izumo S, Arimura K, Osame M   In vivo selection of T-cell receptor junctional region sequences by HLA-DRB1*0101 human T-cell lymphotropic virus type 1 (HTLV-1) envelope gp21 peptide complexes in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP).   International conference

8th International Conference of Neuroimmunology 

Matsuura E, Kubota R, Saito M, Suehara M, Matsuzaki T, Arimura K, Osame M, Izumo S   Visualization of HTLV-I Tax-specific cytotoxic T lymphocytes in the central nervous system of HTLV-I-associated myelopathy   International conference

8th International Conference of Neuroimmunology 

Hayashi D, Kubota R, Nose H, Arimura K, Izumo S, Osame M   Increased CTL responses to CMV in HAM/TSP: a relation of FOXP3+ regulatory T cells.   International conference

8th International Conference of Neuroimmunology 

Kubota R, Arimura K, Osame M, Izumo S   HTLV-I-specific CTL with high TCR degeneracy efficiently recognize naturally occurring mutant viruses in patients with HAM/TSP.   International conference

8th International Conference of Neuroimmunology 

Izumo S, Xing HQ, Kubota R, Hayakawa H, Gelpi E, Budka H   Microglial activation correlated with decreased expression of EAAT-2 in the cerebral cortex of HIV-1 infected patients: a neuroprotective role of microglia in AIDS encephalopathy.   International conference

8th International Conference of Neuroimmunology 

松浦英治、久保田龍二、斉藤峰輝、末原雅人、松崎敏男、有村公良、納光弘、出雲周二   HAM脊髄におけるHTLV-1特異的CTLの検出  

第47回日本神経学会総会 

林大輔、久保田龍二、能勢裕久、有村公良、出雲周二、納光弘   HAMにおける慢性ウイルス感染に対するCTL反応  

第47回日本神経学会総会 

久保田龍二、林大輔、有村公良、納光弘、出雲周二   HAM患者末梢血中HTLV-I感染リンパ球の解析  

第47回日本神経学会総会 

久保田龍二、納光弘、出雲周二   HAMにおけるHTLV-IウイルスとCTLの相互作用  

第10回日本神経感染症学会 

Nose H, Saito M, Usuku K, Matsuzaki T, Izumo S, Kubota R, Furukawa Y, Arimura K, Osame M   Comparison of clinical symptoms and the odds for predicting HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in healthy virus carriers: application of best-fit logistic regression equation based on the genotype, age, and provirus load.   International conference

12th International Conference on Human Retrovirology: HTLV 

Kubota R, Osame M, Izumo S   Degeneracy of HTLV-I-specific CTL inversely correlates with proviral load in patients with HAM/TSP.   International conference

12th International Conference on Human Retrovirology: HTLV. 

久保田龍二、斎藤峰輝、納光弘、出雲周二   HAMにおけるCTLの多様性とHTLV-Iウイルス量およびウイルス変異の検討  

第46回日本神経学会総会 

久保田龍二、古川良尚、出雲周二、納光弘   HAMにおけるCTLによる正の選択圧とウイルスの安定性  

第45回日本神経学会総会 

Kubota R, Izumo S, Osame M   Immunopathogenesis of HAM/TSP.   International conference

Therapeutics in HTLV-I Associated Neurologic Disease Workshop. 

Kubota R, Saito M, Ijichi S, Nakagawa M, Izumo S, Osame M   Interferon-alpha treatment for HAM/TSP.   International conference

Therapeutics in HTLV-I Associated Neurologic Disease Workshop. 

Kubota R, Furukawa Y, Izumo S, Osame M   Mutations in HTLV-I Tax 11-19 epitope and mutant virus-specific T cells in patients with HAM/TSP.  

11th International Conference on Human Retrovirology: HTLV 

Kubota R, Nagai M, Osame M, Jacobson S   Differentiated HTLV-I Tax-specific cells correlate with the proviral load in HAM/TSP patients.   Invited International conference

HTLV-I Molecular Biology and Pathogenesis.  

Izumo S, Takenouchi N, Moritoyo T, Kubota R, Osame M   Pathogenesis of HTLV-I-associated inflammatory disorders.  

10th International Conference on Human Retrovirology: HTLV 

Furukawa Y, Kubota R, Tara M, Izumo S, Osame M   Existence of escape mutant in HTLV-I tax during the development of adult T cell leukemia.  

10th International Conference on Human Retrovirology: HTLV 

Kubota R, Furukawa Y, Izumo S, Usuku K, Jacobson S, Osame M   Diversity of HTLV-I-specific CTL and proviral load in patients with HAM.  

10th International Conference on Human Retrovirology: HTLV 

Nagai M, Kubota R, Greten TF, Schneck JP, Jacobson S   Increased differentiated and activated HTLV-I Tax 11-19-specific CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I proviral load.  

3rd International Symposium on Neurovirology 

Kubota R, Soldan SS, Martin R, Jacobson S   An altered peptide ligand antagonizes antigen-specific CD8+ CTL in peripheral blood of HAM/TSP patients.  

9th International Conference on Human Retrovirology: HTLV 

Nagai M, Kubota R, Schneck JP, Jacobson S   Phenotypic analysis of HTLV-I Tax 11-19 specific CD8+ cells.  

9th International Conference on Human Retrovirology: HTLV 

Umehara F, Izumo S, Moritoyo T, Abe M, Kubota R, Osame M   Immunopathology of HTLV-I-associated myelopathy.  

9th International Conference on Human Retrovirology: HTLV 

Kubota R, Kawanishi T, Mastubara H, Jacobson S   Demonstration of HTLV-I Tax specific CD8+ cells directly in peripheral blood of HAM/TSP patients by intracellular cytokine detection.   Invited International conference

3rd World Congress on Inflammation. 

Levin MC, Lehky T, Bamford R, Kubota R, Xavier A, Soldan S, McFarland, Waldmann T, Jacobson S   Decreased HTLV-I viral load in HAM/TSP patients following treatment with humanized anti-Tac.  

8th International Conference on Human Retrovirology: HTLV 

Kubota R, Kawanishi T, Levin MC, Jacobson S   Quantitative PCR for HTLV-I proviral DNA.  

8th International Conference on Human Retrovirology: HTLV 

Kubota R, Kawanishi T, Mastubara H, Jacobson S   Demonstration of HTLV-I Tax specific CD8+ cells directly in peripheral blood of HAM/TSP patients by intracellular cytokine detection.  

8th International Conference on Human Retrovirology: HTLV 

Saito M, Furukawa Y, Kubota R, Usuku K, Sonoda S, Izumo S, Osame M, Yoshida M   Highly frequent and random mutations of HTLV-I proviral genome within individuals of HAM/TSP patients and asymptomatic carriers.  

1995 Annual meeting sponsored by the Laboratory of Tumor Cell Biology. 

Kubota R, Fujiyoshi T, Izumo S, Yashiki S, Maruyama I, Osame M, Sonoda S   Fluctuation of HTLV-I proviral DNA in peripheral blood mononuclear cells of HTLV-I-associated myelopathy.  

3rd International Conference on Human Retrovirology: HTLV 

Hokezu Y, Izumo S, Maruyama I, Kubota R, Moritoyo T, Osame M   Therapeutic trials in the patients with HAM in our department.  

4th Annual Retrovirology Conference 

Hashimoto K, Machigashira K, Kubota R, Suehara M, Osame M, Lalkaka J, Singhal BS, Fujisawa J, Yoshida M   Sequence analysis of HTLV-I from HAM/TSP in India.  

8th Asian and Oceanian Congress of Neurology 

Kubota R, Nakagawa M, Nakamura A, Osame M   Lymphocytapheresis on HAM.   International conference

WHO Scientific Group on HTLV-I Infections and Associated Diseases.  

隅田 泰生, 立尾 清悟, 内田 友一朗, 久保田 龍二, 吉満 誠   HTLV-1が引き起こす血液癌(ATL)と脊髄症(HAM)の現状と治療法開発　抗糖鎖抗体/CAR-NKによるHTLV-1関連疾患の治療法開発  

日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

久保田 龍二   HTLV-1が引き起こす血液癌(ATL)と脊髄症(HAM)の現状と治療法開発　HAMの病態と治療   Invited

日本生化学会大会プログラム・講演要旨集  2023.10  (公社)日本生化学会

松浦 英治, 田代 雄一, 相良 康子, 久保田 龍二, 高嶋 博   鹿児島県のHTLV-1感染率について　高いHTLV-1感染率を示す鹿児島県の高齢者  

日本老年医学会雑誌  2019.5  (一社)日本老年医学会

松元 陸, 眞弓 芳子, 古園 麻衣, 田代 雄一, 松浦 英治, 荒田 仁, 山野 嘉久, 田中 正和, 久保田 龍二, 高嶋 博   HTLV-1関連脊髄症の初発症状は疾患進行の予測因子である  

NEUROINFECTION  2019.9  日本神経感染症学会

野妻 智嗣, 松浦 英治, 田中 正和, 久保田 龍二, 高嶋 博   HTLV-1関連脊髄症における疾患特異的TCRレパトアの同定  

神経免疫学  2020.10  日本神経免疫学会

古園 麻衣, 眞弓 芳子, 樋口 雄二郎, 野妻 智嗣, 田代 雄一, 中村 友紀, 橋口 昭大, 松浦 英治, 兒玉 大介, 田中 正和, 久保田 龍二, 高嶋 博   HTLV-1関連脊髄症(HAM)患者の臨床経過における排尿障害の意義について  

臨床神経学  2018.12  (一社)日本神経学会

蓮井 和久, 宇都宮 與, 原 博満, 木脇 祐俊, 満田 稔, 斉藤 稔, 久保田 龍二, 出雲 周二   HTLV-1関連細胞株と成人T細胞白血病ないしリンパ腫に於けるサバイビンの抗原回復免疫組織化学  

日本病理学会会誌  2019.4  (一社)日本病理学会

蓮井 和久, 佐藤 榮一, 宇都宮 與, 木脇 祐俊, 満田 稔, 斉藤 稔, 原 博満, 久保田 龍二, 出雲 周二   HTLV-1関連細胞株と成人T細胞白血病ないしリンパ腫(ATL)に於けるサバイビンの抗原回復免疫組織化学  

日本組織細胞化学会総会・学術集会講演プログラム・予稿集  2018.9  日本組織細胞化学会

Kubota Ryuji, Tanaka Masakazu, Matsuura Eiji, Takashima Hiroshi   HTLV-1感染細胞のマイクロアレイ解析によるHAMに対する治療標的分子の検索  

臨床神経学  2020.11  (一社)日本神経学会

Kodama Daisuke, Tanaka Masakazu, Matsuzaki Toshio, Nozuma Satoshi, Matsuura Eiji, Takashima Hiroshi, Izumo Shuji, Kubota Ryuji   HTLV-1型感染者における抗HERV-K10抗体への高い反応性  

臨床神経学  2020.11  (一社)日本神経学会

Kubota Ryuji, Kodama Daisuke, Tanaka Masakazu, Takashima Hiroshi   HTLV-1はHAM/TSP患者におけるToll様受容体遺伝子の発現を抑制する  

臨床神経学  2018.12  (一社)日本神経学会

松浦 英治, 荒田 仁, 東 桂子, 田中 正和, 安藤 匡宏, 平松 有, 野妻 智嗣, 田代 雄一, 崎山 佑介, 久保田 龍二, 高嶋 博   HPVワクチン関連疾患の臨床経過とワクチン接種後血液サイトカイン・自己抗体の検討  

神経免疫学  2020.10  日本神経免疫学会

田代 雄一, 橋口 昭大, 中村 友紀, 野妻 智嗣, 松崎 敏男, 兒玉 大介, 松浦 英治, 久保田 龍二, 高嶋 博   HAM患者に対するアミノ酸内服治療の試み  

NEUROINFECTION  2017.9  日本神経感染症学会

児玉 大介, 松崎 敏男, 高嶋 博, 久保田 龍二, 出雲 周二   HAM患者CD4+T細胞サバイバル遺伝子ABL1の阻害による感染細胞の劇的アポトーシス誘導  

神経免疫学  2017.10  日本神経免疫学会

松浦 英治, 田代 雄一, 荒田 仁, 橋口 昭大, 中村 友紀, 野妻 智嗣, 松崎 敏男, 田中 正和, 久保田 龍二, 高嶋 博   HAMに対するアミノ酸内服治療の効果  

神経免疫学  2018.9  日本神経免疫学会

Kodama Daisuke, Matsuzaki Toshio, Tanaka Masakazu, Matsuura Eiji, Takashima Hiroshi, Kubota Ryuji, Izumo Shuji   HAM/TSPにおける生存遺伝子ABL1の阻害はHTLV-1感染CD4+T細胞を劇的に減少させる  

臨床神経学  2018.12  (一社)日本神経学会

田中 正和, 兒玉 大介, 松浦 英治, 高嶋 博, 久保田 龍二   HAM/TSPにおけるneuraminidase阻害剤がHTLV-1感染症とリンパ球走化性に与える効果  

臨床神経学  2018.12  (一社)日本神経学会

Nozuma Satoshi, Matsuura Eiji, Matsuzaki Toshio, Kubota Ryuji, Jacobson Steven, Takashima Hiroshi   ウイルス性神経疾患における免疫病原性CSFのTCRレパトア特性(Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease)   International coauthorship

臨床神経学  2021.9  (一社)日本神経学会

野妻 智嗣, 松浦 英治, 田中 正和, 松崎 敏男, 久保田 龍二, 高嶋 博   HTLV-1感染細胞を標的としたTCRレパトア解析によるHAMの診断および病勢指標となるバイオマーカーの探索  

神経免疫学  2021.10  (一社)日本神経免疫学会

野妻 智嗣, 松浦 英治, 田中 正和, 児玉 大介, 松崎 敏男, 久保田 龍二, 高嶋 博   感染細胞を標的としたTCRレパトア解析によるHAMでのバイオマーカー探索  

臨床神経学  2022.10  (一社)日本神経学会

松浦 英治, 野妻 智嗣, 東 桂子, 田中 正和, 久保田 龍二, 高嶋 博   HPVワクチン後脳症患者に見られるサイトカインの上昇について  

臨床神経学  2022.10  (一社)日本神経学会

兒玉 大介, 田中 正和, 松崎 敏男, 野妻 智嗣, 松浦 英治, 高嶋 博, 出雲 周二, 久保田 龍二   HAM診断に適した髄液中抗HTLV-1抗体検査法  

臨床神経学  2022.10  (一社)日本神経学会

野妻 智嗣, 松浦 英治, 堂園 美香, 田中 正和, 児玉 大介, 松崎 敏男, 久保田 龍二, 高嶋 博   その他　TCRレパトア解析によるHAMでの病原性クローンの同定・追跡  

神経免疫学  2022.10  (一社)日本神経免疫学会

兒玉 大介, 田中 正和, 松崎 敏男, 野妻 智嗣, 松浦 英治, 高嶋 博, 出雲 周二, 久保田 龍二   抗HTLV-1抗体髄液検査はCLIA法が適している   International coauthorship

NEUROINFECTION  2022.10  日本神経感染症学会

土元 香菜子, 森 理紗, 田中 正和, 兒玉 大介, 野妻 智嗣, 松浦 英治, 高嶋 博, 久保田 龍二   HTLV-1関連疾患における末梢血と気管支肺胞洗浄液中の感染細胞数の比較と肺胞移行能の検討   International coauthorship

NEUROINFECTION  2022.10  日本神経感染症学会

野妻 智嗣, 松浦 英治, 堂園 美香, 田中 正和, 児玉 大介, 松崎 敏男, 久保田 龍二, 高嶋 博   HTLV-1感染細胞を標的としたHAMでのバイオマーカー探索   International coauthorship

NEUROINFECTION  2022.10  日本神経感染症学会

出雲 周二, Xing HuiQin, 久保田 龍二   HIV脳症のUp to Date　HIV脳症の神経病理学   International coauthorship

NEUROINFECTION  2022.10  日本神経感染症学会

田中 正和, 有島 志保, 三輪 正直, 野妻 智嗣, 松浦 英治, 高嶋 博, 出雲 周二, 久保田 龍二   HAMにおけるPARP活性化を介した神経細胞死の検討   International coauthorship

NEUROINFECTION  2022.10  日本神経感染症学会

吉田 崇志, 松浦 英治, 野妻 智嗣, 堂園 美香, 児玉 大介, 田中 正和, 久保田 龍二, 高嶋 博   HTLV-1関連脊髄症/熱帯性痙性対麻痺(HAM/TSP)の診断マーカーとしての腸腰筋の筋力低下について   International coauthorship

神経免疫学  2023.9  (一社)日本神経免疫学会

Kodama Daisuke, Tanaka Masakazu, Matsuzaki Toshio, Nozuma Satoshi, Matsuura Eiji, Takashima Hiroshi, Izumo Shuji, Kubota Ryuji   HTLV-1のcell-to-cell感染におけるLacNAcの関与とその阻害剤の発見(Involvement of LacNAc in HTLV-1 cell-to-cell contact infection and the discovery of its inhibitors)  

臨床神経学  2023.9  (一社)日本神経学会

蓮井 和久, 佐藤 榮一, 原 博満, 木脇 祐俊, 満田 稔, 斉藤 稔, 久保田 龍二, 出雲 周二   成人T細胞白血病(ATL)細胞のリンパ節での動態のSurvivinの抗原回復免疫組織化学による解析  

日本病理学会会誌  2017.3  (一社)日本病理学会

蓮井 和久, 宇都宮 與, 佐藤 榮一, 原 博満, 木脇 祐俊, 満田 稔, 斉藤 稔, 久保田 龍二, 出雲 周二   成人T細胞白血病(ATL)の末梢血組織標本のSurvivinの抗原回復免疫組織化学による解析  

日本病理学会会誌  2018.4  (一社)日本病理学会

松浦 英治, 田代 雄一, 荒田 仁, 崎山 祐介, 中村 友紀, 野妻 智嗣, 松崎 敏男, 兒玉 大介, 橋口 昭大, 岡本 裕嗣, 田中 正和, 久保田 龍二, 高嶋 博   アルギニン塩酸塩を用いたHAM患者治療の試み  

NEUROINFECTION  2018.10  日本神経感染症学会

田代 雄一, 松浦 英治, 橋口 昭大, 中村 友紀, 野妻 智嗣, 松崎 敏男, 兒玉 大介, 田中 正和, 久保田 龍二, 高嶋 博   HAM患者に対するL-アルギニン内服治療の試み  

臨床神経学  2018.12  (一社)日本神経学会

松浦 英治, 田代 雄一, 野妻 智嗣, 安藤 匡宏, 平松 有, 崎山 佑介, 荒田 仁, 田中 正和, 久保田 龍二, 高嶋 博   HAM患者に対するL-アルギニン内服治療の試み  

神経免疫学  2020.10  日本神経免疫学会

HAMガイドライン活用促進と医療水準均てん化に関する研究

2019.4 - 2021.3

厚労科研 

中国福健省ならびに台湾と西南日本におけるHTLV-1関連疾患の比較研究

2017.4 - 2019.3

科研費、基盤(B) 

HTLV-1の疫学研究及び総合対策に資する研究

2017.4 - 2019.3

AMED  AMED 

HTLV-1関連眼疾患の診断法確立のための臨床的研究

Grant number：16K11268  2016.4 - 2023.3

日本学術振興会  科学研究費助成事業  基盤研究(C)

中尾 久美子, 久保田 龍二

HAMならびにHTLV-1陽性難治性疾患に関する国際的な総意形成を踏まえた診療ガイドラインの作成

2016.4 - 2018.3

厚労科研 

Development of HTLV-1 peptide vaccine for treatment and prevention of ATL

Grant number：15K09481  2015.4 - 2018.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Arima Naomichi

HTLV-1疫学研究及び検査法の標準化に関する研究

2014.4 - 2016.3

厚労科研 

Comparable studies on HTLV-1 associated diseases between costal area of Fujian province, China, and south-western Japan. International coauthorship

Grant number：25305017  2013.4 - 2017.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Izumo Shuji

Molecular pathologic study on pathogenesis of HIV-associated neurocognitive disorders (HANDs) International coauthorship

Grant number：25461285  2013.4 - 2016.3

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

IZUMO Syuji, KUBOTA RYUJI, FURUKAWA YOSHITAKA, MORI KAZYYASU

HAM動物モデルの作製と新規治療法開発

2012.4 - 2014.3

科研費、基盤(C) 

Neuropathogenesis of retrovirus infection : diverse in vivo and ex vivo analysis of HAM/TSP and AIDS encephalopathy. International coauthorship

Grant number：19390243  2007 - 2009

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

IZUMO Shuji, KUBOTA Ryuji, HURUKAWA Yoshitaka, OKAMOTO Mika, ARIMURA Kimiyoshi, UMEHARA Hujio, MORI Kazuyasu

The development of a novel molecular targeting therapeutic intervention in HTLV-1-associated myelopathy(HAM)

Grant number：19591015  2007 - 2008

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

YAMANO Yoshihisa

中枢神経組織におけるウイルス特異的細胞傷害性Ｔリンパ球の検出

2005.4 - 2006.3

科研費、萌芽 

中枢神経組織におけるウイルス特異的細胞傷害性Tリンパ球の検出

Grant number：17659267  2005 - 2006

日本学術振興会  科学研究費助成事業  萌芽研究

納 光弘, 出雲 周二, 久保田 龍二

テトラマーを用いた細胞傷害性Tリンパ球の刺激法の開発

2004.4 - 2005.3

科研費、萌芽 

T細胞増殖関連Sonic Hedgehog分子とHAM患者ウイルス抑制機構の研究

Grant number：15659210  2003 - 2004

日本学術振興会  科学研究費助成事業  萌芽研究

宇宿 功市郎, 古川 良尚, 久保田 龍二, 出雲 周二

HTLV-I関連脊髄症における細胞傷害性Tリンパ球動態とウイルス変異に関する研究

2002.4 - 2003.3

科研費、基盤(C) 

Exploitation of new therapies for HTLV-I-assotiated myelopathy

Grant number：14207031  2002 - 2004

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

OSAME Mitsuhiro, ARIMURA Kimiyoshi, UMEHARA Fujio, KUBOTA Ryuji, IZUMO Shuji, USUKU Koichiro

Seminar in Taipei Blood Center, TBSF, Tapiei, Taiwan

Role(s)： Lecturer

2018.3

平成29年度南薩医師会前期医学会

Role(s)： Lecturer

2017.7

第30回鹿児島脊椎脊髄研究会

Role(s)： Lecturer

2016.12

Seminar in Neurology Department of Fujian Medical University

Role(s)： Lecturer

2015.12

HTLV-1 meeting in Xiamen University

Role(s)： Lecturer

Xiamen University  Xiamen University  2014.1

日本赤十字社九州ブロック血液センターセミナー

Role(s)： Lecturer

日本赤十字社九州ブロック血液センター  2013.12

市民公開講座

Role(s)： Lecturer

厚生労働科学研究費補助金難治性疾患克服研究事業  かごしま県民交流センター  2012.11

第44回中国四国医学検査学会

Role(s)： Lecturer

アスティとくしま  2011.11

シスメックスフォーラムイン鹿児島

Role(s)： Lecturer

シスメックス  鹿児島東急ホテル  2011.5

鹿児島県立加治木高校龍門講座

Role(s)： Lecturer

鹿児島県立加治木高校  2010.12