記述言語：日本語   出版者・発行元：Nutrients  

Background/Objectives: We aimed to evaluate the efficacy and safety of a short-term dietary intervention using trigonelline-rich Sakurajima radish on vascular endothelial function in patients with metabolic syndrome (MetS). Methods: In this multicenter, open-label, randomized, three-period crossover phase IIb trial, 21 patients with MetS were assigned to three 14-day sequences (Sakurajima radish powder, Aokubi radish powder, and a usual diet), separated by 14-day washouts. The primary outcome was flow-mediated dilation (FMD). Key Secondary outcomes included blood pressure (BP), urinary nitric oxide metabolites (NOx), and the oxidative stress marker 8-hydroxy-2′-deoxyguanosine (8-OHdG). Results: Sakurajima radish did not improve FMD versus the usual diet (p = 0.58) or Aokubi radish (p = 0.59), although a significant negative carryover effect following the Aokubi period likely confounded this estimation. Despite successfully stimulating NO production (elevated urinary NOx, p = 0.03), the intervention paradoxically increased oxidative stress (elevated 8-OHdG/creatinine, p = 0.02) and significantly elevated systolic BP compared with the usual diet (+9.67 mmHg, p = 0.03) and Aokubi radish (+8.86 mmHg, p = 0.04). Conclusions: Sakurajima radish does not appear to improve endothelial function in patients with MetS within the constraints of this short-term crossover design. Importantly, the unexpected negative carryover effect inherently limits the interpretability of this primary FMD outcome, as it may have masked potential physiological benefits. Despite boosting NO production, the intervention paradoxically exacerbated systemic oxidative stress and elevated systolic BP. These findings suggest that in the pro-oxidant environment of MetS, NO-boosting functional foods may induce unintended adverse hemodynamic responses, underscoring the need for careful risk–benefit evaluation and parallel-group trial designs in this specific population.

DOI： 10.3390/nu18111801

Scopus

PubMed

記述言語：日本語   出版者・発行元：Jacc Case Reports  

Objective: To describe a transcatheter strategy for simultaneous closure of a persistent iatrogenic atrial septal defect (iASD) and adjacent patent foramen ovale (PFO) using a single Cribriform occluder in a patient with exertional hypoxemia. Key Steps: 1) Preprocedural transesophageal echocardiography (TEE) and bubble study to assess both defects, quantify shunting, and their spatial relationship; 2) selective wire crossing of the iASD under real-time 3-dimensional TEE guidance; 3) deployment of a Cribriform occluder to bridge both adjacent defects; and 4) confirm device stability and adequate closure with postdeployment color Doppler and bubble study. Potential Pitfalls: The guidewire may preferentially cross the larger PFO rather than the smaller iASD. Careful assessment of the interdefect distance is essential because widely separated defects may require 2 occluders rather than a single bridging device. Take-Home Messages: Systematic TEE evaluation can identify a concomitant PFO before iASD closure. In anatomically suitable cases, simultaneous single-device closure can effectively eliminate right-to-left shunting.

DOI： 10.1016/j.jaccas.2026.109240

Scopus

PubMed

記述言語：英語   出版者・発行元：(一社)インターナショナルハートジャーナル刊行会  

記述言語：英語   出版者・発行元：一般社団法人 インターナショナル・ハート・ジャーナル刊行会  

No reports compared four indices of myocardial work based on aortic valve stenosis (AS) severity. This study aimed to characterize the four myocardial work indices and global longitudinal strain (GLS) in AS with left ventricular ejection fraction (LVEF) > 50%, and to investigate the association of these indices with severe AS. We measured global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE), and GLS in 154 patients. These indices were compared among three groups: normal, mild-to-moderate, and severe AS. GWI and GCW were significantly higher in mild-to-moderate and severe AS groups than in normal group. GWW was significantly higher in severe AS group than in normal and mild-to-moderate AS groups. GWE and GLS were significantly lower in severe AS group than in normal and mild-to-moderate AS groups. The ability to discriminate severe AS was examined using receiver operating characteristic analysis, and GWW demonstrated the largest area under the curve. Multivariate logistic regression analysis demonstrated that the four myocardial work indices and GLS were significantly associated with severe AS after adjusting for age, height, and brachial systolic blood pressure. In conclusions, GWI, GCW, and GWW, were significantly higher, while GWE and GLS were significantly lower in the severe AS group than in the normal group. These findings suggest that the four indices of myocardial work are valuable in detecting the impairment of left ventricular myocardial workload due to severe AS in patients with preserved LVEF.

DOI： 10.1536/ihj.25-050

Scopus

PubMed

CiNii Research

記述言語：日本語   出版者・発行元：(一社)日本心臓病学会  

記述言語：日本語   出版者・発行元：Ieej Transactions on Electrical and Electronic Engineering  

Adversarial examples are inputs with slight intentional perturbations that lead to incorrect predictions of deep neural networks; they also threaten automatic speech recognition systems. This study proposes a method to uncover such threats in practical environments, focusing on hard-label black-box settings. © 2026 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.

DOI： 10.1002/tee.70269

Scopus

DOI： 10.1016/j.jaccas.2025.106137

記述言語：日本語  

記述言語：英語  

記述言語：英語  

記述言語：日本語  

記述言語：英語