Updated on 2023/08/26

写真a

 
FURUE Kirara
 
Organization
University Hospital, Medical and Dental Sciences Area University Hospital Clinical Center Advanced Dentistry Center Assistant Professor
Title
Assistant Professor

Degree

  • 博士（歯学） ( 2017.3   鹿児島大学 )

Research Interests

  • periodontal regeneration

  • SDF-1

  • BMP9

Research Areas

  • Life Science / Regenerative dentistry and dental engineering

  • Life Science / Conservative dentistry

Education

  • Kagoshima University

    - 2017.3

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    Country： Japan

  • Kagoshima University

    - 2012.3

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    Country： Japan

Research History

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Center Advanced Dentistry Center   Assistant Professor

    2019.3

Professional Memberships

  • 日本歯周病学会

    2013.4

  • 日本歯科保存学会

    2013.4

Qualification acquired

  • Dentist

 

Papers

  • Sena K., Furue K., Setoguchi F., Noguchi K. .  Altered expression of SARS-CoV-2 entry and processing genes by Porphyromonas gingivalis-derived lipopolysaccharide, inflammatory cytokines and prostaglandin E<inf>2</inf> in human gingival fibroblasts .  Archives of Oral Biology129   105201   2021.9

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    Language：Japanese   Publisher：Archives of Oral Biology  

    Objective: The aim of this in vitro study was to investigate the expression of SARS-CoV-2 entry and processing genes in human gingival fibroblasts (HGnF) following treatment with Porphyromonas gingivalis-derived lipopolysaccharide (PgLPS) or inflammatory cytokines/mediators. Design: We assessed the expression of SARS-CoV-2 entry and processing genes; angiotensin-converting enzyme 2 (ACE2), cellular serine proteases transmembrane serine protease 2 (TMPRSS2), Furin, and basigin (BSG) in HGnF by real-time PCR. To further asses the contribution of PgLPS and inflammatory cytokines/mediators to proliferation and SARS-CoV-2 entry and processing gene expression, HGnF were treated with PgLPS, IL1β, TNFα, and PGE2. Results: The expression for ACE2 in HGnF was significantly elevated after PgLPS or IL1β, TNFα, PGE2 treatment. The expression of TMPRSS2 was increased by PgLPS, IL1β, or PGE2 while BSG was elevated by PgLPS and IL1β. The expression of BSG and FURIN decreased after TNFα treatment. Conclusion: SARS-CoV-2 entry and processing genes are expressed in human gingival fibroblasts and their expressions are altered by PgLPS, IL1β, TNFα and PGE2 treatment.

    DOI： 10.1016/j.archoralbio.2021.105201

    Scopus

    PubMed

  • 3. Nakamura T, Shirakata Y, Shinohara Y, Miron RJ, Furue K, Noguchi K. .  Osteogenic potential of recombinant human bone morphogenetic protein-9/absorbable collagen sponge (rhBMP-9/ACS) in rat critical size calvarial defects. .  Clinical Oral Investigations   2017.6Osteogenic potential of recombinant human bone morphogenetic protein-9/absorbable collagen sponge (rhBMP-9/ACS) in rat critical size calvarial defects.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Furue K, Sena K, Sakoda K, Nakamura T, Noguchi K .  nvolvement of PI3K/Akt signaling pathway in BMP9-stimulated osteogenic differentiation and SDF-1 production in human periodontal ligament fibroblasts. .  European journal of oral sciences   2017.4nvolvement of PI3K/Akt signaling pathway in BMP9-stimulated osteogenic differentiation and SDF-1 production in human periodontal ligament fibroblasts. Reviewed

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • Furue K, Sena K, Sakoda K, Nakamura T, Noguchi K .  Involvement of PI3K/Akt signaling pathway in BMP9-stimulated osteogenic differentiation and SDF-1 production in human periodontal ligament fibroblasts. .      2017.3Involvement of PI3K/Akt signaling pathway in BMP9-stimulated osteogenic differentiation and SDF-1 production in human periodontal ligament fibroblasts.Reviewed

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    Language：English   Publishing type：Doctoral thesis  

  • 2. Fuchigami S, Nakamura T, Furue K, Sena K, Shinohara Y, Noguchi K. .  Recombinant human bone morphogenetic protein-9 potently induces osteogenic differentiation of human periodontal ligament fibroblasts. .  European journal of oral sciences   2016.4Recombinant human bone morphogenetic protein-9 potently induces osteogenic differentiation of human periodontal ligament fibroblasts. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

Presentations

  • 瀬名浩太郎, 古江きらら, 野口和行   Porphyromonas gingivalis 由来 lipopolysaccharide の骨細胞への影響  

    第 1 回南九州歯学会総会・学術大会  鹿児島大学

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    Event date： 2019.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島大学  

  • 古江きらら, 瀬名浩太郎, 迫田 賢二, 中村利明, 野口 和行.   Bone morphogenetic protein 9 (BMP9)の歯根膜由来線維芽細胞の機能への影響  

    日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会 

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    Event date： 2016.11

    Language：Japanese   Presentation type：Poster presentation  

  • 篠原敬哉, 中村利明, 白方良典, 古江きらら, 野口和行   Recombinant human bone morphogenetic protein-9/コラーゲン担体がラット頭蓋骨欠損の骨形成に及ぼす影響  

    2. 第59回春季日本歯周病学会学術大会 

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    Event date： 2016.5

    Language：Japanese   Presentation type：Poster presentation  

  • 瀬名 浩太郎，古江 きらら，野口 和行   Porphyromonas gingivalis由来lipopolysaccharideの骨細胞への影響  

    第59回春季日本歯周病学会学術大会 

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    Event date： 2016.5

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 渕上佐和子、中村利明、篠原敬哉、瀬名浩太郎、古江きらら、野口和行   protein-9によるヒト歯根膜線維芽細胞の骨芽細胞様分化  

    平成26年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会 

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    Event date： 2014.11

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 渕上佐和子、中村利明、篠原敬哉、瀬名浩太郎、古江きらら、野口和行   BMP-9 はヒト歯根膜線維芽細胞の新規の骨芽細胞様分化因子である  

    第140回春季日本歯科保存学会 

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    Event date： 2014.6

    Language：Japanese   Presentation type：Oral presentation (general)  

  • 古江きらら、瀬名浩太郎、武内博信、中村利明、野口和行   Bone Morphogenetic Protein 9 による骨芽細胞の分化  

    第57回春季日本歯周病学会学術大会 

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    Event date： 2014.5

    Language：Japanese   Presentation type：Oral presentation (general)  

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Research Projects

  • BMP9の歯周組織におけるSDF-1/CXCR4 axisを中心とした機能の解明

    2018.4

    科学研究費補助金  若手研究(B)