Updated on 2023/08/28

写真a

 
YAMASAKI Yuichi
 
Organization
University Hospital, Medical and Dental Sciences Area University Hospital Clinical Center Medical Children Center Lecturer
Title
Lecturer

Degree

  • 博士(医学) ( 2016.3   鹿児島大学 )

Education

  • Kagoshima University

    - 2003.3

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    Country: Japan

Research History

  • Kagoshima University   Lecturer

    2021.8

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Center Medical Children Center   Assistant Professor

    2015.4 - 2021.7

Qualification acquired

  • リウマチ指導医

  • リウマチ専門医

  • 小児科指導医

  • 小児科専門医

 

Papers

  • Yamasaki Y, Nakamura A, Kubota T, Mitsunobu T, Moriyama M, Takei S, Okamoto Y .  Rheumatoid factor value for determining the first biologic agent to use for non-systemic juvenile idiopathic arthritis .  Modern Rheumatology   2022Rheumatoid factor value for determining the first biologic agent to use for non-systemic juvenile idiopathic arthritisReviewed

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    Authorship:Lead author   Language:English  

    DOI: 10.1093/mr/roac125.

  • Yamasaki Y, Kobayashi N, Akioka S, Yamazaki K, Takezaki S, Nakaseko H, Ohara A, Nishimura K, Nishida Y, Sato S, Kishi T, Hashimoto M, Mori M, Okazaki Y, Kuwana M, Ohta A. .  Clinical impact of myositis-specific autoantibodies on long-term prognosis of juvenile idiopathic inflammatory myopathies: multicenter study. .  Rheumatology (Oxford)   2021Clinical impact of myositis-specific autoantibodies on long-term prognosis of juvenile idiopathic inflammatory myopathies: multicenter study.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Kitagawa Y, Kawasaki Y, Yamasaki Y, Kambe N, Takei S, Saito MK. .  Anti-TNF treatment corrects IFN-gamma-dependent proinflammatory signatures in Blau syndrome patient-derived macrophages. .  Journal of Allergy and Clinical Immunology   2021Anti-TNF treatment corrects IFN-gamma-dependent proinflammatory signatures in Blau syndrome patient-derived macrophages.Reviewed

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    Language:English  

    DOI: 10.1016/j.jaci.2021.05.030.

  • Yamasaki Y, Kubota T, Takei S, Imanaka H, Nonaka Y, Kawano Y. .  A case of cryopyrin-associated periodic fever syndrome during canakinumab administration complicated by inflammatory bowel disease. .  Clinical Rheumatology   2020A case of cryopyrin-associated periodic fever syndrome during canakinumab administration complicated by inflammatory bowel disease.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Kobayashi I, Akioka S, Kobayashi N, Iwata N, Takezaki S, Nakaseko H, Sato S, Nishida Y, Nozawa T, Yamasaki Y, Yamazaki K, Arai S, Nishino I, Mori M. .  Clinical practice guidance for juvenile dermatomyositis (JDM) 2018-update. .  Modern Rheumatology   2020Clinical practice guidance for juvenile dermatomyositis (JDM) 2018-update.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamazaki K, Ohta A, Akioka S, Yamasaki Y, Ohara A, Nakaseko H, Nishimura K, Kobayashi N, Nishida Y, Sato S, Takezaki S, Kishi T, Hashimoto M, Kobayashi I, Mori M. .  External validation of the EULAR/ACR idiopathic inflammatory myopathies classification criteria with a Japanese paediatric cohort. .  Rheumatology (Oxford)   2020External validation of the EULAR/ACR idiopathic inflammatory myopathies classification criteria with a Japanese paediatric cohort.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamasaki Y, Takei S, Imanaka H, Kubota T, Nonaka Y, Takezaki T, Kawano Y .  S100A12 and vascular endothelial growth factor can differentiate Blau syndrome and familial Mediterranean fever from systemic juvenile idiopathic arthritis. .  Clinical Rheumatology   2019S100A12 and vascular endothelial growth factor can differentiate Blau syndrome and familial Mediterranean fever from systemic juvenile idiopathic arthritis.Reviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Hara R, Umebayashi H, Takei S, Okamoto N, Iwata N, Yamasaki Y, Nakagishi Y, Kizawa T, Kobayashi I, Imagawa T, Kinjo N, Amano N, Takahashi Y, Mori M, Itoh Y, Yokota S .  Intravenous abatacept in Japanese patients with polyarticular-course juvenile idiopathic arthritis: results from a phase III open-label study. .  Pediatric Rheumatology Online Journal   2019Intravenous abatacept in Japanese patients with polyarticular-course juvenile idiopathic arthritis: results from a phase III open-label study.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Imamura M, Okamoto Y, Nishikawa T, Yoneyama T, Yamasaki Y, Kawamura J, Kawano Y .  Celecoxib as a Potential Treatment for Intractable Lymphatic Malformation. .  Pediatrics   2019Celecoxib as a Potential Treatment for Intractable Lymphatic Malformation.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Kubota T, Takei S, Shimizu M, Yasumura J, Nakagishi Y, Kizawa T, Yashiro M, Wakiguchi H, Yamasaki Y, Kawano Y. .  Early prediction for over two years efficacy of the first biologic agent for polyarticular juvenile idiopathic arthritis: A multi-institutional study in Japan. .  Modern Rheumatology   2018Early prediction for over two years efficacy of the first biologic agent for polyarticular juvenile idiopathic arthritis: A multi-institutional study in Japan.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Nagakura T, Wakiguchi H, Kubota T, Yamatou T, Yamasaki Y, Nonaka Y, Nerome Y, Akaike H, Takezaki T, Imanaka H, Kawano Y, Takei S. .  Tumor Necrosis Factor Inhibitors Provide Longterm Clinical Benefits in Pediatric and YoungAdult Patients with Blau Syndrome. .  The Journal of Rheumatology   2017Tumor Necrosis Factor Inhibitors Provide Longterm Clinical Benefits in Pediatric and YoungAdult Patients with Blau Syndrome.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Wakiguchi H, Takei S, Imanaka H, Hiraki T, Higashi M, Yamatou T, Yamasaki Y, Kubota T, Kawano Y. .  Severe gluteal skin ulcers in an infant with juvenile dermatomyositis. .  The European Journal of Dermatology   2016Severe gluteal skin ulcers in an infant with juvenile dermatomyositis.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Kubota T, Imanaka H, Takei S, Yamatou T, Nerome Y, Yamasaki Y, Nonaka Y, Akaike H, Takezaki T, Kawano Y. .  Disease activity score in 28 joints at 3 months after the initiation of biologic agent can be a predictive target for switching to the second biologic agent in patients with polyarticular juvenile idiopathic arthritis. .  Modern Rheumatology   2016 Disease activity score in 28 joints at 3 months after the initiation of biologic agent can be a predictive target for switching to the second biologic agent in patients with polyarticular juvenile idiopathic arthritis.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Nerome Y, Akaike H, Nonaka Y, Takezaki T, Kubota T, Yamato T, Yamasaki Y, Imanaka H, Kawano Y, Takei S. .  The safety and effectiveness of HBV vaccination in patients with juvenile idiopathic arthritiscontrolled by treatment. .  Modern Rheumatology   2016The safety and effectiveness of HBV vaccination in patients with juvenile idiopathic arthritiscontrolled by treatment.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamasaki Y, Takei S, Imanaka H, Nerome Y, Kubota T, Nonaka Y, Akaike H, Takezaki T, Kawano Y. .  Prediction of long-term remission of oligo/polyarticular juvenile idiopathic arthritis with S100A12 and Vascular Endothelial Growth Factor .  Modern Rheumatology   2015Prediction of long-term remission of oligo/polyarticular juvenile idiopathic arthritis with S100A12 and Vascular Endothelial Growth FactorReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Shimizu M, Nakagishi Y, Inoue N, Mizuta M, Ko G, Saikawa Y, Kubota T, Yamasaki Y, Takei S, Yachie A. .  Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis. .  Clinical Immunology   2015Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Shimizu M, Nakagishi Y, Kasai K, Yamasaki Y, Miyoshi M, Takei S, Yachie A. .  Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis associated macrophage activation syndrome: the diagnostic significance of interleukin-18 and interleukin-6. .  Cytokine   2012Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis associated macrophage activation syndrome: the diagnostic significance of interleukin-18 and interleukin-6.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamasaki Y, Nishi J, Nishikawa T, Tatsumoto C, Kasano F, Sano N, Kawano Y, Kawakami K .  Descending necrotizing mediastinitis secondary to retropharyngeal abscess in a child .  The Journal of Infection and Chemotherapy   2008Descending necrotizing mediastinitis secondary to retropharyngeal abscess in a childReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Kubota Tomohiro, Takei Syuji, Yamato Tsuyoshi, Yamasaki Yuichi, Kawano Yoshifumi .  指骨マイクロジオディック症候群における超音波画像 1症例報告(Ultrasonographic imaging in phalangeal microgeodic syndrome: a case report) .  Modern Rheumatology Case Reports3 ( 1 ) 67 - 69   2019.1指骨マイクロジオディック症候群における超音波画像 1症例報告(Ultrasonographic imaging in phalangeal microgeodic syndrome: a case report)

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    Publisher:Taylor & Francis  

    症例は11歳女児で、3週前からの左足第4つま先と右手第4/第5指の疼痛と腫脹を認めて来院した。身体検査では、左足第4つま先の腫脹、圧痛、局所熱感が判明した。検査データでは、C反応性蛋白、赤沈、マトリックスメタロプロテアーゼ-3は正常範囲内であった。X線検査では、中節骨に複数の小さな溶骨性領域が認められ、指骨マイクロジオディック症候群(PMS)が示唆された。超音波検査では、グレースケール画像で腫脹つま先の中節骨に小型の骨小腔が認められ、パワードップラーを用いると骨小腔と軟部組織に血流シグナル増大が認められた。3ヵ月後、つま先と指の腫脹は薬物療法を行わずに改善した。超音波検査はMRIなどの画像検査に比べて利便性が高く、費用が安いことから、PMSの診断に有用であると考えられた。

  • Kubota Tomohiro, Takei Syuji, Shimizu Masaki, Yasumura Junko, Nakagishi Yasuo, Kizawa Toshitaka, Yashiro Masato, Wakiguchi Hiroyuki, Yamasaki Yuichi, Kawano Yoshifumi .  多関節型若年性特発性関節炎に対して初回導入した生物学的製剤の2年以上の有効性に関する早期予測 日本における多施設共同研究(Early prediction for over two years efficacy of the first biologic agent for polyarticular juvenile idiopathic arthritis: A multi-institutional study in Japan) .  Modern Rheumatology28 ( 5 ) 826 - 831   2018.9多関節型若年性特発性関節炎に対して初回導入した生物学的製剤の2年以上の有効性に関する早期予測 日本における多施設共同研究(Early prediction for over two years efficacy of the first biologic agent for polyarticular juvenile idiopathic arthritis: A multi-institutional study in Japan)

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    多関節型若年性特発性関節炎(pJIA)に対して初回導入した生物学的製剤の長期有効性の予測マーカーを特定した。2005年3月〜2014年10月に日本の6施設で治療したpJIA患者を後ろ向きに同定した。診療録からマトリックスメタロプロテイナーゼ-3、赤血球沈降速度(ESR)、disease activity score(DAS)28-ESRを調査した。患者を、初回の生物学的製剤によって2年以上治療に成功した継続治療群24例(女児17例、男児7例、発症時年齢1.2〜15.5歳)と、初回の生物学的製剤が無効であったため別の生物学的製剤に切り替えた切り替え群8例(女児7例、男児1例、年齢6〜14.8歳)に分けた。初回導入した生物学的製剤の治療期間中央値は継続治療群が40ヵ月、切り替え群が9.5ヵ月であった。ウェルチのt検定で、ベースラインから3ヵ月までの両群の各マーカー中央値を解析したところ、2、3ヵ月のDAS28-ESRに両群間で有意差があった。受信者動作特性曲線解析では3ヵ月でのDAS28-ESRカットオフ値2.49が最も高い鑑別能を有した。初回導入した生物学的製剤による治療開始から3ヵ月後のDAS28-ESR<2.49は、臨床的寛解が2年以上継続する予測因子であり、治療標的であることが示唆された。

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MISC

  • 小児リウマチ疾患 トシリズマブ治療の理論と実際

    複数名

    メディカルビュー社   2023.3

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    Language:Japanese  

  • 若年性特発性関節炎 カナキヌマブ治療の理論と実際

    監修 森雅亮、武井修治 著者複数名

    メディカルビュー社   2021.4

  • 成人診療科医のための小児リウマチ性疾患移行支援ガイド

    山﨑雄一, 他

    成人診療科医のための小児リウマチ性疾患移行支援ガイド   2020.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)   Publisher:羊土社  

  • Blau症候群

    山﨑雄一, 他

    小児リウマチ学   2020.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)   Publisher:朝倉書店  

  • 若年性皮膚筋炎診療の手引き

    山﨑雄一, 他

    若年性皮膚筋炎診療の手引き   2018.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (other)   Publisher:羊土社  

  • 若年性特発性関節炎と免疫抑制薬/生物学的製剤

    山﨑雄一, 他

    小児科   2016

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • 小児科臨床実習における学生の担当患者数と学生による実習評価との関連. Reviewed

    野村裕一、山﨑雄一、児玉祐一、新小田雄一、江口太助、田邊貴幸、徳田浩一、豊島光雄、岡本康裕、河野嘉文

    日本小児科学会雑誌   2011

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 膠原病に見られる発疹

    山﨑雄一, 他

    小児内科   2010

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • SLEにおける肺出血

    山﨑雄一, 武井修治

    小児リウマチ   2010

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • 若年性皮膚筋炎(JDM)診療の手引き2018年版 最新情報(Clinical practice guidance for juvenile dermatomyositis(JDM) 2018-Update)

    Kobayashi Ichiro, Akioka Shinji, Kobayashi Norimoto, Iwata Naomi, Takezaki Shunichiro, Nakaseko Haruna, Sato Satoshi, Nishida Yutaka, Nozawa Tomo, Yamasaki Yuichi, Yamazaki Kazuko, Arai Satoru, Nishino Ichizo, Mori Masaaki

    Modern Rheumatology   30 ( 3 )   411 - 423   2020.5

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    Publisher:Taylor & Francis  

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Presentations

  • 山﨑雄一   小児からAYA世代のSLE診療   Invited

    第32回日本リウマチ学会近畿支部学術集会  2023.8 

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    Event date: 2023.8

    Venue:奈良県  

  • 山﨑雄一   若年性皮膚筋炎   Invited

    第10回小児リウマチ研修会:日本小児リウマチ学会  2023.6 

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    Event date: 2023.6

  • 山﨑雄一   家族性地中海熱の診断・治療法と課題   Invited

    第31回日本小児リウマチ学会  2022.10 

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    Event date: 2022.10

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:新潟県  

  • 山﨑雄一   少関節炎・多関節炎の病態と分類基準   Invited

    第29回日本小児リウマチ学会 

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    Event date: 2019.10

  • 山﨑雄一   若年性特発性関節炎~自己免疫疾患なのか、自己炎症性疾患なのか~   Invited

    第119回日本小児科学会学術集会 

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    Event date: 2016.5

  • 山﨑雄一   s-JIAの治療方針   Invited

    第21回日本小児リウマチ学会 

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    Event date: 2011.10

  • 山﨑雄一   JIA患者に対するトシリズマブ使用のこつ TCZ投与中におけるMAS早期診断の試み   Invited

    第19回日本小児リウマチ学会  2009.10 

  • 山﨑雄一   イラリス治療中にMASへ移行したsJIAの1例   Invited

    Nation wide symposia for sJIA  2018.12 

  • 山﨑雄一   Drug-free寛解、Bio-Free寛解は可能か   Invited

    第20回日本小児リウマチ学会  2011.2 

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Research Projects

  • 若年性皮膚筋炎の全国前向きコホート研究

    Grant number:科学研究費補助金 若手研究  2021.4 - 2024.3

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    Authorship:Principal investigator  Grant type:Competitive

  • 移行期JIAを中心としたリウマチ性疾患における患者の層別化に基づいた生物学的製剤等の適正使用に資する研究

    2021.4 - 2024.3

    厚生労働科学研究費補助金(免疫・アレルギー疾患政策研究事業) 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

 

Social Activities

  • 発達障害

    Role(s): Lecturer

    枕崎市立病院  市民公開講座  2018.12