Updated on 2022/10/06

写真a

 
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Functional Biology and Pharmacology Assistant Professor
Title
Assistant Professor

Degree

  • 学士(保健学) ( 2020.3   東京医科歯科大学 )

Research Interests

  • 敗血症

  • プテリジン

  • 災害

Education

  • Tokyo Medical and Dental University

    1996.4 - 2000.3

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    Country: Japan

Research History

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course   Assistant Professor

    2017.4

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course

    2014.7 - 2017.3

Professional Memberships

  • 日本集中治療医学会

    2017.1

  • 日本災害医学会

    2019.6

 

Papers

  • Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose and Yasuyuki Kakihana .  Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice .  Frontiers in Pharmacology   2022.10Early ascorbic acid administration prevents vascular endothelial cell damage in septic miceReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fphar.2022.929448

  • Satoshi Hara, Tama Sanatani, Natsuo Tachikawa, Yukihiro Yoshimura, Nobuyuki Miyata, Hiroaki Sasaki, Risa Kuroda, Chinatsu Kamikokuryo, Tomohiro Eguchi, Shuhei Niiyama, Yasuyuki Kakihana, Hiroshi Ichinose .  Comparison of the levels of mneopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-2 .  Heliyon   2022.4Comparison of the levels of mneopterin, CRP, and IL-6 in patients infected with and without SARS-CoV-2Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2139/ssrn.3943412

  • Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama and Yasuyuki Kakihana .  Circulation Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care .  Frontiers in Cardiovascular Medicine   2021.9Circulation Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive CareReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fcvm.2021.730553

  • Hiroaki Furubeppu, Takashi Ito, Midori Kakuuchi, Tomotsugu Yasuda, Chinatsu Kamikokuryo, Shingo Yamada, Ikuro Maruyama and Yasuyuki Kakihana .  Differential Regulation of Damage-Associated Molecular Pattern Skeletal Muscle Ischemia/Reperfusion Injury .  Frontiers in Immunology   2021.7Differential Regulation of Damage-Associated Molecular Pattern Skeletal Muscle Ischemia/Reperfusion InjuryReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2021.628822

  • Koichiro Suemori, Masayuki Saijo , Atsushi Yamanaka, Daisuke Himeji, Masafumi Kawamura, Takashi Haku, Michihiro Hidaka, Chinatsu Kamikokuryo, Yasuyuki Kakihana, Taichi Azuma, Katsuto Takenaka, Toru Takahashi, Akitsugu Furumoto, [ ... ], Masaki Yasukawa .  A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe fever with thrombocytopenia syndrome .  PLOS Neglected Tropical Diseases   2021.2Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pntd.0009103.

  • Yokoyama Y, Ito T, Yasuda T, Furubeppu H, Kamikokuryo C, Yamada S, Maruyama I, Kakihana Y .  Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study. .  Thrombosis Journal17 ( 1 )   2019.1Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12959-018-0190-4

    PubMed

  • Ito T, Nakahara M, Masuda Y, Ono S, Yamada S, Ishikura H, Imaizumi H, Kamikokuryo C, Kakihana Y, Maruyama I. .  Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3. .  Journal of intensive care6 ( 79 )   2018.11Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40560-018-0348-y.

    PubMed

  • Kikuchi K, Setoyama K, Tanaka E, Otsuka S, Terashi T, Nakanishi K, Takada S, Sakakima H, Ampawong S, Kawahara KI, Nagasato T, Hosokawa K, Harada Y, Yamamoto M, Kamikokuryo C, Kiyama R, Morioka M, Ito T, Maruyama I, Tancharoen S. .  Uric acid enhances alteplase-mediated thrombolysis as an antioxidant. .  Scientific Reports8 ( 1 ) 15844   2018.10Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-34220-1.

    PubMed

  • Arishima T, Ito T, Yasuda T, Yashima N, Furubeppu H, Kamikokuryo C, Futatsuki T, Madokoro Y, Miyamoto S, Eguchi T, Haraura H, Maruyama I, Kakihana Y .  Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin. .  Thrombosis Journal16 ( 24 )   2018.9Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12959-018-0178-0

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  • Shotaro Miyamoto, Shinsaku Terada, Chinatsu Kamikokuryo, Takashi Ito, Hayato Nakamura, Junichiro Taniguchi, Tomoyuki Matsuba, Yasuyuki Kakihana .  A case report: consideration for early diagnosis of heparin-induced thrombocytopenia. .  Journal of the Japanese Society of Intensive Care Medicine25 ( 4 ) 259 - 260   2018.7A case report: consideration for early diagnosis of heparin-induced thrombocytopenia.Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3918/jsicm.25_259

  • Kakihana Y, Kamikokuryo C, Furubeppu H, Madokoro Y, Futatsuki T, Miyamoto S, Haraura H, Hatanaka K, Eguchi T, Saitoh Y, Miura N, Suzuki H, Ueda Y, Yasuda T, Ito T. .  Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective porcine Study. .  Advances in Experimental Medicine and Biology1072   83 - 87   2018Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective porcine Study.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/978-3-319-91287-5_14.

    PubMed

  • Kiyoshi Kikuchi, Kentaro Setoyama, Ko-ichi Kawahara, Tomoka Nagasato, Takuto Terashi, Koki Ueda, Kazuki Nakanishi, Shotaro Otsuka, Naoki Miura, Hisayo Sameshima, Kazuya Hosokawa, Yoichiro Harada, Binita Shrestha, Mika Yamamoto, Yoko Morimoto-Yamashita, Haruna Kikuchi, Ryoji Kiyama, Chinatsu Kamikokuryo, Salunya Tancharoen, Harutoshi Sakakima, Motohiro Morioka, Eiichiro Tanaka, Takashi Ito, and Ikuro Maruyama .  Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis .  Oxidative Medicine and Cellular Longevity   2017.10Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated ThrombolysisReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi:10.1155/2017/6873281.

    PubMed

  • Saiko Uchida, Seiichi Yokoo, Yasuo Yanagi, Tomohiko Usui, Chinatsu Yokota, Tatsuya Mimura, Makoto Araie, Satoru Yamagami, Shiro Amano .  Sphere formation and expression of neural proteins by human corneal stromal cells in vitro. .  Investigative ophthalmology & visual science46 ( 5 ) 1620 - 1625   2005.5Sphere formation and expression of neural proteins by human corneal stromal cells in vitro.

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    purpose. To demonstrate the presence of corneal stromal precursors that express neural markers in vitro.

    methods. To isolate sphere-forming cells, human corneal stromal cells were subjected to a reaggregation-free neurosphere assay in medium containing methylcellulose gel matrix. To promote differentiation, the isolated sphere colonies were plated in wells with medium containing fetal bovine serum. Expression of nestin, vimentin, keratocan, α-smooth muscle actin (αSMA), β-III tubulin, neurofilament M (NFM), and glial fibrillary acidic protein (GFAP) was examined in the sphere colonies and their progeny (i.e., cells migrated from sphere colonies), by immunocytochemistry and/or reverse transcription–polymerase chain reaction (RT-PCR).

    results. Human corneal stromal cells formed sphere colonies that had no self-renewal capability. The frequency of sphere-forming cells was 1.5% ± 0.1% (range, 1.3%–1.6%). Most of the cells within these colonies expressed nestin and vimentin, whereas some expressed β-III tubulin, NFM, GFAP, and αSMA by immunocytochemistry. Ninety-one percent and 89% of the progeny expressed vimentin and αSMA, respectively, whereas nestin was undetectable. β-III tubulin-, NFM-, and GFAP-positive cells were detected in the progeny at the frequency of 7.2%, 0.9%, and 0.5%, respectively. Semiquantitative RT-PCR showed that nestin, NFM, GFAP, and keratocan gene expression was higher in the sphere colonies, whereas vimentin and αSMA expression increased in the progeny.

    conclusions. Adult human corneal stroma contains precursor cells that express neural markers.

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