2023/06/01 更新

写真a

ジングウジ　メグミ
神宮司　メグミ
JINGUJI Megumi
所属
医歯学域附属病院 附属病院 診療施設 放射線部 助教
医歯学域医学系 医学部 　
職名
助教

学位

  • 博士（医学） （ 2006年3月   鹿児島大学 ）

研究分野

  • その他 / その他  / 放射線診断

  • その他 / その他  / 核医学

経歴

  • 鹿児島大学   　

    2005年7月 - 現在

所属学協会

  • 日本核医学会

    2002年7月 - 現在

  • 日本医学放射線学会

    1998年5月 - 現在

 

論文

  • Nakajo M., Horizoe Y., Kawaji K., Jinguji M., Tani A., Fukukura Y., Ohishi M., Yoshiura T. .  Application of <sup>123</sup>I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography .  Japanese Journal of Radiology41 ( 4 ) 437 - 448   2023年4月

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    記述言語：日本語   出版者・発行元：Japanese Journal of Radiology  

    Purpose: This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [123I]-metaiodobenzylguanidine ([123I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma. Materials and methods: This study included 18 patients with pheochromocytoma who underwent both planar and [123I]-MIBG single-photon emission computed tomography/computed tomography scans and echocardiography before surgery. Myocardial [123I]-MIBG visibility and SUVmax were compared with echocardiographic parameters related to systolic and diastolic functions. The Mann–Whitney U test, Fisher exact test, or Spearman rank correlation assessed differences or relationships between two quantitative variables. Results: On visual analysis, 6 patients showed normal myocardial [123I]-MIBG uptake, whereas 12 patients showed decreased myocardial [123I]-MIBG uptake. No patients showed systolic dysfunction. A significant difference was observed in the incidence of diastolic dysfunction between the groups with normal and decreased uptake (p = 0.009), and left ventricular (LV) diastolic dysfunction was observed in 9 (75%) of 12 patients with decreased myocardial uptake. The myocardial SUVmax was significantly lower in 9 patients with LV diastolic dysfunction than in 9 patients with normal cardiac function (1.67 ± 0.37 vs. 3.03 ± 1.38, p = 0.047). Myocardial SUVmax was positively correlated with septal e′ (early diastolic velocity of septal mitral annulus) (ρ = 0.51, p = 0.031) and negatively correlated with the septal E/e′ ratio (early mitral E-velocity to early diastolic velocity of septal mitral annulus; ρ = − 0.64, p = 0.004), respectively. Conclusions: LV diastolic dysfunction was inversely related to myocardial [123I]-MIBG uptake. Myocardial [123I]-MIBG SUVmax may be useful for characterizing cardiac function in patients with pheochromocytoma. Second abstract. The semiquantitative analysis using the myocardial SUVmax in 123I-MIBG SPECT/CT was found to be potentially useful for characterizing cardiac function in patients with pheochromocytoma.

    DOI： 10.1007/s11604-022-01365-z

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  • Nakajo M., Kawaji K., Nagano H., Jinguji M., Mukai A., Kawabata H., Tani A., Hirahara D., Yamashita M., Yoshiura T. .  The Usefulness of Machine Learning–Based Evaluation of Clinical and Pretreatment [<sup>18</sup>F]-FDG-PET/CT Radiomic Features for Predicting Prognosis in Hypopharyngeal Cancer .  Molecular Imaging and Biology25 ( 2 ) 303 - 313   2023年4月

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    記述言語：日本語   出版者・発行元：Molecular Imaging and Biology  

    Purpose: To examine whether the machine learning (ML) analyses using clinical and pretreatment 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography ([18F]-FDG-PET)–based radiomic features were useful for predicting prognosis in patients with hypopharyngeal cancer. Procedures: This retrospective study included 100 patients with hypopharyngeal cancer who underwent [18F]-FDG-PET/X-ray computed tomography (CT) before treatment, and these patients were allocated to the training (n=80) and validation (n=20) cohorts. Eight clinical (age, sex, histology, T stage, N stage, M stage, UICC stage, and treatment) and 40 [18F]-FDG-PET–based radiomic features were used to predict disease progression. A feature reduction procedure based on the decrease of the Gini impurity was applied. Six ML algorithms (random forest, neural network, k-nearest neighbors, naïve Bayes, logistic regression, and support vector machine) were compared using the area under the receiver operating characteristic curve (AUC). Progression-free survival (PFS) was assessed using Cox regression analysis. Results: The five most important features for predicting disease progression were UICC stage, N stage, gray level co-occurrence matrix entropy (GLCM_Entropy), gray level run length matrix run length non-uniformity (GLRLM_RLNU), and T stage. Patients who experienced disease progression displayed significantly higher UICC stage, N stage, GLCM_Entropy, GLRLM_RLNU, and T stage than those without progression (each, p<0.001). In both cohorts, the logistic regression model constructed by these 5 features was the best performing classifier (training: AUC=0.860, accuracy=0.800; validation: AUC=0.803, accuracy=0.700). In the logistic regression model, 5-year PFS was significantly higher in patients with predicted non-progression than those with predicted progression (75.8% vs. 8.3%, p<0.001), and this model was only the independent factor for PFS in multivariate analysis (hazard ratio = 3.22; 95% confidence interval = 1.03–10.11; p=0.045). Conclusions: The logistic regression model constructed by UICC, T and N stages and pretreatment [18F]-FDG-PET–based radiomic features, GLCM_Entropy, and GLRLM_RLNU may be the most important predictor of prognosis in patients with hypopharyngeal cancer.

    DOI： 10.1007/s11307-022-01757-7

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  • Kawaji K., Nakajo M., Shinden Y., Jinguji M., Tani A., Hirahara D., Kitazono I., Ohtsuka T., Yoshiura T. .  Application of Machine Learning Analyses Using Clinical and [<sup>18</sup>F]-FDG-PET/CT Radiomic Characteristics to Predict Recurrence in Patients with Breast Cancer .  Molecular Imaging and Biology   2023年

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    記述言語：日本語   出版者・発行元：Molecular Imaging and Biology  

    Purpose: To develop and identify machine learning (ML) models using pretreatment clinical and 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography ([18F]-FDG-PET)-based radiomic characteristics to predict disease recurrences in patients with breast cancers who underwent surgery. Procedures: This retrospective study included 112 patients with 118 breast cancer lesions who underwent [18F]-FDG-PET/ X-ray computed tomography (CT) preoperatively, and these lesions were assigned to training (n=95) and testing (n=23) cohorts. A total of 12 clinical and 40 [18F]-FDG-PET-based radiomic characteristics were used to predict recurrences using 7 different ML algorithms, namely, decision tree, random forest (RF), neural network, k-nearest neighbors, naive Bayes, logistic regression, and support vector machine (SVM) with a 10-fold cross-validation and synthetic minority over-sampling technique. Three different ML models were created using clinical characteristics (clinical ML models), radiomic characteristics (radiomic ML models), and both clinical and radiomic characteristics (combined ML models). Each ML model was constructed using the top ten characteristics ranked by the decrease in Gini impurity. The areas under ROC curves (AUCs) and accuracies were used to compare predictive performances. Results: In training cohorts, all 7 ML algorithms except for logistic regression algorithm in the radiomics ML model (AUC = 0.760) achieved AUC values of >0.80 for predicting recurrences with clinical (range, 0.892–0.999), radiomic (range, 0.809–0.984), and combined (range, 0.897–0.999) ML models. In testing cohorts, the RF algorithm of combined ML model achieved the highest AUC and accuracy (95.7% (22/23)) with similar classification performance between training and testing cohorts (AUC: training cohort, 0.999; testing cohort, 0.992). The important characteristics for modeling process of this RF algorithm were radiomic GLZLM_ZLNU and AJCC stage. Conclusions: ML analyses using both clinical and [18F]-FDG-PET-based radiomic characteristics may be useful for predicting recurrence in patients with breast cancers who underwent surgery.

    DOI： 10.1007/s11307-023-01823-8

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  • 北薗 育美, 霧島 茉莉, 田崎 貴嗣, 田畑 和宏, 東 美智代, 野口 紘嗣, 簗詰 伸太郎, 神宮司 メグミ, 谷本 昭英 .  FDG-PET高集積を示した遺残副腎由来のOncocytomaの1例 .  診断病理39 ( 4 ) 319 - 325   2022年10月

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    記述言語：日本語   出版者・発行元：(一社)日本病理学会  

    遺残副腎は異所性に認められる副腎皮質組織であり,腫瘍化は非常に稀である。80代女性の骨盤腔内にFDGの高集積を呈する腫瘍を認めた。腫瘍は右子宮広間膜内に卵巣とは離れて存在し,好酸性顆粒状の豊富な細胞質を有する腫瘍細胞のびまん性増殖からなり,腫瘍辺縁には非腫瘍性の副腎皮質組織を伴っていた。免疫染色でSF-1,mitochondria陽性であった。Lin-Weiss-Bisceglia criteriaを満たす所見はなく,遺残副腎由来のoncocytomaと診断した。(著者抄録)

  • Yano E., Nakajo M., Jinguji M., Tani A., Kitazono I., Yoshiura T. .  I-131 false-positive uptake in a thymic cyst with expression of the sodium-iodide symporter: A case report .  Medicine (United States)101 ( 26 ) e29282   2022年6月

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    記述言語：日本語   出版者・発行元：Medicine (United States)  

    Rationale: I-131 radioiodine false-positive findings in postoperative patients with differentiated thyroid cancer (DTC) should be recognized to avoid unnecessary therapies. Patient concerns and diagnoses: A 50-year-old man underwent I-131 therapy 3 times, including the initial ablative therapy after total thyroidectomy for papillary thyroid cancer. The initial I-131 posttherapeutic whole-body scintigraphy showed 2 cervical and one superior mediastinal focal I-131 positive uptake lesions. The serum thyroglobulin level was negative every time when the radioiodine therapy was performed. Although the 2 cervical positive uptake lesions disappeared after the second therapy, the superior mediastinal I-131 positive uptake persisted even after the third therapy, and this lesion was suspicion of I-131 therapy-resistant node metastasis. Interventions and outcomes: The lesion was resected, and the pathological diagnosis with immune-histochemical analysis was a thymic cyst with thymic epithelial cells having a weak expression of the sodium-iodide symporter (NIS). Lessons: The false-positive result may be attributed to the NIS expression in the thymic cyst epithelial cells. It is necessary to include a thymic cyst in the differential diagnosis, when I-131 uptake is noted in the superior mediastinal region on I-131 posttherapeutic scans of patients with postoperative DTC. Although the I-131 positive uptake in a thymic cyst may be influenced by the I-131 administered dose and scan timing after I-131 administration, the NIS expression may be essential to the false-positive uptake in a thymic cyst.

    DOI： 10.1097/MD.0000000000029282

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  • Nakajo M., Takeda A., Katsuki A., Jinguji M., Ohmura K., Tani A., Sato M., Yoshiura T. .  The efficacy of<sup>18</sup>F-FDG-PET-based radiomic and deep-learning features using a machine-learning approach to predict the pathological risk subtypes of thymic epithelial tumors .  British Journal of Radiology95 ( 1134 ) 20211050   2022年6月

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    記述言語：日本語   出版者・発行元：British Journal of Radiology  

    Objective: To examine whether the machine-learning approach using 18-fludeoxyglucose positron emission tomography (18F-FDG-PET)-based radiomic and deep-learning features is useful for predicting the pathological risk subtypes of thymic epithelial tumors (TETs). Methods: This retrospective study included 79 TET [27 low-risk thymomas (types A, AB and B1), 31 high-risk thymomas (types B2 and B3) and 21 thymic carcinomas] patients who underwent pre-therapeutic18F-FDG-PET/ CT. High-risk TETs (high-risk thymomas and thymic carcinomas) were 52 patients. The 107 PET-based radiomic features, including SUV-related parameters [maximum SUV (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] and 1024 deep-learning features extracted from the convolutional neural network were used to predict the pathological risk subtypes of TETs using six different machine-learning algorithms. The area under the curves (AUCs) were calculated to compare the predictive performances. Results: SUV-related parameters yielded the following AUCs for predicting thymic carcinomas: SUVmax 0.713, MTV 0.442, and TLG 0.479 or high-risk TETs: SUVmax 0.673, MTV 0.533, and TLG 0.539. The bestperforming algorithm was the logistic regression model for predicting thymic carcinomas (AUC 0.900, accuracy 81.0%), and the random forest (RF) model for high-risk TETs (AUC 0.744, accuracy 72.2%). The AUC was significantly higher in the logistic regression model than three SUV-related parameters for predicting thymic carcinomas, and in the RF model than MTV and TLG for predicting high-risk TETs (each; p < 0.05). Conclusion:18F-FDG-PET-based radiomic analysis using a machine-learning approach may be useful for predicting the pathological risk subtypes of TETs. Advances in knowledge: Machine-learning approach using18F-FDG-PET-based radiomic features has the potential to predict the pathological risk subtypes of TETs.

    DOI： 10.1259/bjr.20211050

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  • Inaki A., Shiga T., Tsushima Y., Jinguji M., Wakabayashi H., Kayano D., Akatani N., Yamase T., Kunita Y., Watanabe S., Hiromasa T., Mori H., Hirata K., Watanabe S., Higuchi T., Tomonaga H., Kinuya S. .  An open-label, single-arm, multi-center, phase II clinical trial of single-dose [<sup>131</sup>I]meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma .  Annals of Nuclear Medicine36 ( 3 ) 267 - 278   2022年3月

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    記述言語：日本語   出版者・発行元：Annals of Nuclear Medicine  

    Objective: In this phase II study, we aimed to investigate the efficacy and safety of single-dose [131I]meta-iodobenzylguanidine (131I-mIBG) therapy in patients with refractory pheochromocytoma and paraganglioma (PPGL). Patients and methods: This study was designed as an open-label, single-arm, multi-center, phase II clinical trial. The enrolled patients were administered 7.4 GBq of 131I-mIBG. Its efficacy was evaluated 12 and 24 weeks later, and its safety was monitored continuously until the end of the study. We evaluated the biochemical response rate as the primary endpoint using the one-sided exact binomial test based on the null hypothesis (≤ 5%). Results: Seventeen patients were enrolled in this study, of which 16 were treated. The biochemical response rate (≥ 50% decrease in urinary catecholamines) was 23.5% (90% confidence interval: 8.5–46.1%, p = 0.009). The radiographic response rates, determined with CT/MRI according to the response evaluation criteria in solid tumors (RECIST) version 1.1 and 123I-mIBG scintigraphy were 5.9% (0.3%–25.0%) and 29.4% (12.4%–52.2%), respectively. The most frequent non-hematologic treatment-emergent adverse events (TEAEs) were gastrointestinal symptoms including nausea, appetite loss, and constipation, which were, together, observed in 15 of 16 patients. Hematologic TEAEs up to grade 3 were observed in 14 of 16 patients. No grade 4 or higher TEAEs were observed. All patients had experienced at least one TEAE, but no fatal or irreversible TEAEs were observed. Conclusion: A single dose 131I-mIBG therapy was well tolerated by patients with PPGL, and statistically significantly reduced catecholamine levels compared to the threshold response rate, which may lead to an improved prognosis for these patients.

    DOI： 10.1007/s12149-021-01699-0

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  • Inaki Anri, Shiga Tohru, Tsushima Yoshito, Jinguji Megumi, Wakabayashi Hiroshi, Kayano Daiki, Akatani Norihito, Yamase Takafumi, Kunita Yuji, Watanabe Satoru, Hiromasa Tomo, Mori Hiroshi, Hirata Kenji, Watanabe Shiro, Higuchi Tetsuya, Tomonaga Hiroyasu, Kinuya Seigo .  難治性の褐色細胞腫・パラガングリオーマに対する、単回[131I]メタ-ヨードベンジルグアニジン治療の非盲検、単一群による多施設共同第II相臨床試験(An open-label, single-arm, multi-center, phase II clinical trial of single-dose [131I]meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma) .  Annals of Nuclear Medicine36 ( 3 ) 267 - 278   2022年3月

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    記述言語：英語   出版者・発行元：(一社)日本核医学会  

    難治性の褐色細胞腫・パラガングリオーマ(PPGL)に対し、単回投与(7.4GBq)による、[131I]メタ-ヨードベンジルグアニジン(131I-mIBG)を用いた内照射療法の有効性と安全性について検討した。PPGL患者17例(男性7例、女性10例、平均年齢59.1±15.2歳)を対象とした、非盲検、単一群による多施設共同第II相臨床試験を実施し、有効性に関しては12週間後と24週間後に、安全性については全期間にわたり評価した。片側二項検定により、主要評価項目として生化学的奏功率を評価した結果、17例中16例が本治療を受けており、生化学的奏功率(尿カテコールアミンの50%以上増加)は23.5%に認められた。また、固形腫瘍におけるRECISTガイドラインver.1.1に準じた腫瘍縮小効果判定では、CT/MRIで決定した放射線撮像による奏功率が5.9%(0.3～25.0%)、123I-mIBGシンチグラフィの奏功率は29.4%(12.4～52.2%)であった。一方、最も高頻度に認められた非血液学的な治験薬投与後の有害事象(TEAE)として、吐き気や食欲不振、便秘等の胃腸症状が16例中15例に認められた。さらに、グレード3までの血液学的TEAEにおいては16例中14例に認められたが、グレード4以上のTEAEを生じた患者は0例で、全例に少なくとも1つのTEAEは発症したが、致命的/不可逆的なTEAEを生じた患者はみられなかった。以上の治験成績から、単回131I-mIBG治療はPPGL患者に対し有効性が高く、カテコールアミン数値を閾値レベルまで統計的に有意に減少させ、予後改善に導くことが示唆された。加えて、短期有害事象においても、試験中止に至るほど重篤な事象もみられなかったことからも、7.4GBq単回投与の安全性も示された。

  • Nakajo M., Jinguji M., Tani A., Yano E., Hoo C.K., Hirahara D., Togami S., Kobayashi H., Yoshiura T. .  Machine learning based evaluation of clinical and pretreatment <sup>18</sup>F-FDG-PET/CT radiomic features to predict prognosis of cervical cancer patients .  Abdominal Radiology47 ( 2 ) 838 - 847   2022年2月

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    記述言語：日本語   出版者・発行元：Abdominal Radiology  

    Purpose: To examine the usefulness of machine learning to predict prognosis in cervical cancer using clinical and radiomic features of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (CT) (18F-FDG-PET/CT). Methods: This retrospective study included 50 cervical cancer patients who underwent 18F-FDG-PET/CT before treatment. Four clinical (age, histology, stage, and treatment) and 41 18F-FDG-PET-based radiomic features were ranked and a subset of useful features for association with disease progression was selected based on decrease of the Gini impurity. Six machine learning algorithms (random forest, neural network, k-nearest neighbors, naive Bayes, logistic regression, and support vector machine) were compared using the areas under the receiver operating characteristic curve (AUC). Progression-free survival (PFS) was assessed using Cox regression analysis. Results: The five top predictors of disease progression were: stage, surface area, metabolic tumor volume, gray-level run length non-uniformity (GLRLM_RLNU), and gray-level non-uniformity for run (GLRLM_GLNU). The naive Bayes model was the best-performing classifier for predicting disease progression (AUC = 0.872, accuracy = 0.780, F1 score = 0.781, precision = 0.788, and recall = 0.780). In the naive Bayes model, 5-year PFS was significantly higher in predicted non-progression than predicted progression (80.1% vs. 9.1%, p < 0.001) and was only the independent factor for PFS in multivariate analysis (HR, 6.89; 95% CI, 1.92–24.69; p = 0.003). Conclusion: A machine learning approach based on clinical and pretreatment 18F-FDG PET-based radiomic features may be useful for predicting tumor progression in cervical cancer patients.

    DOI： 10.1007/s00261-021-03350-y

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  • Nagano H., Takumi K., Nakajo M., Fukukura Y., Kumagae Y., Jinguji M., Tani A., Yoshiura T. .  Dual-Energy CT-Derived Electron Density for Diagnosing Metastatic Mediastinal Lymph Nodes in Non-Small Cell Lung Cancer: Comparison With Conventional CT and FDG PET/CT Findings .  American Journal of Roentgenology218 ( 1 ) 66 - 74   2022年1月

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    記述言語：日本語   出版者・発行元：American Journal of Roentgenology  

    BACKGROUND. Accurate nodal staging is essential to guide treatment selection in patients with non-small cell lung cancer (NSCLC). To our knowledge, measurement of electron density (ED) using dual-energy CT (DECT) is unexplored for this purpose. OBJECTIVE. The purpose of our study was to assess the utility of ED from DECT in diagnosing metastatic mediastinal lymph nodes in patients with NSCLC in comparison with conventional CT and FDG PET/CT. METHODS. This retrospective study included 57 patients (36 men, 21 women; mean age, 68.4 } 8.9 [SD] years) with NSCLC and surgically resected mediastinal lymph nodes who underwent preoperative DECT and FDG PET/CT. The patients had a total of 117 resected mediastinal lymph nodes (33 metastatic, 84 nonmetastatic). Two radiologists independently reviewed the morphologic features of nodes on the 120-kVp images and also measured the iodine concentration (IC) and ED of nodes using maps generated from DECT data; consensus was reached for discrepancies. Two different radiologists assessed FDG PET/CT examinations in consensus for positive node uptake. Diagnostic performance was evaluated for individual and pairwise combinations of features. RESULTS. The sensitivity, specificity, and accuracy for nodal metastasis were 15.2%, 98.8%, and 75.2% for the presence of necrosis, respectively; 54.5%, 85.7%, and 76.9% for short-axis diameter greater than 8.5 mm; 63.6%, 73.8%, and 70.9% for long-axis diameter greater than 13.0 mm; 51.5%, 79.8%, and 71.8% for attenuation on 120-kVp images of 95.8 HU or less; 87.9%, 58.3%, and 66.7% for ED of 3.48 × 1023/cm3 or less; and 66.7%, 75.0%, and 72.6% for positive FDG uptake. Among pairwise combinations of features, accuracy was highest for the combination of ED and short-axis diameter (accuracy, 82.9%; sensitivity, 54.5%; specificity, 94.0%) and the combination of ED and positive FDG uptake (accuracy, 82.1%; sensitivity, 60.6%; specificity, 90.5%); these accuracies were greater than those for the individual features (p < .05). The remaining combinations exhibited accuracies ranging from 74.4% to 77.8%. Interobserver agreement analysis showed an intraclass correlation coefficient of 0.90 for ED. IC was not significantly different between metastatic and nonmetastatic nodes (p = .18) and was excluded from the diagnostic performance analysis. CONCLUSION. ED derived from DECT may help diagnose metastatic lymph nodes in NSCLC given decreased ED in metastatic nodes.

    DOI： 10.2214/AJR.21.26208

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  • 長谷川 知仁, 福倉 良彦, 神宮司 メグミ, 吉浦 敬 .  特集 診断の決め手となった画像･所見Ⅲ-胸部･腎泌尿器･婦人科 腎泌尿器-副腎腫瘍(副腎腺腫など) .  臨床放射線66 ( 13 ) 1551 - 1557   2021年12月

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    出版者・発行元：金原出版  

    DOI： 10.18888/rp.0000001797

  • Nakajo M. .  Value of Patlak Ki images from <sup>18</sup>F-FDG-PET/CT for evaluation of the relationships between disease activity and clinical events in cardiac sarcoidosis .  Scientific Reports11 ( 1 ) 2729   2021年12月

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    記述言語：日本語   出版者・発行元：Scientific Reports  

    The association between 18F-fluorodeoxyglucose (18F-FDG) myocardial uptake and clinical presentations in cardiac sarcoidosis (CS) has not yet been clarified. The Patlak slope, Ki, which represents the rate of 18F-FDG uptake is a quantitative index of 18F-FDG metabolism. This study aims to investigate the usefulness of standardized uptake value (SUV) and Patlak Ki images (Ki images) extracted from dynamic 18F-FDG-PET/CT for evaluating the risk of clinical events (CEs) in CS. The SUV and Ki myocardial images were generated from 30 dynamic 18F-FDG-PET/CT scans of 21 CS patients. The SUV and Ki images both were rated as positive in 19 scans and negative in 11 scans with the same incidence of CEs which were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11); arrhythmic events: 65.5% (10/19) vs. 0% (0/11)]. In 19 positive scans, the three Ki parameters (Ki max, Ki mean and Ki volume) were significantly higher in scans for patients with arrhythmic events than in those without. Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events. Our study suggests that Ki images may add value to SUV images for evaluating the risk of CEs in CS patients.

    DOI： 10.1038/s41598-021-82217-0

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  • Hozaka Y., Kurahara H., Oi H., Idichi T., Yamasaki Y., Kawasaki Y., Tanoue K., Jinguji M., Nakajo M., Tani A., Nakajo A., Mataki Y., Fukukura Y., Noguchi H., Higashi M., Yoshiura T., Tanimoto A., Ohtsuka T. .  Clinical utility and limitation of diagnostic ability for different degrees of dysplasia of intraductal papillary mucinous neoplasms of the pancreas using <sup>18</sup> F-fluorodeoxyglucose-positron emission tomography/ computed tomography .  Cancers13 ( 18 )   2021年9月

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    記述言語：日本語   出版者・発行元：Cancers  

    The diagnostic value of18F-fluorodeoxyglucose (FDG) uptake in the management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas remains unclear. This study aimed to assess the role of FDG uptake in the diagnosis of different degrees of dysplasia of IPMNs. We retrospectively analyzed the following three points in 84 patients with IPMNs: (1) risk factors to predict high-grade dysplasia (HGD) and invasive carcinoma (INV); (2) the relationship between FDG uptake and glucose transporter 1 (GLUT-1) expression; and (3) the relationship between FDG uptake and the presence of mural nodules. The histopathological diagnosis was low-grade dysplasia (LGD) in 43 patients, HGD in 16, and INV in 25. The maximum standardized uptake value (SUV-max) was significantly higher in INV than in LGD/HGD (p < 0.0001, p = 0.0136). The sensitivity and specificity to discriminate INV from LGD/HGD were 80.0% and 86.2%, respectively, using the receiver operator characteristic curve, when the optimal cutoff score of SUV-max was set at 4.03. Those values were not different between HGD and LGD. More than half of HGD patients had low GLUT-1 expression. Taken together, FDG-PET/CT is useful in distinguishing between non-invasive and invasive IPMN. Our results offer critical information that may determine surgical treatment strategies.

    DOI： 10.3390/cancers13184633

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    PubMed

  • Kawamura J. .  Case Report: <sup>18</sup>F-FDG PET-CT for Diagnosing Prosthetic Device-Related Infection in an Infant With CHD .  Frontiers in Pediatrics9   584741   2021年3月

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    記述言語：日本語   出版者・発行元：Frontiers in Pediatrics  

    Patients who have undergone cardiac surgery using prosthetic devices have an increased risk of developing prosthetic device-related infection and mediastinitis. However, accurate diagnosis of prosthetic device-related infection can be difficult to evaluate and treat with antibiotic therapy alone. In recent years, 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) has made promising contributions to detect infective endocarditis, pacemaker infections, or other inflammations. Nevertheless, 18F-FDG PET-CT for congenital heart disease (CHD) with device infection has been sparsely reported. We present an infantile girl diagnosed with pulmonary atresia with a ventricular septal defect who underwent replacement of the right ventricle-to-pulmonary artery (RV-PA) conduit for improvement cyanosis. She developed high fever and was diagnosed with mediastinitis and bacteremia by Pseudomonas aeruginosa (P. aeruginosa) on postoperative day 4. Mediastinal drainage and 6 weeks of antibiotic therapy improved her condition, but bacteremia flared up on postoperative day 56. Despite a long course of antibiotic therapy, she had two more recurrences of bacteremia with the detection of P. aeruginosa. Echocardiography and chest contrast CT showed no evidence of vegetation and mediastinitis. On postoperative day 115, 18F-FDG PET-CT revealed an accumulation on the RV-PA conduit (SUV max 3.4). Finally, she developed an infectious ventricular pseudo-aneurysm on postoperative day 129 and underwent aneurysm removal and RV-PA conduit replacement on postoperative day 136. Our case showed the importance of 18F-FDG PET-CT for diagnosing specific localization of prosthetic device-related infection which is hard to detect using other imaging techniques. It can be a useful diagnostic tool for infantile patients with CHD with cardiac prosthetic devices and improve subsequent clinical treatments.

    DOI： 10.3389/fped.2021.584741

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    PubMed

  • Nakajo M. .  Application of a Machine Learning Approach for the Analysis of Clinical and Radiomic Features of Pretreatment [<sup>18</sup>F]-FDG PET/CT to Predict Prognosis of Patients with Endometrial Cancer .  Molecular Imaging and Biology23 ( 5 ) 756 - 765   2021年

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    記述言語：日本語   出版者・発行元：Molecular Imaging and Biology  

    Purpose: To examine the prognostic significance of pretreatment 2-deoxy-2-[18F]fluoro-d-glucose ([18F]-FDG) positron emission tomography (PET)-based radiomic features using a machine learning approach in patients with endometrial cancers. Procedures: Included in this retrospective study were 53 patients with endometrial cancers who underwent [18F]-FDG PET/X-ray computed tomography (CT) before treatment. Since two different PET scanners were used, post-reconstruction harmonization was performed for all PET parameters using the ComBat harmonization method. Four clinical (age, histological type, stage, and treatment method) and 40 [18F]-FDG PET-based radiomic features were ranked, and a subset of useful features was selected based on the decrease in the Gini impurity in terms of associations with disease progression. The machine learning algorithms (random forest, neural network, k-nearest neighbors (kNN), naive Bayes, logistic regression, and support vector machine) were compared using the areas under the receiver operating characteristic curve (AUC) and validated by the random sampling method. Progression-free survival (PFS) and overall survival (OS) were assessed by the Cox regression analysis. Results: The five best predictors of disease progression were coarseness, gray-level run length nonuniformity, stage, treatment method, and gray-level zone length nonuniformity. The kNN model obtained the best performance classifier for predicting the disease progression (AUC =0.890, accuracy =0.849, F1 score =0.848, precision =0.857, and recall =0.849). Coarseness which was the first ranked radiomic feature was selected for survival analyses, and only coarseness remained as a significant and independent factor for both PFS (hazard ratios (HR), 0.65; 95 % confidence interval [CI], 0.49–0.86; p=0.003) and OS (HR, 0.52; 95 % CI, 0.36–0.76; p<0.001) at multivariate Cox regression analysis. Conclusions: [18F]-FDG PET-based radiomic analysis using a machine learning approach may be useful for predicting tumor progression and prognosis in patients with endometrial cancers.

    DOI： 10.1007/s11307-021-01599-9

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    PubMed

  • Nakajo M. .  Application of a machine learning approach to characterization of liver function using <sup>99m</sup>Tc-GSA SPECT/CT .  Abdominal Radiology46 ( 7 ) 3184 - 3192   2021年

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    記述言語：日本語   出版者・発行元：Abdominal Radiology  

    Purpose: To assess the utility of a machine-learning approach for predicting liver function based on technetium-99 m-galactosyl serum albumin (99mTc-GSA) single photon emission computed tomography (SPECT)/CT. Methods: One hundred twenty-eight patients underwent a 99mTc-GSA SPECT/CT-based liver function evaluation. All were classified into the low liver-damage or high liver-damage group. Four clinical (age, sex, background liver disease and histological type) and 8 quantitative 99mTc-GSA SPECT/CT features (receptor index [LHL15], clearance index [HH15], liver-SUVmax, liver-SUVmean, heart-SUVmax, metabolic volume of liver [MVL], total lesion GSA [TL-GSA, liver-SUVmean × MVL] and SUVmax ratio [liver-SUVmax/heart-SUVmax]) were obtained. To predict high liver damage, a machine learning classification with features selection based on Gini impurity and principal component analysis (PCA) were performed using a support vector machine and a random forest (RF) with a five-fold cross-validation scheme. To overcome imbalanced data, stratified sampling was used. The ability to predict high liver damage was evaluated using a receiver operating characteristic (ROC) curve analysis. Results: Four indices (LHL15, HH15, heart SUVmax and SUVmax ratio) yielded high areas under the ROC curves (AUCs) for predicting high liver damage (range: 0.89–0.93). In a machine learning classification, the RF with selected features (heart SUVmax, SUVmax ratio, LHL15, HH15, and background liver disease) and PCA model yielded the best performance for predicting high liver damage (AUC = 0.956, sensitivity = 96.3%, specificity = 90.0%, accuracy = 91.4%). Conclusion: A machine-learning approach based on clinical and quantitative 99mTc-GSA SPECT/CT parameters might be useful for predicting liver function.

    DOI： 10.1007/s00261-021-02985-1

    Scopus

    PubMed

  • Nakajo M, Jinguji M, Tani A, Yoshiura T .  Application of adrenal maximum standardized uptake value to 131I-6β-iodomethyl-19-norcholesterol SPECT/CT for characterizing unilateral hyperfunctioning adrenocortical masses. .  European Journal of Radiology   2020年12月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Jinguji M, Tani A, Kajiya Y, Nandate T, Kitazano I, Yoshiura T .  [18F]-FDG-PET/CT and [18F]-FAZA-PET/CT Hypoxia Imaging of Metastatic Thyroid Cancer: Association with Short-Term Progression after Radioiodine Therapy. .  Molecular Imaging and Biology   2020年12月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Higo K, Kubota K, Hiwatari Takeshita S, Iwatani N, Minayaga S, Jinguji M, Ohishi M .  The potential for early diagnosis of pulmonary arterial hypertension using lung iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake: A case report. .  Radiology Case Reports   2020年6月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Jinguji M, Aoki M, Tani A, Sato M, Yoshiura T. .  The clinical value of texture analysis of dual-time-point 18F-FDG-PET/CT imaging to differentiate between 18F-FDG-avid benign and malignant pulmonary lesions. .  European Radiology   2020年3月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Wakabayashi H, Inaki A, Yoshimura K, Murayama T, Imai Y, Higuchi T, Jinguji M, Shiga T, Kinuya S. .  A phase I clinical trial for [131I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma. .  Scientific Reports   2019年5月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Jinguji M, Shinaji T, Aoki M, Tani A, Nakabeppu Y, Nakajo M, Sato M, Yoshiura T. .  A Pilot Study of Texture Analysis of Primary Tumor [18F]FDG Uptake to Predict Recurrence in Surgically Treated Patients with Non-small Cell Lung Cancer. Mol Imaging .  Molecular Imaging and Biology   2019年5月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Jinguji M, Shinaji T, Tani A, Nakabeppu Y, Nakajo M, Nakajo A, Natsugoe S, Yoshiura T. .  18F-FDG-PET/CT features of primary tumours for predicting the risk of recurrence in thyroid cancer after total thyroidectomy: potential usefulness of combination of the SUV-related, volumetric, and heterogeneous texture parameters. .  British Journal of Radiology   2019年2月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Jinguji M, Shinaji T, Tani A, Nakabeppu Y, Nakajo M, Nakajo A, Natsugoe S, Yoshiura T .  18F-FDG-PET/CT features of primary tumours for predicting the risk of recurrence in thyroid cancer after total thyroidectomy: potential usefulness of combination of the SUV-related, volumetric, and heterogeneous texture parameters. .  British journal of radiology   2018年11月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Jinguji M, Shinaji T, Aoki M, Tani A, Nakabeppu Y, Nakajo M, Sato M, Yoshiura T .  A Pilot Study of Texture Analysis of Primary Tumor [18F]FDG Uptake to Predict Recurrence in Surgically Treated Patients with Non-small Cell Lung Cancer. .  Molecular Imaging and Biology   2018年11月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo Masatoyo, Jinguji Megumi, Shinaji Tetsuya, Nakajo Masayuki, Aoki Masaya, Tani Atsushi, Sato Masami, Yoshiura Takashi .  Texture analysis of 18F-FDG PET/CT for grading thymic epithelial tumours: usefulness of combining SUV and texture parameters. .  British journal of radiology   2018年2月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Higo Kenjyuro, Kubota Kayoko, Miyanaga Sunao, Miyata Masaaki, Nakajo Masatoyo, Jinguji Megumi, Ohishi Mitsuru .  Impairment of Iodine-123-Metaiodobenzylguanidine (123I-MIBG) Uptake in Patients with Pulmonary Artery Hypertension. .  International Heart Journal   2018年1月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo Masatoyo, Kajiya Yoriko, Tani Atsushi, Jinguji Megumi, Nakajo Masayuki, Kitazono Makoto, Yoshiura Takashi .  A pilot study for texture analysis of 18F-FDG and 18F-FLT-PET/CT to predict tumor recurrence of patients with colorectal cancer who received surgery. .  European Journal of Nuclear Medicine and Molecular Imaging   2017年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nagano Hiroaki, Jinguji Megumi, Nakajo Masanori, Higashi Michiyo, Yoshiura Takashi .  Bilateral Tibial Osteofibrous Dysplasia on 18F-FDG PET/CT .  Clinical Nuclear Medicine42 ( 8 ) 375 - 376   2017年8月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Megumi Jinguji, Masayuki Nakajo, Masatoyo Nakajo, Chihaya Koriyama, Takashi Yoshiura .  Thymic Involution After Radioiodine Therapy for Graves Disease: Relationships With Serum Thyroid Hormones and TRAb .  Journal of the Endocrine Society2017 ( 7 ) 852 - 860   2017年7月査読

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo Masatoyo, Jinguji Megumi, Nakajo Masayuki, Shinaji Tetsuya, Nakabeppu Yoshiaki, Fukukura Yoshihiko, Yoshiura Takashi .  Texture analysis of FDG PET/CT for differentiating between FDG-avid benign and metastatic adrenal tumors: efficacy of combining SUV and texture parameters. .  Abdominal Radiology   2017年6月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Kajiya Y, Tani A, Jinguji M, Nakajo M, Nihara T, Fukukura Y, Yoshiura T .  A pilot study of the diagnostic and prognostic values of FLT-PET/CT for pancreatic cancer: comparison with FDG-PET/CT. .  Abdominal Radiology   2017年4月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00261-016-0987-1

  • Inaki Anri, Yoshimura Kenichi, Murayama Toshinori, Imai Yasuhito, Kuribayashi Yoshikazu, Higuchi Tetsuya, Jinguji Megumi, Shiga Tohru, Kinuya Seigo. .  A phase I clinical trial for [131I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma: a study protocol. .  Journal of Medical Investigation64 ( 3.4 ) 205 - 209   2017年査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • 19. Masatoyo Nakajo, Yoriko Kajiya, Megumi Jinguji, Yoshiaki Nakabeppu, Masayuki Nakajo, Tohru Nihara, Takashi Yoshiura .  Current clinical status of 18F-FLT PET or PET/CT in digestive and abdominal organ oncology. Abdominal Radiology. .  Abdominal Radiology   2016年10月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Masatoyo Nakajo, Megumi Jinguji, Yoshiaki Nakabeppu, Masayuki Nakajo, Ryuatro Higashi, Yoshihiko Fukukura Y, Ken Sasaki, Yasuto Uchikado, Shoji Natsugoe, Takashi Yoshiura .  Texture analysis of 18F-FDG PET/CT to predict tumour response and prognosis of patients with esophageal cancer treated by chemoradiotherapy .  Eur J Nucl Med Mol Imaging   2016年9月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • 17. Masatoyo Nakajo, Yoriko Kajiya, Atsushi Tani, Megumi Jinguji, Masayuki Nakajo, Takashi Yoshiura .  FLT-PET/CT diagnosis of primary and metastatic nodal lesions of gastric cancer: comparison with FDG-PET/CT .  Abdominal Radiology41 ( 10 ) 1891 - 1898   2016年6月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Jinguji M, Nakajo M, Nakajo M, Nakabeppu Y, Yoshiura T .  Vasovagal-related stress immediately before FDG injection may increase bilateral adrenal FDG uptake. .  British Journal of Radiology 89 ( 1061 )   2016年5月査読

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Jinguji M, Kajiya Y, Nakajo M, Nakajo M, Yoshiura T. .  Increased 18F-FDG Uptake in the Spleen and Multiple Lymph Nodes in Dengue Fever. .  Clinical Nuclear Medicine41 ( 5 ) e255 - 256   2016年5月査読

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Nakajo M, Nakayama H, Jinguji M, Nakabeppu Y, Higashi M, Nakamura Y, Sato M, Yoshiura T. .  Dexamethasone Suppression FDG PET/CT for Differentiating between True- and False-Positive Pulmonary and Mediastinal Lymph Node Metastases in Non-Small Cell Lung Cancer: A Pilot Study of FDG PET/CT after Oral Administration of Dexamethasone. .  Radiology279 ( 1 ) 246 - 253   2016年4月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Jinguji M, Fukukura Y, Kajiya Y, Tani A, Nakajo M, Nakabeppu Y, Arimura H, Nishio Y, Nakamura F, Yoshiura T. .  FDG-PET/CT and FLT-PET/CT for differentiating between lipid-poor benign and malignant adrenal tumours. .  Europian Radiology25 ( 12 ) 3696 - 3705   2015年12月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Jinguji M, Kajiya Y, Nakajo M, Higashi M, Yoshiura T. .  A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT. .  Clinical Nuclear Medicine40 ( 11 ) 905 - 907   2015年11月査読

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Seigo Kinuya,Keiichiro Yoshinaga,Tetsuya Higuchi,Megumi Jinguji,Hiroaki Kurihara,Hiroshi Kawamoto .  Draft guidelines regarding appropriate use of 131I-MIBG radiotherapy for neuroendocrine tumors : Guideline Drafting Committee for Radiotherapy with 131I-MIBG, Committee for Nuclear Oncology and Immunology, The Japanese Society of Nuclear Medicine. .  Annals of Nuclear Medicine 29 ( 6 ) 543 - 552   2015年3月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Nakajo M, Nakajo M, Jinguji M, Fukukura Y, Nakabeppu Y, Tani A, Yoshiura T .  The value of intratumoral heterogeneity of (18)F-FDG uptake to differentiate between primary benign and malignant musculoskeletal tumours on PET/CT. .  British Journal of Radiology 88 ( 1055 )   2015年査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Masatoyo Nakajo,Masayuki Nakajo,Yoshihiko Fukukura,Megumi Jinguji,Toshikazu Shindo,Yoshiaki Nakabeppu,Kiyohisa Kamimura,Tomohide Yoneyama,Koji Takumi,Takashi Yoshiura .  Diagnostic performances of FDG-PET/CT and diffusion-weigheted imaging indices for differenting benign pheochromocytoma from other benign adrenal tumors. .  Abdom Imaging40 ( 6 ) 1655 - 1665   2014年11月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Keiichiro Yoshinaga, Noboru Oriuchi, Hiroshi Wakabayashi, Yuuki Tomiyama, Megumi Jinguji, Tetsuya Higuchi, Daiki Kayano, Makoto Fukuoka, Anri Inaki, Ayane Toratani, Shozo Okamoto, Tohru Shiga, Yoichi M. Ito, Masatoyo Nakajo, Masayuki Nakajo, Seigo Kinuya .  Effects and safety of 131I-metaiodobenzylguanidine (MIBG) radiotherapy in malignant neuroendocrine tumors: Results from a multicenter observational registry. .  Endocrine journal61 ( 12 ) 1171 - 1180   2014年9月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Masatoyo Nakajo , Masayuki Nakajo,Yoriko Kajiya ,Yuko Goto ,Megumi Jinguji , Sadao Tanaka, Yoshihiko Fukukura ,Atsushi Tani ,Michiyo Higashi .  Correlations of 18F-fluorothymidine uptake with pathological tumour size, Ki-67 and thymidine kinase expressions in primary and metastatic lymph node colorectal cancer foci. .  Europian Jounal of Radiology.24 ( 12 ) 3199 - 3209   2014年8月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Masatoyo Nakajo, Masayuki Nakajo, Yoriko Kajiya, Megumi Jinguji, Nibuaki Nishimata,Shunji Shimaoka, Tohru Nihara, Kuniaki Aridome, Sadao Tanaka, Yoshihiko Fukukura，Atsushi Tani, Chihaya Koriyama .  Diagnostic performance of 118F-fluorothymidine PET/CT for primary colorectal cancer and its lymph node metastasis: comparison with 118F-fluorodeoxyglucose PET/CT. .  European Journal of Nuclear Medicine and Molecular Imaging 40 ( 8 ) 1223 - 1232   2013年8月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Masatoyo Nakajo, Masayuki Nakajo, Megumi Jinguji, Atsushi Tani, Yoriko Kajiya, Hiroaki Tanabe, Yoshihiko Fukukura, Yoshiaki Nakabeppu, Chihaya Koriyama .  Diagnosis of metastases from postoperative differentiated thyroid cancer: comparison between FDG and FLT PET/CT studies. .  Radiology267 ( 3 ) 891 - 901   2013年6月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Yasutaka Baba, Sadao Hayashi, Shunichiro Ikeda, Megumi Jinguji, Masatoyo Nakajo, Masayuki Nakajo .  Evaluation of split renal function before and after renal arterial embolization for angiomyolipoma using absolute ethanol. .  Cardiovascular interventional Radiology37 ( 5 ) 1200 - 1225   2013年6月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Megumi Jinguji,Hiroaki Tanabe,Masayuki Nakajo,Yoshiaki Nakabeppu,Yoshihiko Fukukura,Shoji Matsune,Takako Yoshioka .  99mTc Pertechnetate Scintigraphy for Warthin Tumors of the Parotid Gland: Comparison of Histopathological and Magnetic Resonance Imaging findings. .  鹿児島大学医学雑誌65 ( 1 ) 9 - 18   2013年1月査読

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Masatoyo Nakajo,Masayuki Nakajo,Yoriko Kajiya,Megumi Jinguji,Shinichiro MoriKuniaki Aridome,Toyokuni Suenaga: .  High FDG and Low FLT Uptake in a Thyroid Papillary Carcinoma Incidentally Discovered by FDG PET/CT .  Clinical Nuclear Medicine37 ( 6 ) 607 - 608   2012年6月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • 中別府良昭，田邉博昭，神宮司メグミ，馬ノ段智一，中條正豊，立野利衣，陣之内正史，中條政敬 .  加齢に伴う脳FDG分布の男女差の検討 .  臨床放射線52 ( 13 ) 1783 - 1794   2007年12月査読

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

  • Masayuki Nakajo,Shinsaku Tsuchimochi,Megumi Jinguji,Hiroaki Tanabe,Tomokazu Umanodan,Yoshiaki Nakabeppu .  A possible method using baseline hormonal levels to prescribe the appropriate oral therapeutic radioiodine dosage for Graves’ disease .  Annals of Nuclear Medicine21 ( 8 ) 471 - 476   2007年10月査読

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

  • Yuichi Kumagae, Megumi Jinguji, Daizo Tanaka, Masayuki Nakajo .  An adult case of bilateral true tracheal bronchi associated with hemoptysis .  Journal of thoracic imaging21 ( 4 ) 293 - 295   2006年11月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Megumi Jinguji, Yoriko Kajiya, Kiyohisa Kamimura, Masayuki Nakajo, Yoshiaki Sagara, Tetsuya Takahama, Mitsutake Ando, Yoshiaki Rai, Yoshiatsu Sagara, Yasuyo Ohi, Hiroki Yoshida .  Rim Enhancement of breast cancers on contrast-enhanced MR imaging : Relationship with prognostic factors .  Breast Cancer.13 ( 1 ) 64 - 73   2006年1月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • 加治屋より子,上村清央,神宮司メグミ,中條政敬,土持進作,迫勝巳,小森園康二 .  多血性肝細胞癌の検出に対する至適動脈相の検討． .  日本医学放射線学会雑誌．65 ( 2 ) 99 - 104   2005年1月査読

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

  • Masayuki Nakajo, Shinsaku Tsuchimochi, Hiroaki Tanabe, Yoshiaki Nakabeppu, Megumi Jinguji .  Three basic patterns of changes in serum thyroid hormone levels in Graves’ disease during the ne-year period after radioiodine therapy. .  Annals of Nuclear Medicine.19 ( 4 ) 297 - 308   2005年1月査読

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    記述言語：日本語   掲載種別：研究論文（学術雑誌）  

  • Masayuki Nakajo, Hiroaki Tanabe, Shinsaku Tsuchimochi, Humihiko Nakamura, Megumi Jinguji .  Estimation of small thyroid phantom volume by computed tomography. .  Journal of Computed Tomography.31 ( 3 ) 140 - 146   2004年1月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Megumi Jinguji, Shinsaku Tsuchimochi, Masayuki Nakajo, Hiroaki Hamada, Takuro Kamiyama, Tomokazu Umanodan, Atsushi Tani, Yoshiaki Nakabeppu, Tatsuru Kaji, Hideo Takamatsu, Hironori Haga .  Scintigraphic progress of the liver in a patient with Alagille syndrome (arteriohepatic dysplasia). .  Annals of Nuclear Medicine17 ( 8 ) 693 - 697   2003年1月査読

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

  • Higo Kenjuro, Kubota Kayoko, Miyanaga Sunao, Miyata Masaaki, Nakajo Masatoyo, Jinguji Megumi, Ohishi Mitsuru .  肺動脈高血圧症患者におけるヨード123-メタヨードベンジルグアニジン(123I-MIBG)の取り込み低下(Impairment of Iodine-123-Metaiodobenzylguanidine(123I-MIBG) Uptake in Patients with Pulmonary Artery Hypertension) .  International Heart Journal59 ( 1 ) 112 - 119   2018年1月

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    出版者・発行元：(一社)インターナショナルハートジャーナル刊行会  

    肺高血圧症(PH)患者では肺の123-メタヨードベンジルグアニジン(123I-MIBG)取り込みが低下しているとの仮説を立て、PH患者の肺123I-MIBG取り込みを評価し、心エコー検査や右心カテーテル法で得られた各指標と比較検討した。2003年12月〜2014年12月に123I-MIBGシンチを施行されたPH患者21例と、性別・年齢を一致させた対照8例を対象とした。心エコー、6分間歩行試験、B型ナトリウム利尿ペプチド測定、肺機能検査、右心カテーテル法を施行した。PH患者を慢性血栓塞栓性肺高血圧症(CTEPH)9例(男性2例、女性7例、平均69.1±7.5歳)と肺動脈高血圧症(PAH)12例(男性3例、女性9例、平均54.1±13.4歳)に分けた。平均肺動脈圧はCTEPH群が37.7±6.8mmHg、PAH群が32.3±5.3mmHgで有意差はなかった。両群間でその他の血行動態パラメーターに有意差はなかった。123I-MIBGの肺取り込みはPAH群ではearly image(EI)1.54±0.18、delayed image(DI) 1.41±0.16で、CTEPH群のEI 2.17±0.25、DI 1.99±0.20、対照群のEI2.32±0.27、DI 1.92±0.19よりも有意に低かった。PAH患者では肺血管内皮機能が低下している可能性が示唆された。

  • 加治屋 より子, 谷 淳至, 南立 亮, 仮屋 圭佑, 神宮司 メグミ, 中條 正豊, 西俣 寛人, 福永 秀敏, 中條 政敬, 吉浦 敬 .  PET検診がん発見率と年代や性別、受診回数との関連性　どのような人がFDG-PET検診を受けるとよいか .  臨床放射線62 ( 9 ) 1157 - 1163   2017年9月

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    出版者・発行元：金原出版(株)  

    PET検診6256件を対象に、癌発見率と年代や性別、受診回数との関連を検討した。実受診者数は4898人で、うち複数回受検者が710人、内訳は男3562人・女2694人・平均年齢58.0歳であった。162件(167の癌病変、重複癌3人、3重複癌1人を含む)の癌が発見され、癌発見率は延べで3.3%、初回で3.0%、癌病変発見率は延べで2.7%、初回で3.1%、2回目で1.4%であった。男女あわせた年代別発見率の推移では、加齢により有意に癌の発見率が上昇していた。男女別で50歳を境とした2群で年齢と発見率を比較したところ、男性では50歳以上で50歳未満に比べて発見率が高く、女性では有意差はなかった。初回受診者のみの病変発見率をみると、全体と同様に男性で発見率が高く、加齢によりその傾向が顕著であったが、各年代での発見率がより高かった。以上、PET癌検診発見率は受検者の年齢や性別、特に年齢に大きく影響されると考えられた。

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MISC

  • Author Correction: A phase I clinical trial for [<sup>131</sup>I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma (Scientific Reports, (2019), 9, 1, (7625), 10.1038/s41598-019-43880-6)

    Wakabayashi H., Inaki A., Yoshimura K., Murayama T., Imai Y., Higuchi T., Jinguji M., Shiga T., Kinuya S.

    Scientific Reports   12 ( 1 )   1347   2022年12月

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    記述言語：日本語   出版者・発行元：Scientific Reports  

    The original version of this article contained an error in the 95% confidence intervals calculated for the second and third courses of 131I-mIBG. As a result, in the Results section under the subheading ‘Response evaluation’, “Eight patients received a second course of 131I-mIBG therapy. The scintigraphic response in the second course was 5% in CR (1/20), 10% in PR (2/20), 20% in SD (4/20), 5% in PD (1/20), and 60% in unknown (12/20). The response rate was 15% (95% CI: 6.0–61.0%).” now reads: “Eight patients received a second course of 131I-mIBG therapy. The scintigraphic response in the second course was 5% in CR (1/20), 10% in PR (2/20), 20% in SD (4/20), 5% in PD (1/20), and 60% in unknown (12/20). The response rate was 15% (95% CI: 3.2–37.9%).” “Three patients received a third course of 131I-mIBG therapy. There were three patients with PR (15%) and 17 patients with unknown (85%) in the scintigraphic response. The response rate was 15% (95% CI: 29.2–100.0%).” now reads: “Three patients received a third course of 131I-mIBG therapy. There were three patients with PR (15%) and 17 patients with unknown (85%) in the scintigraphic response. The response rate was 15% (95% CI: 3.2–37.9%).” The original Article has been corrected.

    DOI： 10.1038/s41598-022-05239-2

    Scopus

    PubMed

  • 【診断の決め手となった画像・所見III-胸部・腎泌尿器・婦人科】腎泌尿器　副腎腫瘍(副腎腺腫など)

    長谷川 知仁, 福倉 良彦, 神宮司 メグミ, 吉浦 敬

    臨床放射線   66 ( 13 )   1551 - 1557   2021年12月

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    記述言語：日本語   出版者・発行元：金原出版(株)  

  • Correction to: [18F]-FDG-PET/CT and [18F]-FAZA-PET/CT Hypoxia Imaging of Metastatic Thyroid Cancer: Association with Short-Term Progression after Radioiodine Therapy (Molecular Imaging and Biology, (2020), 22, 6, (1609-1620), 10.1007/s11307-020-01516-6)

    Nakajo M.

    Molecular Imaging and Biology   22 ( 6 )   1621   2020年12月

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    出版者・発行元：Molecular Imaging and Biology  

    DOI： 10.1007/s11307-020-01525-5

    Scopus

    PubMed

  • 核医学治療について

    神宮司 メグミ

    核医学技術   39 ( 1 )   65 - 69   2019年1月

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    出版者・発行元：(NPO)日本核医学技術学会  

  • 【副腎の画像診断・IVR:診断に必要な基礎から臨床まで】副腎疾患の核医学診断

    神宮司 メグミ, 中條 正豊, 中條 政敬, 谷 淳至, 吉浦 敬

    臨床画像   34 ( 3 )   306 - 316   2018年3月

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    出版者・発行元：(株)メジカルビュー社  

    副腎の画像診断においては、代謝機能を反映する核医学画像は古くから非常に重要な役割を果たしてきた。最近ではSPECTやPETの核医学画像と形態画像のCTやMRIとの融合も容易となり、よりわかりやすい画像が得られるようになってきた。(著者抄録)

  • 難治性褐色細胞腫および傍神経節腫患者における[131I]メタヨードベンジルグアニジン療法に対する第I相臨床試験　研究プロトコル(A phase I clinical trial for [131I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma: a study protocol)

    Inaki Anri, Yoshimura Kenichi, Murayama Toshinori, Imai Yasuhito, Kuribayashi Yoshikazu, Higuchi Tetsuya, Jinguji Megumi, Shiga Tohru, Kinuya Seigo

    The Journal of Medical Investigation   64 ( 3-4 )   205 - 209   2017年8月

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    出版者・発行元：徳島大学医学部  

    難治性褐色細胞腫および傍神経節腫(PPGL)患者に対する[131I]メタヨードベンジルグアニジン(131I-mIBG)療法の安全性および有効性を前向きに評価することとした。本研究は非盲検多施設共同単群臨床試験で行うこととし、難治性PPGLと確認され外科的治療および根治的外部照射歴のない20歳以上等の選択基準を満たす患者20例を被験者とする。患者には固定用量7400メガベクレルの131I-mIBGを投与し、投与後20週以内における有害事象とすべての重篤な有害事象を詳細に記録することとした。当該療法の有効性は131I-mIBG投与前と投与後12週での比較し、主要評価項目は用量制限毒性、副次評価項目はResponse Evaluation Criteria in Solid Tumorsによる反応率、シンチグラフィー評価、全生存率、無増悪生存率、有害事象/反応とした。本研究は当該療法に関する最初の多施設共同前向き試験である。

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講演・口頭発表等

  • Nakajo Masatoyo, Jinguji Megumi, Hirahara Mitsuho, Tani Atsushi, Yoshiura Takashi .  Value of Volumetric Analysis of 18F-FDG-PET/CT for Predicting the Prognosis in Patients with Gallbladder Cancer(タイトル和訳中) .  日本医学放射線学会学術集会抄録集  2023年3月  (公社)日本医学放射線学会

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    記述言語：英語  

  • 谷 淳至, 中條 正豊, 神宮司 メグミ, 吉浦 敬 .  転移性肺腫瘍へのFDG集積におけるデバイスレス呼吸同期撮影法の影響　領域毎の評価 .  核医学  2022年8月  (一社)日本核医学会

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    記述言語：日本語  

  • Nakajo Masatoyo, Jinguji Megumi, Tani Atsushi, Horizoe Yoshihisa, Yoshiura Takashi .  褐色細胞腫患者の心機能評価における123I-MIBG心筋集積の視覚的およびSUV定量解析の有用性の検討(Value of Myocardial 123I-MIBG Uptake Assessed by Visual and Semiquantitative Analyses for Characterizing the Cardiac Function in Patients with Pheochromocytoma) .  日本医学放射線学会学術集会抄録集  2022年3月  (公社)日本医学放射線学会

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    記述言語：英語  

  • 谷 淳至, 神宮司 メグミ, 中條 正豊, 吉浦 敬 .  肺動静脈奇形に対する血管内治療前後のTc-99m MAAを用いた評価法に関する検討 .  核医学  2021年10月  (一社)日本核医学会

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    記述言語：日本語  

  • 田中 嵩人, 中條 正豊, 本村 江利子, 藤阪 智史, 神宮司 メグミ, 谷 淳至, 西郷 康正 .  心サルコイドーシスの18F-FDG-PET/CT速度定数画像の短時間撮像による画像再構成法の検討 .  核医学技術  2021年10月  (NPO)日本核医学技術学会

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    記述言語：日本語  

  • 中條 正豊, 神宮司 メグミ, 谷 淳至, 吉浦 敬 .  子宮頸癌の予後予測におけるFDG-PET特徴量を利用した機械学習解析について .  核医学  2021年10月  (一社)日本核医学会

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    記述言語：英語  

  • Nakajo Masatoyo, Jinguji Megumi, Tani Atsushi, Yoshiura Takashi .  子宮内膜癌患者における術前18F-FDG-PET/CTのボリューム解析およびテクスチャー解析を用いたリスク分類(Risk Stratification using Volumetric and Texture Analyses of Preoperative 18F-FDG-PET/CT in Patients with Endometrial Cancer) .  日本医学放射線学会学術集会抄録集  2021年3月  (公社)日本医学放射線学会

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    記述言語：英語  

  • Nakajo Masatoyo, Jinguji Megumi, Tani Atsushi, Yoshiura Takashi .  胸腺上皮性腫瘍の悪性度を予測する18F-FDG PET/CTの有用性(Value of 18F-FDG PET/CT in Predicting the Malignant Grade of Thymic Epithelial Tumors) .  日本医学放射線学会学術集会抄録集  2017年2月  (公社)日本医学放射線学会

  • 中條 正豊, 神宮司 メグミ, 谷 淳至, 吉浦 敬 .  肝機能評価における99mTc GSA SPET/CTのSUV値解析の有用性に関する研究 .  核医学  2020年10月  (一社)日本核医学会

  • 長谷川 知仁, 林 完勇, 瀬之口 輝寿, 永里 耕平, 熊谷 雄一, 神宮司 メグミ, 福倉 良彦, 吉浦 敬 .  肝外門脈静脈短絡による繰り返す肝性脳症に対してコイルアシスト逆行性経静脈的塞栓が有用であった1例 .  Japanese Journal of Radiology  2018年2月  (公社)日本医学放射線学会

  • 谷 淳至, 神宮司 メグミ, 吉浦 敬, 中條 正豊 .  甲状腺癌術後の胸腺過形成と考えられた1例　FDG-PET/CTとI-131 SPECT/CTとの比較 .  Japanese Journal of Radiology  2019年2月  (公社)日本医学放射線学会

  • 谷 淳至, 神宮司 メグミ, 吉浦 敬, 中條 正豊 .  甲状腺癌に対する複数回の放射性ヨード内用療法が耳下腺への放射性ヨード集積に与える影響についての検討 .  核医学  2017年9月  (一社)日本核医学会

  • Nakajo Masatoyo, Jinguji Megumi, Tani Atsushi, Yoshiura Takashi .  甲状腺癌におけるFDG-PET/CTのvolumetric解析による術後高リスク再発群予測の有用性について(Value of Volumetric Analysis of 18F-FDG-PET/CT for Predicting the Risk of Recurrence in Differentiated Thyroid Cancer after Total Thyroidectomy) .  日本医学放射線学会学術集会抄録集  2018年2月  (公社)日本医学放射線学会

  • Tani Atsushi, Kajiya Yoriko, Nakajo Masatoyo, Jinguji Megumi, Yoshiura Takashi .  消化管膵神経内分泌腫瘍　FDG-PET/CTと拡散強調MRIの比較(Gastroenteropancreatic Neuroendocrine Tumor: Comparison of FDG-PET/CT and Diffusion-weighted MRI) .  日本医学放射線学会学術集会抄録集  2017年2月  (公社)日本医学放射線学会

  • 神宮司 メグミ .  核医学治療について .  核医学技術  2018年10月  (NPO)日本核医学技術学会

  • 河路 広大, 神宮司 メグミ, 中條 正豊, 谷 淳至, 吉浦 敬 .  急性下顎骨骨髄炎における骨シンチグラフィの検討 .  核医学  2019年  (一社)日本核医学会

  • 神宮司 メグミ, 中條 正豊, 谷 淳至, 中條 政敬, 吉浦 敬 .  巨大な甲状腺腫を有するバセドウ病に対するI-131治療経験 .  核医学  2017年9月  (一社)日本核医学会

  • 谷 淳至, 神宮司 メグミ, 中條 正豊, 吉浦 敬 .  少量(1110MBq)のI-131を用いた甲状腺癌術後アブレーション治療の効果判定 .  核医学  2020年10月  (一社)日本核医学会

  • 谷 淳至, 神宮司 メグミ, 中條 正豊, 吉浦 敬 .  多発する弾性線維腫へのFDG集積と思われる所見を認めた1例 .  Japanese Journal of Radiology  2020年2月  (公社)日本医学放射線学会

  • 中條 正豊, 神宮司 メグミ, 谷 淳至, 吉浦 敬 .  副腎腫瘍の良悪性鑑別におけるFDG-PET/CTでのテクスチャー解析の有用性の検討 .  核医学  2017年9月  (一社)日本核医学会

  • 萱野 大樹, 若林 大志, 稲木 杏吏, 村山 敏典, 神宮司 メグミ, 樋口 徹也, 志賀 哲, 絹谷 清剛 .  先進医療Bとして実施した難治性褐色細胞腫に対するI-131 MIBG治療の第1相試験 .  日本内分泌学会雑誌  2019年4月  (一社)日本内分泌学会

  • 谷 淳至, 神宮司 メグミ, 中條 正豊, 吉浦 敬 .  下顎骨骨髄炎・骨壊死の定量的な骨SPECT/CT評価の試み .  核医学  2019年10月  (一社)日本核医学会

  • 神宮司 メグミ, 中別府 良昭, 吉浦 敬, 加治屋 より子, 谷 淳至, 中條 政敬 .  デング熱のFDG-PET/CTの1例 .  Japanese Journal of Radiology  2017年2月  (公社)日本医学放射線学会

  • Nakajo Masatoyo, Jinguji Megumi, Tani Atsushi, Yoshiura Takashi .  テクスチャー解析を用いた18F-FDG PET/CTによる肺腫瘤の良悪性鑑別の有用性の検討(Value of Texture Features of 18F-FDG-PET/CT Imaging for Differentiating between Benign and Malignant Pulmonary Lesions) .  日本医学放射線学会学術集会抄録集  2019年2月  (公社)日本医学放射線学会

  • 長谷川 知仁, 谷 淳至, 神宮司 メグミ, 吉浦 敬 .  エトレチナート長期内服中の症例における骨シンチグラフィの経験 .  核医学  2018年12月  (一社)日本核医学会

  • 谷 淳至, 中條 正豊, 神宮司 メグミ, 吉浦 敬, 加治屋 より子 .  FLTの大動脈壁への集積と思われる所見が認められた一例 .  核医学  2017年2月  (一社)日本核医学会

  • 神宮司 メグミ, 中條 正豊, 谷 淳至, 吉浦 敬 .  FDG-PET/CTの腹壁異常集積の検討 .  核医学  2019年10月  (一社)日本核医学会

  • 袴田 裕人, 内匠 浩二, 福倉 良彦, 神宮司 メグミ, 吉浦 敬, 中村 好宏, 佐藤 雅美, 北薗 育美 .  EWSR1-CREB1転座肺粘液腫様肉腫の1例 .  日本医学放射線学会秋季臨床大会抄録集  2017年8月  (公社)日本医学放射線学会

  • 長野 広明, 神宮司 メグミ, 谷 淳至, 中條 正豊, 吉浦 敬 .  111In-pentetreotideシンチグラフィの撮像タイミングと腫瘍/正常臓器集積比に関する検討 .  核医学  2017年2月  (一社)日本核医学会

  • 惠島 史貴, 長野 広明, 神宮司 メグミ, 谷 淳至, 中條 正豊, 吉浦 敬 .  111In-pentetreotideシンチグラフィにおける膵鉤部生理的集積についての検討 .  核医学  2017年2月  (一社)日本核医学会

  • 谷 淳至, 神宮司 メグミ, 中條 正豊, 吉浦 敬 .  褐色脂肪組織へのFDG集積に関する患者因子の検討 .  核医学  2018年11月  (一社)日本核医学会

  • Tani Atsushi, Jinguji Megumi, Nakajo Masatoyo, Yoshiura Takashi .  骨軟骨腫のSPECT/CT　トレーサー集積分布および強度の視覚的評価(Bone SPECT/CT in Osteochondromas: Visual Analysis of Tracer Distribution and Intensity) .  日本医学放射線学会学術集会抄録集  2019年2月  (公社)日本医学放射線学会

  • 長野 広明, 神宮司 メグミ, 中條 正典, 中條 正豊, 吉浦 敬, 中條 政敬, 東 美智代, 永野 聡 .  骨シンチグラフィおよびFDG-PET/CTで高集積を認めた両脛骨の骨線維性異形成(Osteofibrous dysplasia)の1例 .  Japanese Journal of Radiology  2018年2月  (公社)日本医学放射線学会

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