Faculty Profiles - UNO Seiichi

Papers - UNO Seiichi

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Shusaku Fukugami, Masatoshi Yamasaki, Emiko Kokushi, Seiichi Uno. . Influence of CYP1A and AhR modulation on polycyclic aromatic hydrocarbon-induced developmental defects in Japanese medaka. . Aquatic Toxicology 280 107267 2025.2Reviewed

関圭樹、松尾純平、川上泰佑、國師恵美子、宇野誠一． . セルトラリン暴露によるヒメダカ(Oryzias latipes)体内の代謝攪乱に基づいた影響評価 . 環境毒性学会誌28 1 - 11 2025.2セルトラリン暴露によるヒメダカ(Oryzias latipes)体内の代謝攪乱に基づいた影響評価Reviewed

Widodo O, Uno S, Kokushi E, Yamato O, Mardianto M, Shinya U, Kano Y, Kawashima C, Fushimi Y, Ono T, Taniguchi M, Takagi M. . Exposure of Cattle Breeding Herds to Naturally Co-Contaminated Zearalenone and Deoxynivalenol: The Relevance of a Urinary Mycotoxin Monitoring System for Herd Health and Food Safety. . Toxins.16 402 2024.9Exposure of Cattle Breeding Herds to Naturally Co-Contaminated Zearalenone and Deoxynivalenol: The Relevance of a Urinary Mycotoxin Monitoring System for Herd Health and Food Safety.Reviewed International coauthorship

Seki, T., Katsura, M., Yamasaki, M., Yamashita, K., Kokushi, E., & Uno, S. . Effects of diphenhydramine exposure on reproduction of mature Japanese medaka (Oryzias latipes). . Chemosphere358 142163 2024.5Reviewed

Topas Wicaksono Priyo Jr, Seiichi Uno, Emiko Kokushi, Katsuki Toda, Hiroshi Hasunuma, Daisaku Matsumoto, Osamu Yamato, Masayuki Ohtani, Oky Setyo Widodo, Dhidhi Pambudi, Masayasu Taniguchi, Mitsuhiro Takagi. . Measurement of serum short-chain fatty acid concentrations in cattle after oral administration of difructose anhydride III. . Veterinary World16 ( 7 ) 1505 - 1511 2023.5Measurement of serum short-chain fatty acid concentrations in cattle after oral administration of difructose anhydride III.Reviewed International coauthorship

Oky Setyo Widodo, Dhidhi Pambudi, Makoto Eto, Emiko Kokushi, Seiichi Uno, Osamu Yamato, Masayasu Taniguchi, Mirni Lamid, Mitsuhiro Takagi. . Practical application of a urinary zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—Relevance to Anti-Müllerian Hormone and Serum Amyloid A Clarified from a Two-Year Survey. . Toxins15 317 2023.5 Practical application of a urinary zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—Relevance to Anti-Müllerian Hormone and Serum Amyloid A Clarified from a Two-Year Survey. Reviewed International coauthorship

Mohd Yusoff Nurulnadia, Baharom Mohamad Zahid, Ku Mohd Kalkausar Ku Yusof, Fatin Izzati Minhat, Seiichi Uno & Hafiz Ikhwan Abdul Hamid. . Occurrence of octylphenol and nonylphenol in the sediment of South China Sea and Malacca Strait, Peninsular Malaysia. . Environmental Monitoring and Assessment195 355 2023.2Occurrence of octylphenol and nonylphenol in the sediment of South China Sea and Malacca Strait, Peninsular Malaysia. Reviewed International coauthorship

Toxicity evaluations using Japanese medaka embryos in sediments collected from Kahoku-gata, Ishikawa prefecture . 25 48 - 60 2022.8Toxicity evaluations using Japanese medaka embryos in sediments collected from Kahoku-gata, Ishikawa prefecture

Oky Setyo Widodo; Makoto Etoh; Emiko Kokushi; Seiichi Uno; Osamu Yamato; Dhidhi Pambudi; Hiroaki Okawa; Masayasu Taniguchi; Mirni Lamid; Mitsuhiro Takagi . Practical Application of Urinary Zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—The Relationship between Monthly Anti-Müllerian Hormone and Serum Amyloid A Concentrations . Toxins14 ( 2 ) 143 2022.2Practical Application of Urinary Zearalenone Monitoring System for Feed Hygiene Management of a Japanese Black Cattle Breeding Herd—The Relationship between Monthly Anti-Müllerian Hormone and Serum Amyloid A ConcentrationsReviewed

仲山慶, 池田踏青, 黒川大輔, 北條裕也, 宇野誠一 . 魚類初期生活段階毒性試験の海産魚モデルとしてのクサフグの利用可能性について . 環境毒性学会誌25 1 - 9 2022.1 魚類初期生活段階毒性試験の海産魚モデルとしてのクサフグの利用可能性についてReviewed

Validation of a short-term toxicity bioassay using three marine sh species in embryonic to larval stages . 24 70 - 79 2021.12Validation of a short-term toxicity bioassay using three marine sh species in embryonic to larval stagesReviewed

Naoya Sasazaki, Seiich Uno, Emiko Kokushi, Katsuki Toda, Hiroshi Hasunuma, Daisaku Matsumoto, Ayaka Miyashita, Osamu Yamato, Hiroaki Okawa, Masayuki Ohtani, Johanna Fink-Gremmels,Masayasu Taniguchi, Mitsuhiro Takagi. . Mitigation of sterigmatocystin exposure in cattle by difructose anhydride III feed supplementation and detection of urinary sterigmatocystin and serum amyloid A concentrations. . Arch. Anim. Breed.64 257 - 264 2021.1Mitigation of sterigmatocystin exposure in cattle by difructose anhydride III feed supplementation and detection of urinary sterigmatocystin and serum amyloid A concentrations. Reviewed

Honda M. . Correlation between polycyclic aromatic hydrocarbons in wharf roach (Ligia spp.) and environmental components of the intertidal and supralittoral zone along the japanese coast . International Journal of Environmental Research and Public Health18 ( 2 ) 1 - 16 2021.1

Amano H. . Development of specific enzyme-linked immunosorbent assays for multiple vitellogenins in marbled sole, Pleuronectes yokohamae . General and Comparative Endocrinology281 67 - 72 2019.9

Billah M. . Distribution, Geochemical Speciation, and Bioavailable Potencies of Cadmium, Copper, Lead, and Zinc in Sediments from Urban Coastal Environment in Osaka Bay, Japan . Water, Air, and Soil Pollution230 ( 7 ) 2019.7

Koyama T. . A SNP in a Steroidogenic Enzyme Is Associated with Phenotypic Sex in Seriola Fishes . Current Biology29 ( 11 ) 1901 - 1909.e8 2019.6

BILLAH Md. Masum, KOKUSHI Emiko, UNO Seiichi . Metal bioavailability and bioaccumulation in the polychaete Perinereis nuntia: relationship between predictions using chemical analysis and accumulation through actual exposures . 環境毒性学会誌22 ( 2 ) 41 - 52 2019

Publisher：日本環境毒性学会

In the present study, we have examined whether the predicted bioavailability for heavy metals in sediments obtained through chemical analysis reflected the actual accumulation by the polychaete, Perinereis nuntia. In this study, P. nuntia was exposed to sediments collected from two sites of Kagoshima Bay, Japan, for 28 days. The polychaete adsorbed metals such as copper (Cu) and zinc (Zn) from sediments. Biomagnification factors from sediment to polychaete for Cu and Zn were 0.002–0.052 and 0.062–0.066, respectively, and Zn tended to be in higher concentrations in polychaete than Cu. Additionally, we measured metal content in geochemical fractions to predict the bioavailability through chemical analysis and was found to be 2–4% for Cu, and 16–21% for Zn. The prediction of bioavailability through chemical analysis could roughly reflect the actual absorbance of metals in the polychaete. Therefore, we conclude that the prediction of metal bioavailability through geochemical speciation is useful to reliably estimate actual bioaccumulation in the benthic organism.

DOI： 10.11403/jset.22.41

Kawai Chouji, Kokushi Emiko, Uno Seiichi . Toxicity Assessment of Coastal Sediments Using Marine Fish . Marine Engineering54 ( 6 ) 865 - 870 2019

Publisher：The Japan Institute of Marine Engineering

Anthropogenic substances reach sea areas, absorb particles and finally pile up on sediments. Although previous studies investigated the distribution of pollutants and detected a high concentration of pollutant residues in Japanese coastal areas, the effects of these residues on benthic organisms have been almost unknown. In fact, methods to assess sediment toxicity have not been established, and it is not easy to assess the toxicity of sediments collected from the sea bottom. In this study, we worked to assess the maximum impact of toxic sediments on benthic organisms by exposing marine medaka to extracts from sediments collected from five sites in Tokyo Bay, Japan. The results showed that sediments collected at two sites caused fatal effects on marine medaka. Furthermore, marine medaka were also exposed to three fractionation processes of varying polarity extracts. The results of these exposure tests indicated the possibility that such sediment extracts may have caused antagonistic effects.

DOI： 10.5988/jime.54.865

Seki Tamaki, Uno Seiichi . Metabolomics Approach to Assess Effects of Chemicals on Fish . Marine Engineering54 ( 6 ) 871 - 874 2019

Publisher：The Japan Institute of Marine Engineering

Metabolomics allows for comprehensive assessment of the current state of organisms by collecting information on variations on low₋molecular₋metabolites, which can take different forms to maintain homeostasis even under the influence of chemical exposures or external stressors. Metabolomics workflows include chemical analysis designed to obtain the assessment of metabolites, statistical analysis, research on the metabolic state of organisms and the prediction of their health trajectories. Until now, we have examined and assessed the effects of pollutants on Japanese medaka through the metabolomics approach. In this publication, we describe the metabolomics approach with GC/MS analysis, which includes fish treatment procedures, and its assessment process.

DOI： 10.5988/jime.54.871

Uno Seiichi, Nakayama Kei, Hashimoto Momoka, Kawai Chouji, Kokushi Emiko . Toxicity Assessment of Sediments Collected from Hiroshima Bay, Japan, Using Java Medaka Embryos . Marine Engineering54 ( 6 ) 860 - 864 2019

Publisher：The Japan Institute of Marine Engineering

The effects of chemicals in sediments in coastal areas on environmental organisms are almost unknown, although a number of investigations on the distribution of pollutants in these sediments were performed, often resulting in the detection of chemical residues with high concentrations. In this study, toxicities of sediments collected from 11 locations in Hiroshima Bay, Japan, was assessed using embryos of Java medaka, Oryzias javanicus. The embryos were placed on sediments containing a little pore water without adding overlying water. The results showed that as high as 37% of the embryos exposed to sediments collected near Hatsukaichi City died. Additionally, the mortality was 33% at a site distant slightly from an industrial area in Otake City. Delayed hatching was observed at six locations. Thus, the certain effects of exposure to sediments collected from the bay in the embryos were observed, and the authors concluded that these effects are most likely to have been caused by chemicals in the sediments.

DOI： 10.5988/jime.54.860

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