記述言語：日本語   出版者・発行元：(株)デンタルダイヤモンド社  

記述言語：日本語   出版者・発行元：Cleft Palate Craniofacial Journal  

This case report aimed to clarify the long-term bone formation from the grafting of octacalcium phosphate granules and atelocollagen complex (OCP/Col) into the alveolar cleft until the completion of orthodontic treatment in 2 patients with unilateral CLA. Both patients underwent OCP/Col grafting at age 9 years and 3 months. Clear bone bridging was observed 6 months or 3 years after grafting, and bone formation was further promoted by the edgewise treatment. The results suggested that the osteogenic induction phase can last for several years in some cases, and it is important to understand this characteristic when formulating treatment plans.

DOI： 10.1177/10556656261455547

Scopus

PubMed

記述言語：日本語   出版者・発行元：(一社)日本口蓋裂学会  

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Clinical and Experimental Dental Research  

Objectives: Late-stage secondary alveolar bone grafting (SBG) has a poor prognosis; however, the case selection and timing of orthodontic treatment have not been thoroughly investigated. This study aimed to clarify the prognosis of early-SBG and late-SBG in patients with unilateral or bilateral cleft lip and palate. Materials and Methods: Fifty-six patients underwent early-SBG performed before the eruption of the cleft-adjacent lateral incisors or canines (early-SBG group). Ten patients underwent late-SBG requiring significant tooth movement for gap closure; SBG was performed before phase II treatment for treatment efficiency, and tooth movement began approximately 3 months post-SBG (late-SBG group). Pre-SBG cleft width was measured; bone-bridge formation using the Chelsea scale and cleft gap closure post-SBG were evaluated. Types A and C bone bridges were considered adequate. These items were statistically compared between groups. Results: Cleft width in the early-SBG group was significantly smaller than that in the late-SBG group (p < 0.001). There were no significant differences in the percentage of adequate bone-bridge formation (p = 0.055) and cleft-gap closure (p = 1.000) between groups. However, the ratio of type A bone bridges was significantly higher in the early-SBG group than in the late-SBG group (p = 0.035). Conclusion: These results suggest that, even in late-SBG, early orthodontic tooth movement to the graft bone leads to the formation of an adequate bone bridge, similar to early-SBG. However, the maintenance of cervical grafted bone after late-SBG may be less than that after early-SBG.

DOI： 10.1002/cre2.70116

Web of Science

Scopus

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Frontiers in Neuroscience  

Introduction: Occlusal disharmony induced by deteriorating oral health conditions, such as tooth loss and decreased masticatory muscle due to sarcopenia, is one of the causes of cognitive impairment. Chewing is an essential oral function for maintaining cognitive function not only in the elderly but also in young people. Malocclusion is an occlusal disharmony that commonly occurs in children. The connection between a decline in cognitive function and malocclusion in children has been shown with chronic mouth breathing, obstructive sleep apnea syndrome, and thumb/digit sucking habits. However, the mechanism of malocclusion-induced cognitive decline is not fully understood. We recently reported an association between feeding-related neuropeptides and cognitive decline in adolescent mice with activity-based anorexia. The aim of the present study was to assess the effects of malocclusion on cognitive behavior and clarify the connection between cognitive decline and hypothalamic feeding-related neuropeptides in adolescent mice with malocclusion. Methods: Four-week-old mice were randomly assigned to the sham-operated solid diet-fed (Sham/solid), sham-operated powder diet-fed (Sham/powder), or malocclusion-operated powder diet-fed (Malocclusion/powder) group. We applied composite resin to the mandibular anterior teeth to simulate malocclusion. We evaluated cognitive behavior using a novel object recognition (NOR) test, measured hypothalamic feeding-related neuropeptide mRNA expression levels, and enumerated c-Fos-positive cells in the hypothalamus 1 month after surgery. We also evaluated the effects of central antibody administration on cognitive behavior impairment in the NOR test. Results: The NOR indices were lower and the agouti-related peptide (AgRP) mRNA levels and number of c-Fos-positive cells were higher in the malocclusion/powder group than in the other groups. The c-Fos-positive cells were also AgRP-positive. We observed that the central administration of anti-AgRP antibody significantly increased the NOR indices. Discussion: The present study suggests that elevated cerebral AgRP signaling contributes to malocclusion-induced cognitive decline in adolescents, and the suppression of AgRP signaling can be a new therapeutic target against cognitive decline in occlusal disharmony.

DOI： 10.3389/fnins.2023.1156523

Scopus

PubMed

記述言語：日本語   出版者・発行元：東京矯正歯科学会  

記述言語：日本語   出版者・発行元：南九州歯学会  

口唇裂・口蓋裂は,顔面の形成不全や口腔の機能障害を伴う先天性疾患であり,上顎骨の劣成長や上顎歯列の狭窄を伴う反対咬合,顎裂に隣接した歯の萌出位置の異常を認めるなど,重度の不正咬合を呈することが多い.口唇裂・口蓋裂治療の中でも,矯正歯科治療は長い期間を要する治療である.鹿児島大学病院矯正歯科における乳歯列期および混合歯列期に行う第一期治療では,主に上顎骨の前方成長促進や上顎歯列の拡大,顎裂部骨移植後の顎裂部に隣接する犬歯・側切歯などの萌出誘導もしくは矯正学的歯の移動を行っている.永久歯列期に行う第二期治療では,マルチブラケット装置による最終的な咬合の確立を行うが,上下顎骨の不調和が大きい場合は,外科的矯正治療を選択している.マルチブラケット装置撤去後は,必要に応じて補綴治療を行い,咬合の安定のため長期間の保定を行う.このように,治療が長期間に及ぶことから,患者や保護者の心理状態を把握し,多職種連携を強化したチーム医療を提供することが重要である.鹿児島大学病院矯正歯科では,長期的評価による臨床研究や症例報告を行うことで,治療成績の向上に努めてきた.今回,我々は,鹿児島大学矯正歯科で行っている口唇裂・口蓋裂治療の概要を紹介するとともに,当科で報告してきた臨床研究や症例報告について紹介する.(著者抄録)

記述言語：日本語   掲載種別：記事・総説・解説・論説等（大学・研究所紀要）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（大学・研究所紀要）  

開催年月日： 2022年5月

開催地：鹿児島   国名：日本国  

開催年月日： 2022年5月

記述言語：日本語  

開催地：鹿児島   国名：日本国  

開催年月日： 2022年1月

記述言語：日本語  

開催地：佐賀  

開催年月日： 2020年10月

記述言語：英語   会議種別：口頭発表（一般）  

開催年月日： 2020年10月

記述言語：英語   会議種別：ポスター発表