2021/04/01 更新

写真a

ウラタ ユカ
浦田 結嘉
URATA Yuka
所属
医歯学域医学系 医歯学総合研究科 健康科学専攻 社会・行動医学講座 助教
職名
助教

学位

  • 博士 (医学) ( 2019年9月   鹿児島大学 )

研究キーワード

  • 分子精神医学

経歴

  • 鹿児島大学   医歯学域医学系 医歯学総合研究科 健康科学専攻 社会・行動医学講座   助教

    2020年4月 - 現在

  • 鹿児島大学   医歯学域医学部・歯学部附属病院 医学部・歯学部附属病院 診療施設 緩和ケアセンター   特任助教

    2019年10月 - 2020年3月

所属学協会

  • 日本老年精神医学会

    2020年7月 - 現在

  • 日本児童青年精神医学会

    2020年7月 - 現在

  • 日本生物学的精神医学会

    2010年4月 - 現在

  • 日本精神神経学会

    2009年8月 - 現在

  • 九州精神神経学会

    2009年8月 - 現在

 

論文

  • Yuka Urata, Masayuki Nakamura*, Nari Shiokawa, Aiko Yasuniwa, Nagisa Takamori, Kensuke Imamura, Takehiro Hayashi, Takanori Ishizuka, Motofumi Kasugai and Akira Sano .  Sleep Disorders in Four Patients With Myotonic Dystrophy Type 1 .  Frontiers in Neurology   2020年2月査読

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  


    Sleep disturbances such as excessive daytime sleepiness, central and obstructive sleep apneas, restless legs syndrome, and rapid eye movement sleep dysregulation are prominent in patients with myotonic dystrophy type 1 (DM1). Mild intellectual deficits presented in many patients with DM1. In addition, psychosocial issues caused by neuropsychiatric symptoms are a clinical problem. We herein present the cases of four DM1 patients with sleep disturbances and neuropsychiatric symptoms in the preceding stage of clinically significant muscle symptoms. One of the cases exhibited a sleep disorder and neuropsychiatric symptoms before electromyography showed myotonic discharge, suggesting that careful follow-up is also important. Patients 1 and 2 were first referred to our department due to daytime sleepiness. Patients 3 and 4 were objectively suffering from daytime sleepiness of which they were not subjectively aware of. Patients 1, 3, and 4 obtained high apnea–hypopnea index (AHI) scores, which reflected central and/or obstructive apnea, whereas patient 2 had an AHI score of zero. The daytime cerebrospinal fluid (CSF) orexin levels of all patients ranged from the normal lower limit to low, although they were not as low as those observed in narcolepsy with typical cataplexy. Neuropsychological tests of patients 1 and 2 showed frontal lobe dysfunction. Patients 3 and 4 were diagnosed with mild intellectual disability and autism spectrum disorder, respectively. All patients exhibited indifference toward their own symptoms, which may have resulted from the cognitive decline caused by DM1. Based on family history and/or neurological findings such as myotonia, we suspected DM1 as the cause of their sleep disturbances. Molecular analysis using the triplet repeat-primed polymerase chain reaction (TP PCR) method and Southern blotting, which provided a genetic confirmation of the diagnosis of DM1, were performed. These clinical features of sleep disturbances were unrelated to the length of CTG repeats and are caused by unknown molecular mechanisms. Clinicians should take into account that multisystem involvement in DM1 is hugely variable, and thus, a disabling sleep disorder could overshadow muscle impairment in DM1 patients.

    DOI: 10.3389/fneur.2020.00012

  • Terasaki A. .  DNA analysis of benign adult familial myoclonic epilepsy reveals associations between the pathogenic TTTCA repeat insertion in SAMD12 and the nonpathogenic TTTTA repeat expansion in TNRC6A .  Journal of Human Genetics66 ( 4 ) 419 - 429   2020年

     詳細を見る

    出版者・発行元:Journal of Human Genetics  

    DOI: 10.1038/s10038-020-00855-0

    Scopus

    PubMed

  • Murakami T. .  A patient with McLeod syndrome showing involvement of the central sensorimotor tracts for the legs .  BMC Neurology19 ( 1 ) 301   2019年11月

     詳細を見る

    出版者・発行元:BMC Neurology  

    DOI: 10.1186/s12883-019-1526-9

    Scopus

    PubMed

  • Yuka Urata, MD, Masayuki Nakamura, MD, PhD, Natsuki Sasaki, MD, PhD, Nari Shiokawa, MD, PhD, Yoshiaki Nishida, MD, Kaoru Arai, MD, Hanae Hiwatashi, MS, Izumi Yokoyama, BS, Shinsuke Narumi, MD, Yasuo Terayama, MD, PhD, Takenobu Murakami, MD, PhD, Yoshikazu Ugawa, MD, PhD, Hiroki Sakamoto, MD, Satoshi Kaneko, MD, PhD, Yusuke Nakazawa, MD, Ryo Yamasaki, MD, PhD, Shoko Sadashima, MD, Toshiaki Sakai, MD, Hiroaki Arai, MD, and Akira Sano, MD, PhD .  Novel pathogenic XK mutations in McLeod syndrome and interaction between XK protein and chorein. .  Neurology Genetics5 ( e328 )   2019年9月査読

     詳細を見る

    記述言語:英語   掲載種別:学位論文(博士)  

    Abstract
    Objective
    To identify XK pathologic mutations in 6 patients with suspected McLeod syndrome (MLS) and a possible interaction between the chorea-acanthocytosis (ChAc)- and MLS-responsible proteins: chorein and XK protein.
    Methods
    Erythrocyte membrane proteins from patients with suspected MLS and patients with ChAc, ChAc mutant carriers, and normal controls were analyzed by XK and chorein immunoblotting. We performed mutation analysis and XK immunoblotting to molecularly diagnose the patients with suspected MLS. Lysates of cultured cells were co-immunoprecipitated with anti-XK and anti-chorein antibodies.
    Results
    All suspected MLS cases were molecularly diagnosed with MLS, and novel mutations were identified. The average onset age was 46.8 ± 8 years, which was older than that of the patients with ChAc. The immunoblot analysis revealed remarkably reduced chorein immunoreactivity in all patients with MLS. The immunoprecipitation analysis indicated a direct or indirect chorein-XK interaction.
    Conclusions
    In this study, XK pathogenic mutations were identified in all 6 MLS cases, including novel mutations. Chorein immunoreactions were significantly reduced in MLS erythrocyte mem- branes. In addition, we demonstrated a possible interaction between the chorein and XK protein via molecular analysis. The reduction in chorein expression is similar to that between Kell antigens and XK protein, although the chorein-XK interaction is a possibly noncovalent binding unlike the covalent Kell-XK complex. Our results suggest that reduced chorein levels following lack of XK protein are possibly associated with molecular pathogenesis in MLS.

  • Urata Y. .  Novel pathogenic XK mutations in McLeod syndrome and interaction between XK protein and chorein .  Neurology: Genetics5 ( 3 ) e328   2019年6月

     詳細を見る

    出版者・発行元:Neurology: Genetics  

    DOI: 10.1212/NXG.0000000000000328

    Scopus

    PubMed

  • Nishida Y. .  Novel pathogenic VPS13A gene mutations in Japanese patients with chorea-acanthocytosis .  Neurology: Genetics5 ( 3 ) e332   2019年6月

     詳細を見る

    出版者・発行元:Neurology: Genetics  

    DOI: 10.1212/NXG.0000000000000332

    Scopus

    PubMed

  • Nagata O. .  Mouse model of chorea-acanthocytosis exhibits male infertility caused by impaired sperm motility as a result of ultrastructural morphological abnormalities in the mitochondrial sheath in the sperm midpiece .  Biochemical and Biophysical Research Communications503 ( 2 ) 915 - 920   2018年9月

     詳細を見る

    出版者・発行元:Biochemical and Biophysical Research Communications  

    DOI: 10.1016/j.bbrc.2018.06.096

    Scopus

    PubMed

▼全件表示

講演・口頭発表等

  • 有村 尚也, 浦田 結嘉, 瀬戸下 玄郎, 新井 薫, 佐々木 なつき, 石塚 貴周, 佐野 のぞみ, 中村 雅之 .  解離性けいれんを呈した筋強直性ジストロフィーの1例 .  日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集  2020年8月  日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会

  • 浦田 結嘉, 今村 研介, 塩川 奈理, 林 岳宏, 石塚 貴周, 中村 雅之, 神林 崇, 佐野 輝 .  1型筋強直性ジストロフィー4症例の分子診断と睡眠障害 .  精神神経学雑誌  2019年6月  (公社)日本精神神経学会

  • 吉水 宗裕, 塩川 奈理, 笠毛 渓, 永田 青海, 浦田 結嘉, 新井 薫, 林 岳宏, 石塚 貴周, 中村 雅之, 佐野 輝 .  レビー小体型認知症と診断されていたが、精査の結果アルツハイマー型認知症の診断に至った1例 .  九州神経精神医学  2018年8月  九州精神神経学会

  • 田川 真一朗, 寺崎 茜, 浦田 結嘉, 塩川 奈理, 石塚 貴周, 中村 雅之 .  抑うつ気分や被害妄想などの精神症状を呈した脊髄小脳変性症1型の1例 .  日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集  2020年8月  日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会

  • 古江 ナオミ, 中村 雅之, 浦田 結嘉, 崎元 仁志, 肝付 洋, 石塚 貴周 .  抗NMDA抗体受容体抗体脳炎を発症した60代男性の一例 抗VGKC複合体抗体脳炎との比較 .  精神神経学雑誌  2020年9月  (公社)日本精神神経学会