研究者詳細 - 大西　智和

論文 - 大西　智和

分割表示 >> ／全件表示 62 件中 1 - 62 件目

Chiba N, Noguchi Y, Seong CH, Ohnishi T, Matsuguchi T . EGR1 plays an important role in BMP9-mediated osteoblast differentiation by promoting SMAD1/5 phosphorylation. . FEBS letters596 ( 13 ) 1720 - 1732 2022年7月

Ohnishi T, Nakamura T, Shima K, Noguchi K, Chiba N, Matsuguchi T . Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). . Journal of oral biosciences64 ( 2 ) 229 - 236 2022年6月

Amir MS, Chiba N, Seong CH, Kusuyama J, Eiraku N, Ohnishi T, Nakamura N, Matsuguchi T . HIF-1α plays an essential role in BMP9-mediated osteoblast differentiation through the induction of a glycolytic enzyme, PDK1. . Journal of cellular physiology237 ( 4 ) 2183 - 2197 2022年4月

Ohnishi T, Hisadome M, Joji K, Chiba N, Amir MS, Kanekura T, Matsuguchi T . Ultraviolet B irradiation decreases CXCL10 expression in keratinocytes through endoplasmic reticulum stress. . Journal of cellular biochemistry 2021年4月査読

Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts . 595 ( 3 ) 389 - 403 2021年2月査読

Tomokazu Ohnishi , Joji Kusuyama , Kenjiro Bandow , Tetsuya Matsuguchi . Glut1 Expression Is Increased by p53 Reduction to Switch Metabolism to Glycolysis During Osteoblast Differentiation . Biochemical Journal477 ( 10 ) 1795 - 1811 2020年5月査読

Joji Kusuyama, Kenjiro Bandow , Tomokazu Ohnishi , Muhammad Subhan Amir Kaori Shima , Ichiro Semba , Tetsuya Matsuguchi . CXCL13 Is a Differentiation- And Hypoxia-Induced Adipocytokine That Exacerbates the Inflammatory Phenotype of Adipocytes Through PHLPP1 Induction . Biochemical Journal476 ( 22 ) 3533 - 3548 2019年11月査読

Joji Kusuyama , Changhwan Seong , Toshiaki Nakamura , Tomokazu Ohnishi, Muhammad Subhan Amir , Kaori Shima, Ichiro Semba , Kazuyuki Noguchi , Tetsuya Matsuguchi . BMP9 Prevents Induction of Osteopontin in JNK-inactivated Osteoblasts via Hey1-Id4 Interaction . nt J Biochem Cell Biol .2019 ( 116 ) 2019年9月査読

Nahoko Eiraku , Norika Chiba , Toshiaki Nakamura , Muhammad Subhan Amir 3 , Chang-Hwan Seong 3 , Tomokazu Ohnishi , Joji Kusuyam, Kazuyuki Noguchi, Tetsuya Matsuguchi . BMP9 Directly Induces Rapid GSK3-β Phosphorylation in a Wnt-independent Manner Through Class I PI3K-Akt Axis in Osteoblasts . FASEB J . 2019年7月査読

Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T. . Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. . Cell Signal 109345 2019年6月査読

Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T. . JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4). . FASEB J33 ( 6 ) 7331 - 7347 2019年6月査読

Kusuyama J, Nakamura T, Ohnishi T, Albertson BG, Ebe Y, Eiraku N, Noguchi K, Matsuguchi T. . Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts. . J Cell Biochem 10 2019年4月査読

Kusuyama J, Kamisono A, ChangHwan S, Amir MS, Bandow K, Eiraku N, Ohnishi T, Matsuguchi T. . Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. . J Cell Physiol233 ( 3 ) 2549 - 2559 2018年3月査読

Kusuyama J, Ohnishi T, Bandow K, Amir MS, Shima K, Semba I, Matsuguchi T. . Constitutive activation of p46JNK2 is indispensable for C/EBPホエ induction in the initial stage of adipogenic differentiation. . Biochem J474 ( 20 ) 3421 - 3437 2017年10月査読

Kusuyama J, Nakamura T, Ohnishi T, Eiraku N, Noguchi K, Matsuguchi T. . Low-Intensity Pulsed Ultrasound (LIPUS) Promotes BMP9-Induced Osteogenesis and Suppresses Inflammatory Responses in Human Periodontal Ligament-Derived Stem Cells. . J Orthop Trauma31 ( 7 ) S4 2017年7月査読

Kusuyama J, Bandow K, Ohnishi T, Hisadome M, Shima K, Semba I, Matsuguchi T. . Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low-molecular weight protein tyrosine phosphatase. . Mol Biol Cell28 ( 10 ) 1326 - 1336 2017年5月査読

Kusuyama J, Komorizono A, Bandow K, Ohnishi T, Matsuguchi T. . CXCL3 positively regulates adipogenic differentiation. . J Lipid Res57 ( 10 ) 1806 - 1820 2016年10月査読

Hisadome M, Ohnishi T, Kakimoto K, Kusuyama J, Bandow K, Kanekura T, Matsuguchi T. . Hepatocyte growth factor reduces CXCL10 expression in keratinocytes. . FEBS Lett590 ( 20 ) 3595 - 3605 2016年10月査読

Kusuyama J, Hwan Seong C, Ohnishi T, Bandow K, Matsuguchi T. . Low-Intensity Pulsed Ultrasound (LIPUS) Stimulation Helps to Maintain the Differentiation Potency of Mesenchymal Stem Cells by Induction in Nanog Protein Transcript Levels and Phosphorylation. . J Orthop Trauma30 ( 8 ) S4 - S5 2016年8月査読

Maeda A, Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Miyawaki S, Matsuguchi T. . Induction of CXCL2 and CCL2 by pressure force requires IL-1ホイ-MyD88 axis in osteoblasts. . Bone74 76 - 82 2015年5月査読

Bandow K, Kusuyama J, Kakimoto K, Ohnishi T, Matsuguchi T. . AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation. . Bone74 125 - 133 2015年5月査読

Kusuyama J, Bandow K, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T. . Low intensity pulsed ultrasound (LIPUS) influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathway. . J Biol Chem289 ( 15 ) 10330 - 10344 2014年4月査読

Ohnishi T, Bandow K, Kakimoto K, Kusuyama J, Matsuguchi T. . Long-time treatment by low-dose N-acetyl-L-cysteine enhances proinflammatory cytokine expressions in LPS-stimulated macrophages. . PLoS One9 ( 2 ) e87229 2014年2月査読

Nakao J, Fujii Y, Kusuyama J, Bandow K, Kakimoto K, Ohnishi T, Matsuguchi T. . Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4-MyD88 dissociation. . Bone58 17 - 25 2014年1月査読

Matsui I, Hamano T, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Michigami T, Ohnishi T, Fujii N, Nakano C, Kusunoki Y, Kitamura H, Iwatani H, Takabatake Y, Kaimori JY, Matsuba G, Okoshi K, Kimura-Suda H, Tsubakihara Y, Rakugi H, Isaka Y. . Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats. . Am J Physiol Renal Physiol304 ( 6 ) F751 - F760 2013年3月査読

Bandow K, Kusuyama J, Shamoto M, Kakimoto K, Ohnishi T, Matsuguchi T. . LPS-induced chemokine expression in both MyD88-dependent and -independent manners is regulated by Cot/Tpl2-ERK axis in macrophages. . FEBS Lett586 ( 10 ) 1540 - 1546 2012年5月査読

Okamoto A, Ohnishi T, Bandow K, Kakimoto K, Chiba N, Maeda A, Fukunaga T, Miyawaki S, Matsuguchi T. . Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice. . Eur J Oral Sci117 ( 3 ) 238 - 247 2009年6月査読

Matsuguchi T, Chiba N, Bandow K, Kakimoto K, Masuda A, Ohnishi T. . JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation. . J Bone Miner Res24 ( 3 ) 398 - 410 2009年3月査読

Bandow K, Nishikawa Y, Ohnishi T, Kakimoto K, Soejima K, Iwabuchi S, Kuroe K, Matsuguchi T. . Low-intensity pulsed ultrasound (LIPUS) induces RANKL, MCP-1, and MIP-1beta expression in osteoblasts through the angiotensin II type 1 receptor. . J Cell Physiol211 ( 2 ) 392 - 398 2007年5月査読

Bandow K, Ohnishi T, Tamura M, Semba I, Daikuhara Y. . Hepatocyte growth factor/scatter factor stimulates migration of muscle precursors in developing mouse tongue. . J Cell Physiol201 ( 2 ) 236 - 243 2004年11月査読

Padalko E, Ohnishi T, Matsushita K, Sun H, Fox-Talbot K, Bao C, Baldwin WM 3rd, Lowenstein CJ . Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry. . Proceedings of the National Academy of Sciences of the United States of America101 ( 32 ) 11731 - 6 2004年8月

Padalko E, 大西智和(OhnishiTomokazu), Matsushita K, Sun H, Fox-Talbot K, Bao C, Baldwin WM 3rd, Lowenstein CJ. . Peroxynitrite inhibition of Coxackievirus infection by prevention of viral RNA entry. . Proc Natl Acad Sci USA101 ( 32 ) 11731 - 11736 2004年1月査読国際共著

Ohnishi T, Daikuhara Y. . Hepatocyte growth factor/scatter factor in development, inflammation and carcinogenesis: its expression and role in oral tissues. . Arch Oral Biol48 ( 12 ) 797 - 804 2003年12月査読

Ohnishi Tomokazu, Daikuhara Yasushi . 口腔生物学における肝細胞増殖因子(Hepatocyte Growth Factor in Oral Biology) . Dentistry in Japan39 48 - 51 2003年3月

Tsuboi Y, Kakimoto K, Nakajima M, Akatsu H, Yamamoto T, Ogawa K, Ohnishi T, Daikuhara Y, Yamada T. . Increased hepatocyte growth factor level in cerebrospinal fluid in Alzheimer's disease. . Acta Neurol Scand107 ( 2 ) 81 - 86 2003年2月査読

大西智和(OhnishiTomokazu) . Hepatocyte growth factor in oral biology . Dentistry in Japan39 ( ※ ) 48 - 51 2003年

Ito T, Suzuki A, Imai E, Horimoto N, Ohnishi T, Daikuhara Y, Hori M. . Tornado extraction: a method to enrich and purify RNA from the nephrogenic zone of the neonatal rat kidney. . Kidney Int62 ( 3 ) 763 - 769 2002年9月査読

Matsumori A, Takano H, Obata JE, Takeda S, Tsuyuguchi N, Ono K, Okada M, Miyamoto T, Ohnishi T, Daikuhara Y, Sasayama S. . Circulating hepatocyte growth factor as a diagnostic marker of thrombus formation in patients with cerebral infarction. . Circ J66 ( 2 ) 216 - 218 2002年2月査読

Matsumori Akira, Takano Hajime, Obata Jun-ei, Takeda Satoshi, Tsuyuguchi Naohiko, Ono Koh, Okada Masaharu, Miyamoto Tadashi, Ohnishi Tomokazu, Daikuhara Yasushi, Sasayama Shigetake . 脳梗塞患者における血栓形成診断の標識としての血中肝細胞増殖因子(Circulating Hepatocyte Growth Factor as a Diagnostic Marker of Thrombus Formation in Patients With Cerebral Infarction) . Circulation Journal66 ( 2 ) 216 - 218 2002年1月

出版者・発行元：(一社)日本循環器学会

急性心筋梗塞の超早期に血中肝細胞増殖因子(HGF)濃度が上昇することを見出したので脳梗塞の場合も血中HGFが血栓形成の標識となるか否かを検討した.脳梗塞32例中,血中HGFが対照者の平均+2SD以上を示したのは発症6時間以内で20例中10例,発症24時間以内で32例中15例であった.HGF高値の患者の約半数で血漿中D-dimerも高値であった

Qian Z, Gelzer-Bell R, Yang Sx SX, Cao W, Ohnishi T, Wasowska BA, Hruban RH, Rodriguez ER, Baldwin WM 3rd, Lowenstein CJ. . Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection. . Circulation104 ( 19 ) 2369 - 2375 2001年11月査読国際共著

Ohnishi T, Kakimoto K, Hashida S, Fujii M, Hirono S, Nishiyama K, Amita Y, Ishikawa E, Tsubouchi H, Daikuhara Y. . Development of highly sensitive enzyme-linked immunosorbent assays for hepatocyte growth factor/scatter factor (HGF/SF): determination of HGF/SF in serum and urine from normal human subjects. . J Immunol Methods244 ( 43467 ) 163 - 173 2000年10月査読

Matsumori A, Miyazaki S, Takano H, Ono K, Okada M, Miyamoto T, Nonogi H, Daikoku S, Mitsudo K, Matsunaga Y, Ohnishi T, Daikuhara Y, Sasayama S. . Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris. . Jpn Circ J64 ( 10 ) 805 - 807 2000年10月査読

Matsumori Akira, Miyazaki Shun-ichi, Takano Hajime, Ono Koh, Okada Masaharu, Miyamoto Tadashi, Nonogi Hiroshi, Daikoku Satoshi, Mitsudo Kazuaki, Matsunaga Yoichi, Ohnishi Tomokazu, Daikuhara Yasushi, Sasayama Shigetake . 不安定狭心症における血栓形成標識としての血中肝細胞増殖因子 . Japanese Circulation Journal64 ( 10 ) 805 - 807 2000年9月

記述言語：英語出版者・発行元：(一社)日本循環器学会

新しい酵素結合免疫測定法によると10pg/mlのヒト肝細胞増殖因子(HGF)の測定が可能である.本法によると不安定狭心症患者36例の血中HGFは296±184pg/mlで健康者250例の201±64pg/mlより有意に大であった(p<0.0001).不安定狭心症36例中12例では健康者の平均+2SD,即ち321pg/ml以上の高値であった

Dziegielewska KM, Daikuhara Y, Ohnishi T, Waite MP, Ek J, Habgood MD, Lane MA, Potter A, Saunders NR. . Fetuin in the developing neocortex of the rat: distribution and origin. . J Comp Neurol423 ( 3 ) 373 - 388 2000年7月査読

OHNISHI T., SUWA M., OYAMA T., ARAKAKI N., TORII M., DAIKUHARA Y. . Prostaglandin E_2 Predominantly Induces Production of Hepatocyte Growth Factor/Scatter Factor in Human Dental Pulp in Acute Inflammation . Journal of dental research79 ( 2 ) 748 - 755 2000年2月

Ohnishi T, Suwa M, Oyama T, Arakaki N, Torii M, Daikuhara Y. . Prostaglandin E2 predominantly induces production of hepatocyte growth factor/scatter factor in human dental pulp in acute inflammation. . J Dent Res79 ( 2 ) 748 - 755 2000年2月査読

Abdullah Abu Musa DM, Kobayashi K, Yasuda I, Iijima M, Christoffels VM, Tomomura M, Horiuchi M, Ohnishi T, Kajihara T, Daikuhara Y, Lamers WH, Saheki T. . Involvement of a cis-acting element in the suppression of carbamoyl phosphate synthetase I gene expression in the liver of carnitine-deficient mice. . Mol Genet Metab68 ( 3 ) 346 - 356 1999年11月査読

Nakamura O, Kazi JA, Ohnishi T, Arakaki N, Shao Q, Kajihara T, Daikuhara Y. . Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone. . Biosci Biotechnol Biochem63 ( 8 ) 1383 - 1391 1999年8月査読

中村修, ジャミール・アハサン・カジ , 大西智和, 新垣尚捷, シャオ・チン , 梶原武弘, 大工原恭 . 副甲状腺ホルモン存在下における骨吸収促進に及ぼすラットフェチュインの効果 . Bioscience, Biotechnology, and Biochemistry63 ( 8 ) 1383 - 1391 1999年8月

出版者・発行元：(公社)日本農芸化学会

ラットフェチュインは骨基質から精製された59kDaのシアロ蛋白質で,ヒトα2-HS糖蛋白質及びウシフェチュインの分子ホモログである.本蛋白質を,45Ca標識した骨片からの45Caの遊離を指標にした骨吸収系に添加したところ,本蛋白質単独では何の効果もなかったが,低濃度の副甲状腺ホルモンにより誘導される骨吸収を用量依存的に促進した.この効果は,カテプシンLの阻害剤であるキモスタチンによって阻害された.I型コラーゲンを本蛋白質とプレインキュベーションすると,カテプシンLによるI型コラーゲンの分解が用量依存的に促進された

Arakaki N, Kajihara T, Arakaki R, Ohnishi T, Kazi JA, Nakashima H, Daikuhara Y. . Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth factor/scatter factor. . J Biol Chem274 ( 19 ) 13541 - 13546 1999年5月査読

Kajihara T, Ohnishi T, Arakaki N, Semba I, Daikuhara Y. . Expression of hepatocyte growth factor/scatter factor and c-Met in human dental papilla and fibroblasts from dental papilla. . Arch Oral Biol44 ( 2 ) 135 - 147 1999年2月査読

Kazi JA, Nakamura O, Ohnishi T, Arakaki N, Kajihara T, Nakagawa S, Daikuhara Y. . Changes with age of the rat fetuin concentration in serum and its mRNA expression. . J Biochem124 ( 1 ) 179 - 186 1998年7月査読

Arakaki N, Kazi JA, Kazihara T, Ohnishi T, Daikuhara Y. . Hepatocyte growth factor/scatter factor activates the apoptosis signaling pathway by increasing caspase-3 activity in sarcoma 180 cells. . Biochem Biophys Res Commun245 ( 1 ) 211 - 215 1998年4月査読

Ohnishi T, Nakamura O, Arakaki N, Daikuhara Y. . Effect of phosphorylated rat fetuin on the growth of hepatocytes in primary culture in the presence of human hepatocyte-growth factor. Evidence that phosphorylated fetuin is a natural modulator of hepatocyte-growth factor. . Eur J Biochem243 ( 3 ) 753 - 761 1997年2月査読

Shao Q, Arakaki N, Ohnishi T, Nakamura O, Daikuhara Y. . Effect of hepatocyte growth factor/scatter factor on lipogenesis in adult rat hepatocytes in primary culture. . J Biochem119 ( 5 ) 940 - 946 1996年5月査読

Sugiyama A, Arakaki R, Ohnishi T, Arakaki N, Daikuhara Y, Takada H. . Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture. . Infect Immun64 ( 4 ) 1426 - 1431 1996年4月査読

Arakaki N, Kawakami S, Nakamura O, Ohnishi T, Miyazaki H, Ishii T, Tsubouchi H, Daikuhara Y. . Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases. . Hepatology22 ( 6 ) 1728 - 1734 1995年12月査読

Ohnishi T, Nakamura O, Arakaki N, Miyazaki H, Daikuhara Y. . Effects of cytokines and growth factors on phosphorylated fetuin biosynthesis by adult rat hepatocytes in primary culture. . Biochem Biophys Res Commun200 ( 1 ) 598 - 605 1994年4月査読

Ohnishi T, Nakamura O, Ozawa M, Arakaki N, Muramatsu T, Daikuhara Y. . Molecular cloning and sequence analysis of cDNA for a 59 kD bone sialoprotein of the rat: demonstration that it is a counterpart of human alpha 2-HS glycoprotein and bovine fetuin. . J Bone Miner Res8 ( 3 ) 367 - 377 1993年3月査読

Ohnishi T, Arakaki N, Nakamura O, Hirono S, Daikuhara Y. . Purification, characterization, and studies on biosynthesis of a 59-kDa bone sialic acid-containing protein (BSP) from rat mandible using a monoclonal antibody. Evidence that 59-kDa BSP may be the rat counterpart of human alpha 2-HS glycoprotein and is synthesized by both hepatocytes and osteoblasts... . J Biol Chem266 ( 22 ) 14636 - 14645 1991年8月査読

27. S. Kumasa, H. Mori, M. Mori, T. Shibutani, Y. Iwayama, T. Tsujimura, T. Ohnishi, N. Arakaki, M. Nakata, K. Kurisu. . Heterotopic bone formation in tumor stroma tissue . Acta Histochim Cytochim23 427 - 439 1990年11月査読

KUMASA SHUNSUKE, MORI HIROMITSU, MORI MASAHIKO, SHIBUTANI TOSHIAKI, IWAYAMA YUKIO, TSUJIMURA TAKAHIRO, OHNISHI TOMOKAZU, ARAKAKI NAOKATSU, NAKATA MINORU, KURISU KOJIRO . Heterotopic bone formation in tumor stromal tissue. Immunohistochemical considerations. . ACTA HISTOCHEMICA ET CYTOCHEMICA23 ( 4 ) 427 - 439 1990年

記述言語：英語出版者・発行元：JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

Ectopic and heterotopic bone formation rarely occur in stromal tissues of various epithelial tumors. In the present study, ectopic bone forming tumors; calcifying epithelioma Malherbe (6), renal cell carcinoma (1), thyroid adenocarcinoma (1) and ovary carcinoma (1) were examined. The process of ectopic bone formation could be classified into 1) bone formation related to epithelial tissue as found in calcifying epithelioma of Malherbe, 2) bone formation from perivascular smooth muscle, and 3) that due to metaplasia occurring in stromal connective tissue of epithelial tumors. Immunohistochemical detection of proteoglycans (PG) was made in bone-forming matrix areas, and these areas were positive for chondrotin 4 and 6 sulfate, and dermatan and heparan sulfate PGs. Immunohistochemically, fibronectin, collagen III and bone sialoprotein as matrix proteins, and carbonic anhydrase as calcification marker were tested and they appeared in these pre-calcifying tissues.

DOI： 10.1267/ahc.23.427

　前のページ - 次のページ　

<大西 智和>

論文 - 大西 智和

<大西　智和>

論文 - 大西　智和