Updated on 2023/12/26

写真a

 
KUMAGAI Momochika
 
Organization
Research Field in Fisheries, Agriculture, Fisheries and Veterinary Medicine Area Faculty of Fisheries Department of Fisheries Science and Technology Assistant Professor
Title
Assistant Professor

Degree

  • 博士(理学) ( 2018.3   大阪市立大学 )

Research Interests

  • 天然物化学

  • 水産食品科学

Research History

  • Kagoshima University   Research Field in Fisheries, Agriculture, Fisheries and Veterinary Medicine Area Faculty of Fisheries Department of Fisheries Science and Technology   Assistant Professor

    2019.7

Professional Memberships

  • 日本水産学会

    2019.8

  • 日本食品科学工学会

    2020.6

  • 米国化学会

    2019.12

  • 日本農芸化学会

    2015.8

 

Papers

  • Kumagai Momochika, Nishikawa Keisuke, Mishima Takashi, Yoshida Izumi, Ide Masahiro, Watanabe Akio, Fujita Kazuhiro, Morimoto Yoshiki .  フッ素化カバラクトンはRAW264細胞のRANKL誘発性破骨細胞の分化を阻害する(Fluorinated Kavalactone Inhibited RANKL-Induced Osteoclast Differentiation of RAW264 Cells) .  Biological & Pharmaceutical Bulletin43 ( 5 ) 898 - 903   2020.5フッ素化カバラクトンはRAW264細胞のRANKL誘発性破骨細胞の分化を阻害する(Fluorinated Kavalactone Inhibited RANKL-Induced Osteoclast Differentiation of RAW264 Cells)

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    Publisher:(公社)日本薬学会  

    抗破骨細胞形成剤としての修飾カバラクトン類似体を発見することを目的として、破骨細胞の分化に及ぼす26の類似体の影響をin vitroで評価した。最も強力な化合物である(E)-6-(2-フルオロスチリル)-4-メトキシ-2H-ピラン-2-オン(I)は、RAW264細胞のreceptor activator of nuclear factor-κB ligand(RANKL)誘発性破骨細胞分化を4.3μMのIC50で阻害した。部分的構造活性相関研究により、5,6-デヒドロカイン骨格内のフッ素とその位置の重要性が明らかになった。ピット形成アッセイより、Iは破骨細胞形成を阻害することにより破骨細胞の骨吸収を防ぐと考えられた。Iは、RANKL誘発性nuclear factor of activated T cells c1と破骨細胞形成関連遺伝子のmRNA発現レベルを下方制御した。以上より、I足場が新しい抗吸収剤の特定につながると考えられた。

  • Kumagai Momochika, Watanabe Akio, Yoshida Izumi, Mishima Takashi, Nakamura Munetomo, Nishikawa Keisuke, Morimoto Yoshiki .  Toddalia asiaticaから単離された抗炎症物質アクレアチンおよびトダクリンのLPS-刺激RAW264マクロファージにおける評価(Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages) .  Biological & Pharmaceutical Bulletin41 ( 1 ) 132 - 137   2018.1Toddalia asiaticaから単離された抗炎症物質アクレアチンおよびトダクリンのLPS-刺激RAW264マクロファージにおける評価(Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages)

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    Publisher:(公社)日本薬学会  

    Toddalia asiatica(L.)LAM.から単離される類似の構造を有するクマリンであるアクアレラチン(ACU)およびトダクリン(TOD)の抗炎症活性を、リポ多糖(LPS)刺激RAW264マウスマクロファージ細胞を用いて評価した。ACUおよびTODは、炎症性メディエーターおよび酸化窒素産生のmRNA発現を有意に阻害した。TODは、p38および細胞外シグナル調節キナーゼ1/2のLPS誘発リン酸化を抑制し、核因子-κBのLPS誘発活性化を阻害した。TODは異なる機構を介してRAW264細胞のLPS誘導性炎症を抑制すると考えられた。これらの化合物の細胞取り込みも評価した。TODは4時間後と24時間後にRAW264細胞で検出されたが、ACUはすべてのインキュベーション間隔で検出されなかった。以上より、プレニル基の脱エポキシ化が分子の疎水性を増加させ、細胞取り込みおよび/または細胞膜のリン脂質二重層との相互作用を促進すると考えられた。

  • Momochika Kumagai , Keigo Ogasawara , Masahiro Ide , Hideyuki Kurihara , Sanae Kato .  Acid extraction enzymatic method to measure laminaran in edible brown algae .  Fisheries Science89 ( 3 ) 409 - 414   2023.3Acid extraction enzymatic method to measure laminaran in edible brown algaeReviewed

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12562-023-01684-8

  • Keisuke Nishikawa , Naoto Taki , Kento Nishikibe , Momochika Kumagai , Yoshiki Morimoto .  Total Synthesis, Revised Structure, and Cytotoxic Activities of Iubol .  Chemistry Letters51 ( 10 ) 1000 - 1003   2022.10Total Synthesis, Revised Structure, and Cytotoxic Activities of IubolReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.220312

  • Tomonori Teranishi , Keisuke Nishikawa , Akihisa Matsuura , Momochika Kumagai , Yoshiki Morimoto .  Divergent Synthesis of Nerolidol-Type Sesquiterpenoids Produced by Soil Bacterium from an Identical Starting Material via Diepoxide Precursors: Stereochemical Revision and Absolute Configuration of a THF Natural Product .  Chemistry Letters   2022.9Divergent Synthesis of Nerolidol-Type Sesquiterpenoids Produced by Soil Bacterium from an Identical Starting Material via Diepoxide Precursors: Stereochemical Revision and Absolute Configuration of a THF Natural ProductReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.220390

  • 小泉 慶子 , 吉田 泉 , 熊谷 百慶 , 井出 将博 , 加藤 毅 , 三嶋 隆 , 小谷口 美也子 , 北村 進一 , 藤田 和弘 , 五十嵐 友二 .  ポストカラム誘導体化法を用いた分子量に依存しないヒアルロン酸の新規定量法の開発 .  日本食品科学工学会誌69 ( 1 ) 17 - 29   2022.1ポストカラム誘導体化法を用いた分子量に依存しないヒアルロン酸の新規定量法の開発Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3136/nskkk.69.17

  • Kento Nishikibe , Keisuke Nishikawa , Momochika Kumagai , Matsumi Doe , Yoshiki Morimoto .  Asymmetric Total Syntheses, Stereostructures, and Cytotoxicities of Marine Bromotriterpenoids Aplysiol B (Laurenmariannol) and Saiyacenol A .  Chemistry - An Asian Journal17 ( 1 )   2022.1Asymmetric Total Syntheses, Stereostructures, and Cytotoxicities of Marine Bromotriterpenoids Aplysiol B (Laurenmariannol) and Saiyacenol A Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.202101137

  • Establishing a “Ring-Size-Divergent” Synthetic Strategy: Synthesis, Structural Revision, and Absolute Configuration of Feroniellins .    27 ( 43 ) 11045 - 11049   2021.8Establishing a “Ring-Size-Divergent” Synthetic Strategy: Synthesis, Structural Revision, and Absolute Configuration of Feroniellins Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.202101603

  • Momochika Kumagai, Sanae Kato, Nanami Arakawa, Mika Otsuka, Takahisa Hamano, Nobuyuki Kashiwagi, Akira Yabuki, Osamu Yamato .  Quantification of histidine-containing dipeptides in dolphin serum using a reversed-phase ion-pair high-performance liquid chromatography method .  Separations8 ( 8 )   2021.8Quantification of histidine-containing dipeptides in dolphin serum using a reversed-phase ion-pair high-performance liquid chromatography methodReviewed

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    Authorship:Lead author, Corresponding author  

    DOI: 10.3390/separations8080128

  • 西川 慶祐, 熊谷 百慶, 松村 匡浩, 錦部 健人, 森本 善樹 .  直鎖分子からの環骨格一挙構築をコンセプトとした天然物合成戦略 .  有機合成化学協会誌79 ( 3 ) 197 - 209   2021.3直鎖分子からの環骨格一挙構築をコンセプトとした天然物合成戦略Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.5059/yukigoseikyokaishi.79.197

  • Kumagai M. .  4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion .  Journal of Natural Medicines75 ( 1 ) 232 - 239   2021.1

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    Publisher:Journal of Natural Medicines  

    DOI: 10.1007/s11418-020-01458-x

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  • Ide M, Yoshida I, Kumagai M, Mishima T, Takahashi Y, Fujita K, Igarashi T, Matsuura E .  Tithonia diversifolia-derived orizabin suppresses cell adhesion, differentiation, and oxidized LDL accumulation by Akt signaling suppression via PTEN promotion in THP-1 cells. .  Journal of food biochemistry44 ( 7 ) e13268   2020.7Tithonia diversifolia-derived orizabin suppresses cell adhesion, differentiation, and oxidized LDL accumulation by Akt signaling suppression via PTEN promotion in THP-1 cells.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jfbc.13268

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  • Yoshida I. .  Polymethoxyflavones in black ginger (Kaempferia parviflora) regulate the expression of circadian clock genes .  Journal of Functional Foods68   103900   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Functional Foods  

    DOI: 10.1016/j.jff.2020.103900

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  • Kumagai Momochika, Nishikawa Keisuke, Mishima Takashi, Yoshida Izumi, Ide Masahiro, Watanabe Akio, Fujita Kazuhiro, Morimoto Yoshiki .  Fluorinated Kavalactone Inhibited RANKL-Induced Osteoclast Differentiation of RAW264 Cells .  Biological & Pharmaceutical Bulletin43 ( 5 ) 898 - 903   2020

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:公益社団法人 日本薬学会  

    <p>Bone loss and bone-related disease are associated with the deregulation of osteoclast function, and therefore agents that affect osteoclastogenesis have attracted attention. The purpose of the present study was to discover modified kavalactone analogs as potential anti-osteoclastogenic agents. We assessed the effect of 26 analogs on osteoclast differentiation <i>in vitro</i>. The most potent compound, (<i>E</i>)-6-(2-fluorostyryl)-4-methoxy-2<i>H</i>-pyran-2-one (<b>22</b>), suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenic differentiation of RAW264 cells with IC<sub>50</sub> values of 4.3 µM. A partial structure–activity relationship study revealed the importance of fluorine and its position within the 5,6-dehydrokawain skeleton. The results of a pit formation assay suggested that compound <b>22</b> prevents osteoclastic bone resorption by inhibiting osteoclastogenesis. Moreover, compound <b>22</b> downregulated mRNA expression levels of RANKL-induced nuclear factor of activated T cells c1 (NFATc1) and osteoclastogenesis-related genes. These results suggest that (<i>E</i>)-6-(2-fluorostyryl)-4-methoxy-2<i>H</i>-pyran-2-one scaffold could lead to the identification of new anti-resorptive agents.</p>

    DOI: 10.1248/bpb.b20-00063

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  • Nishikawa K, Morita K, Hashimoto S, Hoshino A, Ikeuchi T, Kumagai M, Morimoto Y .  Critical Switching of Cyclization Modes of Polyepoxides in Acidic Aqueous Media and Neutral Water: Synthesis and Revised Structure of a Nerolidol-Type Sesquiterpenoid. .  Angewandte Chemie (International ed. in English)58 ( 30 ) 10168 - 10172   2019.7Critical Switching of Cyclization Modes of Polyepoxides in Acidic Aqueous Media and Neutral Water: Synthesis and Revised Structure of a Nerolidol-Type Sesquiterpenoid.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201906039

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  • Kumagai M, Nishikawa K, Matsuura H, Umezawa T, Matsuda F, Okino T .  Antioxidants from the Brown Alga <i>Dictyopteris undulata</i>. .  Molecules (Basel, Switzerland)23 ( 5 ) 1214   2018.5Antioxidants from the Brown Alga <i>Dictyopteris undulata</i>.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/molecules23051214

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  • Ide M, Okumura M, Koizumi K, Kumagai M, Yoshida I, Yoshida M, Mishima T, Nakamura M .  Novel Method to Quantify β-Glucan in Processed Foods: Sodium Hypochlorite Extracting and Enzymatic Digesting (SEED) Assay. .  Journal of agricultural and food chemistry66 ( 4 ) 1033 - 1038   2018.1Novel Method to Quantify β-Glucan in Processed Foods: Sodium Hypochlorite Extracting and Enzymatic Digesting (SEED) Assay.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jafc.7b05044

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  • Kumagai M, Watanabe A, Yoshida I, Mishima T, Nakamura M, Nishikawa K, Morimoto Y .  Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. .  Biological & pharmaceutical bulletin41 ( 1 ) 132 - 137   2018Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1248/bpb.b17-00607

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  • Kumagai M, Nishikawa K, Mishima T, Yoshida I, Ide M, Koizumi K, Nakamura M, Morimoto Y .  Synthesis of novel 5,6-dehydrokawain analogs as osteogenic inducers and their action mechanisms. .  Bioorganic & medicinal chemistry letters27 ( 11 ) 2401 - 2406   2017.6Synthesis of novel 5,6-dehydrokawain analogs as osteogenic inducers and their action mechanisms.

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bmcl.2017.04.016

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  • Nishikawa, K. and Yamauchi, K. and Kikuchi, S. and Ezaki, S. and Koyama, T. and Nokubo, H. and Matsumura, K. and Kodama, T. and Kumagai, M. and Morimoto, Y. .  Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)<inf>2</inf>-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities .  Chemistry - A European Journal23 ( 40 ) 9535 - 9545   2017Total Syntheses of Lepadiformine Marine Alkaloids with Enantiodivergency, Utilizing Hg(OTf)<inf>2</inf>-Catalyzed Cycloisomerization Reaction and their Cytotoxic Activities

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chem.201701475

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  • Kumagai, M. and Mishima, T. and Watanabe, A. and Harada, T. and Yoshida, I. and Fujita, K. and Watai, M. and Tawata, S. and Nishikawa, K. and Morimoto, Y. .  5,6-Dehydrokawain from alpinia zerumbet promotes osteoblastic MC3T3-E1 cell differentiation .  Bioscience, Biotechnology and Biochemistry80 ( 7 ) 1425 - 1432   20165,6-Dehydrokawain from alpinia zerumbet promotes osteoblastic MC3T3-E1 cell differentiation

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2016.1153959

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  • Watanabe, A. and Kumagai, M. and Mishima, T. and Ito, J. and Otoki, Y. and Harada, T. and Kato, T. and Yoshida, M. and Suzuki, M. and Yoshida, I. and Fujita, K. and Watai, M. and Nakagawa, K. and Miyazawa, T. .  Toddaculin, isolated from of Toddala asiatica (L) Lam., inhibited osteoclastogenesis in RAW 264 cells and enhanced osteoblastogenesis in MC3T3-E1 cells .  PLoS ONE10 ( 5 ) e0127158   2015Toddaculin, isolated from of Toddala asiatica (L) Lam., inhibited osteoclastogenesis in RAW 264 cells and enhanced osteoblastogenesis in MC3T3-E1 cells

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0127158

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  • Shimura, A. and Esaki, H. and Mori, K. and Kumagai, M. and Nakamura, Y. .  Evaluation of an Okara Beni Koji based on antioxidant properties, and an application to cookie making .  Nippon Shokuhin Kagaku Kogaku Kaishi61 ( 9 ) 409 - 417   2014Evaluation of an Okara Beni Koji based on antioxidant properties, and an application to cookie making

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3136/nskkk.61.409

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  • Shibata, M. and Onodera, K. and Kumagai, M. and Shah, A.K.M.A. and Ogasawara, M. and Kurihara, H. and Okino, T. and Takahashi, K. .  Supercritical fluid extraction of "Koku" enhancing compounds from fish and fishery by-products .  Food Science and Technology Research20 ( 6 ) 1199 - 1205   2014Supercritical fluid extraction of "Koku" enhancing compounds from fish and fishery by-products

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3136/fstr.20.1199

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MISC

  • 4β-Hydroxywithanolide E and withanolide E from Physalis peruviana L. inhibit adipocyte differentiation of 3T3-L1 cells through modulation of mitotic clonal expansion(和訳中)

    Kumagai Momochika, Yoshida Izumi, Mishima Takashi, Ide Masahiro, Fujita Kazuhiro, Doe Matsumi, Nishikawa Keisuke, Morimoto Yoshiki

    Journal of Natural Medicines   75 ( 1 )   232 - 239   2021.1

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    Publisher:シュプリンガー・ジャパン(株)  

Presentations

  • 熊谷 百慶, 西川 慶祐, 井出 将博, 小泉 慶子, 吉田 泉, 三嶋 隆, 中村 宗知, 森本 善樹   食用ホオズキ(Physalis sp.)廃棄部より得られた3T3-L1細胞脂肪蓄積抑制物質の同定と作用機序の解明  

    日本栄養・食糧学会大会講演要旨集  2017.4  (公社)日本栄養・食糧学会

  • 井出 将博, 小泉 慶子, 吉田 泉, 熊谷 百慶, 奥村 雅人, 吉田 幹彦, 三嶋 隆, 中村 宗知   加工食品中のβグルカンを測定するための新規定量法(次亜塩素酸ナトリウム抽出-酵素分解法)  

    日本栄養・食糧学会大会講演要旨集  2017.4  (公社)日本栄養・食糧学会

  • 井出 将博, 熊谷 百慶, 三嶋 隆, 吉田 泉, 高橋 有志, 中村 宗知, 松浦 栄次   ニトベギク茎葉由来orizabinのヒト臍帯静脈内皮細胞とヒト単球細胞THP1における細胞接着と泡沫化の抑制作用  

    日本生化学会大会プログラム・講演要旨集  2018.9  (公社)日本生化学会

  • 井出 将博, 三嶋 隆, 吉田 泉, 高橋 有志, 熊谷 百慶, 五十嵐 友二, 松浦 栄次   ニトベギク由来オリザビンはPMA刺激ヒト単球THP-1細胞のPTEN発現を促進しAktリン酸化とCD36の発現を抑制する  

    日本栄養・食糧学会大会講演要旨集  2019.4  (公社)日本栄養・食糧学会