研究者詳細 - 河原　康一

論文 - 河原　康一

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Hikasa H, Kawahara K, Inui M, Yasuki Y, Yamashita K, Otsubo K, Kitajima S, Nishio M, Arima K, Endo M, Taira M, Suzuki A . A highly sensitive reporter system to monitor endogenous YAP1/TAZ activity and its application in various human cells. . Cancer science115 ( 10 ) 3370 - 3383 2024年10月

Furukawa T, Tabata S, Minami K, Yamamoto M, Kawahara K, Tanimoto A . Metabolic reprograming of cancer as a therapeutic target. . Biochimica et biophysica acta. General subjects1867 ( 3 ) 130301 2023年3月

Miyao S, Saito K, Oshima R, Kawahara K, Nagahama M . MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing. . Biochemical and biophysical research communications637 203 - 209 2022年12月

Ishihara Y, Nakamura K, Nakagawa S, Okamoto Y, Yamamoto M, Furukawa T, Kawahara K . Nucleolar Stress Response via Ribosomal Protein L11 Regulates Topoisomerase Inhibitor Sensitivity of P53-Intact Cancers. . International journal of molecular sciences23 ( 24 ) 15986 2022年12月

記述言語：英語出版者・発行元：MDPI AG

<jats:p>Nucleolar stress response is caused by perturbations in ribosome biogenesis, induced by the inhibition of ribosomal RNA processing and synthesis, as well as ribosome assembly. This response induces p53 stabilization and activation via ribosomal protein L11 (RPL11), suppressing tumor progression. However, anticancer agents that kill cells via this mechanism, and their relationship with the therapeutic efficiency of these agents, remain largely unknown. Here, we sought to investigate whether topoisomerase inhibitors can induce nucleolar stress response as they reportedly block ribosomal RNA transcription. Using rhabdomyosarcoma and rhabdoid tumor cell lines that are sensitive to the nucleolar stress response, we evaluated whether nucleolar stress response is associated with sensitivity to topoisomerase inhibitors ellipticine, doxorubicin, etoposide, topotecan, and anthracyclines. Cell proliferation assay indicated that small interfering RNA-mediated RPL11 depletion resulted in decreased sensitivity to topoisomerase inhibitors. Furthermore, the expression of p53 and its downstream target proteins via western blotting showed the suppression of p53 pathway activation upon RPL11 knockdown. These results suggest that the sensitivity of cancer cells to topoisomerase inhibitors is regulated by RPL11-mediated nucleolar stress responses. Thus, RPL11 expression may contribute to the prediction of the therapeutic efficacy of topoisomerase inhibitors and increase their therapeutic effect of topoisomerase inhibitors.</jats:p>

DOI： 10.3390/ijms232415986

PubMed

Nakagawa S, Kawahara K, Okamoto Y, Kodama Y, Nishikawa T, Kawano Y, Furukawa T . Association between Dysfunction of the Nucleolar Stress Response and Multidrug Resistance in Pediatric Acute Lymphoblastic Leukemia. . Cancers14 ( 20 ) 5127 2022年10月

記述言語：英語出版者・発行元：MDPI AG

<jats:p>Approximately 20% of pediatric patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) relapse or are refractory to chemotherapy despite the low frequency of TP53 mutations. The nucleolar stress response is a P53-activating mechanism via MDM2 inhibition by ribosomal protein L11 (RPL11). We analyzed the role of the nucleolar stress response using BCP-ALL cell lines and patient samples by drug sensitivity tests, Western blotting, and reverse transcription polymerase chain reaction. We revealed that the nucleolar stress response works properly in TP53 wild-type human BCP-ALL cell lines. Next, we found that 6-mercaptopurine, methotrexate, daunorubicin, and cytarabine had anti-leukemic effects via the nucleolar stress response within BCP-ALL treatment. Comparing the samples at onset and relapse in children with BCP-ALL, RPL11 mRNA expression decreased at relapse in seven of nine cases. Furthermore, leukemia cells with relapse acquired resistance to these four drugs and suppressed P53 and RPL11 expression. Our findings suggest that the nucleolar stress response is a novel anti-leukemia mechanism in BCP-ALL. As these four drugs are key therapeutics for BCP-ALL treatment, dysfunction of the nucleolar stress response may be related to clinical relapse or refractoriness. Nucleolar stress response may be a target to predict and improve the chemotherapy effect for pediatric BCP-ALL.</jats:p>

DOI： 10.3390/cancers14205127

PubMed

Nagata T, Minami K, Yamamoto M, Hiraki T, Idogawa M, Fujimoto K, Kageyama S, Tabata K, Kawahara K, Ueda K, Ikeda R, Kato Y, Komatsu M, Tanimoto A, Furukawa T, Sato M . BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma. . International journal of molecular sciences22 ( 21 ) 11509 2021年10月

記述言語：英語出版者・発行元：MDPI AG

<jats:p>Lung cancer constitutes a threat to human health. BHLHE41 plays important roles in circadian rhythm and cell differentiation as a negative regulatory transcription factor. This study investigates the role of BHLHE41 in lung cancer progression. We analyzed BHLHE41 function via in silico and immunohistochemical studies of 177 surgically resected non-small cell lung cancer (NSCLC) samples and 18 early lung squamous cell carcinoma (LUSC) cases. We also examined doxycycline (DOX)-inducible BHLHE41-expressing A549 and H2030 adenocarcinoma cells. BHLHE41 expression was higher in normal lung than in lung adenocarcinoma (LUAD) tissues and was associated with better prognosis for the overall survival (OS) of patients. In total, 15 of 132 LUAD tissues expressed BHLHE41 in normal lung epithelial cells. Staining was mainly observed in adenocarcinoma in situ and the lepidic growth part of invasive cancer tissue. BHLHE41 expression constituted a favorable prognostic factor for OS (p = 0.049) and cause-specific survival (p = 0.042) in patients with LUAD. During early LUSC, 7 of 18 cases expressed BHLHE41, and this expression was inversely correlated with the depth of invasion. DOX suppressed cell proliferation and increased the autophagy protein LC3, while chloroquine enhanced LC3 accumulation and suppressed cell death. In a xenograft model, DOX suppressed tumor growth. Our results indicate that BHLHE41 expression prevents early lung tumor malignant progression by inducing autophagic cell death in NSCLC.</jats:p>

DOI： 10.3390/ijms222111509

PubMed

Jingushi K, Aoki M, Ueda K, Kogaki T, Tanimoto M, Monoe Y, Ando M, Matsumoto T, Minami K, Ueda Y, Kitae K, Hase H, Nagata T, Harada-Takeda A, Yamamoto M, Kawahara K, Tabata K, Furukawa T, Sato M, Tsujikawa K . ALKBH4 promotes tumourigenesis with a poor prognosis in non-small-cell lung cancer. . Scientific reports11 ( 1 ) 8677 2021年4月

Kogaki T, Ohshio I, Ura H, Iyama S, Kitae K, Morie T, Fujii S, Sato S, Nagata T, Takeda AH, Aoki M, Ueda K, Minami K, Yamamoto M, Kawahara K, Furukawa T, Sato M, Ueda Y, Jingushi K, Tozuka Z, Saigusa D, Hase H, Tsujikawa K . Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS. . Journal of pharmaceutical and biomedical analysis197 113943 2021年4月

Kawahata T, Kawahara K, Shimokawa M, Sakiyama A, Shiraishi T, Minami K, Yamamoto M, Shinsato Y, Arima K, Hamada T, Furukawa T . Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5-FU. . Oncology letters19 ( 3 ) 2258 - 2264 2020年3月

Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S. . FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer. . Oncogenesis9 ( 2 ) 13 - 13 2020年2月査読

Higa N, Shinsato Y, Kamil M, Hirano T, Takajo T, Shimokawa M, Minami K, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K. . Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis. . Int J Mol Sci20 ( 24 ) 2019年12月査読

Nishizawa Y, Ikeda R, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Nitta M, Terazono H, Akiyama SI, Furukawa T, Takeda Y. . 5-Aza-2-deoxycytidine Enhances the Sensitivity of 5-Fluorouracil by Demethylation of the Thymidine Phosphorylase Promoter. . Anticancer Research39 ( 8 ) 4129 - 4136 2019年8月査読

Hirono T, Jingushi K, Nagata T, Sato M, Minami K, Aoki M, Takeda AH, Umehara T, Egawa H, Nakatsuji Y, Kitae K, Ueda Y, Hase H, Yamamoto M, Shinsato Y, Kawahara K, Furukawa T, Tsujikawa K . MicroRNA-130b functions as an oncomiRNA in non-small cell lung cancer by targeting tissue inhibitor of metalloproteinase-2. . Scientific reports9 ( 1 ) 6956 2019年5月

Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K . High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme. . British journal of cancer120 ( 8 ) 819 - 826 2019年4月

Li Y, Kobayashi K, Murayama K, Kawahara K, Shima Y, Suzuki A, Tani K, Takahashi A. . FEAT enhances INSL3 expression in testicular Leydig cells. . Genes to Cells23 ( 11 ) 952 - 962 2018年10月査読

Furukawa T, Tabata S, Yamamoto M, Kawahara K, Shinsato Y, Minami K, Shimokawa M, Akiyama SI . Thymidine phosphorylase in cancer aggressiveness and chemoresistance. . Pharmacological research132 15 - 20 2018年6月

Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Toyoda Y, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI. . Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells. . Scientific Reports8 ( 1 ) 6760 2018年4月査読

Kamijo Y, Kawahara K, Yoshinaga T, Kurata H, Arima K, Furukawa T. . A novel isolation method for cancer prognostic factors via the p53 pathway by a combination of in vitro and in silico analyses. . Oncoscience.5 ( 3-4 ) 88 - 98 2018年4月査読

Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI . Thymidine Catabolism as a Metabolic Strategy for Cancer Survival. . Cell reports19 ( 7 ) 1313 - 1321 2017年5月

Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S. . Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma. . Oncotarget8 ( 4 ) 6353 - 6363 2017年1月査読

Moinuddin FM, Shinsato Y, Komatsu M, Mitsuo R, Minami K, Yamamoto M, Kawahara K, Hirano H, Arita K, Furukawa T. . ATP7B expression confers multidrug resistance through drug sequestration. . Oncotarget7. ( 16 ) 22779 - 22790 2016年4月査読

Murata Y, Kotani T, Supriatna Y, Kitamura Y, Imada S, Kawahara K, Nishio M, Daniwijaya EW, Sadakata H, Kusakari S, Mori M, Kanazawa Y, Saito Y, Okawa K, Takeda-Morishita M, Okazawa H, Ohnishi H, Azuma T, Suzuki A, Matozaki T . Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium . Proc Natl Acad Sci U S A112 ( 31 ) E4264 - E4271 2015年8月査読

Minami K, Shinsato Y, Yamamoto M, Takahashi H, Zhang S, Nishizawa Y, Tabata S, Ikeda R, Kawahara K, Tsujikawa K, Chijiiwa K, Yamada K, Akiyama S, Perez-Torras S, Pastor-Anglada M, Furukawa T, Yasuo T. . Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors . J Pharmacol Sci127 ( 3 ) 319 - 325 2015年3月査読

Minami K, Kamijo Y, Nishizawa Y, Tabata S, Horikuchi F, Yamamoto M, Kawahara K, Shinsato Y, Tachiwada T, Chen ZS, Tsujikawa K, Nakagawa M, Seki N, Akiyama S, Arima K, Takeda Y, Furukawa T . Expression of ABCB6 Is Related to Resistance to 5-FU, SN-38 and Vincristine . Anticancer Res34 ( 9 ) 4767 - 4773 2014年9月査読

Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K . Nucleolar Stress Induces Ubiquitination-Independent Proteasomal Degradation of PICT1 . J. Biol. Chem289 ( 30 ) 20802 - 20812 2014年7月査読

Okamura K, Takayama K, Kawahara K, Harada T, Nishio M, Otsubo K, Ichijo K, Kohno M, Iwama E, Fujii A, Ota K, Koga T, Okamoto T, Suzuki A, Nakanishi Y . PICT1 expression is a good prognostic factor in non-small cell lung cancer . ONCOSCIENCE 1 ( 5 ) 375 2014年5月査読

Shinsato Y, Furukawa T, Yunoue S, Yonezawa H, Minami K, Nishizawa Y, Ikeda R, Kawahara K, amamoto M, Hirano H, Tokimura H, and Arita K . Reduction of MLH1 and PMS2 confers temozolomide resistance and is associated with recurrence of glioblastoma . Oncotarget4 ( 12 ) 2261 - 2270 2013年12月査読

Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, Sugimachi K, Maehama T, Mori M, Suzuki A, Komune S, Mimori K. . PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression . British Journal of Cancer109 ( 8 ) 2199 - 2206 2013年9月査読

Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y, Tani K . Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells . Molecular Therapy21 ( 6 ) 1242 - 1250 2013年4月査読

Kahori Miyoshi* ,Shigehisa Yanagi* , Kohichi Kawahara, Miki Nishio,Hironobu Tsubouchi, Yoshifumi Imazu, Ryusuke Koshida, Nobuhiro Matsumoto, Akiko Taguchi, Shu-ichi Yamashita, Akira Suzuki, and Masamitsu Nakazato . Epithelial Pten Controls Acute Lung Injury and Fibrosis by Regulating Alveolar Epithelial Cell Integrity . American Journal of Respiratory and Critical Care MedicineEpub ahead of print 2012年12月査読

Miki Nishio, Koichi Hamada*, Kohichi Kawahara*, Masato Sasaki, Fumihito Noguchi, Shuhei Chiba, Kensaku Mizuno, Satoshi O. Suzuki, Youyi Dong, Masaaki Tokuda, Takumi Morikawa, Hiroki Hikasa, Jonathan Eggenschwiler, Norikazu Yabuta, Hiroshi Nojima, Kentaro Nakagawa, Yutaka Hata, Hiroshi Nishina, Koshi Mimori, Masaki Mori, Takehiko Sasaki, Tak W. Mak, Toru Nakano, Satoshi Itami and Akira Suzuki ( *: Equally contribution) . Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice . The Journal of Clinical Investigation 122 ( 12 ) 4505 - 4518 2012年11月査読

Ryunosuke Kogo, Teppei Shimamura, Koshi Mimori, Kohichi Kawahara, Seiya Imoto, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Akira Suzuki, Shizuo Komune, Satoru Miyano, and Masaki Mori . Long non-coding RNA HOTAIR regulates Polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers . Cancer Research71 ( 20 ) 6320 - 6326 2011年10月査読

Masato Sasaki*, Kohichi Kawahara*, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori & Akira Suzuki ( *: Equally contribution) . Regulation of the MDM2-p53 Pathway and Tumor Growth by PICT1/GLTSCR2 via Nucleolar RPL11 . Nature Medicine17 ( 8 ) 944 - 951 2011年8月査読

Tae Inoue-Narita, Koichi Hamada, Takehiko Sasaki, Sachiko Hatakeyama, Sachiko Fujita, Kohichi Kawahara, Masato Sasaki, Hiroyuki Kishimoto, Satoshi Eguchi, Itaru Kojima, Friedrich Beermann, Tetsunori Kimura, Masatake Osawa, Satoshi Itami, Tak Wah Mak, Toru Nakano, Motomu Manabe, and Akira Suzuki . Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis . Cancer Reseach68 ( 14 ) 5760 - 5768 2008年7月査読

Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard F rster, Tak W. Mak, Toru Nakano and Akira Suzuki . Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages . European Journal of Immunology38 ( 5 ) 1331 - 1340 2008年5月査読

Kohichi Kawahara, Makoto Hashimoto, Pazit Bar-On, Gilbert J. Ho, Leslie Crews, Hideya Mizuno, Edward Rockenstein, Syed Z. Imamand Eliezer Masliah . alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. . The Journal of Biological Chemistry283 ( 11 ) 6979 - 6987 2008年3月査読

Shigehisa Yanagi, Hiroyuki Kishimoto, Kohichi Kawahara, Takehiko Sasaki, Masato Sasaki, Miki Nishio, Nobuyuki Yajima, Koichi Hamada, Yasuo Horie, Hiroshi Kubo, Jeffrey A. Whitsett, Tak Wah Mak, Toru Nakano, Masamitsu Nakazato, and Akira Suzuki . Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice . The Journal of Clinical Investigation 117 ( 10 ) 2929 - 2940 2007年10月査読

Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki show all authors . The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells., . Blood109 ( 8 ) 3316 - 3324 2007年4月査読

Hiroshi Tsuruta, Hiroyuki Kishimoto, Takehiko Sasaki, Yasuo Horie, Miyuki Natsui, Yoshiko Shibata, Koichi Hamada, Nobuyuki Yajima, Koichi Kawahara, Masato Sasaki, Norihiko Tsuchiya, Katsuhiko Enomoto, Tak Wah Mak, Toru Nakano, Tomonori Habuchi, and Akira Suzuki . Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients . Cancer Reseach66 ( 17 ) 8389 - 8396 2006年4月査読

Kohichi Kawahara, Tsuyoshi Morishita, Tsutomu Nakamura, Fumihiko Hamada, Kumao Toyoshima and Tetsu Akiyama . Downregulation of beta-catenin by The Colorectal Tumor Suppressor APC Requires Association with Axin and beta-catenin . The Journal of Biological Chemistry 275 ( 12 ) 8369 - 8374 2000年1月査読

Tsutomu Nakamura, Fumihiko Hamada, Takao Ishidate, Ken-ichi Anai, Kohichi Kawahara, Kumao Toyoshima, Tetsu Akiyama . Axin, an inhibitor of the Wnt signaling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level . Genes to Cells 3 ( 6 ) 395 - 403 1998年12月査読

河原康一、植月太一、斎藤泉、吉川和明 . ニューロン特異的核蛋白質necdinの機能解析 . 神経化学35 ( 3 ) 374 - 375 1996年9月査読

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論文 - 河原 康一

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論文 - 河原　康一