Updated on 2024/04/08

写真a

 
Yuichi Goto
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Oral and Maxillofacial Rehabilitation Assistant Professor
Title
Assistant Professor
Profile
口腔扁平上皮癌の浸潤転移における分子メカニズムの解明 近年は口腔細菌叢と大腸のマイクロバイオームを研究
External link

Degree

  • 博士(歯学)(2012年3月九州大学) ( 2012.3   九州大学 )

Research Interests

  • 上皮間葉転換

  • 浸潤転移

  • 口腔扁平上皮癌

  • 大腸がん

  • マイクロバイオーム

Research Areas

  • Others / Others  / 口腔腫瘍学

  • Others / Others  / 口腔外科学

Education

  • Kyushu University

    2008.4 - 2012.3

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    Country: Japan

  • Kagoshima University

    2001.4 - 2007.3

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    Country: Japan

Research History

  • Kyushu University   Graduate student(doctorate program)

    2008.4 - 2012.3

  • Kyushu University   Oral and maxillofacial surgery   Part-time researcher for university or other academic organization

    2012.4 - 2015.3

  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Oral and Maxillofacial Rehabilitation   Assistant Professor

    2016.9

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Center Oral and Maxillofacial Center   Assistant Professor

    2015.4 - 2016.8

Professional Memberships

  • 日本口腔外科学会

    2008.4

  • 日本口腔科学会

    2008.5

  • 日本口腔腫瘍学会

    2009.1

  • 日本癌学会

    2015.9

  • 日本細菌学会

    2023.3

  • 日本障害者歯科学会

    2018.8

  • 日本摂食嚥下リハビリテーション学会

    2012.9 - 2017

  • 日本口腔インプラント学会

    2009.1 - 2018.7

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Qualification acquired

  • 精密触覚機能検査研修

  • OSCE認定評価者講習会

  • CPX認定評価者講習会

  • 日本口腔外科学会認定医

  • Automatic Two-Wheeled Vehicle License

  • Usual Car License (first kind)

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Papers

  • Yoshinori Uchino , Yuichi Goto , Yusuke Konishi , Kan Tanabe , Hiroko Toda , Masumi Wada , Yoshiaki Kita , Mahiro Beppu , Shinichiro Mori , Hiroshi Hijioka , Takao Otsuka , Shoji Natsugoe , Eiji Hara , Tsuyoshi Sugiura .  Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common-A Metagenomic Comparison with Healthy Subjects .  Cancers13 ( 13 ) 3332   2021.7Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers13133332

  • Hashiguchi Y, Kawano S, Goto Y, Yasuda K, Kaneko N, Sakamoto T, Matsubara R, Jinno T, Maruse Y, Tanaka H, Morioka M, Hattori T, Tanaka S, Kiyoshima T, Nakamura S. .  Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2. .  J Cell Physiol.   2017.11Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.26267.

  • Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mituhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Takeshi Toyoshima, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura .  Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype. .  Clin Exp Metastasis.31 ( 3 ) 293 - 306   2014.3Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype.Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Yuichi Goto • Hiroshi Hijioka • Yoshinori Uchino • Tsuyoshi Sugiura • Tatsuo Okui .  Numb Chin Syndrome as the Initial Presentation of Mandibular Metastasis of Colorectal Cancer: A Case Report .  Cureus16 ( 3 ) e56133   2024.3Numb Chin Syndrome as the Initial Presentation of Mandibular Metastasis of Colorectal Cancer: A Case ReportReviewed

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7759/cureus.56133

  • Hiroe Kakehashi, Mizuki Sakamoto, Masafumi Moriyama, Yuichi Goto, Ryoji Kitamura, Kenichi Ogata, Seiji Nakamura, Shintaro Kawano .  The clinical effectiveness of conservative surgical management in medication-related osteonecrosis of the Jaw .  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology4   2023.11Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.ajoms.2023.11.001

  • Yuto Hozaka, Hideyuki Oi, Souichi Satake, Yoshinori Uchino, Yuichi Goto, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Akihiro Nakajo, Michiyo Higashi, Akihide Tanimoto, Tsuyoshi Sugiura, Takao Ohtsuka .  Are intratumoral microbiota involved in the progression of intraductal papillary mucinous neoplasms of the pancreas? .  Surgery   2022.11Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.surg.2022.10.003.

  • Yuichi Goto・Haruyuki Imamura・Ryoichi Sakamoto・Yoshinori Uchino・Hiroshi Hijioka・Tsuyoshi Sugiura .  Conservative treatment of unilateral chylothorax developed after radical neck dissection: A case report .    34 ( 3 )   2022.9Conservative treatment of unilateral chylothorax developed after radical neck dissection: A case reportReviewed

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  • Kazuki Mori, Tomofumi Hamada, Mahiro Beppu, Hiroki Tsuchihashi, Yuichi Goto, Kenichi Kume, Hiroshi Hijioka, Keitaro Nishi, Yumiko Mishima, Tsuyoshi Sugiura .  Detecting Early-Stage Oral Cancer from Clinically Diagnosed Oral Potentially Malignant Disorders by DNA Methylation Profile .  Cancers14 ( 11 ) 2646   2022.5Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers14112646

  • Keitaro Nishi, Hiroaki Kanouchi, Akihiko Tanaka, Maya Nakamura, Tomofumi Hamada, Yumiko Mishima, Yuichi Goto, Kenichi Kume, Mahiro Beppu, Hiroshi Hijioka, Hiroaki Tabata, Kazuki Mori, Yoshinori Uchino, Kouta Yamashiro, Yoshiaki Matsumura, Yutaro Higashi, Hyuma Makizako, Takuro Kubozono, Toshihiro Takenaka, Mitsuru Ohishi, Tsuyoshi Sugiura .  Relationship between Oral Hypofunction, and Protein Intake: A Cross-Sectional Study in Local Community-Dwelling Adults .  neutrients13 ( 12 ) 4377   2021.12Reviewed

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    Other Link: https://www.mdpi.com/2072-6643/13/12/4377

  • Nakamura M, Hamada T, Tanaka A, Nishi K, Kume K, Goto Y, Beppu M, Hijioka H, Higashi Y, Tabata H, Mori K, Mishima Y, Uchino Y, Yamashiro K, Matsumura Y, Makizako H, Kubozono T, Tabira T, Takenaka T, Ohishi M, Sugiura T. .  Association of Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional Study of Community-Dwelling Japanese Older Adults .  Journal of clinical medicine10 ( 8 ) 1626   2021.4Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/jcm10081626

  • 新田 哲也, 坂元 亮一, 平原 成浩, 松村 吉晃, 中村 康大, 後藤 雄一 .  ビスフォスフォネート製剤の不適切な服用方法による発症が疑われた口腔粘膜潰瘍 .  日本口腔外科学会雑誌65 ( 9 ) 599 - 604   2019.9ビスフォスフォネート製剤の不適切な服用方法による発症が疑われた口腔粘膜潰瘍Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    The side effects of peroral bisphosphonate may cause mucous membrane disorders and oral exulceration if individuals dissolve the drug inside the oral cavity on oral administration. We experienced two cases in which we strongly suspected mucous ulcurs due to this drug. Finally, the oral exulceration disappeared after providing instructions on correct administration.
     An 83-year-old woman was referred because of exulceration of the right mandible. She suffered from osteoporosis, thoracic vertebra compression fracture, and dementia, while taking alendronate weekly. The exulceration appeared from the right lower lip to the right mandibular molar gingiva when we absorbed pooled saliva in the right oral cavity when the patient was lying down. We instructed the patient to confirm that the tablet was completely swallowed. The ulcers in the oral cavity completely disappeared 17 days after presentation.
     A 74-year-old woman with osteoporosis presented because of bleeding and pain in the gingiva of the right mandible. She was taking monthly minodronate while wearing incompatible dentures. Exulceration occurred with peripheral redness ranging from the right buccal mucosa to the right molar gingiva of the mandible and the tongue/floor of her mouth, along with a ventrolateral tongue. We taught her how to swallow minodoronate correctly without dentures, and the ulcers healed 4 weeks later.

    DOI: https://doi.org/10.5794/jjoms.65.599

  • Maruse Y, Kawano S, Jinno T, Matsubara R, Goto Y, Kaneko N, Sakamoto T, Hashiguchi Y, Moriyama M, Toyoshima T, Kitamura R, Tanaka H, Oobu K, Kiyoshima T, Nakamura S. .  Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma. .  Int J Oral Maxillofac Surg.47 ( 7 ) 836 - 845   2018.7Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma.Reviewed

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    DOI: 10.1016/j.ijom.2018.01.004.

  • Kitamura R, Toyoshima T, Tanaka H, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Oobu K, Nakamura S. .  Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma. .  Oncol Lett.14 ( 6 ) 6735 - 6743   2017.12Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2017.7066.

  • Kaneko N, Kawano S, Yasuda K, Hashiguchi Y, Sakamoto T, Matsubara R, Goto Y, Jinno T, Maruse Y, Morioka M, Hattori T, Tanaka S, Tanaka H, Kiyoshima T, Nakamura S. .  Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma. .  Oral Oncol.75   148 - 157   2017.12Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.oraloncology.2017.11.004.

  • Sakamoto T, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Kaneko N, Hashiguchi Y, Hattori T, Tanaka S, Kitamura R, Kiyoshima T, Nakamura S. .  Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition. .  Oral Oncol.69   15 - 25   2017.6Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition.Reviewed

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    OBJECTIVES: We previously showed that ΔNp63β, a splicing variant of ΔNp63, mediated EMT and affected cell motility. DNA microarray was thus performed to elucidate the mechanism that ΔNp63β affects cell motility. As the results, Wnt5a was significantly down-regulated by ΔNp63β overexpression in tongue SCC cell line (SQUU-B) with EMT phenotype.
    MATERIALS AND METHODS:
    Seven OSCC cell lines were used. Expression of ΔNp63, Wnt5a, its receptor Ror2, and matrix metalloproteinases (MMPs) were analyzed by RT-PCR, real-time PCR, and western blotting, and gelatin zymography. Furthermore, we examined the effects of siRNA for Wnt5a or Ror2 and recombinant human Wnt5a (rhWnt5a) on motility of tongue SCC cells. Biopsy specimens from tongue SCC patients were used for immunohistochemical staining of Wnt5a and Ror2.
    RESULTS:
    Wnt5a and Ror2 were expressed only in SQUU-B cells without ΔNp63 expression, and negatively associated with ΔNp63 expression in other cells. ΔNp63β overexpression in SQUU-B cells decreased Wnt5a and Ror2 expression. By Wnt5a or Ror2 knockdown, cell motility was remarkably inhibited, but EMT markers expression was unaffected. MMP-2 expression and the activities inversely correlated with ΔNp63 expression, and were inhibited by Wnt5a or Ror2 knockdown. Cell motility and MMP-2 activities were recovered by adding rhWnt5a in the cells with Wnt5a knockdown, but not in those with Ror2 knockdown. Moreover, immunohistochemical analyses in tongue SCC specimens found that high expression of Wnt5a or Ror2 was associated with poorer prognosis.
    CONCLUSION:
    Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following ΔNp63β-mediated EMT.

    DOI: 10.1016/j.oraloncology.2017.03.019.

  • Sakamoto T, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Kaneko N, Hashiguchi Y, Hattori T, Tanaka S, Kitamura R, Kiyoshima T, Nakamura S. .  Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition. .  Oral Oncol.69   15 - 25   2017.6Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.oraloncology.2017.03.019.

  • 見立 英史, 川野 真太郎, 清島 保, 三上 友里恵, 後藤 雄一, 河津 俊幸, 池邉 哲郎, 中村 誠司 .  巨舌を呈した舌対称性脂肪腫症の1例 .  日本口腔腫瘍学会誌28 ( 4 ) 293 - 298   2016.9巨舌を呈した舌対称性脂肪腫症の1例Reviewed

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    DOI: 10.5843/jsot.28.293

  • Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Taiki Sakamoto, Yuma Hashiguchi, Masakazu Iida, Seiji Nakamura .  Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factor .  World Journal of Surgical Oncology14 ( 1 ) 161   2016.6Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factorReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12957-016-0918-1

  • Kawano S, Zheng Y, Oobu K, Matsubara R, Goto Y, Chikui T, Yoshitake T, Kiyoshima T, Jinno T, Maruse Y, Mitate E, Kitamura R, Tanaka H, Toyoshima T, Sugiura T, Nakamura S. .  Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma. .  Oncol Lett.11 ( 5 ) 3369 - 3376   2016.5Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma.Reviewed

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    DOI: 10.3892/ol.2016.4411

  • Jinno T, Kawano S, Maruse Y, Matsubara R, Goto Y, Sakamoto T, Hashiguchi Y, Kaneko N, Tanaka H, Kitamura R, Toyoshima T, Jinno A, Moriyama M, Oobu K, Kiyoshima T, Nakamura S. .  Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma. .  Oncol Rep.33 ( 5 ) 2161 - 2168   2015.5Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.Reviewed

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  • Furukawa S, Moriyama M, Kawano S, Tanaka A, Maehara T, Hayashida JN, Goto Y, Kiyoshima T, Shiratsuchi H, Ohyama Y, Ohta M, Imabayashi Y, Nakamura S. .  Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis. .  Oral Dis.21 ( 2 ) 257 - 262   2015.3Clinical relevance of Kuttner tumour and IgG4-related dacryoadenitis and sialoadenitis.Reviewed

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  • Maruse Y, Kawano S, Kiyoshima T, Goto Y, Matsubara R, Chikui T, Yoshiga D, Nakamura S. .  A case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation. .  Head Neck.   2015.3A case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation.Reviewed

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  • Ohta M, Moriyama M, Goto Y, Kawano S, Tanaka A, Maehara T, Furukawa S, Hayashida JN, Kiyoshima T, Shimizu M, Arinobu Y, Nakamura S .  A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis. .  World J Surg Oncol.13 ( 1 ) 67   2015.2A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis.Reviewed

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  • Shintaro Kawano, Yanqun Zheng, Kazunari Oobu, Ryota Matsubara, Yuichi Goto, Toru Chikui, Tadamasa Yoshitake, Tamotsu Kiyoshima, Teppei Jinno, Yasuyuki Maruse, Eiji Mitate, Ryoji Kitmura, Hideaki Tanaka, Takeshi Toyoshima, Tsuyoshi Sugiura, and Seiji Nakamura .  Clinicopathological evaluation of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma .  Oncology Letters   2014.11Clinicopathological evaluation of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinomaReviewed

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  • Moriyama M, Furukawa S, Kawano S, Goto Y, Kiyoshima T, Tanaka A, Maehara T, Hayashida JN, Ohta M, Nakamura S. .  The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. .  Int J Oral Maxillofac Surg.43 ( 10 ) 1276 - 1281   2014.10The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease.Reviewed

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  • Mitate E, Kawano S, Kiyoshima T, Kawazu T, Chikui T, Goto Y, Matsubara R, Nakamura S. .  Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma. .  World J Surg Oncol. 17(11): 234. 20147 ( 11 ) 234 - 234   2014.9Carcinoma ex pleomorphic adenoma of the upper lip: a case of an unusual malignant component of squamous cell carcinoma.Reviewed

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  • Tanaka H, Toyoshima T1, Sonoda K, Kitamura R, Sasaguri M, Kawano S, Matsubara R, Goto Y, Nakamura S. .  Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma. .  J Transl Med.6 ( 12 ) 112   2014.5Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma.Reviewed

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  • Kanda S, Mitsuyasu T, Nakao Y, Kawano S, Goto Y, Matsubara R, Nakamura S. .  Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma. .  Int J Oncol. 43(3): 695-702. 201343 ( 3 ) 695 - 702   2013.9Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma.Reviewed

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  • Kiyosue T, Kawano S, Matsubara R, Goto Y, Hirano M, Jinno T, Toyoshima T, Kitamura R, Oobu K, Nakamura N. .  Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma. .  Int J Clin Oncol.18 ( 1 ) 154 - 163   2013.2Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma.Reviewed

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  • Mitate E, Kawano S, Nakao Y, Goto Y, Kobayashi I, Onozawa K, Hashimoto T, Nakamura S. .  Concurrence of autoantibodies to both laminin γ1 and γ2 subunits in a patient with rejection response to transplanted kidney .  Acta Derm Venereol. 93(1): 114-5. 201393 ( 1 ) 114 - 115   2013.1Concurrence of autoantibodies to both laminin γ1 and γ2 subunits in a patient with rejection response to transplanted kidneyReviewed

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  • Kakehashi H, Kawano S, Moriyama M, Kiyosue T, Matsubara R, Goto Y, Hirano M, Kiyoshima T, Shimizu M, Nakamura S. .  Parotid gland myoepithelioma with remarkable cystic formation: A case report. .  J Oral Maxillofac Surg Pathol Med.25 ( 2 ) 183 - 188   2013Parotid gland myoepithelioma with remarkable cystic formation: A case report. Reviewed

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  • 森山雅文,神田詩織,川野真太郎,立石康一郎,後藤雄一,中村誠司 .  口腔扁平苔癬および掌蹠膿疱症の発症と金属アレルギーとの関連についての検討 .  日本口腔外科学会雑誌58 ( 12 ) 718 - 722   2012.12口腔扁平苔癬および掌蹠膿疱症の発症と金属アレルギーとの関連についての検討Reviewed

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  • 吉賀大午,川野真太郎,鈴木華子,小林家吉,後藤雄一,中村誠司 .  下顎臼後部に生じた多形腺腫の1例 .  日本口腔外科学会雑誌 第58巻9号 541-45頁 2012年58 ( 9 ) 541 - 545   2012.9下顎臼後部に生じた多形腺腫の1例Reviewed

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  • Kitamura R, Toyoshima T. Tanaka H, Kawano S, Takahiro K, Matsubara R, Goto Y, Oobu K, and Nakamura S .  Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma .  J Cancer Res Clin Oncol.138 ( 8 ) 1299 - 1310   2012.8Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma Reviewed

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  • Matsubara R, Kawano S, Chikui T, Kiyosue T, Goto Y, Hirano M, Jinno T, Nagata T, Oobu K, Abe K, Nakamura S .  Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma. .  Acad Radiol.19 ( 6 ) 708 - 717   2012.6Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma.Reviewed

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  • Goto Y, Kawano S, Matsubara R, Kiyosue T, Hirano M, Jinno T, Maruse Y, Toyoshima T, Kitamura R, Tanaka H, Oobu K, Nakamura S. .  Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype. .  Clin Exp Metastasis.31 ( 3 ) 293 - 306   2012.3Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype.Reviewed

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    Language:English   Publishing type:Doctoral thesis  

    PubMed

  • Ryota Matsubara, Shintaro Kawano, Takahiro Kiyosue, Yuichi Goto, Mituhiro Hirano, Teppei Jinno, Takeshi Toyoshima, Ryoji Kitamura, Kazunari Oobu, Seiji Nakamura .  Increased DeltaNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma. .  Int J Oncol, 39(6): 1391-9. 201139 ( 6 ) 1391 - 1399   2011.12Increased DeltaNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma.Reviewed

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  • 井出文雄, 小林家吉, 川野真太郎, 後藤雄一 .  Letters to the Editor著明な嚢胞形成を伴った顎下腺多形腺腫の1例 .  日本口腔腫瘍学会雑誌23 ( 2 ) 47 - 48   2011.6Letters to the Editor著明な嚢胞形成を伴った顎下腺多形腺腫の1例Reviewed

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  • 後藤雄一,川野真太郎,大部一成,鈴木華子,松原良太,清末崇裕,小林家吉,白土雄司,中村誠司 .  著明な嚢胞形成を伴った顎下腺多形腺腫の1例 .  日本口腔腫瘍学会雑誌23 ( 1 ) 17 - 23   2011.3著明な嚢胞形成を伴った顎下腺多形腺腫の1例Reviewed

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Presentations

  • 柳田侑整,後藤雄一,内野祥徳,久米健一,別府真広,林 瑶大,宮腰昌明,田中達朗,比地岡浩志   サイトメガロウイルスの関与が疑われた壊死性リンパ節炎の1例  

    第56回口腔科学会九州地方会  2023.12  日本口腔科学会

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    Event date: 2023.12

    Venue:北九州市   Country:Japan  

  • 後藤雄一,谷 美香,比地岡浩志,嶋 香織,笹平智則,杉浦 剛   診断に苦慮し開口部形質細胞症を疑われた難治性潰瘍の一例  

    第68回日本口腔外科学会総会  2023.11 

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    Event date: 2023.11

    Country:Japan  

  • Involvement of the fungal flora in the colonic microbiota of the colorectal cancer  

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    Event date: 2023.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  • Yodai Hayashi¹, Yoshinori Uchino², Yuichi Goto², Hiroshi Hijioka², Tsuyoshi Sugiura   Involvement of the fungal flora in the colonic microbiota of the colorectal cancer​  

    The 82nd Annual Meeting of the Japanese Cancer Association  2023.9 

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    Event date: 2023.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  • 後藤雄一、比地岡浩志、谷 美香、吉永 悠、土橋宏輝、別府真広、杉浦 剛   Numb chin 症候群を初発症状とした大腸癌下顎骨転移の1例  

    第54回口腔科学会九州地方会  2021.11  日本口腔科学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市  

  • 後藤雄一、田畑博章、比地岡浩志、東友太郎、西慶太郎、内野祥徳、田中昭彦、久米健一、別府真広、杉浦 剛   Inflammation based prognostic scoreを用いたARONJにおける外科的治療の予後予測  

    日本口腔科学会九州地方部会  日本口腔科学会

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大分市  

    【目的】当科では難治性の骨髄炎であるARONJに対し、近年積極的な感染骨削除による外科的治療を行っている。術後の経過はその後の治癒を左右し、追加治療が必要となることがある。今回われわれは、外科的治療の経過が術前のInflammation based prognostic score(IBPS)を用いて予測が可能か検討を行ったので報告する。【対象と方法】2018年10月から1年間に当科にてARONJと診断し、全身麻酔下に外科的治療を行った24例を対象とし、IBPSと術後経過との関連を検討した。【結果】対象の平均年齢は72.9歳、男性10名、女性14名であった。術後早期の創部し開を11例に認めた。予後は治癒が18例、骨露出の持続や再発を認めたものは6例であった。IBPSとの比較では、創部し開とPrognostic nutrition indexおよび血小板・リンパ球比の間に有意な差を認めた。【結論】術前のIBPSはARONJの外科的治療において、術後早期の経過を予測できる可能性が示された。

  • 東友太郎、後藤雄一、山城康太、松村吉晃、田中秀明、久米健一、田中昭彦、別府真広、山下真由美、浜田倫史、比地岡浩志、杉浦剛   口腔癌におけるInflammation based prognostic score(IBPS)の有用性の検討  

    第64回日本口腔外科学会  日本口腔外科学会

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌市  

    血液データの炎症に関連する項目の割合を指標とするInflammation based prognostic score(IBPS)は、近年消化器系の癌を中心として予後推定の指標になると研究されている。また、血液データをもとにすることから患者に対して比較的低侵襲という点でも注目されている。今回、予後推定栄養指数(PNI)、好中球・リンパ球数比(NLR)、血小板・リンパ球数比(PLR)、リンパ球単球数比(LMR)、Japan modified Glasgow prognostic score(JMGPS)、CRP・アルブミン比(CAR)の6つのIBPSに着目した。
    【対象と方法】2014年1月から2019年3月までに口腔扁平上皮癌と診断された121例中上皮内癌を除いた109症例のうち、当科で根治的手術を行った103例で上記した各IBPSを求めることができた99例を対象とした。臨床病理的所見を元に2群間に分け各IBPSの有用性ついて検討を行った。

  • 松村吉晃、後藤雄一、比地岡浩志、吉村卓也、別府真広、今村晴幸、坂元亮一、杉浦 剛   医療用ヒルにて腹直筋皮弁のうっ血状態が改善した1例  

    第35回日本口腔腫瘍学会総会・学術大会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Poster presentation  

  • 金子直樹, 川野真太郎, 松原良太, 後藤雄一, 坂本泰基, 橋口有真, 神野哲平, 丸瀬靖之, 松村万由, 服部多市, 田中秀明, 大部一成, 中村誠司   口腔扁平上皮癌におけるkallikrein related peptidase 6の発現と機能に関する研究  

    第35回 日本口腔腫瘍学会総会・学術大会  日本口腔腫瘍学会

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    Event date: 2017.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡国際会議場  

  • 後藤雄一、今村晴幸、坂元亮一、松村吉晃、石田喬之、別府真広、杉浦 剛   左側全頸部郭清後に乳糜胸をきたした1例  

    第35回日本口腔腫瘍学会総会・学術大会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Poster presentation  

  • 後藤雄一、濵田倫史、山下麻由美、中村康大、上川善昭、杉浦 剛   右側下顎疼痛を初発症状とし脳腫瘍が発見された症候性三叉神経痛の一例  

    第84回日本口腔外科学会九州支部学術集会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州市  

  • 橋口有真、川野真太郎、後藤雄一、松原良太、神野哲平、丸瀬靖之、金子直樹、坂本泰基、松村万由、中村誠司   口腔扁平上皮癌におけるmiR-205の発現と機能に関する研究 ?特にΔNp63との関連について?  

    第70回NPO法人日本口腔科学会学術集会  日本口腔科学会

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    Event date: 2016.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:福岡  

  • 金子直樹、川野真太郎、松原良太、後藤雄一、神野哲平、丸瀬靖之、金子直樹、橋口有真、松村万由、中村誠司   口腔扁平上皮癌におけるchalkier related peptidase 6の発現と機能 ?上皮間葉転換におけるΔNp63との関わりについて?  

    第70回NPO法人日本口腔科学会学術集会  日本口腔科学会

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    Event date: 2016.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡  

  • 坂本泰基、川野真太郎、松原良太、後藤雄一、神野哲平、丸瀬靖之、金子直樹、橋口有真、松村万由、大部一成、中村誠司   口腔扁平上皮癌の遊走能におけるΔNp63を介したEnt5a-Ror2シグナル経路の関連  

    第70回NPO法人日本口腔科学会学術集会  日本口腔科学会

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    Event date: 2016.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡  

  • Taiki SAKAMOTO, Shintaro KAWANO, Ryota MATSUBARA, Teppei JINNO, Yasuyuki MARUSE, Yuichi GOTO, Naoki KANEKO, Yuma HASHIGUCHI, Ryoji KITAMURA, Hideaki TANAKA, and Seiji NAKAMURA   Involvement of Wnt5a-Ror2 signaling in migration of oral squamous cell c arcinoma cells through ΔNp63 down-regulation   International conference

    2016 Annual Congress of ROC Association of Oral and Maxillofacial Surgeons, Taiwan  台湾口腔外科学会

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    Event date: 2016.3

    Language:English   Presentation type:Poster presentation  

    Venue:台湾  

  • Naoki KANEKO, Shintaro KAWANO, Ryota MATSUBARA, Teppei JINNO, Yasuyuki MARUSE, Yuichi GOTO, Taiki SAKAMOTO, Yuma HASHIGUCHI, Ryoji KITAMURA, Hideaki TANAKA, and Seiji NAKAMURA   Expression and function of kallikrein-related peptidase 6 in oral squamous cell carcinoma: the association with epithelial-mesenchymal transition mediated by ΔNp63   International conference

    2016 Annual Congress of ROC Association of Oral and Maxillofacial Surgeons, Taiwan  台湾口腔外科学会

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    Event date: 2016.3

    Language:English   Presentation type:Poster presentation  

    Venue:台湾  

  • 坂本泰基、川野真太郎、松原良太、後藤雄一、神野哲平、丸瀬靖之、金子直樹、橋口有真、松村万由、大部一成、中村誠司   口腔扁平上皮癌におけるΔNp63を介した浸潤・転移の分子生物学的メカニズムの 解明 ?Wnt5a-Ror2シグナル経路との関連?  

    第34回日本口腔腫瘍学会総会・学術大会  日本口腔腫瘍学会

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜  

  • Yuichi Goto, Shintaro Kawano, Koudai Nakamura, Tomofumi Hamada, Seiji Nakamura, Tsuyoshi Sugiura   Downregulation of delta-Np63 induces a mesenchymal cell phenotype, possibly involving invasion and metastasis of OSCC  

    第74回日本癌学会学術総会  日本癌学会

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Venue:名古屋国際会議場  

  • Taiki Sakamoto, Kazunari Oobu, Ryota Matsubara, Yuichi Goto, Shintaro Kawano, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Masahiko Morioka, Seiji Nakamura   A clinicopathological study of malignant salivary gland tumors  

    第39回日本頭頸部癌学会 第4回アジア頭頸部癌学会   日本頭頸部癌学会

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    Event date: 2015.6

    Language:English   Presentation type:Poster presentation  

    Venue:神戸  

  • Naoki Kaneko, Kazunari Oobu, Ryota Matsubara, Yuichi Goto, Shintaro Kawano, Teppei Jinno, Yasuyuki Maruse,Taiki Sakamoto, Yuma Hashiguchi, Masahiko Morioka, Seiji Nakamura   Usefulness of postoperative chemoradiotherapy for cervical lymph nodes metastasis of OSCC   International conference

    第39回日本頭頸部癌学会 第4回アジア頭頸部癌学会   日本頭頸部癌学会

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    Event date: 2015.6

    Language:English   Presentation type:Poster presentation  

    Venue:神戸  

  • Yuma hashiguchi , Shintaro Kawano , Kazunari Oobu , Ryota Matsubara , Yuichi Goto , Teppei Jinno , Yasuyuki Maruse , Taiki Sakamoto , Naoki Kaneko , Masahiko Morioka , and Seiji Nakamura   Clinicopathological evaluation of preoperative chemoradiotherapy with S-1 for locally advanced OSCC  

    第39回日本頭頸部癌学会 第4回アジア頭頸部癌学会  日本頭頸部癌学会

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    Event date: 2015.6

    Language:English   Presentation type:Poster presentation  

    Venue:神戸  

  • 後藤 雄一, 川野 真太郎, 松原 良太, 神野 哲平, 丸瀬 靖之, 橋口 有真, 金子 直樹, 坂本 泰基, 豊嶋 健史, 北村 亮二, 田中 秀明, 大部 一成, 杉浦 剛, 中村 誠司   口腔扁平上皮癌の浸潤・転移におけるΔNp63を介した上皮 間葉転換の関与  

    第69回日本口腔科学会学術総会  日本口腔科学会

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    Event date: 2015.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪国際会議場  

  • Yuma Hashiguchi, Shintaro Kawano, Yuichi Goto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Taiki Sakamoto, Kazunari Oobu, and Seiji Nakamura   A function of microRNA-205 associated withΔNp63 in oral squamous cell carcinoma   International conference

    2016 Annual Congress of ROC Association of Oral and Maxillofacial Surgeons, Taiwan  台湾口腔外科学会

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    Event date: 2015.3

    Language:English   Presentation type:Poster presentation  

    Venue:台湾  

  • 後藤 雄一,大部 一成,星野 亜紀,金子 直樹,今利 一寿,三上 友理恵,森 悦秀,中村 誠司   口腔癌手術後に経口にて栄養摂取できなかった症例についての検討  

    第20回日本摂食嚥下リハビリテーション学会  第20回日本摂食嚥下リハビリテーション学会

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    Event date: 2014.9

    Language:Japanese  

    Venue:東京  

    国内学会

  • Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Takeshi Toyoshima, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, and Seiji Nakamura   Down-regulation of ΔNp63 possibly involves in the progression of oral squamous cell carcinoma by inducing mesenchymal phenotype   International conference

    6th International p63/p73 Workshop  6th International p63/p73 Workshop

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    Event date: 2013.9

    Language:English  

    Venue:Chiba  

    国際学会

  • 後藤 雄一, 川野 真太郎, 松原 良太, 清末 崇裕, 平野 充広, 豊嶋 健史, 北村 亮二, 大部 一成, 中村 誠司   口腔扁平上皮癌における浸潤・転移の分子機構の解明 ΔNp63の発現と上皮-間葉転換との関連について  

    第66回日本口腔科学会総会  第66回日本口腔科学会総会

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    Event date: 2012.4

    Language:Japanese  

    Venue:東京  

    国内学会

  • 後藤 雄一、川野 真太郎、松原 良太、清末 崇裕、平野 充広、神野 哲平、豊嶋 健史、北村 亮二、田中 秀明、大部 一成、中村 誠司   口腔扁平上皮癌の浸潤・転移におけるΔNp63 を介した上皮-間葉転換 の関与  

    第30回日本口腔腫瘍学会総会  第30回日本口腔腫瘍学会総会

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    Event date: 2012.1

    Language:Japanese  

    Venue:埼玉  

    国内学会

  • 後藤 雄一, 川野 真太郎, 松原 良太, 清末 崇裕, 平野 充広, 神野 哲平, 豊嶋 健史, 北村 亮二, 大部 一成, 中村 誠司   口腔扁平上皮癌の浸潤・転移におけるΔNp63を介した上皮ー間葉転換の関与  

    第56回日本口腔外科学会総会  第56回日本口腔外科学会総会

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    Event date: 2011.10

    Language:Japanese  

    Venue:大阪  

    国内学会

  • Goto Y, Kawano S, Matsubara R, Kiyosue T, Hirano M, Jinno T, Maruse Y, Toyoshima T, Kitamura R, Oobu K, Nakamura S.   Possible involvement of ΔNp63 in invasion and metastasis of OSCC   International conference

    JADR  JADR

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    Event date: 2011.9

    Language:English  

    Venue:Hiroshima  

    国際学会

  • 後藤 雄一, 川野 真太郎, 松原 良太, 清末 崇裕, 平野 充広, 豊嶋 健史, 北村 亮二, 大部 一成, 中村 誠司   口腔扁平上皮癌における浸潤、転移の分子機構の解明 ΔNp63を介した上皮-間葉転換の関与について  

    第35回日本頭頸部癌学会  第35回日本頭頸部癌学会

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    Event date: 2011.6

    Language:Japanese  

    Venue:東京  

    国内学会

  • 後藤雄一、川野真太郎、南里篤太郎、清末崇裕、松原良太、林田淳之介、碇 竜也、蔵原慎一、大部一成、竹之下康治、森 悦秀、白土雄司、中村誠司   ビスフォスフォネート関連顎骨壊死の臨床的検討 ー保存的治療におけるリスクファクター  

    第55回日本口腔外科学会総会  第55回日本口腔外科学会総会

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    Event date: 2010.10

    Language:Japanese  

    Venue:千葉  

    国内学会

  • Goto Y., Kawano S., Hayashida J., Ikari T., Kurahara S., Toyoshima T., Minamizato T., Kiyosue T ., Matsubara R., Oobu K., Takenoshita Y., Mori Y., Shiratsuchi Y., Nakamura S.   Resistant factors of the conservative therapy to BRONJ   International conference

    10th Biennial Congress of the European Association of Oral Medicine  10th Biennial Congress of the European Association of Oral Medicine

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    Event date: 2010.9

    Language:English  

    Venue:U.K  

    国際学会

  • 後藤雄一、川野真太郎、大部一成、清島 保、中尾 祐、森 康一郎、清末崇裕、松原良太、白土雄司、中村誠司   著明な嚢胞化を伴った顎下腺多形腺腫の1例  

    第54回日本口腔外科学会総会  第54回日本口腔外科学会総会

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    Event date: 2009.10

    Language:Japanese  

    Venue:北海道  

    国内学会

  • 後藤雄一・川野真太郎・中尾 祐・南里篤太郎・見立英史・梯 裕恵・松原良太・大部一成・白土雄司、中村誠司   保存的治療が有効であったビスフォスフォネート関連顎骨壊死(Stage 3)の2例  

    第77回日本口腔外科学会 九州地方会  第77回日本口腔外科学会 九州地方会

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    Event date: 2009.9

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 後藤雄一、立石康一郎、川野真太郎、原田志織、松原良太、山城崇裕、大部一成、竹之下康治、白砂兼光、中村誠司   ビスフォスフォネート系薬剤関連顎骨壊死の臨床的検討  

    第53回日本口腔外科学会総会  第53回日本口腔外科学会総会

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    Event date: 2008.9

    Language:Japanese  

    Venue:徳島  

    国内学会

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Research Projects

  • 口腔細菌叢のオミクス解析による口腔癌発症機序の解明とリスク診断の構築

    Grant number:22K10224  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    宮田 昌明、大塚 隆生、杉浦剛、比地岡浩志

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  • ナノポアシーケンスを用いた口腔細菌叢解析によるARONJリスク診断の構築

    Grant number:23K09336  2023.4 - 2026.3

    基盤研究(C)

    比地岡 浩志

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  • 摂食機能評価に基づいた栄養食事指導の有効性と体組成改善への影響の検討

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

  • 口腔・大腸マイクロバイオーム解析による大腸がんリスク診断および予防概念の創生

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

  • 癌遺伝子ΔNp63とmicroRNAを介した癌の浸潤・転移機構の解析と治療応用

    2016.4 - 2019.3

    科学研究費補助金  平成28年度 若手研究(B)

    後藤雄一、杉浦剛、川野真太郎、松原良太

  • 口腔扁平上皮癌におけるΔNp63を介した上皮-間葉転換の浸潤・転移における役割

    2013.4 - 2016.3

    科学研究費補助金  平成25年度 若手研究(B)

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Teaching Experience

  • 口腔外科学

    2015.4

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    Level:Undergraduate (specialized) 

 

Social Activities

  • 口腔癌検診

    Role(s): Planner, Organizing member

    指宿市歯科医師会  ふれ愛フェスタ  鹿児島県指宿市開聞総合体育館  2017.10

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    Audience: General

    Type:Science festival

    フェスタイベント内にブースを設け口腔癌の早期発見啓蒙活動と実際の検診を行う。

  • 口腔がん検診 2016年〜

    Role(s): Organizing member, Investigater

    2016

Academic Activities

  • 鹿児島大学歯学部卒後研修委員

    Role(s): Planning, management, etc., Panel moderator, session chair, etc., Planning/Implementing academic research

    鹿児島大学歯学部同窓会  2026

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    Type:Academic society, research group, etc.