Updated on 2021/06/18

写真a

 
Munekazu Yamakuchi
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Cardiovascular and Respiratory Disorders Associate Professor
Title
Associate Professor

Degree

  • Doctor (Medicine) ( 1994.3   Kagoshima University )

Research Interests

  • thrombosis

  • microRNA

  • vascular biology

Research History

  • Kagoshima University   Associate Professor

    2003.4

Studying abroad experiences

  • 2002.10 - 2009.6   Johns Hopkins University   Research Associate

  • 2009.6 - 2013.3   University of Rochester   Research Associate Professor

 

Papers

  • Shimizu T, Yamakuchi M, Biswas KK, Aryal B, Yamada S, Hashiguchi T, Maruyama I. .  HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin. .  Obesity (Silver Spring)   2016HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin.Reviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/oby.21549.

  • Mukaihara K, Yamakuchi M, Kanda H, Shigehisa Y, Arata K, Matsumoto K, Takenouchi K, Oyama Y, Koriyama T, Hashiguchi T, Imoto Y .  Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting. .  Heart and vessels   2021.4Evaluation of VEGF-A in platelet and microRNA-126 in serum after coronary artery bypass grafting.

  • Kanda H, Yamakuchi M, Matsumoto K, Mukaihara K, Shigehisa Y, Tachioka S, Okawa M, Takenouchi K, Oyama Y, Hashiguchi T, Imoto Y .  Dynamic changes in platelets caused by shear stress in aortic valve stenosis. .  Clinical hemorheology and microcirculation77 ( 1 ) 71 - 81   2021Dynamic changes in platelets caused by shear stress in aortic valve stenosis.

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  • Yamamoto M, Harada Y, Suzuki T, Fukushige T, Yamakuchi M, Kanekura T, Dohmae N, Hori K, Maruyama I .  Application of high-mannose-type glycan-specific lectin from Oscillatoria Agardhii for affinity isolation of tumor-derived extracellular vesicles. .  Analytical biochemistry580   21 - 29   2019.9Application of high-mannose-type glycan-specific lectin from Oscillatoria Agardhii for affinity isolation of tumor-derived extracellular vesicles.

  • Koriyama T, Yamakuchi M, Takenouchi K, Oyama Y, Takenaka H, Nagakura T, Masamoto I, Hashiguchi T .  Legionella pneumophila infection-mediated regulation of RICTOR via miR-218 in U937 macrophage cells. .  Biochemical and biophysical research communications508 ( 2 ) 608 - 613   2019.1Legionella pneumophila infection-mediated regulation of RICTOR via miR-218 in U937 macrophage cells.

  • Namino F, Yamakuchi M, Iriki Y, Okui H, Ichiki H, Maenosono R, Oketani N, Masamoto I, Miyata M, Horiuchi M, Hashiguchi T, Ohishi M, Maruyama I .  Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation. .  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis25   1076029619851570   2019.1Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation.

  • Aryal B, Yamakuchi M, Shimizu T, Kadono J, Furoi A, Gejima K, Komokata T, Koriyama C, Hashiguchi T, Imoto Y .  Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer. .  Journal of oncology2019   1925315   2019Predictive Value of Diminished Serum PDGF-BB after Curative Resection of Hepatocellular Cancer.

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  • Aryal B, Yamakuchi M, Hashiguchi T, Imoto Y .  Intra-platelet Serotonin as a Biomarker in HCC Recurrence: When Time Matters. .  Journal of Cancer10 ( 11 ) 2384 - 2385   2019Intra-platelet Serotonin as a Biomarker in HCC Recurrence: When Time Matters.

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  • Aryal B, Yamakuchi M, Shimizu T, Kadono J, Furoi A, Gejima K, Takenouchi K, Komokata T, Hashiguchi T, Imoto Y .  Bivalent property of intra-platelet VWF in liver regeneration and HCC recurrence: A prospective multicenter study. .  Cancer biomarkers : section A of Disease markers26 ( 1 ) 51 - 61   2019Bivalent property of intra-platelet VWF in liver regeneration and HCC recurrence: A prospective multicenter study.

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  • Aryal B, Yamakuchi M, Shimizu T, Kadono J, Furoi A, Gejima K, Komokata T, Hashiguchi T, Imoto Y .  Therapeutic implication of platelets in liver regeneration -hopes and hues. .  Expert review of gastroenterology & hepatology12 ( 12 ) 1219 - 1228   2018.12Therapeutic implication of platelets in liver regeneration -hopes and hues.

  • Yamakuchi M, Hashiguchi T .  Endothelial Cell Aging: How miRNAs Contribute? .  Journal of clinical medicine7 ( 7 )   2018.7Endothelial Cell Aging: How miRNAs Contribute?

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  • Higashi Y, Yamakuchi M, Fukushige T, Ibusuki A, Hashiguchi T, Kanekura T .  High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice. .  Experimental dermatology27 ( 2 ) 178 - 184   2018.2High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice.

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  • Takagi K, Yamakuchi M, Matsuyama T, Kondo K, Uchida A, Misono S, Hashiguchi T, Inoue H .  IL-13 enhances mesenchymal transition of pulmonary artery endothelial cells via down-regulation of miR-424/503 in vitro. .  Cellular signalling42   270 - 280   2018.1IL-13 enhances mesenchymal transition of pulmonary artery endothelial cells via down-regulation of miR-424/503 in vitro.

  • Aryal B, Yamakuchi M, Shimizu T, Kadono J, Furoi A, Gejima K, Komokata T, Hashiguchi T, Imoto Y .  Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma. .  Canadian journal of gastroenterology & hepatology2018   9142672   2018Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma.

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  • Tanaka K, Salunya T, Motomiya Y, Motomiya Y, Oyama Y, Yamakuchi M, Maruyama I .  Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor-23/α-Klotho. .  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy21 ( 4 ) 395 - 404   2017.8Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor-23/α-Klotho.

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  • Panta S, Yamakuchi M, Shimizu T, Takenouchi K, Oyama Y, Koriyama T, Kojo T, Hashiguchi T .  Low grade inflammation inhibits VEGF induced HUVECs migration in p53 dependent manner. .  Biochemical and biophysical research communications483 ( 2 ) 803 - 809   2017.2Low grade inflammation inhibits VEGF induced HUVECs migration in p53 dependent manner.

  • Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Kitazono I, Koriyama C, Yamakuchi M, Hashiguchi T, Imoto Y .  Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence? .  Journal of Cancer8 ( 19 ) 3984 - 3991   2017Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?

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  • Shimizu T, Yamakuchi M, Biswas KK, Aryal B, Yamada S, Hashiguchi T, Maruyama I .  HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin. .  Obesity (Silver Spring, Md.)24 ( 9 ) 1913 - 21   2016.9HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin.

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  • Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Inoue M, Ikeda S, Fukukura Y, Nakamura M, Yamakuchi M, Hashiguchi T, Imoto Y. .  A Switch in the Dynamics of Intra-Platelet VEGF-A from Cancer to the Later Phase of Liver Regeneration after Partial Hepatectomy in Humans. .  PLoS One   2016.3A Switch in the Dynamics of Intra-Platelet VEGF-A from Cancer to the Later Phase of Liver Regeneration after Partial Hepatectomy in Humans.Reviewed

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  • Aryal B, Shimizu T, Kadono J, Furoi A, Komokata T, Inoue M, Ikeda S, Fukukura Y, Nakamura M, Yamakuchi M, Hashiguchi T, Imoto Y .  A Switch in the Dynamics of Intra-Platelet VEGF-A from Cancer to the Later Phase of Liver Regeneration after Partial Hepatectomy in Humans. .  PloS one11 ( 3 ) e0150446   2016A Switch in the Dynamics of Intra-Platelet VEGF-A from Cancer to the Later Phase of Liver Regeneration after Partial Hepatectomy in Humans.

  • Zhu QM, Yamakuchi M, Lowenstein CJ .  Correction: SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor. .  PloS one11 ( 1 ) e0147167   2016Correction: SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor.

  • Zhu Q, Yamakuchi M, Lowenstein CJ .  SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor. .  PloS one10 ( 8 ) e0118737   2015SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor.

  • Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ .  Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion. .  The Journal of clinical investigation124 ( 10 ) 4503 - 16   2014.10Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.

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  • Huang J, Huffman JE, Yamakuchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Böhm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA, Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group., Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, CARDIoGRAM Consortium., Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ, CHARGE Consortium Hemostatic Factor Working Group. .  Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. .  Arteriosclerosis, thrombosis, and vascular biology34 ( 5 ) 1093 - 101   2014.5Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

  • Huang J, Huffman JE, Yamakuchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Tregouet DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Oudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM, Chen F, Keene KL, Franco OH, Bohm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA; Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group, Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP; CARDIoGRAM Consortium, Tracy RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, Marz W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O'Donnell CJ; CHARGE Consortium Hemostatic Factor Working Group. .  Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. .  Arterioscler Thromb Vasc Biol.34 ( 5 ) 1093 - 1101   2014.1Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.Reviewed

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  • Shrestha C, Ito T, Kawahara K, Shrestha B, Yamakuchi M, Hashiguchi T, Maruyama I .  Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis. .  Biochemical and biophysical research communications437 ( 4 ) 573 - 8   2013.8Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis.

  • Yamakuchi M .  Endothelial senescence and microRNA. .  Biomolecular concepts3 ( 3 ) 213 - 23   2012.6Endothelial senescence and microRNA.

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  • Yamakuchi M .  MicroRNA Regulation of SIRT1. .  Frontiers in physiology3   68   2012MicroRNA Regulation of SIRT1.

  • Yamakuchi M .  MicroRNAs in Vascular Biology. .  International journal of vascular medicine2012   794898   2012MicroRNAs in Vascular Biology.

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  • Ito T, Yamakuchi M, Lowenstein CJ .  Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor. .  The Journal of biological chemistry286 ( 13 ) 11179 - 84   2011.4Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor.

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  • Ito T, Yamakuchi M, Lowenstein CJ .  Thioredoxin Increases Exocytosis by Denitrosylating N-Ethylmaleimide-sensitive Factor. . 2011 ;286(13):11179-84. .  J Biol Chem286 ( 13 ) 11179 - 11184   2011.1Thioredoxin Increases Exocytosis by Denitrosylating N-Ethylmaleimide-sensitive Factor. . 2011 ;286(13):11179-84.Reviewed

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  • Yamakuchi M, Yagi S, Ito T, Lowenstein CJ. .  MicroRNA-22 regulates hypoxia signaling in colon cancer cells .  PLoS One6 ( 5 ) e20291   2011.1 MicroRNA-22 regulates hypoxia signaling in colon cancer cellsReviewed

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  • Yamakuchi M, Yagi S, Ito T, Lowenstein CJ .  MicroRNA-22 regulates hypoxia signaling in colon cancer cells. .  PloS one6 ( 5 ) e20291   2011MicroRNA-22 regulates hypoxia signaling in colon cancer cells.

  • Harris TA, Yamakuchi M, Kondo M, Oettgen P, Lowenstein CJ .  Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells. .  Arteriosclerosis, thrombosis, and vascular biology30 ( 10 ) 1990 - 7   2010.10Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells.

  • Ito T, Yagi S, Yamakuchi M .  MicroRNA-34a regulation of endothelial senescence. .  Biochemical and biophysical research communications398 ( 4 ) 735 - 40   2010.8MicroRNA-34a regulation of endothelial senescence.

  • Srivastava K, Field DJ, Aggrey A, Yamakuchi M, Morrell CN .  Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. .  PloS one5 ( 5 ) e10413   2010.5Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria.

  • Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, Huso D, Lowenstein CJ .  P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. .  Proceedings of the National Academy of Sciences of the United States of America107 ( 14 ) 6334 - 9   2010.4P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis.

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  • Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, Huso D, Lowenstein CJ. .  P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. .  Proc Natl Acad Sci U S A107 ( 14 ) 6334 - 6339   2010.1P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Reviewed

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  • Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ .  Aldosterone activates endothelial exocytosis. .  Proceedings of the National Academy of Sciences of the United States of America106 ( 10 ) 3782 - 7   2009.3Aldosterone activates endothelial exocytosis.

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  • Yamakuchi M, Lowenstein CJ .  MiR-34, SIRT1 and p53: the feedback loop. .  Cell cycle (Georgetown, Tex.)8 ( 5 ) 712 - 5   2009.3MiR-34, SIRT1 and p53: the feedback loop.

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  • Yamakuchi M, Ferlito M, Lowenstein CJ .  miR-34a repression of SIRT1 regulates apoptosis. .  Proceedings of the National Academy of Sciences of the United States of America105 ( 36 ) 13421 - 6   2008.9miR-34a repression of SIRT1 regulates apoptosis.

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  • Yamakuchi M, Bao C, Ferlito M, Lowenstein CJ .  Epigallocatechin gallate inhibits endothelial exocytosis. .  Biological chemistry389 ( 7 ) 935 - 41   2008.7Epigallocatechin gallate inhibits endothelial exocytosis.

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  • Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ .  MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. .  Proceedings of the National Academy of Sciences of the United States of America105 ( 5 ) 1516 - 21   2008.2MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1.

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  • Yamakuchi M, Ferlito M, Morrell CN, Matsushita K, Fletcher CA, Cao W, Lowenstein CJ .  Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor. .  Methods in molecular biology (Clifton, N.J.)440   203 - 15   2008Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor.

  • Calvert JW, Gundewar S, Yamakuchi M, Park PC, Baldwin WM 3rd, Lefer DJ, Lowenstein CJ .  Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury. .  Circulation research101 ( 12 ) 1247 - 54   2007.12Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury.

  • Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT .  Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. .  Molecular cell26 ( 5 ) 745 - 52   2007.6Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.

  • Yamakuchi M, Kirkiles-Smith NC, Ferlito M, Cameron SJ, Bao C, Fox-Talbot K, Wasowska BA, Baldwin WM 3rd, Pober JS, Lowenstein CJ .  Antibody to human leukocyte antigen triggers endothelial exocytosis. .  Proceedings of the National Academy of Sciences of the United States of America104 ( 4 ) 1301 - 6   2007.1Antibody to human leukocyte antigen triggers endothelial exocytosis.

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  • Lowenstein CJ, Morrell CN, Yamakuchi M .  Regulation of Weibel-Palade body exocytosis. .  Trends in cardiovascular medicine15 ( 8 ) 302 - 8   2005.11Regulation of Weibel-Palade body exocytosis.

  • Matsushita K, Morrell CN, Mason RJ, Yamakuchi M, Khanday FA, Irani K, Lowenstein CJ .  Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor. .  The Journal of cell biology170 ( 1 ) 73 - 9   2005.7Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.

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  • Yamakuchi M, Greer JJ, Cameron SJ, Matsushita K, Morrell CN, Talbot-Fox K, Baldwin WM 3rd, Lefer DJ, Lowenstein CJ .  HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size. .  Circulation research96 ( 11 ) 1185 - 92   2005.6HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size.

  • Morrell CN, Matsushita K, Chiles K, Scharpf RB, Yamakuchi M, Mason RJ, Bergmeier W, Mankowski JL, Baldwin WM 3rd, Faraday N, Lowenstein CJ .  Regulation of platelet granule exocytosis by S-nitrosylation. .  Proceedings of the National Academy of Sciences of the United States of America102 ( 10 ) 3782 - 7   2005.3Regulation of platelet granule exocytosis by S-nitrosylation.

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  • Matsushita K, Yamakuchi M, Morrell CN, Ozaki M, O'Rourke B, Irani K, Lowenstein CJ .  Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis. .  Blood105 ( 1 ) 207 - 14   2005.1Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis.

  • Sarker KP, Biswas KK, Yamaji K, Yamakuchi M, Hashiguchi T, Lee KY, Maruyama I .  Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban. .  Pathophysiology of haemostasis and thrombosis34 ( 1 ) 41 - 7   2005Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban.

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  • Iino S, Abeyama K, Kawahara K, Yamakuchi M, Hashiguchi T, Matsukita S, Yonezawa S, Taniguchi S, Nakata M, Takao S, Aikou T, Maruyama I .  The antimetastatic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic value. .  Clinical cancer research : an official journal of the American Association for Cancer Research10 ( 18 Pt 1 ) 6179 - 88   2004.9The antimetastatic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic value.

  • Bhatia R, Matsushita K, Yamakuchi M, Morrell CN, Cao W, Lowenstein CJ .  Ceramide triggers Weibel-Palade body exocytosis. .  Circulation research95 ( 3 ) 319 - 24   2004.8Ceramide triggers Weibel-Palade body exocytosis.

  • Motobe T, Hashiguchi T, Uchimura T, Yamakuchi M, Taniguchi N, Komiya S, Maruyama I .  Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome. .  Shock (Augusta, Ga.)21 ( 1 ) 8 - 12   2004.1Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome.

  • Biswas KK, Sarker KP, Abeyama K, Kawahara K, Iino S, Otsubo Y, Saigo K, Izumi H, Hashiguchi T, Yamakuchi M, Yamaji K, Endo R, Suzuki K, Imaizumi H, Maruyama I .  Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. .  Hepatology (Baltimore, Md.)38 ( 5 ) 1167 - 77   2003.11Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis.

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  • Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ .  Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. .  Cell115 ( 2 ) 139 - 50   2003.10Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor.

  • Yamaji K, Sarker KP, Kawahara K, Iino S, Yamakuchi M, Abeyama K, Hashiguchi T, Maruyama I .  Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications. .  Thrombosis and haemostasis89 ( 5 ) 875 - 84   2003.5Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications.

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  • Sarker KP, Biswas KK, Yamakuchi M, Lee KY, Hahiguchi T, Kracht M, Kitajima I, Maruyama I .  ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death. .  Journal of neurochemistry85 ( 1 ) 50 - 61   2003.4ASK1-p38 MAPK/JNK signaling cascade mediates anandamide-induced PC12 cell death.

  • Taniguchi N, Kawahara K, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S, Maruyama I .  High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. .  Arthritis and rheumatism48 ( 4 ) 971 - 81   2003.4High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine.

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MISC

  • p53分子と血管炎症のかかわり

    山口 宗一

    細胞   52 ( 3 )   146 - 149   2020.3

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    Publisher:(株)ニュー・サイエンス社  

    多くのがんで変異があり、がん治療のターゲットになっているp53は多彩な機能を持っている。このp53の心血管系におけるダイナミックな役割とp53分子機能の重要性は多数報告されている。ここでは、血管の微小な炎症low grade inflammationについてもp53の働きが重要である事実の一端を紹介し、この分野の今後の展望について論じる。(著者抄録)

  • バイオマーカーを理解する von Willebrand因子

    山口 宗一

    Cardio-Coagulation   7 ( 1 )   42 - 46   2020.3

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    Publisher:(株)メディカルレビュー社  

  • miRNAによる自然免疫制御機構

    山口 宗一, 郡山 豊泰, 清水 利昭, 竹之内 和則, 大山 陽子, 政元 いずみ, 橋口 照人

    臨床病理   67 ( 8 )   803 - 814   2019.8

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    Publisher:(一社)日本臨床検査医学会  

    マイクロRNA(miRNA)は細胞機能調節分子としての役割がクローズアップされ、さまざまな生理的、病的状態において重要な働きを持つことが証明されている。18〜22塩基の低分子非翻訳一本鎖RNA(small non-coding RNA)は、その役割や組織分布などからカテゴリー化されるようになり、がん関連miRNAはOnco-miRと呼ばれ、多くの腫瘍細胞の増殖能、転移能を増強していることが明らかになった。本稿では、細菌感染症、自然免疫を制御するmiRNAについて、以下の項目で最新の話題を紹介した。1)細菌感染による活性化マクロファージとmiRNA,2)細胞内寄生細菌感染による活性化マクロファージとmiRNA,3)レジオネラ菌感染とmiRNA,4)miR-218のレジオネラ菌感染における意味付け、5)Rictorとマクロファージ、6)細胞外分泌小胞のmiRNA。

  • 【ポストゲノムダイナミクスと検査医学への展望】検査医学へつながるmiRNA研究

    山口 宗一, 橋口 照人

    臨床化学   47 ( 3 )   229 - 236   2018.7

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    Publisher:(一社)日本臨床化学会  

  • Endothelial Senescence and MicroRNAs Reviewed

    Yamakuchi, M.

    Biomol Concepts   3 ( 3 )   213 - 223   2013.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • vascular miRNAs and microRNAs Reviewed

    Yamakuchi, M.

    International journal of vascular medicine   2012:794898   2012.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • SIRT1 and microRNAs Reviewed

    Yamakuchi, M.

    Frontiers in Vascular Physiology   3 ( 68 )   2012.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations

  • 中村 政敏, 舞木 公子, 高手 恵美, 高味 聡子, 竹之下 友寿, 佐藤 香奈子, 政元 いずみ, 大山 陽子, 竹之内 和則, 山口 宗一, 橋口 照人   電子カルテ(HIS)更新時における検査部情報システム(LIS)を用いた結果報告の検討  

    日本臨床検査自動化学会会誌  2018.9  (一社)日本医療検査科学会

  • 中島 篤人, 山口 宗一, 吉村 明子, 古城 剛, 小濱 祐行, 竹之内 和則, 大山 陽子, 政元 いずみ, 高嶋 博, 橋口 照人   親子間で病型の異なるフォン・ヴィレブランド病の一家系  

    日本血栓止血学会誌  2019.5  (一社)日本血栓止血学会

  • 大山 陽子, 竹之内 和則, 古城 剛, 郡山 豊泰, 福山 竜子, 川畑 恵, 山口 宗一, 橋口 照人   血液培養陽性データよりみる真菌検出とその臨床背景  

    臨床病理  2017.10  (一社)日本臨床検査医学会

  • 東 貞行, 山口 宗一, 竹之内 和則, 大山 陽子, 橋口 照人   臨床検査専門医プログラムを選択して 現在の研修風景  

    臨床病理  2019.10  (一社)日本臨床検査医学会

  • 中島 一壽, 小森園 康二, 迫 勝巳, 柴藤 俊彦, 北薗 正樹, 田中 貞夫, 東 貞行, 大山 陽子, 竹之内 和則, 山口 宗一, 橋口 照人   未破裂肝細胞癌に対しマイクロスフィア塞栓後(DEB-TACE後)に肝切除を行った症例の病理学的検討  

    臨床化学  2019.8  (一社)日本臨床化学会

  • 波野 真伍, 波野 史典, 小濱 祐行, 古城 剛, 前之園 隆一, 政元 いずみ, 山口 宗一, 橋口 照人   心房細動アブレーション治療における長期予後予測バイオマーカーの検討 血管内皮機能関連マーカーの可能性  

    日本検査血液学会雑誌  2020.6  (一社)日本検査血液学会

  • 波野 史典, 山口 宗一, 前之園 隆一, 入來 泰久, 二宮 雄一, 市來 仁志, 政元 いずみ, 大石 充, 堀内 正久, 橋口 照人, 丸山 征郎   心房細動アブレーション治療における可溶性トロンボモジュリンと循環miRNAの動態  

    臨床病理  2019.10  (一社)日本臨床検査医学会

  • 波野 史典, 山口 宗一, 前之園 隆一, 入來 泰久, 奥井 英樹, 市來 仁志, 大石 充, 橋口 照人   心房細動アブレーションにおける血管内皮機能変化と血清primary microRNAの関連究明  

    日本循環器学会学術集会抄録集  2018.3  (一社)日本循環器学会

  • 中村 政敏, 宮内 恵美, 佐藤 香奈子, 伊藤 隆史, 山口 宗一, 政元 いずみ, 橋口 照人   当院でクロスミキシングテストが有用であった波形/数値 判定パターン解析について  

    日本臨床検査自動化学会会誌  2017.8  (一社)日本医療検査科学会

  • 東 裕子, 山口 宗一, 坂ノ上 正直, 福重 智子, 金蔵 拓郎   好中球性皮膚疾患の病勢マーカーとしてのmicroRNAの検索  

    日本皮膚免疫アレルギー学会雑誌  2018.10  (一社)日本皮膚免疫アレルギー学会

  • 上田 英昭, 山口 宗一, 松本 和久, 竹之内 和則, 大山 陽子, 橋口 照人, 井本 浩   大動脈弁狭窄症に対する大動脈弁置換術前後での末梢血、凝固系の検討  

    日本臨床検査自動化学会会誌  2019.8  (一社)日本医療検査科学会

  • 上田 英昭, 松本 和久, 向原 公介, 重久 喜哉, 立石 直毅, 井本 浩, 山口 宗一, 橋口 照人   大動脈弁狭窄症における弁置換術前後の末梢血の推移  

    日本外科学会定期学術集会抄録集  2018.4  (一社)日本外科学会

  • 上田 英昭, 山口 宗一, 竹之内 和則, 大山 陽子, 井本 浩, 橋口 照人   大動脈弁狭窄症における弁置換術前後の末梢血の推移  

    臨床化学  2018.7  (一社)日本臨床化学会

  • 向原 公介, 山口 宗一, 松本 和久, 上田 英昭, 重久 喜哉, 大川 政士, 橋口 照人, 井本 浩   冠動脈バイパス術周術期における血小板内VEGFの推移  

    日本外科学会定期学術集会抄録集  2020.8  (一社)日本外科学会

  • 山口 宗一, 向原 公介, 上田 英昭, 重久 善哉, 大川 政士, 松本 和久, 竹之内 和則, 大山 陽子, 井本 浩, 橋口 照人   冠動脈バイパス術周術期における血小板内VEGF-Aの変化についての検討  

    臨床化学  2020.10  (一社)日本臨床化学会

  • 山口 宗一, 向原 公介, 上田 英昭, 重久 善哉, 大川 政士, 松本 和久, 竹之内 和則, 大山 陽子, 東 貞行, 藤崎 知園子, 井本 浩, 橋口 照人   冠動脈バイパス術周術期におけるmicroRNA-126についての検討  

    臨床病理  2020.10  (一社)日本臨床検査医学会

  • 山口 宗一, スシル・パンタ , 郡山 豊泰, 清水 利昭, 大山 陽子, 竹之内 和則, 橋口 照人   低グレードの炎症はVEGF誘発性のHUVECsの遊走をp53依存的な様式で阻害する(Low grade inflammation inhibits VEGF induced HUVECs migration in p53 dependent manner)  

    日本血栓止血学会誌  2017.4  (一社)日本血栓止血学会

  • 上田 英昭, 山口 宗一, 松本 和久, 大川 政士, 向原 公介, 重久 喜哉, 橋口 照人, 井本 浩   マイクロRNAが血管平滑筋の石灰化に与える影響の解析  

    日本外科学会定期学術集会抄録集  2020.8  (一社)日本外科学会

  • 郡山 豊泰, 山口 宗一, 竹之内 和則, 大山 陽子, 政元 いずみ, 橋口 照人   ヒト巨核芽球細胞株における高血糖時のGLP-1受容体発現と機能の解析  

    臨床病理  2018.10  (一社)日本臨床検査医学会

  • 小戝 健一郎, 永野 聡, 伊地知 暢広, 二川 俊隆, 角 栄里子, 山口 宗一, 中條 正典, 橋口 照人, 武田 泰生, 吉浦 敬, 清水 章, 高谷 宗男, 小宮 節郎   トランスレーショナルリサーチの現状と展望 次世代の腫瘍溶解性ウイルス・免疫遺伝子治療の独自開発と実用化を目指したFirst-in-human医師主導治験(Current status and prospects in translational research Development of next-generation oncolytic viro-immuno-therapy and investigator-initiated first-in-human clinical trial)  

    日本癌学会総会記事  2018.9  日本癌学会

  • 中村 政敏, 高手 恵美, 神宮司 真子, 小濱 祐行, 竹之下 友寿, 政元 いずみ, 伊藤 隆史, 大山 陽子, 竹之内 和則, 山口 宗一, 橋口 照人   クロスミキシングテストを施行した28症例の考察  

    日本臨床検査自動化学会会誌  2018.9  (一社)日本医療検査科学会

  • 山本 美佳, 原田 陽一郎, 山口 宗一, 伊藤 隆史, 永里 朋香, 丸山 征郎   エキソソームの凝血学的諸性質の解析  

    日本血栓止血学会誌  2017.4  (一社)日本血栓止血学会

  • 上田 英昭, 重久 喜哉, 向原 公介, 井本 浩, 山口 宗一, 橋口 照人   せん断応力が大動脈弁狭窄における血小板分布幅に及ぼす影響(The Impact of Shear Stress on Platelet Distribution Width in Aortic Stenosis)  

    日本循環器学会学術集会抄録集  2018.3  (一社)日本循環器学会

  • アリアル・ビベック , 清水 利昭, 門野 潤, 風呂井 彰, 槐島 健太郎, 菰方 輝夫, 郡山 千早, 山口 宗一, 橋口 照人, 井本 浩   PDGF-BB低値はHCC切除後再発のリスク因子なのか、単なる指標なのか?(Depleted PDGF-BB Kinetic In Post-Resection HCC Recurrence: A Risk Factor or Merely an Indicator?)  

    臨床病理  2018.10  (一社)日本臨床検査医学会

  • 波野 史典, 前之園 隆一, 入來 泰久, 奥井 英樹, 市來 仁志, 政元 いずみ, 山口 宗一, 橋口 照人   NT-proBNPを用いた心房細動アブレーション治療後の長期洞調律維持予測  

    日臨技九州支部医学検査学会  2017.10  日臨技九州支部医学検査学会

  • 山口 宗一, 上田 英昭, 大川 政士, 向原 公介, 重久 善哉, 松本 和久, 竹之内 和則, 大山 陽子, 東 貞行, 藤崎 知園子, 井本 浩, 橋口 照人   microRNAによる血管平滑筋石灰化制御の検討  

    臨床病理  2020.10  (一社)日本臨床検査医学会

  • 山口 宗一, 高木 弘一, 松山 崇弘, 近藤 清貴, 内田 章文, 大山 陽子, 清水 利昭, 竹之内 和則, 井上 博雅, 橋口 照人   IL-13はmiR-424/503を介して肺動脈血管内皮細胞の遊走能を亢進する  

    臨床病理  2017.10  (一社)日本臨床検査医学会

  • 古城 剛, 山口 宗一, 吉村 明子, 竹之内 和則, 清水 利昭, 大山 陽子, 郡山 豊泰, 波野 史典, 高嶋 博, 橋口 照人   CalDAG-GEFI分子異常による血小板機能異常症  

    日本検査血液学会雑誌  2017.6  (一社)日本検査血液学会

  • 大山 陽子, 竹之内 和則, 舞木 公子, 郡山 豊泰, 福山 竜子, 川畑 恵, 古城 剛, 山口 宗一, 政元 いずみ, 橋口 照人   24時間体制で血液培養陽性検体のサブカルチャーを可能にしたことによる患者アウトカムの検討  

    臨床病理  2018.10  (一社)日本臨床検査医学会

  • YAMAKUCHI Munekazu, MARUYAMA Ikuro, KITAJIMA Isao   The gene of rat skeletal muscle that change under the microgravity-myocyte-specific enhancer binging factor 2c(MEF2c)  

    1998.12 

  • 川上 雅之, 垣花 泰之, 上村 裕一, 川原 幸一, 山口 宗一, 丸山 征郎   62 敗血症および多臓器不全におけるPlatelet Satellitismとanandamide,2-AGの意義  

    日本アフェレシス学会雑誌  2002  日本アフェレシス学会

  • 小戝 健一郎, 永野 聡, 伊地知 暢広, 二川 俊隆, 角 栄里子, 山口 宗一, 中條 正典, 橋口 照人, 武田 泰生, 吉浦 敬, 清水 章, 高谷 宗男, 小宮 節郎   トランスレーショナルリサーチの現状と展望 次世代の腫瘍溶解性ウイルス・免疫遺伝子治療の独自開発と実用化を目指したFirst-in-human医師主導治験(Current status and prospects in translational research Development of next-generation oncolytic viro-immuno-therapy and investigator-initiated first-in-human clinical trial)  

    日本癌学会総会記事  2018.9  (一社)日本癌学会

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Research Projects

  • 血管内皮細胞由来microRNAによる糖尿病性血管障害機構の空間統合的解明

    2015.4 - 2018.3

    科学研究費補助金  科学研究費

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    血管内皮細胞由来microRNAによる糖尿病性血管障害機構の空間統合的解明

  • 新規内因性低分子RNAによる大血管機能評価の臨床検査システム構築への挑戦

    2015.4 - 2018.3

    科学研究費補助金  挑戦的萌芽研究

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    新規内因性低分子RNAによる大血管機能評価の臨床検査システム構築への挑戦

  • microRNAによる糖尿病性血管病変形成のメカニズムの解明

    2013.4 - 2015.3

    科学研究費補助金  研究活動スタート支援

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    microRNAによる糖尿病性血管病変形成のメカニズムの解明