Updated on 2021/12/11

写真a

 
Kuramoto Eriko
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology Assistant Professor
Title
Assistant Professor
Homepage
http://tgoto9.wixsite.com/gotolab-site
Profile
視床-大脳皮質の相互結合が高次脳機能、たとえば運動学習、認知などにおいて、果たしている機能を明らかにしたい。
External link

Degree

  • 医学博士 ( 2019.3   京都大学 )

Research Interests

  • cortex

  • thalamus

  • neuroanatomy

Research Areas

  • Life Science / Oral biological science

Research History

  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course   Assistant Professor

    2014.9

Professional Memberships

  • 歯科基礎医学会

    2015.6

  • Society for Neuroscience

    2010.1

  • 解剖学会

    2005.4

  • 神経科学学会

    2004.4

 

Papers

  • Eriko Kuramoto, Yasuhiro Tanaka, Hiroyuki Hioki, Tetsuya Goto, Takeshi Kaneko .  Local Connections of Pyramidal Neurons to Parvalbumin-Producing Interneurons in Motor-Associated Cortical Areas of Mice .  eNeuro   2021.12Local Connections of Pyramidal Neurons to Parvalbumin-Producing Interneurons in Motor-Associated Cortical Areas of MiceReviewed

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • Iwai H. .  Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury .  Journal of Neuroinflammation18 ( 1 ) 227   2021.12

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    Language：Japanese   Publisher：Journal of Neuroinflammation  

    DOI： 10.1186/s12974-021-02283-z

    Scopus

    PubMed

  • Ayako Niiro, Sachi N Ohno, Kanae A Yamagata, Kazuaki Yamagata, Kazuo Tomita, Eriko Kuramoto, Yoshiaki Oda, Takahiro J Nakamura, Wataru Nakamura, Mitsutaka Sugimura .  Diurnal Variation in Trigeminal Pain Sensitivity in Mice. .  Frontiers in neuroscience15   703440 - 703440   2021International journal

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    Language：English   Publishing type：Research paper (scientific journal)  

    Management of time and circadian disruption is an extremely important factor in basic research on pain and analgesia. Although pain is known to vary throughout the day, the mechanism underlying this circadian variation remains largely unknown. In this study, we hypothesized that the process of pain transmission to the central nervous system (after receiving nociceptive stimuli from outside the body) would show day-night differences. Ten-week-old male mice were kept under a strict 12/12-h light/dark cycle for at least 10 days. Formalin was then injected into the second branch region of the trigeminal nerve and the duration of pain-related behaviors (PRBs) was assessed. Immunohistochemical staining was then performed, and the c-Fos-immunopositive cells in the trigeminal spinal tract subnucleus caudalis (Sp5C) were counted. The results showed that the duration of PRBs was longer and the number of c-Fos immunopositive cells in the Sp5C was higher at nighttime than during the day. In addition, the trigeminal ganglia (TG) were extracted from the mice and examined by quantitative real-time PCR to evaluate the daytime and nighttime expression of nociceptive receptors. The results showed that the mRNA expression of transient receptor potential ankyrin 1 in the TG was significantly higher at night than during the day. These results suggest that pain in the trigeminal nerve region is more intense at nighttime, when rodents are active, than during the daytime, partly due to differences in nociceptor expression.

    DOI： 10.3389/fnins.2021.703440

    Scopus

    PubMed

  • Kayo Nishimura, Masahiro Ohta, Mitsuru Saito, Yukako Morita-Isogai, Hajime Sato, Eriko Kuramoto, Dong Xu Yin, Yoshinobu Maeda, Takeshi Kaneko, Takashi Yamashiro, Kenji Takada, Seog Bae Oh, Hiroki Toyoda, Youngnam Kang .  Electrophysiological and morphological properties of α and γ motoneurons in the rat trigeminal motor nucleus .  Frontiers in Cellular Neuroscience12   9   2018.1Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Frontiers Media S.A.  

    The muscle contraction during voluntary movement is regulated by activities of α- and γ-motoneurons (αMNs and γMNs, respectively). The tension of jaw-closing muscles can be finely tuned over a wide range. This excellent function is likely to be achieved by the specific populations of αMNs innervating jaw-closing muscles. Indeed, we have recently demonstrated that in the rat dorsolateral trigeminal motor nucleus (dl-TMN), the size distribution of αMNs was bimodal and the population of smaller αMNs showed a size distribution similar to that of γMNs, by immunohistochemically identifying αMNs and γMNs based on the expressions of estrogen-related receptor gamma (Err3) and neuronal DNA binding protein NeuN together with ChAT. This finding suggests the presence of αMNs as small as γMNs. However, differences in the electrophysiological membrane properties between αMNs and γMNs remain unknown also in the dl-TMN. Therefore, in the present study, we studied the electrophysiological membrane properties of MNs in the dl-TMN of infant rats at postnatal days 7–12 together with their morphological properties using whole-cell current-clamp recordings followed by immunohistochemical staining with an anti-NeuN and anti-ChAT antibodies. We found that the ChAT-positive and NeuN-positive αMNs were divided into two subclasses: the first one had a larger cell body and displayed a 4-aminopyridine (4-AP)-sensitive current while the second one had a smaller cell body and displayed a less prominent 4-AP-sensitive current and a low-threshold spike, suitable for their orderly recruitment. We finally found that γMNs showing ChAT-positive and NeuN-negative immunoreactivities had smaller cell bodies and displayed an afterdepolarization mediated by flufenamate-sensitive cation current. It is suggested that these electrophysiological and morphological features of MNs in the dl-TMN are well correlated with the precise control of occlusion.

    DOI： 10.3389/fncel.2018.00009

    Scopus

    PubMed

  • Unzai T, Kuramoto E, Kaneko T, Fujiyama F. .  Quantitative analysis of the projection of individual neurons from the midline thalamic nuclei to the striosome and matrix compartments of the rat striatum. Cerebral Cortex .  Cerebral Cortex   2016Quantitative analysis of the projection of individual neurons from the midline thalamic nuclei to the striosome and matrix compartments of the rat striatum. Cerebral CortexReviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Eriko Kuramoto, Sachi Ohno, Takahiro Furuta, Tomo Unzai, Yasuhiro R. Tanaka, Hiroyuki Hioki, *Takeshi Kaneko. .  Ventral medial nucleus neurons send thalamocortical afferents more widely and more preferentially to layer 1 than neurons of the ventral anterior-ventral lateral nuclear complex in the rat. .  Cerebral Cortex25 ( 1 ) 221 - 235   2015Ventral medial nucleus neurons send thalamocortical afferents more widely and more preferentially to layer 1 than neurons of the ventral anterior-ventral lateral nuclear complex in the rat.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Hiroyuki Hioki, Shinichi Okamoto, Michiteru Konno, Hiroshi Kameda, Jaerin Sohn, Eriko Kuramoto, Fumino Fujiyama, Takeshi Kaneko. .  Cell-type specific inhibitory inputs to dendritic and somatic components of parvalbumin-expressing neocortical interneuron. .  Journal of Neuroscience33 ( 2 ) 544 - 555   2013.2Cell-type specific inhibitory inputs to dendritic and somatic components of parvalbumin-expressing neocortical interneuron.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Sachi Ohno, Eriko Kuramoto, Fumino Fujiyama, Hiroyuki Hioki, Yasuhiro R. Tanaka , Fumino Fujiyama, Takahiro Sonomura, Masanori Uemura, Kazuna Sugiyama, Takeshi Kaneko. .  A morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: A single neuron tracing study with viral vectors. .  Cerebral Cortex22 ( 12 ) 2840 - 2857   2012.12A morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: A single neuron tracing study with viral vectors. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Eriko Kuramoto, Fumino Fujiyama, Kouichi C. Nakamura, Yasuhiro Tanaka, Hiroyuki Hioki, Takeshi Kaneko .  Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei. .  European Journal of Neuroscience33 ( 1 ) 95 - 109   2011Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Koji Ohira, Takahiro Furuta, Hiroyuki Hioki, Kouichi C. Nakamura, Eriko Kuramoto, Yasuyo Tanaka, Nobuo Funatsu, Keiko Shimizu, Takao Oishi, Motoharu Hayashi, Tsuyoshi Miyakawa, Takeshi Kaneko, Shun Nakamura. .  Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. .  Nature Neuroscience13 ( 2 ) 173 - 179   2010Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells.Reviewed

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  • Hiroyuki Hioki, Eriko Kuramoto, Michiteru Konno, Hiroshi Kameda, Yasuhiro Takahashi, Takashi Nakano, Kouichi C. Nakmura, Takeshi Kaneko .  High-level transgene expression in neurons by lentivirus with Tet-Off system. .  Neuroscience Research63 ( 2 ) 149 - 154   2009High-level transgene expression in neurons by lentivirus with Tet-Off system.Reviewed

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  • Eriko Kuramoto, Takahiro Furuta, Kouichi C Nakamura, Tomo Unzai, Hiroyuki Hioki, Takeshi Kaneko .  Two types of thalamocortical projections from the motor thalamic nuclei of the rat: a single neuron tracing study using viral vectors. .  Cerebral Cortex9 ( 9 ) 2065 - 2077   2009Two types of thalamocortical projections from the motor thalamic nuclei of the rat: a single neuron tracing study using viral vectors.Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Eriko Kuramoto, Fumino Fujiyama, Tomo Unzai, Kouichi C. Nakamura, Hiroyuki Hioki, Takahiro Furuta, Ryuichi Shigemoto, Francesco Ferraguti, Takeshi Kaneko. .  Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum. .  Journal of Comparative Neurology500 ( 5 ) 908 - 922   2007Metabotropic glutamate receptor 4-immunopositive terminals of medium-sized spiny neurons selectively form synapses with cholinergic interneurons in the rat neostriatum.Reviewed

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  • Fumino Fujiyama, Eriko Kuramoto, Keiko Okamoto, Hiroyuki Hioki, Takahiro Furuta, Ligang Zhou, Sakashi Nomura, Takeshi Kaneko. .  Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. .  European Journal of Neuroscience20 ( 12 ) 3322 - 3330   2004Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals. Reviewed

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    Language：English   Publishing type：Research paper (scientific journal)  

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MISC

  • IV. 基底核と小脳：その相違と連関. 4. 運動野での両者の差. Invited

    KURAMOTO, Eriko

    Clinical Neuroscience.   35 ( 1 )   28 - 42   2017.1

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Novel single-neuron-tracing method using Sindbis viral vectors. Reviewed

    Eriko Kuramoto, Takahiro Furuta, Hiroyuki Hioki, Fumino Fujiyama, Takeshi Kaneko.

    顕微鏡   46 ( 2 )   125 - 131   2011

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)