Updated on 2024/10/07

写真a

 
SHIMA Kaori
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Oncology Associate Professor
Title
Associate Professor

Degree

  • 博士(歯学) ( 2000.3   九州大学 )

Research Interests

  • epigenetics

  • 前癌病変

  • 口腔扁平上皮癌

  • Oral Oncology

Research Areas

  • Life Science / Oral biological science

  • Others / Others  / 口腔病理学

Research History

  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Department of Molecular Oral Pathology and Oncology   Associate Professor

    2021.4

  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Department of Oral Pathology   Associate Professor

    2019.5 - 2021.3

  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Department of Oral Pathology   Assistant Professor

    2011.6 - 2019.4

  • Tokyo Dental College   Department of Pathology   Lecturer

    2003.10 - 2008.3

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    Country:Japan

  • Tokyo Dental College   Department of Pathology   Research Assistant

    2001.10 - 2003.9

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    Country:Japan

Professional Memberships

  • 歯科基礎医学会

    2017.8

  • 日本口腔腫瘍学会

    2016.10

  • 日本臨床細胞学会

    2013.5

  • 日本口腔科学会

    2012.10

  • 日本臨床口腔病理学会

    2011.6

  • The American Association for Cancer Research

    2009.5

  • 日本病理学会

    1996.4

  • 頭頸部癌学会

    1993.10

  • 日本口腔外科学会

    1993.5

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Committee Memberships

  • 日本病理学会   評議員  

    2020.4   

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    Committee type:Other

  • 歯科基礎医学会   代議員  

    2019.10   

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    Committee type:Academic society

Studying abroad experiences

  • 2008.4 - 2011.3   Dana-Farber Cancer Institute   Research Fellow

  • 2006.4 - 2008.3   Department of Pathology, Harvard University   Research Fellow

 

Papers

  • Phuong Thao Nguyen, Yudai Shimojukkoku, Yuka Kajiya, Yasunobu Oku, Ayami Tomishima, Kaori Shima, Tomonori Sasahira .  Gene alterations in the nuclear transport receptor superfamily: A study of head and neck cancer .  PLOS ONE19 ( 5 ) e0300446 - e0300446   2024.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    In cancer cells, the nuclear transport system is often disrupted, leading to abnormal localization of nuclear proteins and altered gene expression. This disruption can arise from various mechanisms such as mutations in genes that regulate nuclear transport, altered expression of transport proteins, and changes in nuclear envelope structure. Oncogenic protein build-up in the nucleus due to the disturbance in nuclear transport can also boost tumor growth and cell proliferation. In this study, we performed bioinformatic analyses of 23 key nuclear transport receptors using genomic and transcriptomic data from pancancer and head and neck squamous cell carcinoma (HNSCC) datasets from The Cancer Genome Atlas (TCGA) and Cancer Cell Line Encyclopedia and found that the total alteration frequency of 23 nuclear transport receptors in 2691 samples of the PCAWG Consortium was 42.1% and a high levels of genetic alterations was significantly associated with poor overall survival. Amplification was the most common type of genetic alterations, and results in the overexpression of nuclear transport receptors in HNSCC compared to normal tissues. Furthermore, our study revealed that seven out of eight cell cycle genes (CDK1, CDK2, CDK4, CDK6, CCNA1, CCNB1, and CCNE2) were significantly and positively correlated with nuclear transport receptor genes in TCGA pancancer and CCLE datasets. Additionally, functional enrichment analysis showed that nuclear transport receptor genes were mainly enriched in the adhesion junction, cell cycle, ERBB, MAPK, MTOR and WNT signaling pathways.

    DOI: 10.1371/journal.pone.0300446

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  • Shima K., Shimojukkoku Y., Hijioka H., Ishihata K., Sasahira T. .  Spindle cell squamous cell carcinoma of the maxillary sinus as a metachronous head and neck cancer .  Oral Science International   2024

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    Language:Japanese   Publisher:Oral Science International  

    Background: Spindle cell squamous cell carcinoma (SpSCC) is a rare subtype of squamous cell carcinoma (SCC) showing an unfavorable prognosis. Histologically, SpSCC shows biphasic proliferation of spindle cells and nests of SCC. Case presentation: An 85-year-old Japanese man with a medical history of oral SCC three years ago had SpSCC of the right maxillary sinus. The tumor showed aggressive proliferation of spindle cells with nests of conventional SCC. Subsequent lymph node metastases revealed findings of conventional SCC. Conclusion: This case report contributes to the accumulation of a rare subtype of SCC and multiple cancers of the head and neck region.

    DOI: 10.1002/osi2.1268

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  • Hiromoto S., Nozoe E., Hanada K., Yoshimura T., Shima K., Nakamura N., Chiba A. .  Comparative Degradation Behavior of Carbonate Apatite-Coated and Hydroxyapatite-Coated Mg-Ca Alloy Plates and Screws in Rabbit Femurs .  Biomedical Materials and Devices   2024

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    Language:Japanese   Publisher:Biomedical Materials and Devices  

    Carbonate apatite (CAp) and hydroxyapatite (HAp) coatings were formed on Mg-0.8 mass% Ca (MgCa) alloy plates and screws as bioabsorbable and non-absorbable corrosion suppression coatings, respectively, and implanted in rabbit femurs alongside uncoated devices for 8 and 24 weeks. The degradation behavior of CAp-coated and HAp-coated MgCa, as well as the surrounding bone formation were investigated using scanning electron microscopy and histological observations. The CAp and HAp coatings effectively suppressed the initial rapid corrosion of MgCa devices. Subsequently, while the CAp-coated devices showed no apparent corrosion pits, the HAp-coated devices showed millimeter-sized pits. The 24-week mean corrosion rate of CAp-coated devices was about half that of HAp-coated devices and about one-fifth of uncoated devices. Initially, both CAp and HAp coatings equivalently enhanced new bone formation, promoting screw-bone bonding. However, over time, the screw-bone bonding remained unchanged for CAp-coated screws, whereas it decreased for HAp-coated screws due to substrate corrosion and dissolution of corrosion products. Notably, the CAp coating began to dissolve between 8 and 24 weeks without harming the surrounding tissue, particularly in areas where new bone had adhered. In contrast, the HAp coating almost remained its original shape. It was demonstrated that the CAp coating can effectively suppress MgCa device corrosion and gradually dissolve over time.

    DOI: 10.1007/s44174-024-00217-w

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  • Kaori Shima, Phuong Thao Nguyen, Yudai Shimojukkoku, Yuka Kajiya, Tomonori Sasahira .  Solitary circumscribed neuroma of the upper lip: A case report .  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology36 ( 4 ) 657 - 659   2023.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.ajoms.2023.11.009

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  • Two cases of primordial odontogenic tumor in the maxilla .    40 ( 3 ) 265 - 271   2023.7Two cases of primordial odontogenic tumor in the maxillaReviewed

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Hung Trong Hoang, Phuong Thao Nguyen, Nam Cong-Nhat Huynh, Tam Thi-Thanh Nguyen, Trang Thi Huyen Tu, Michael George Botelho, Lan Van Nguyen, Kaori Shima, Tomonori Sasahira .  Reliability of online dental final exams in the pre and post COVID-19 era: A comparative study. .  PloS one18 ( 5 ) e0286148   2023International journal

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Amidst the fourth COVID-19 wave in Viet Nam, national lockdowns necessitated the closure of numerous dental schools. To assess DDS (Doctor of Dental Surgery) graduation exams, this study analyzed their 2021 implementation in comparison to onsite exams conducted in 2020 and 2022 at the Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam (FOS-UMPH). The final online examination comprises two main sessions: a synchronous online examination using FOS-UMPH e-Learning for theories (consisting of 200 MCQs and 3 written tests with 3 clinical situations needed be solved) and a synchronous online examination using Microsoft Teams for practicum (comprising of 12 online OSCE stations). The final grades were evaluated using the same metrics in face-to-face final examinations in 2022 and 2020. A total of 114, 112 and 95 students were recruited for the first-time exams in 2020, 2021 and 2022, respectively. In order to analyze the reliability, histogram and k-mean clustering were employed. The histograms from 2020, 2021 and 2022 showed a striking similarity. However, fewer students failed in 2021 and 2022 (13% and 12.6%, respectively) compared to 2020 (28%), with clinical problem-solving part grades (belonging to theory session) being notably higher in 2021 and 2022. Intriguingly, the MCQ Score results showed the identical patterns. The courses of orthodontics, dental public health, and pediatrics subjects (in the group of prevention and development dentistry) stood out for their exceptional accuracy across both sessions. After examining data gathered over three years, we identified three distinct clusters: the first comprised of scattered average and low scores, the second characterized by high scores but unstable and scattered and the third cluster boasting consistently high and centered scores. According to our study, online and onsite traditional graduation exam results are relatively equivalent, but additional measures are necessary to standardize the final examination and adapt to the new normal trend in dental education.

    DOI: 10.1371/journal.pone.0286148

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  • Miyakoshi Masaaki, Abe Hiroshi, Hagimoto Aya, Kawashima Yusuke, Kawabata Yoshihiro, Indo Hiroko, Hijioka Hiroshi, Shima Kaori, Sugiura Tsuyoshi, Sasahira Tomonori, Tanaka Tatsurou .  Mucoepidermoid Carcinoma of the Maxilla with Multiple Spreading Patterns: A Case Report .  Shika Hoshasen63 ( 1 ) 20 - 24   2023Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Oral and Maxillofacial Radiology  

    DOI: 10.11242/dentalradiology.63.20

  • 近藤 智之, 嶋 香織, 杉浦 剛, 中村 典史, 笹平 智則 .  口腔に発生したアミロイドーシス13例の臨床病理学的検討 .  南九州歯学会雑誌3 ( 1 ) 18 - 24   2022.9口腔に発生したアミロイドーシス13例の臨床病理学的検討

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    Language:Japanese   Publisher:南九州歯学会  

    【緒言】アミロイドーシスはアミロイド蛋白が沈着する疾患の総称であり,アミロイド前駆蛋白の種類により細分類される。なかでもALアミロイドーシスは比較的頻度が高く,口腔症状としては巨舌を呈する。アミロイドーシスは進行性の病変で予後不良なため,早期発見・治療が重要である。本研究では,我々は口腔ALアミロイドーシス症例の臨床病理学的特徴を検討した。【対象と方法】1981年から2021年に当科においてアミロイドーシスと診断された13例を対象とした。組織学的にコンゴーレッド染色および抗アミロイドA抗体と抗軽鎖抗体の免疫組織化学染色によりアミロイドーシスの細分類を行った。【結果】組織学的な特徴ではびまん性ないし結節状のアミロイド沈着を認めるものが11例,血管周囲性のアミロイド沈着を示すものが2例であった。組織学的な病型診断では13例中4例がALアミロイドーシスに分類された(口蓋2例,舌1例,舌と口唇1例)。【考察】アミロイドーシスの臨床診断がされたのは13例中1例のみであった。臨床症状は腫瘤形成が8例であり,巨舌症をきたしていたのは1例のみであった。口腔に発生したアミロイドーシスでは巨舌以外の症状を認識することが大切であると考えられた。また,顕微鏡上でアミロイドーシスの沈着を確認することや治療選択のためにアミロイド型の検索を行うことも必要である。(著者抄録)

  • Tomokazu Ohnishi, Toshiaki Nakamura, Kaori Shima, Kazuyuki Noguchi, Norika Chiba, Tetsuya Matsuguchi .  Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). .  Journal of oral biosciences64 ( 2 ) 229 - 236   2022.6International journal

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    OBJECTIVES: The oral cavity is one of the main entry sites for SARS-CoV-2. Gingival keratinocytes express transmembrane serine protease 2 (TMPRSS2), responsible for priming the SARS-CoV-2 spike protein. We investigated whether periodontitis increased the expression of TMPRSS2. METHODS: To investigate gene expression in periodontitis, we analyzed the expression of specific genes from (1) the Gene Expression Omnibus (GEO) dataset of 247 human gingival tissues and (2) an experimentally-induced periodontitis mouse model. Human gingival tissues with or without periodontitis were immunohistochemically stained using an anti-TMPRSS2 antibody. Analysis of the TMPRSS2 promoter was performed using a ChIP-Atlas dataset. TMPRSS2 expression was detected in cultured human keratinocytes using quantitative reverse transcription (qRT)-PCR and Western blot analysis. RESULTS: GEO dataset analysis and an experimentally-induced periodontitis model revealed increased expression of TMPRSS2 in periodontitis gingiva. The keratinocyte cell membrane in periodontitis gingiva was strongly immunohistochemically stained for TMPRSS2. Using ChIP-Atlas and GEO datasets, we screened for transcription factors that bind to the TMPRSS2 promoter region. We found one candidate, estrogen receptor 1 (ESR1), highly expressed in periodontitis gingiva. Analysis of the GEO dataset revealed a correlation between ESR1 and TMPRSS2 expression in gingival tissues. An ESR1 ligand induced TMPRSS2 expression in cultured keratinocytes. CONCLUSIONS: Periodontitis increases TMPRSS2 expression in the cell membrane of gingival keratinocytes.

    DOI: 10.1016/j.job.2022.04.004

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  • Tomonori Sasahira, Miyako Kurihara-Shimomura, Yudai Shimojjukoku, Kaori Shima, Tadaaki Kirita .  Searching for New Molecular Targets for Oral Squamous Cell Carcinoma with a View to Clinical Implementation of Precision Medicine. .  Journal of personalized medicine12 ( 3 )   2022.3International journal

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    Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the eighth most common malignancy globally and is characterized by local invasiveness and high nodal metastatic potential. The OSCC incidence is also increasing, and the number of deaths is also rising steadily in Japan. The development of molecular markers to eradicate OSCC is an urgent issue for humankind. The increase in OSCC despite the declining smoking rate may be due to several viral infections through various sexual activities and the involvement of previously unfocused carcinogens, and genetic alterations in individual patients are considered to be more complicated. Given this situation, it is difficult to combat OSCC with conventional radiotherapy and chemotherapy using cell-killing anticancer drugs alone, and the development of precision medicine, which aims to provide tailor-made medicine based on the genetic background of each patient, is gaining attention. In this review article, the current status of the comprehensive search for driver genes and biomarkers in OSCC will be briefly described, and some of the candidates for novel markers of OSCC that were found will be outlined.

    DOI: 10.3390/jpm12030413

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  • Ono Y, Murakami-Yunoki J, Miyashita K, Matsunaga K, Ishihata K, Fuchigami T, Shima K, Chairani E, Nakamura N. .  An advanced primary ameloblastoma in the maxilla extending into the maxillary and ethmoid sinus tract: A case report .  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology34 ( 4 ) 403 - 410   2022Reviewed

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    DOI: 10.1016/j.ajoms.2021.11.002

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  • Hiromoto S, Nozoe E, HanadaK, Yoshimura T, Shima K, Kibe T, Nakamura N, Doi K .  In vivo degradation and bone formation behaviors of hydroxyapatite-coated Mg alloys in rat femur .  Materials Science and Engineering C122   111942   2021.3Reviewed

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    Publisher:Materials Science and Engineering C  

    DOI: 10.1016/j.msec.2021.111942

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  • Ikeda M, Shima K, Kondo T, Semba I. .  Atypical immunohistochemical patterns can complement the histopathological diagnosis of oral premalignant lesions. .  Journal of Oral Biosciences62 ( 1 ) 93 - 98   2020.3Atypical immunohistochemical patterns can complement the histopathological diagnosis of oral premalignant lesions.Reviewed

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    DOI: 10.1016/j.job.2020.01.003.

  • Kusuyama J, Seong C, Nakamura T, Ohnishi T, Amir MS, Shima K, Semba I, Noguchi K, Matsuguchi T .  BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction. .  The international journal of biochemistry & cell biology116   105614 - 105614   2019.11Reviewed International journal

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    Osteopontin (OPN) is an osteoblast-derived secretory protein that plays a role in bone remodeling, osteoblast responsiveness, and inflammation. We recently found that osteoblast differentiation is type-specific, with conditions of JNK inactivation inducing osteoblasts that preferentially express OPN (OPN-type). Since OPN-type osteoblasts highly express osteogenesis-inhibiting proteins and Rankl, an important inducer of osteoclastogenesis, an increased appearance of OPN-type osteoblasts may be associated with inefficient and poor-quality bone regeneration. However, whether specific osteogenic inducers can modulate OPN-type osteoblast differentiation is completely unknown. Here, we demonstrate that bone morphogenic protein 9 (BMP9) prevents induction of OPN-type osteoblast differentiation under conditions of JNK inhibition. Although JNK inactivation suppressed both BMP2- and BMP9-induced matrix mineralization and osteocalcin expression, the expression of Rankl and specific cytokines such as Gpha2, Esm1, and Sfrp1 under similar conditions was increased in all cells except those treated with BMP9. Increased expression of Id4, a critical transcriptional regulator of OPN-type osteoblast differentiation, was similarly prevented only in BMP9-treated cells. We also found that BMP9 specifically induces the expression of Hey1, a bHLH transcriptional repressor, and that Id4 inhibits the suppressive effects of Hey1 on Opn promoter activity by forming Id4-Hey1 complexes in osteoblasts. Using site-direct mutagenesis, ChIP, and immunoprecipitation, we elucidated that BMP9-induced overexpression of Hey1 can overcome the effects of Id4 and suppress OPN expression. We further found that p38 activation and JNK inactivation are involved in BMP9-induced Hey1 expression. Collectively, these data suggest that BMP9 is a unique osteogenic inducer that regulates OPN-type osteoblast differentiation.

    DOI: 10.1016/j.biocel.2019.105614

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  • Kusuyama J, Seong C, Makarewicz NS, Ohnishi T, Shima K, Semba I, Bandow K, Matsuguchi T .  Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. .  Cellular signalling62   109345 - 109345   2019.10Reviewed International journal

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    Mesenchymal stem cells (MSCs) are a powerful tool for cell-based, clinical therapies like bone regeneration. Therapeutic use of cell transplantation requires many cells, however, the expansion process needed to produce large quantities of cells reduces the differentiation potential of MSCs. Here, we examined the protective effects of low intensity pulsed ultrasound (LIPUS) on the maintenance of osteogenic potency. Primary osteoblastic cells were serially passaged between 2 and 12 times with daily LIPUS treatment. We found that LIPUS stimulation maintains osteogenic differentiation capacity in serially passaged cells, as characterized by improved matrix mineralization and Osteocalcin mRNA expression. Decreased expression of Nanog, Sox2, and Msx2, and increased expression of Pparg2 from serial passaging was recovered in LIPUS-stimulated cells. We found that LIPUS stimulation not only increased but also sustained expression of Nanog in primary osteoblasts and ST2 cells, a mouse mesenchymal stromal cell line. Nanog overexpression in serially passaged cells mimicked the recuperative effects of LIPUS on osteogenic potency, highlighting the important role of Nanog in LIPUS stimulation. Additionally, we found that spleen tyrosine kinase (Syk) is an important signaling molecule to induce Nanog expression in LIPUS-stimulated cells. Syk activation was regulated by both Rho-associated kinase 1 (ROCK1) and extracellular ATP in a paracrine manner. Interestingly, the LIPUS-induced increase in Nanog mRNA expression was regulated by ATP-P2X4-Syk Y323 activation, while the improvement of Nanog protein stability was controlled by the ROCK1-Syk Y525/526 pathway. Taken together, these results indicate that LIPUS stimulation recovers and maintains the osteogenic potency of serially passaged cells through a Syk-Nanog axis.

    DOI: 10.1016/j.cellsig.2019.109345

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  • Kusuyama J, Amir MS, Albertson BG, Bandow K, Ohnishi T, Nakamura T, Noguchi K, Shima K, Semba I, Matsuguchi T .  JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4). .  FASEB J33 ( 6 ) 7331 - 7347   2019.6JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4).Reviewed

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  • Kusuyama J. .  CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction .  Biochemical Journal476 ( 22 ) 3533 - 3548   2019

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    Publisher:Biochemical Journal  

    DOI: 10.1042/BCJ20190709

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  • Ma S, Ogino S, Parsana P, Nishihara R, Qian Z, Shen J, Mima K, Masugi Y, Cao Y, Nowak JA, Shima K, Hoshida Y, Giovannucci EL, Gala MK, Chan AT, Fuchs CS, Parmigiani P, Huttenhower C, Waldron L. .  Continuity of Transcriptomes Among Colorectal Cancer Subtypes Based on Meta-analysis. .  Genome Biology19   142   2018Continuity of Transcriptomes Among Colorectal Cancer Subtypes Based on Meta-analysis.Reviewed

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  • 村上寿理,石畑清秀,野添悦郎,松本幸三,嶋香織,中村典史. .  口腔内病変から診断しえたメトトレキセート関連リンパ増殖性疾患の1例. .  日本口腔外科学会雑誌63 ( 11 ) 552 - 557   2017.11口腔内病変から診断しえたメトトレキセート関連リンパ増殖性疾患の1例. Reviewed

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  • Kusuyama J, Ohnishi T, Bandow K, Amir MS, Shima K, Semba I, Matsuguchi T. .  Constitutive activation of p46JNK2 is indispensable for C/EBPdelta induction in the initial stage of adipogenic differentiation. .  Biochem Journal474 ( 20 ) 3421 - 3437   2017.10Constitutive activation of p46JNK2 is indispensable for C/EBPdelta induction in the initial stage of adipogenic differentiation. Reviewed

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    DOI: 10.1042/BCJ20170332

  • 豊留宗一郎,野添悦郎,石畑清秀,大河内孝子,嶋香織,中村典史 .  下顎骨に生じた骨芽細胞腫の1例 .  日口腔外誌. 63 ( 8 ) 388 - 393   2017.8下顎骨に生じた骨芽細胞腫の1例Reviewed

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  • Kusuyama J, Bandow K, Ohnishi T, Hisadome M, Shima K, Semba I, Matsuguchi T. .  Osteopontin inhibits osteoblast responsiveness through the downregulation of focal adhesion kinase mediated by the induction of low molecular weight-protein tyrosine phosphatase. .  Molecular biology of the cell28 ( 10 ) 1326 - 1336   2017.5Osteopontin inhibits osteoblast responsiveness through the downregulation of focal adhesion kinase mediated by the induction of low molecular weight-protein tyrosine phosphatase.Reviewed

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  • Higashi Y, Yoshioka T, Kawai K, Fujii K, Yoshimitsu M, Kusuyama J, Shima K, Tanimoto A, Kanekura T .  Lymphomatoid granulomatosis initially presenting as ulcerated subcutaneous and muscle lesions without pulmonary involvement. .  Journal of Dermatology44 ( 5 ) e107 - e108   2017.5Lymphomatoid granulomatosis initially presenting as ulcerated subcutaneous and muscle lesions without pulmonary involvement. Reviewed

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  • 中井大史、嶋香織、國芳秀晴、吉武義泰、竹部史朗、篠原正徳 .  舌に発生した軟骨脂肪腫の1例. .  日口腔外誌. 63 ( 1 ) 21 - 24   2017.1舌に発生した軟骨脂肪腫の1例.Reviewed

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  • Nagata M, Kanie T, Shima K .  Cemental tear in an autotransplanted tooth that had been functioning for 15 years. Clinical Advances in Periodontics .  Clinical Advances in Periodontics6 ( 3 ) 111 - 117   2016Cemental tear in an autotransplanted tooth that had been functioning for 15 years. Clinical Advances in PeriodonticsReviewed

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  • Yoshimura T, Yamada S, Shima K, Nakamura N, Tanimoto A. .  An elastofibromatous lesion at the tip of the sublingual fold. .  J Dent & Oral Disord.   2016An elastofibromatous lesion at the tip of the sublingual fold.

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  • Nagata M, Nagata M, Kanie T, Shima K. .  Clinical and histologic aspect of cervical cemental tears as a risk for periodontal diseases. .  Clinical Advances in Periodontics.6 ( 4 ) 167 - 174   2016Clinical and histologic aspect of cervical cemental tears as a risk for periodontal diseases. Reviewed

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  • Hijioka H, Nishihara K, Suzuki H, Ishida T, Kume K, Yoshimura T, Shima K, Semba I, Nakamura N. .  Primary intraosseous squamous cell carcinoma arising from ameloblastomaof the mandible: A case report .  Journal of oral and maxillofacial surgery, medicine, and pathology27   693 - 697   2015Primary intraosseous squamous cell carcinoma arising from ameloblastomaof the mandible: A case reportReviewed

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  • Li T, Liao X, Lochhead P, Morikawa T, Yamauchi M, Nishihara R, Inamura K, Kim SA, Mima K, Sukawa Y, Kuchiba A, Imamura Y, Baba Y, Shima K, Meyerhardt JA, Chan AT, Fuchs, CS, Ogino S, Qian ZR .  SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features. .  Ann Surg Oncol21 ( 13 ) 4164 - 4173   2014.12SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features.Reviewed

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  • Nishihara R, Morikawa T, Kuchiba A, Lochhead P, Yamauchi M, Liao X, Imamura Y, Nosho K, Shima K, Kawachi I, Qian ZR, Fuchs CS, Chan AT, Giovannucci E, Ogino S. .  A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification. .  Am J Epidemiol.178 ( 1 ) 84 - 100   2013.7A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification.Reviewed

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  • Yamauchi M, Lochhead P, Imamura Y, Kuchiba A, Liao X, Qian ZR, Nishihara R, Morikawa T, Shima K, Wu K, Giovannucci E, Meyerhardt JA, Fuchs CS, Chan AT, Ogino S .  Physical Activity, Tumor PTGS2 Expression, and Survival in Patients with Colorectal Cancer. .  Cancer Epidemiol Biomarkers Prev. 22 ( 6 ) 1142 - 1152   2013.6Physical Activity, Tumor PTGS2 Expression, and Survival in Patients with Colorectal Cancer.Reviewed

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  • Li S, Sheng J, Hu JK, Yu W, Kishikawa H, Hu MG, Shima K, Wu D, Xu Z, Xin W, Sims KB, Landers JE, Brown RH Jr, Hu GF. .  Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. .  Angiogenesis16 ( 2 ) 387 - 404   2013.4Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress.Reviewed

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  • Waldron L, Ogino S, Hoshida Y, Shima K, McCart Reed AE, Simpson PT, Baba Y, Nosho K, Segata N, Vargas AC, Cummings MC, Lakhani SR, Kirkner GJ, Giovannucci E, Quackenbush J, Golub TR, Fuchs CS, Parmigiani G, Huttenhower C. .  Expression Profiling of Archival Tumors for Long-term Health Studies. .  Clin Cancer Res. 18 ( 22 ) 6136 - 6146   2012.11Expression Profiling of Archival Tumors for Long-term Health Studies.Reviewed

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  • Liao X, Lochhead P, Nishihara R, Morikawa T, Kuchiba A, Yamauchi M, Imamura Y, Qian ZR, Baba Y, Shima K, Sun R, Nosho K, Meyerhardt JA, Giovannucci E, Fuchs CS, Chan AT, Ogino S. .  Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. .  N Engl J Med367 ( 17 ) 1596 - 1606   2012.10Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.Reviewed

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  • Morikawa T, Shima K, Kuchiba A, Yamauchi M, Tanaka N, Imamura Y, Liao X, Qian ZR, Brahmandam M, Longtine JA, Lindeman NI, Fuchs CS, Ogino S (Co-first author) .  No Evidence for Interference of H&E Staining in DNA Testing. Usefulness of DNA Extraction From H&E-Stained Archival Tissue Sections. .  Am J Clin Pathol138 ( 1 ) 122 - 129   2012.7No Evidence for Interference of H&E Staining in DNA Testing. Usefulness of DNA Extraction From H&E-Stained Archival Tissue Sections.Reviewed

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  • Lin JH, Morikawa T, Chan AT, Kuchiba A, Shima K, Nosho K, Kirkner G, Zhang SM, Manson JE, Giovannucci E, Fuchs CS, Ogino S. .  Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression. .  Cancer Res72 ( 12 ) 3020 - 3028   2012.6Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression. Reviewed

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  • Ogino S, Shima K, Meyerhardt JA, McCleary NJ, Ng K, Hollis D, Saltz LB, Mayer RJ, Schaefer P, Whittom R, Hantel A, Benson AB 3rd, Spiegelman D, Goldberg RM, Bertagnolli MM, Fuchs CS. .  Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803. .  Clin Cancer Res18 ( 3 ) 890 - 900   2012.2Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803.Reviewed

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  • Shima K, Morikawa T, Yamauchi M, Kuchiba A, Imamura Y, Liao X, Meyerhardt JA, Fuchs CS, Ogino S. .  TGFBR2 and BAX Mononucleotide Tract Mutations, Microsatellite Instability, and Prognosis in 1072 Colorectal Cancers. .  PLoSOne6 ( 9 ) e25062.   2011.6TGFBR2 and BAX Mononucleotide Tract Mutations, Microsatellite Instability, and Prognosis in 1072 Colorectal Cancers.Reviewed

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  • Morikawa T, Kuchiba A, Yamauchi M, Meyerhardt JA, Shima K, Nosho K, Chan AT, Giovannucci E, Fuchs CS, Ogino S. .  Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. .  JAMA. 305 ( 16 ) 1685 - 1694   2011.4Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer.Reviewed

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  • Shima K, Nosho K, Baba Y, Cantor M, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S. .  Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review. .  Int J Cancer.128 ( 5 ) 1280 - 1294   2011.3Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.Reviewed

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  • Shima K, Morikawa T, Baba Y, Nosho K, Suzuki M, Yamauchi M, Hayashi M, Giovannucci E, Fuchs CS, Ogino S. .  MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. .  Cancer Causes Control.22 ( 2 ) 301 - 209   2011.2MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Reviewed

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  • Firestein R, Shima K, Nosho K, Irahara N, Baba Y, Bojarski E, Giovannucci EL, Fuchs CS, Ogino S. .  CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. .  Int J Cancer. 126 ( 12 ) 2863 - 2873   2010.12CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. Reviewed

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  • Yamamoto D, Shima K, Matsuo K, Nishioka T, Chen CY, Hu GF, Sasaki A, Tsuji T. .  Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line. .  PLoS One.5 ( 9 ) e12554   2010Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line.Reviewed

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  • Nosho K, Shima K, Irahara N, Kure S, Baba Y, Kirkner GJ, Chen L, Gokhale S, Hazra A, Spiegelman D, Giovannucci EL, Jaenisch R, Fuchs CS, Ogino S. .  DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. .  Clin Cancer Res. 15 ( 11 ) 3663 - 3671   2009.11DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.Reviewed

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  • Ogino S, Shima K, Baba Y, Nosho K, Irahara N, Kure S, Chen L, Toyoda S, Kirkner GJ, Wang YL, Giovannucci EL, Fuchs CS. .  Colorectal cancer expression of PPARG (peroxisome proliferator-activated receptor-gamma) is associated with good prognosis. .  Gastroenterology136   1240 - 1250   2009Colorectal cancer expression of PPARG (peroxisome proliferator-activated receptor-gamma) is associated with good prognosis.Reviewed

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  • Tsuji T, Ibaragi S, Shima K, Hu MG, Katsurano M, Sasaki A, Hu GF. .  Epithelial- mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. .  Cancer Res. 68 ( 24 ) 10377 - 10386   2008.12Epithelial- mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Reviewed

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  • Kitagawa M, Ogawa I, Shima K, Hashimoto S, Kudo Y, Miyauchi M, Tahara H, Shimono M, Takata T. .  Immortalization and characterization of pleomorphic adenoma cells by transfect ion with the hTERT gene. .  Int J Oncology.31 ( 2 ) 339 - 344   2007.4Immortalization and characterization of pleomorphic adenoma cells by transfect ion with the hTERT gene.Reviewed

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  • Matsuzaki H, Shima K, Muramatsu T, Ro Y, Hashimoto S, Shibahara T, Shimono M. .  Osteopontin as biomarker in early invasion by squamous cell carcinoma in tongue. .  J Oral Pathol Med. 36 ( 1 ) 30 - 34   2007.1Osteopontin as biomarker in early invasion by squamous cell carcinoma in tongue. Reviewed

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  • Okumura R, Shima K, Muramatsu T, Nakagawa K, Shimono M, Suzuki T, Magloire H, Shibukawa Y. .  The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels. .  Arch Histol Cytol.68 ( 4 ) 251 - 257   2006.4The odontoblast as a sensory receptor cell? The expression of TRPV1 (VR-1) channels. Reviewed

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  • Shima K, Muramatsu T, Abiko Y, Yamaoka Y, Sasaki H. Shimono M. .  Connexin 43 transfection in basaloid squamous cell carcinoma cells. .  Oncol Rep.16 ( 2 ) 285 - 288   2006.2Connexin 43 transfection in basaloid squamous cell carcinoma cells.Reviewed

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  • Ro Y, Muramatsu T, Shima K, Yajima Y, Shibahara T, Noma H, Shimono M. .  Correlation between reduction of syndecan-1 expression and clinico-pathological parameters in squamous cell carcinoma of tongue. .  Int J Oral Maxillofac Surg.35   252 - 7   2006.1Correlation between reduction of syndecan-1 expression and clinico-pathological parameters in squamous cell carcinoma of tongue. Reviewed

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  • Shima K, Hashimoto S, Inoue T, Muramatsu T, Takasaki Y, Shibahara T, Shimono M. .  Papillary thyroid carcinoma revealed by metastasis to the lateral neck region. .  Oral Med Pathol. 10 ( 4 ) 145 - 148   2005.12Papillary thyroid carcinoma revealed by metastasis to the lateral neck region. Reviewed

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  • Muramatsu T, Shima K, Ohta K, Kizaki H, Ro Y, Kohno Y, Abiko Y, Shimono M. .  Inhibition of osteopontin expression and function in oral cancer cell lines by antisense oligonucleotide. .  Cancer Letters.217 ( 1 ) 87 - 95   2005.1Inhibition of osteopontin expression and function in oral cancer cell lines by antisense oligonucleotide. Reviewed

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  • Shima K, Hashimoto S, Muramatsu T, Takasaki Y, Kakizawa T, Inoue T, Shimono M. .  Expression of Ki-67, Osteocalcin and Osteopontin in Cementoblastoma. .  Oral Med Pathol.9 ( 3 ) 91 - 94   2004.9Expression of Ki-67, Osteocalcin and Osteopontin in Cementoblastoma.Reviewed

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  • Shima K, Shiratsuchi Y, Sakai H. .  Schwannoma of the Mandible. .  Oral Med Patho. 9 ( 3 ) 119 - 121   2004.9Schwannoma of the Mandible.Reviewed

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  • Okamura K, Kiyoshima T, Shima K, Kobayashi I, Matsuo K, Ishibashi H, Komatsu S, Rasul AM, Sakai H. .  Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. .  Oral Oncol.38 ( 3 ) 244 - 250   2002.6Immunohistochemical expression of CA19-9 and CA125 in mucoepidermoid and adenoid cystic carcinomas of the salivary gland. Reviewed

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  • Kiyoshima T, Shima K, Kobayashi I, Matsuo K, Okamura K, Komatsu S, Rasul AM, Sakai H. .  Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands. .  Oral Oncol137 ( 3 ) 315 - 322   2001.6Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands. Reviewed

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  • 嶋香織、大関悟、大部一成、長田哲次、笹栗正明、吉川博政、高力佐知子、大石正道. .  口腔癌切除後の欠損に対する頬脂肪体有茎移植術. .  日口腔外誌.46 ( 7 ) 433 - 435   2000.7口腔癌切除後の欠損に対する頬脂肪体有茎移植術.Reviewed

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  • Shima K, Kobayashi I, Saito I, Kiyoshima T, Matsuo K, Ozeki S, Ohishi M, Sakai H. .  Incidence of human papillomavirus 16 and 18 infection and p53 mutation in patients with oral squamous cell carcinoma in Japan. .  Br J Oral Maxillofac Surg38 ( 5 ) 445 - 450   2000.5Incidence of human papillomavirus 16 and 18 infection and p53 mutation in patients with oral squamous cell carcinoma in Japan.Reviewed

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  • Kobayashi I, Shima K, Saito I, Kiyoshima T, Matsuo K, Ozeki S, Ohishi M, Sakai H. .  Prevalence of Epstein-Barr virus in oral squamous cell carcinoma. .  J Pathol.189 ( 1 ) 34 - 39   1999.1Prevalence of Epstein-Barr virus in oral squamous cell carcinoma. Reviewed

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  • 嶋香織、緒方克哉、鈴木陽、中村典史、本田康生、後藤圭也、中島昭彦、大石正道. .  顎裂部への二次的自家海綿骨細片移植術における移植骨の術後吸収の評価 .  日本口蓋誌. 23 ( 4 ) 203 - 213   1998顎裂部への二次的自家海綿骨細片移植術における移植骨の術後吸収の評価Reviewed

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MISC

  • 特集 頭頸部腫瘍II 歯原性腫瘍と顎顔面骨の病変 歯原性嚢胞

    仙波伊知郎、嶋香織

    病理と臨床   36 ( 4 )   335 - 339   2018

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  • 解説・特集 歯原性腫瘍の病理診断 その他の歯原性腫瘍

    仙波伊知郎、嶋香織

    病理と臨床・文光堂   31 ( 5 )   515 - 520   2013.5

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  • Regulatory mechanisms of periodontal regeneration. Reviewed

    Shimono M, Ishikawa T, Ishikawa H, Matsuzaki H, Hashimoto S, Muramatsu T, Shima K, Matsuzaka K, Inoue T.

    Microsc Res Tech.   60 ( 5 )   491 - 502   2003

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Presentations

  • 嶋香織、Nguyen Phuong Thao、下拾石雄大、笹平智則   口腔扁平上皮癌におけるm6AメチルトランスフェラーゼMETTL5の発現解析  

    第65回歯科基礎医学会学術大会   2023.9  日本大学歯学部

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    Event date: 2023.9

    Language:English   Presentation type:Poster presentation  

    Venue:日本大学歯学部   Country:Japan  

  • 下拾石雄大、Nguyen Phuong Thao、嶋香織、石田喬之、石畑清英、笹平智則   口腔扁平上皮癌における癌抑制遺伝子としてのEGR-1の機能解析  

    第65回歯科基礎医学会学術大会  2023.9  日本大学歯学部

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    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:日本大学歯学部   Country:Japan  

  • 嶋香織、野間優作、別府真広、萩元綾、田中達朗、廣瀬勝俊、豊澤悟、笹平智則   下顎骨病変  

    第34回 日本臨床口腔病理学会総会・学術大会  2023.8  大阪大学・院・歯学研究科 顎顔面口腔病理学講座

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    Event date: 2023.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪大学コンベンションセンター   Country:Japan  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   EPS8L3はYAPの核内転座を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis)  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Event date: 2023.4

    Language:English  

  • 奥 康伸, Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   細胞質内のTCF19転座はHNSCCにおけるDNA損傷修復を阻害する(Cytoplasmic TCF19 translocation impairs DNA damage repair in HNSCC)  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Event date: 2023.4

    Language:English  

  • 冨嶋 彩未, Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   口腔癌におけるMCTP1とMCTP2の機能的な差異についての検討  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Event date: 2023.4

    Language:Japanese  

  • 嶋 香織, Nguyen Phuong Thao, 下拾石 雄大, 笹平 智則   口腔扁平上皮癌におけるMETTL5発現と機能の解析  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Event date: 2023.4

    Language:Japanese  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   KPNA7の増幅および過剰発現がHNSCCの腫瘍浸潤免疫細胞に及ぼす影響(Impacts of KPNA7 amplification and overexpression on tumor infiltrating immune cells of HNSCCs)  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Event date: 2023.4

    Language:English  

  • 東 友太郎, 久米 健一, 松村 吉晃, 別府 真広, 高田 耕児, 嶋 香織, 笹平 智則, 杉浦 剛   口腔扁平上皮癌患者における循環腫瘍細胞のDNA解析  

    口腔組織培養学会誌  2023.2  日本口腔組織培養学会

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    Event date: 2022.12

    Language:Japanese  

  • 廣本 祥子, 野添 悦郎, 花田 幸太郎, 吉村 卓也, 嶋 香織, 中村 典史   生体吸収性炭酸アパタイトおよび水酸アパタイト被覆Mg合金のin vivo腐食挙動  

    日本バイオマテリアル学会大会予稿集  2022.11  日本バイオマテリアル学会

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    Event date: 2022.11

    Language:Japanese  

  • Nguyen Thao, Sasahira Tomonori, Shima Kaori   肝がん発生を促進するYAP核内転位の新しい知見(New insights into YAP nuclear translocation to promote liver tumorigenesis)  

    日本癌学会総会記事  2022.9  (一社)日本癌学会

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    Event date: 2022.9 - 2022.10

    Language:English  

  • 大西 智和, 中村 利明, 嶋 香織, 野口 和行, 千葉 紀香, 松口 徹也   歯周炎によるSARS-CoV-2のプライミング因子であるTMPRSS2の歯肉発現増強(Periodontitis promotes gingival expression of TMPRSS2, a priming factor for SARS-CoV-2)  

    Journal of Oral Biosciences Supplement  2022.9  (一社)歯科基礎医学会

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    Event date: 2022.9

    Language:Japanese  

  • 嶋香織、下拾石雄大、杉浦剛、中村典史、笹平智則   口腔粘膜病変における擦過細胞診の有用性について  

    第4回南九州歯学会  2022.8  鹿児島大学歯学部

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    Event date: 2022.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:online  

  • 嶋香織、近藤智之、笹平智則   多発性口腔扁平上皮癌におけるRNAメチル化関連因子の検索  

    第111回日本病理学会総会  2022.4 

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    Event date: 2022.4

    Language:English   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  • 近藤智之、嶋香織、笹平智則.   自己免疫疾患モデルにおけるPD-1陽性T細胞の増加による大腸化学発癌の亢進  

    第111回日本病理学会総会  2022.4 

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    Event date: 2022.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市  

  • 近藤智之、嶋香織、吉村卓也、 野添悦郎、中村典史、笹平智則   診断に苦慮した頬粘膜mucoepidermoid carcinomaの一例  

    第3回南九州歯学会学術大会  2021.9  鹿児島大学歯学部

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催  

  • 嶋香織、近藤智之、別府真広、杉浦剛、笹平智則   顎下部腫瘍  

    第32回日本臨床口腔病理学会総会  2021.8  神奈川歯科大学

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    Event date: 2021.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催  

  • 新田 哲也、嶋 香織、平原 成浩、西 慶太郎、田畑 博章、仙波 伊知郎   診断に苦慮した下顎前歯部に生じた紡錘細胞癌の 1 例  

    第39回日本口腔腫瘍学会総会、学術大会  2021.1  信州大学

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    Event date: 2021.1 - 2021.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:web開催  

  • 楠山 譲二, 成 昌奐, 大西 智和, 嶋 香織, 仙波 伊知郎, 松口 徹也   JNK活性の減弱は正常な骨芽細胞分化を阻害し、転写因子Id4を介してオステオポンチン高発現細胞を誘導する  

    Journal of Oral Biosciences Supplement  2020.9  (一社)歯科基礎医学会

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    Event date: 2020.9 - 2020.12

  • 嶋香織、近藤智之、内野祥徳、杉浦剛、仙波伊知郎   多様な間質変化を示した明細胞性歯原性癌の1例  

    第109回日本病理学会総会  九州大学医学部病理学分野

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    Event date: 2020.7

    Language:English   Presentation type:Poster presentation  

    Venue:web  

  • 嶋香織、近藤智之、仙波伊知郎   Two cases of granular cell ameloblastoma  

    第108回日本病理学会総会 

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    Event date: 2019.5

    Language:English   Presentation type:Poster presentation  

    Venue:東京  

  • 野添悦郎、廣本祥子、花田幸太郎、古閑崇、吉村卓也、嶋香織、岐部俊郎、久米健一、中村典史   次世代型生体吸収性ハイドロキシアパタイト表面被覆Mg合金の骨内変化に関する研究  

    第63回公益社団法人日本口腔外科学会総会・学術大会 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Poster presentation  

  • 近藤智之、嶋香織、仙波伊知郎   再検討によりPrimordial odontogenic tumorが鑑別診断として考えられた3症例  

    第29回日本臨床口腔病理学会総会 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Poster presentation  

  • 奥田瑛士、別府真広、中村康大、有村麻弥、嶋香織、杉浦剛   顔面非対称を伴った片側性下顎頭過形成症に対し下顎頭切除術を行った1例  

    第86回日本口腔外科学会九州地方部会  

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    Event date: 2018.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 石田喬之、比地岡浩志、宮脇昭彦、嶋香織、久米健一、品川憲穂、本庄希江、野村綾子、野添悦郎、仙波伊知郎、中村典史   口腔扁平上皮癌症例におけるリンパ節転移予測因子としてのbudding scoreの有用性の評価  

    第36回日本口腔腫瘍学会総会・学術大会 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Poster presentation  

  • 山城康太、濵田倫史、嶋香織、仙波伊知郎、杉浦剛   多数の石灰化菌塊を伴った智歯周囲放線菌症の1例  

    第50回日本口腔科学会九州地方部会 

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    Event date: 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 山下麻由美、永山知宏、嶋香織、濱田倫史、別府真広、後藤雄一、上川善昭、杉浦剛   当科における過去10年間の歯原性角化嚢胞の臨床的検討  

    第62回日本口腔外科学会総会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

  • 吉村卓也,石畑清秀,本庄希江,村上寿理,豊留宗一郎,福元祥子,嶋香織,西原一秀,野添悦郎,中村典史    舌アミロイドーシスを契機に発見された多発性骨髄腫の一例  

    第62回日本口腔外科学会総会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

  • 近藤智之、嶋香織、仙波伊知郎   口腔に症状を呈したアミロイドーシスの臨床病理学的検討  

    第28回日本臨床口腔病理学会総会 

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    Event date: 2017.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:川越市  

  • 嶋香織, 近藤智之, 仙波伊知郎   顎骨に症状を示した悪性リンパ腫の2例  

    第106回日本病理学会総会 

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    Event date: 2017.4

    Language:English   Presentation type:Poster presentation  

    Venue:東京都  

  • 98. 石田喬之、比地岡浩志、宮脇昭彦、末永重明、嶋香織、久米健一、品川憲穂、本庄希江、野添悦郎、馬嶋秀行、仙波伊知郎、中村典史   舌扁平上皮癌T1・T2症例における頸部リンパ節転移予測因子の検討  

    第35回日本口腔腫瘍学会総会・学術大会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡市  

  • Shima K, Kondo T, Semba I   The Evaluation of Immunohistochemical Examination of Oral Intraepithelial Neoplasia   International conference

    16th IAOMP 

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    Event date: 2016.9

    Language:English   Presentation type:Poster presentation  

    Venue:Chennai, India  

  • 嶋香織、近藤智之、仙波伊知郎   Peripheral odontogenic hamartomaの病理組織学的検討  

    第27回日本臨床口腔病理学会総会  広島大学口腔病理学講座

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    Event date: 2016.8

    Language:English   Presentation type:Poster presentation  

    Venue:広島大学  

  • 嶋香織、仙波伊知郎   診療領域別特別プログラム研究講演会15 口腔癌の前駆・初期病変の病理診断?組織学的特徴と診断クライテリア 「口腔粘膜上皮内病変における免疫組織化学染色の評価」   Invited

    第105回日本病理学会総会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:仙台市  

  • 嶋 香織, 仙波 伊知郎   口腔癌の前駆・初期病変の病理診断 組織学的特徴と診断クライテリア 口腔粘膜内病変における免疫組織化学染色の評価  

    日本病理学会会誌  2016.4  (一社)日本病理学会

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    Event date: 2016.4

    Language:Japanese  

  • 嶋香織、楠山譲二、仙波伊知郎   上唇腫瘍  

    第26回日本臨床口腔病理学会総会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌市   

  • SHIMA KAORI, KUSUYAMA JOJI, HIJIOKA HIROSHI, SEMBA ICHIRO   頸部にGranulomatous lymphadenitis(sarcoid‐like reaction)を随伴した舌扁平上皮癌の1例  

    日本病理学会会誌  2015.3  (一社)日本病理学会

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    Event date: 2015.3

    Language:Japanese  

  • 嶋香織、野添悦郎、楠山譲二、仙波伊知郎   下顎骨腫瘍(症例検討)  

    第25回日本臨床口腔病理学会総会  第25回日本臨床口腔病理学会総会

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    Event date: 2014.8

    Language:Japanese  

    Venue:新潟  

    国内学会

  • ISHIDA TAKAYUKI, NOZOE ETSURO, HIJIOKA HIROSHI, NISHIHARA KAZUHIDE, ISHIHATA KIYOHIDE, SHIMA KAORI, OYAZATO YOSHITAKA, SEMBA ICHIRO, NAKAMURA NORIFUMI   口蓋に発生した多形腺腫由来癌(筋上皮癌)の1例  

    日本口腔科学会雑誌  2014.7  (NPO)日本口腔科学会

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    Event date: 2014.7

    Language:Japanese  

  • 嶋香織、親里嘉貴、仙波伊知郎   下顎骨骨肉腫の1例  

    第103回日本病理学会総会  第103回日本病理学会総会

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    Event date: 2014.4

    Language:Japanese  

    Venue:広島  

    国内学会

  • HAMADA MICHIFUMI, IMAMURA HARUYUKI, YAMAGUCHI KOJIRO, MUKAI HIROSHI, OYASATO YOSHITAKA, SHIMA KAORI, SEMBA ICHIRO, SUGIHARA KAZUMASA   左頬粘膜に発生した紡錘細胞脂肪腫の1例  

    日本口腔科学会雑誌  2014.1  (NPO)日本口腔科学会

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    Event date: 2014.1

    Language:Japanese  

  • SHIMA KAORI, NOZOE ETSURO, KUSUYAMA JOJI, SEMBA ICHIRO   下顎骨腫瘍  

    日本臨床口腔病理学会総会・学術大会プログラム・抄録集  2014 

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    Event date: 2014

    Language:Japanese  

  • 嶋香織、親里嘉貴、仙波伊知郎   口腔に生じたleiomyomatous hamartoma の病理組織学的検討  

    第24回日本臨床口腔病理学会総会・学術大会  第24回日本臨床口腔病理学会総会・学術大会

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    Event date: 2013.8

    Language:Japanese  

    Venue:東京  

    国内学会

  • 嶋香織、親里嘉貴、仙波伊知郎   顎骨中心性扁平上皮癌の病理組織学的検討  

    第102回 日本病理学会総会  第102回 日本病理学会総会

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    Event date: 2013.6

    Language:Japanese  

    Venue:北海道  

    国内学会

  • SHIMA KAORI, OYAZATO YOSHITAKA, SEMBA ICHIRO   顎骨中心性扁平上皮癌の病理学組織学的検討  

    日本病理学会会誌  2013.4  (一社)日本病理学会

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    Event date: 2013.4

    Language:Japanese  

  • 嶋香織、親里嘉貴、下松孝太、仙波伊知郎   上顎洞に発生した紡錘細胞癌の1例  

    第23回日本臨床口腔病理学会総会・学術大会  第23回日本臨床口腔病理学会総会・学術大会

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    Event date: 2012.8

    Language:Japanese  

    Venue:東京  

    国内学会

  • 嶋香織、親里嘉貴、平野真人、仙波伊知郎   口蓋に発生したCarcinoma ex pleomorphic adenomaの2例  

    第101回 日本病理学会総会  第101回 日本病理学会総会

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    Event date: 2012.4

    Language:Japanese  

    Venue:東京  

    国内学会

  • OYASATO YOSHITAKA, HIRANO MASATO, SHIMA KAORI, SEMBA ICHIRO   4NQO誘発ラット舌前癌病変モデル確立と前癌病変におけるDNA損傷修復機構の解析  

    日本病理学会会誌  2012.3  (一社)日本病理学会

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    Event date: 2012.3

    Language:Japanese  

  • Kaori Shima, Katsuhiko Nosho, Yoshifumi Baba, Mami Cantor, Edward L. Giovannucci, Charles S. Fuchs, Shuji Ogino   Prognostic significance and molecular associations of CDKN2A (p16) promoter methylation and loss of expression in colorectal cancer  

    CANCER RESEARCH  2010.4  AMER ASSOC CANCER RESEARCH

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    Event date: 2010.4

    Language:English  

  • K. Shima, K. Nosho, L. Chen, C. S. Fuchs, S. Ogino   Loss of PPARG Expression Is Common in CpG Island Methylator Phenotype-Low (CIMP-Low) Colorectal Cancer  

    MODERN PATHOLOGY  2010.2  NATURE PUBLISHING GROUP

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    Event date: 2010.2

    Language:English  

  • Yoshifumi Baba, Katsuhiko Nosho, Kaori Shima, Natsumi Irahara, Shoko Kure, Saori Toyoda, Gregory Kirkner, Ajay Goel, Charles Fuchs, Shuji Ogino   AURKA (Aurora-A) expression is independently associated with chromosomal instability in colorectal cancer  

    CANCER RESEARCH  2009.5  AMER ASSOC CANCER RESEARCH

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    Event date: 2009.5

    Language:English  

  • Katsuhiko Nosho, Kaori Shima, Natsumi Irahara, Shoko Kure, Yoshifumi Baba, Saori Toyoda, Gregory Kirkner, Aditi Hazra, Edward Giovannucci, Sumita Gokhale, Chen Li, Rudolf Jaenisch, Charles Fuchs, Shuji Ogino   DNA methyltransferase-3B (DNMT3B) expression may contribute to CpG island methylator phenotype in colorectal cancer  

    CANCER RESEARCH  2009.5  AMER ASSOC CANCER RESEARCH

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    Event date: 2009.5

    Language:English  

  • Katsuhiko Nosho, Natsumi Irahara, Kaori Shima, Shoko Kure, Yoshifumi Baba, Saori Toyoda, Gregory Kirkner, Eva Schernhammer, Aditi Hazra, David Hunter, John Quackenbush, Donna Spiegelman, Edward Giovannucci, Charles Fuchs, Shuji Ogino   Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample  

    CANCER RESEARCH  2009.5  AMER ASSOC CANCER RESEARCH

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    Event date: 2009.5

    Language:English  

  • R. Firestein, K. Shima, K. Nosho, S. Kure, N. Irahara, E. Bojarski, G. J. Kirkner, W. C. Hahn, E. L. Giovannucci, C. S. Fuchs, S. Ogino   CDK8 Expression Is Associated with beta-Catenin Activation and Poor Outcome in Colon Cancer  

    MODERN PATHOLOGY  2009.1  NATURE PUBLISHING GROUP

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    Event date: 2009.1

    Language:English  

  • S. Ogino, K. Nosho, S. Kure, N. Irahara, K. Shima, Y. Baba, E. L. Giovannucci, C. S. Fuchs   Cyclin D1 Expression Marks a Subset of Colon Cancer with Good Prognosis  

    MODERN PATHOLOGY  2009.1  NATURE PUBLISHING GROUP

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    Event date: 2009.1

    Language:English  

  • M. Shimono, Y. Enokiya, S. Hashimoto, K. Shima, H. Sasaki, K. Matsuzaka, T. Shibahara, T. Inoue   Two cases of acinic cell carcinomas arising in the ranula  

    JOURNAL OF ORAL PATHOLOGY & MEDICINE  2006.8  BLACKWELL PUBLISHING

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    Event date: 2006.8

    Language:English  

  • 奥村礼二郎, 嶋香織, 村松敬, 中川寛一, 下野正基, 鈴木隆, 鈴木惠子, MAGROIRE Henry, SCHNETKAMP Paul, 澁川義幸   エナメル芽細胞のCa<sup>2+</sup>輸送はNa<sup>+</sup>/Ca<sup>2+</sup> exchanger(NCX)によって制御されるか?  

    歯科学報  2006.4 

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    Event date: 2006.4

    Language:Japanese  

  • Shima K. Muramatsu T, Ro Y, Sazuka A, Shimono M.   Expression of osteopontin in oral squamous cell carcinoma.   International conference

    10th International Cogress on Oral Cancer  10th International Cogress on Oral Cancer

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    Event date: 2005.4

    Language:English  

    Venue:ギリシャ  

    国際学会

  • Shima K, Hashimoto S, Sasaki H, Enokiya Y, Inoue T, Shimono M.   Glandular odontogenic cyst, analysis of cytokeratins expression.   International conference

    The 12th International Congress of the IAOP  The 12th International Congress of the IAOP

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    Event date: 2004.9

    Language:English  

    Venue:スペイン  

    国際学会

  • Shima K, Muramatsu T, Abiko Y, Yamaoka Y, Shimono M.   Effedt of Connexin43 transfection on Basaloid Squamous Cell Carcionma Cells.   International conference

    82nd International Association for Dental Research  82nd International Association for Dental Research

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    Event date: 2004.3

    Language:English  

    Venue:米国  

    国際学会

  • 嶋香織、村松敬、佐々木穂高、安彦善裕、山岡雄司、橋本貞充、下野正基   類基底扁平上皮癌細胞におけるconnexin43の役割  

    第45回歯科基礎医学会学術大会  第45回歯科基礎医学会学術大会

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    Event date: 2003.9

    Language:Japanese  

    Venue:岩手  

    国内学会

  • 嶋香織、橋本貞充、佐々木穂高、高野正行、井上孝、下野正基   歯原性石灰化上皮腫のアミロイド様物質形成に関する検討  

    第14回日本口腔病理学会総会・学術大会  第14回日本口腔病理学会総会・学術大会

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    Event date: 2003.8

    Language:Japanese  

    Venue:兵庫  

    国内学会

  • 嶋香織、橋本貞充、高野正行、瀬田修一、柿澤卓、井上孝、下野正基   上顎に発生した歯原性石灰化上皮腫の1例  

    第57回日本口腔科学会総会  第57回日本口腔科学会総会

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    Event date: 2003.5

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 嶋香織、村松敬、盧靖文、橋本貞充、下野正基   ヒト口腔扁平上皮癌におけるSyndecan-1の発現について  

    第92回病理学会総会  第92回病理学会総会

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    Event date: 2003.4

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 嶋香織、橋本貞充、榎谷保信、村松敬、高崎義人、松坂賢一、井上孝、下野正基   Benign Cementoblastomaの免疫組織学的検討  

    第13回日本口腔病理学会総会  第13回日本口腔病理学会総会

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    Event date: 2002.8

    Language:Japanese  

    Venue:東京  

    国内学会

  • 嶋香織、小林家吉、清島保、 松尾拡、坂井英隆   口腔粘膜上皮におけるHPV16,18感染とp53遺伝子変異について  

    第88回日本病理学会総会  第88回日本病理学会総会

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    Event date: 1999.4

    Language:Japanese  

    Venue:東京  

    国内学会

  • 廣本 祥子, 野添 悦郎, 花田 幸太郎, 吉村 卓也, 嶋 香織, 中村 典史   炭酸/水酸アパタイト被覆によるマグネシウム合金製スクリュー・プレートの腐食溶解速度制御  

    日本整形外科学会雑誌  2023.8  (公社)日本整形外科学会

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    Language:Japanese  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   EPS8L3はYAPの核内移行を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis)  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Language:English  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   EPS8L3はYAPの核内移行を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis)  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Language:English  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   EPS8L3はYAPの核内移行を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis)  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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    Language:English  

  • Nguyen Thao, Shima Kaori, Shimojukkoku Yudai, Kajiya Yuka, Sasahira Tomonori   核輸入受容体KPNA7の増幅は頭頸部癌の全生存率の低下と関連する(Amplication of the nuclear import receptor KPNA7 is associated with poor overall survival in head and neck cancer)  

    日本癌学会総会記事  2023.9  (一社)日本癌学会

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    Language:English  

  • Nguyen Phuong Thao, 嶋 香織, 下拾石 雄大, 笹平 智則   EPS8L3はYAPの核内移行を仲介し肝腫瘍化を促進する(EPS8L3 mediates YAP nuclear translocation and promotes liver tumorigenesis)  

    日本病理学会会誌  2023.3  (一社)日本病理学会

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Research Projects

  • 次世代型生体吸収性アパタイト表面被覆Mg合金の骨表面変化に関する研究

    2021.4

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 口腔粘膜前癌病変の病理診断基準の確立

    2017.4 - 2020.3

    科学研究費補助金  (基盤研究C)

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    Authorship:Coinvestigator(s) 

  • 歯性感染症における異種細胞相互作用ならびに細胞極性調節因子と感染防御能の関連解析

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 次世代型生体吸収性ハイドロキシアパタイト表面被覆Mg合金の骨内変化に関する研究

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 歯性感染症病変形成時の上皮発現における上皮-間葉移行 (EMT) の関与に関する研究

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 多発性口腔扁平上皮癌におけるDNAメチル化に関する研究

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  • 唾液腺腫瘍構成細胞の分化におけるアクアポリンの関与について

    2005.4 - 2007.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  • 口腔扁平上皮癌細胞の生物学的活性におけるEBV感染の関与

    2002.4 - 2005.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  • Tight junctionを介した唾液蛋白・水分泌制御と細胞内情報伝達

    2002.4 - 2005.3

    科学研究費補助金  (基盤研究C)

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    Authorship:Coinvestigator(s) 

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Teaching Experience

  • 口と顔の科学

    2020.4
    Institution:鹿児島大学

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    Level:Undergraduate (liberal arts)  Country:Japan

  • 病因論

    2020.4
    -
    2024.3
    Institution:鹿児島大学

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    Level:Postgraduate  Country:Japan

  • 総合歯科学

    2019.4
    Institution:鹿児島大学

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    Level:Undergraduate (specialized) 

  • 口腔腫瘍発生論実験

    2012.4
    Institution:鹿児島大学

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    Level:Postgraduate  Country:Japan

  • 口腔腫瘍発生論演習

    2012.4
    Institution:鹿児島大学

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    Level:Postgraduate  Country:Japan

  • 病理学、口腔病理学

    2011.6
    Institution:鹿児島大学

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    Level:Undergraduate (specialized)  Country:Japan

  • 口腔腫瘍学

    2011.6
    -
    2014.3
    Institution:鹿児島大学

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    Level:Undergraduate (specialized) 

  • 病理学、口腔病理学

    2001.10
    -
    2006.3
    Institution:東京歯科大学

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    Level:Undergraduate (specialized)  Country:Japan

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