Updated on 2024/05/27

写真a

 
IWAI Haruki
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
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Degree

  • 博士 (歯学) ( 2015.10   鹿児島大学 )

  • 修士 (医科学) ( 2007.3   鹿児島大学 )

  • 学士 (美術) ( 2005.3   東京芸術大学 )

Research Interests

  • pain

  • taste

  • Nervous system

  • 視床

  • 美術解剖学

  • 線条体

  • 神経科学

  • 神経回路

  • 内臓感覚

  • 痛覚

  • 味覚

  • 三叉神経

Research Areas

  • Life Science / Oral biological science  / 口腔顔面痛

  • Humanities & Social Sciences / Family and consumer sciences, and culture and living  / 摂食行動

  • Humanities & Social Sciences / Theory of art practice  / 美術解剖学

Education

  • Kagoshima University

    - 2012.3

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    Country: Japan

  • Kagoshima University

    - 2007.3

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    Country: Japan

  • Tokyo University of the Arts   先端芸術表現科

    - 2005.3

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    Country: Japan

Research History

  • Tokyo University of the Arts   Faculty of Fine Arts

    2023.4

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  • Nagaoka Institute of Design   Faculty of Design

    2023.4

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  • 加治木看護専門学校   非常勤講師

    2021.9

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  • Nagoya Zokei University of Art & Design   The Department of Art & Design

    2009.4

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  • 鹿児島看護専門学校   非常勤講師

    2008.6 - 2021.9

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  • Kagoshima University   Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology   Assistant Professor

    2007.4

  • Kagoshima University   Assistant Professor

    2007.4

  • Kagoshima University   Assistant Professor

    2007.4

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Professional Memberships

  • INTERNATIONAL ASSOCIATION FOR DENTAL RESEARCH

    2016.1

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  • Society for Neuroscience

    2015.7

  • 歯科基礎医学会

    2007.4

  • THE JAPAN NEUROSCIENCE SOCIETY

    2007.4

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  • 日本解剖学会

    2005.4

  • Japanese Society of Artistic Anatomy

    2004.4

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Committee Memberships

  • 美術解剖学会   理事  

    2024.4   

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  • 美術解剖学会   幹事  

    2017.10 - 2024.3   

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Papers

  • Eriko Kuramoto, Makoto Fukushima, Ryozo Sendo, Sachi Ohno, Haruki Iwai, Atsushi Yamanaka, Mitsutaka Sugimura, Tetsuya Goto .  Three-dimensional topography of rat trigeminal ganglion neurons using a combination of retrograde labeling and tissue-clearing techniques .  Journal of Comparative Neurology532 ( 2 ) e25584   2024.2Reviewed

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    The trigeminal nerve is the sensory afferent of the orofacial regions and divided into three major branches. Cell bodies of the trigeminal nerve lie in the trigeminal ganglion and are surrounded by satellite cells. There is a close interaction between ganglion cells via satellite cells, but the function is not fully understood. In the present study, we clarified the ganglion cells’ three-dimensional (3D) localization, which is essential to understand the functions of cell–cell interactions in the trigeminal ganglion. Fast blue was injected into 12 sites of the rat orofacial regions, and ganglion cells were retrogradely labeled. The labeled trigeminal ganglia were cleared by modified 3DISCO, imaged with confocal laser-scanning microscopy, and reconstructed in 3D. Histograms of the major axes of the fast blue-positive somata revealed that the peak major axes of the cells innervating the skin/mucosa were smaller than those of cells innervating the deep structures. Ganglion cells innervating the ophthalmic, maxillary, and mandibular divisions were distributed in the anterodorsal, central, and posterolateral portions of the trigeminal ganglion, respectively, with considerable overlap in the border region. The intermingling in the distribution of ganglion cells within each division was also high, in particular, within the mandibular division. Specifically, intermingling was observed in combinations of tongue and masseter/temporal muscles, maxillary/mandibular molars and masseter/temporal muscles, and tongue and mandibular molars. Double retrograde labeling confirmed that some ganglion cells innervating these combinations were closely apposed. Our data provide essential information for understanding the function of ganglion cell–cell interactions via satellite cells.

    DOI: 10.1002/cne.25584

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  • Junya Kusumoto, Koji Ataka, Haruki Iwai, Yasuhiko Oga, Keita Yamagata, Kanako Marutani, Takanori Ishikawa, Akihiro Asakawa, Shouichi Miyawaki .  Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice. .  Frontiers in neuroscience17   1156523 - 1156523   2023Reviewed International journal

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    INTRODUCTION: Occlusal disharmony induced by deteriorating oral health conditions, such as tooth loss and decreased masticatory muscle due to sarcopenia, is one of the causes of cognitive impairment. Chewing is an essential oral function for maintaining cognitive function not only in the elderly but also in young people. Malocclusion is an occlusal disharmony that commonly occurs in children. The connection between a decline in cognitive function and malocclusion in children has been shown with chronic mouth breathing, obstructive sleep apnea syndrome, and thumb/digit sucking habits. However, the mechanism of malocclusion-induced cognitive decline is not fully understood. We recently reported an association between feeding-related neuropeptides and cognitive decline in adolescent mice with activity-based anorexia. The aim of the present study was to assess the effects of malocclusion on cognitive behavior and clarify the connection between cognitive decline and hypothalamic feeding-related neuropeptides in adolescent mice with malocclusion. METHODS: Four-week-old mice were randomly assigned to the sham-operated solid diet-fed (Sham/solid), sham-operated powder diet-fed (Sham/powder), or malocclusion-operated powder diet-fed (Malocclusion/powder) group. We applied composite resin to the mandibular anterior teeth to simulate malocclusion. We evaluated cognitive behavior using a novel object recognition (NOR) test, measured hypothalamic feeding-related neuropeptide mRNA expression levels, and enumerated c-Fos-positive cells in the hypothalamus 1 month after surgery. We also evaluated the effects of central antibody administration on cognitive behavior impairment in the NOR test. RESULTS: The NOR indices were lower and the agouti-related peptide (AgRP) mRNA levels and number of c-Fos-positive cells were higher in the malocclusion/powder group than in the other groups. The c-Fos-positive cells were also AgRP-positive. We observed that the central administration of anti-AgRP antibody significantly increased the NOR indices. DISCUSSION: The present study suggests that elevated cerebral AgRP signaling contributes to malocclusion-induced cognitive decline in adolescents, and the suppression of AgRP signaling can be a new therapeutic target against cognitive decline in occlusal disharmony.

    DOI: 10.3389/fnins.2023.1156523

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  • Koji Ataka, Akihiro Asakawa, Haruki Iwai, Ikuo Kato .  Musclin prevents depression-like behavior in male mice by activating urocortin 2 signaling in the hypothalamus. .  Frontiers in endocrinology14   1288282 - 1288282   2023Reviewed International journal

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    INTRODUCTION: Physical activity is recommended as an alternative treatment for depression. Myokines, which are secreted from skeletal muscles during physical activity, play an important role in the skeletal muscle-brain axis. Musclin, a newly discovered myokine, exerts physical endurance, however, the effects of musclin on emotional behaviors, such as depression, have not been evaluated. This study aimed to access the anti-depressive effect of musclin and clarify the connection between depression-like behavior and hypothalamic neuropeptides in mice. METHODS: We measured the immobility time in the forced swim (FS) test, the time spent in open arm in the elevated-plus maze (EPM) test, the mRNA levels of hypothalamic neuropeptides, and enumerated the c-Fos-positive cells in the paraventricular nucleus (PVN), arcuate nucleus (ARC), and nucleus tractus solitarii (NTS) in mice with the intraperitoneal (i.p.) administration of musclin. Next, we evaluated the effects of a selective corticotropin-releasing factor (CRF) type 1 receptor antagonist, selective CRF type 2 receptor antagonist, melanocortin receptor (MCR) agonist, and selective melanocortin 4 receptor (MC4R) agonist on changes in behaviors induced by musclin. Finally we evaluated the antidepressant effect of musclin using mice exposed to repeated water immersion (WI) stress. RESULTS: We found that the i.p. and i.c.v. administration of musclin decreased the immobility time and relative time in the open arms (open %) in mice and increased urocortin 2 (Ucn 2) levels but decreased proopiomelanocortin levels in the hypothalamus. The numbers of c-Fos-positive cells were increased in the PVN and NTS but decreased in the ARC of mice with i.p. administration of musclin. The c-Fos-positive cells in the PVN were also found to be Ucn 2-positive. The antidepressant and anxiogenic effects of musclin were blocked by central administration of a CRF type 2 receptor antagonist and a melanocortin 4 receptor agonist, respectively. Peripheral administration of musclin also prevented depression-like behavior and the decrease in levels of hypothalamic Ucn 2 induced by repeated WI stress. DISCUSSION: These data identify the antidepressant effects of musclin through the activation of central Ucn 2 signaling and suggest that musclin and Ucn 2 can be new therapeutic targets and endogenous peptides mediating the muscle-brain axis.

    DOI: 10.3389/fendo.2023.1288282

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  • Kento Igarashi, Haruki Iwai, Koh-Ichi Tanaka, Yoshikazu Kuwahara, Junichi Kitanaka, Nobue Kitanaka, Akihiro Kurimasa, Kazuo Tomita, Tomoaki Sato .  Neuroprotective effect of oxytocin on cognitive dysfunction, DNA damage, and intracellular chloride disturbance in young mice after cranial irradiation. .  Biochemical and biophysical research communications612   1 - 7   2022.4Reviewed International journal

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    Cranial radiation therapy (CRT) is an effective treatment for brain tumors; however, it also causes brain injuries. The pediatric brain is considered especially vulnerable compared to the adult brain; thus, brain injuries caused by CRT may severely affect their quality of life. In this study, we determined the neuroprotective effects of nasal oxytocin administration following cranial radiation in mice. We investigated the cognitive behavior of mice (novel object recognition test and novel object location test), phosphorylated histone H2AX (γ-H2AX) and K+-Cl- transporter (KCC2) by immunohistochemical analysis of the hippocampal sections, and neuronal cells by immunocytochemistry after radiation and oxytocin administration. We found that the number of γ-H2AX foci was increased, and the surface signal intensity of KCC2 immunofluorescence was decreased in cells that were irradiated with X-rays (1.5 Gy, for three consecutive days) compared with cells that were not. Furthermore, using MQAE, we found that the intracellular chloride ion concentration was downregulated in oxytocin-treated cells by increasing surface KCC2 expression. These results indicate that nasal oxytocin administration after cranial irradiation attenuates cognitive dysfunction in mice and exerts multifaceted neuroprotective effects on DNA damage and maintains chloride ion concentration in neuronal cells.

    DOI: 10.1016/j.bbrc.2022.04.099

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  • Eriko Kuramoto, Ayano Kitawaki, Takakazu Yagi, Hiroshi Kono, Shin-Ei Matsumoto, Hiromitsu Hara, Yasumasa Ohyagi, Haruki Iwai, Atsushi Yamanaka, Tetsuya Goto .  Development of a system to analyze oral frailty associated with Alzheimer's disease using a mouse model. .  Frontiers in aging neuroscience14   935033 - 935033   2022Reviewed International journal

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    The rapid aging of the population makes the detection and prevention of frailty increasingly important. Oral frailty has been proposed as a novel frailty phenotype and is defined as a decrease in oral function coexisting with a decline in cognitive and physical functions. Oral frailty has received particular attention in relation to Alzheimer's disease (AD). However, the pathomechanisms of oral frailty related to AD remain unknown. It is assumed that the mesencephalic trigeminal nucleus (Vmes), which controls mastication, is affected by AD pathology, and as a result, masticatory function may be impaired. To investigate this possibility, we included male 3 × Tg-AD mice and their non-transgenic counterpart (NonTg) of 3-4 months of age in the present study. Immunohistochemistry revealed amyloid-β deposition and excessive tau phosphorylation in the Vmes of 3 × Tg-AD mice. Furthermore, vesicular glutamate transporter 1-immunopositive axon varicosities, which are derived from Vmes neurons, were significantly reduced in the trigeminal motor nucleus of 3 × Tg-AD mice. To investigate whether the AD pathology observed in the Vmes affects masticatory function, we analyzed electromyography of the masseter muscle during feeding. The 3 × Tg-AD mice showed a significant delay in masticatory rhythm compared to NonTg mice. Furthermore, we developed a system to simultaneously record bite force and electromyography of masseter, and devised a new method to estimate bite force during food chewing in mice. Since the muscle activity of the masseter showed a high correlation with bite force, it could be accurately estimated from the muscle activity. The estimated bite force of 3 × Tg-AD mice eating sunflower seeds was predominantly smaller than that of NonTg mice. However, there was no difference in masseter weight or muscle fiber cross-sectional area between the two groups, suggesting that the decreased bite force and delayed mastication rhythm observed in 3 × Tg-AD mice were not due to abnormality of the masseter. In conclusion, the decreased masticatory function observed in 3 × Tg-AD mice was most likely caused by AD pathology in the Vmes. Thus, novel quantitative analyses of masticatory function using the mouse model of AD enabled a comprehensive understanding of oral frailty pathogenesis.

    DOI: 10.3389/fnagi.2022.935033

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  • Haruki Iwai, Koji Ataka, Hajime Suzuki, Ashis Dhar, Eriko Kuramoto, Atsushi Yamanaka, Tetsuya Goto .  Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury. .  Journal of neuroinflammation18 ( 1 ) 227 - 227   2021.10Reviewed International journal

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    BACKGROUND: Macrophages in the peripheral nervous system are key players in the repair of nerve tissue and the development of neuropathic pain due to peripheral nerve injury. However, there is a lack of information on the origin and morphological features of macrophages in sensory ganglia after peripheral nerve injury, unlike those in the brain and spinal cord. We analyzed the origin and morphological features of sensory ganglionic macrophages after nerve ligation or transection using wild-type mice and mice with bone-marrow cell transplants. METHODS: After protecting the head of C57BL/6J mice with lead caps, they were irradiated and transplanted with bone-marrow-derived cells from GFP transgenic mice. The infraorbital nerve of a branch of the trigeminal nerve of wild-type mice was ligated or the infraorbital nerve of GFP-positive bone-marrow-cell-transplanted mice was transected. After immunostaining the trigeminal ganglion, the structures of the ganglionic macrophages, neurons, and satellite glial cells were analyzed using two-dimensional or three-dimensional images. RESULTS: The number of damaged neurons in the trigeminal ganglion increased from day 1 after infraorbital nerve ligation. Ganglionic macrophages proliferated from days 3 to 5. Furthermore, the numbers of macrophages increased from days 3 to 15. Bone-marrow-derived macrophages increased on day 7 after the infraorbital nerve was transected in the trigeminal ganglion of GFP-positive bone-marrow-cell-transplanted mice but most of the ganglionic macrophages were composed of tissue-resident cells. On day 7 after infraorbital nerve ligation, ganglionic macrophages increased in volume, extended their processes between the neurons and satellite glial cells, and contacted these neurons. Most of the ganglionic macrophages showed an M2 phenotype when contact was observed, and little neuronal cell death occurred. CONCLUSION: Most of the macrophages that appear after a nerve injury are tissue-resident, and these make direct contact with damaged neurons that act in a tissue-protective manner in the M2 phenotype. These results imply that tissue-resident macrophages signal to neurons directly through physical contact.

    DOI: 10.1186/s12974-021-02283-z

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  • Kento Igarashi, Toshiko Kuchiiwa, Satoshi Kuchiiwa, Haruki Iwai, Kazuo Tomita, Tomoaki Sato .  Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels. .  Brain research1768   147580 - 147580   2021.10Reviewed International journal

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    Kamishoyosan (KSS), a Japanese traditional herbal formula, is used to treat symptoms related to the autonomic nervous system in men and women; it is especially known for improving the symptoms of irritability (e.g., bad temper and persistent anger). Although clinical and ethological studies of KSS have been conducted, its efficacy in reducing irritability remains to be validated. In the present study, male and female ddY-strain mice were isolation-reared for 8 weeks (from the third postnatal week) to induce pathologically aggressive biting behavior (ABB), which was used as an indicator of irritability. The ABB of mice toward metal rods was measured using the Aggressive Response Meter. An intraperitoneal administration of KSS (100 mg/kg) effectively reduced ABB in male and female mice at 2 h after the administration; however, this effect was canceled by prior administration of WAY-100635 [a 5-hydroxytryptoamine (5-HT)-1A receptor antagonist; 0.5 mg/kg] and bicuculline (a type-A gamma-aminobutyric acid receptor antagonist; 1.0 mg/kg). Additionally, tamoxifen, ICI-182780, and G-15 (all estrogen receptor antagonists) inhibited the action of KSS in a dose-dependent manner. Furthermore, gene expression of tryptophan hydroxylase (Tph) 1 and Tph2 were increased and 5-HT immunofluorescence was slightly increased in the dorsal raphe nucleus (DRN) of isolation-reared mice administered with KSS. Collectively, these results indicate that KSS effectively reduces ABB in isolation-reared male and female mice through stimulation of 5-HT production in the DRN. Our findings also suggest that gene expression of estrogen receptor (Esr) 2 increased in the DRN might be associated with the reduction of ABB.

    DOI: 10.1016/j.brainres.2021.147580

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  • Natasya Trivena Rokot, Koji Ataka, Haruki Iwai, Hajime Suzuki, Homare Tachibe, Timothy Sean Kairupan, Kai-Chun Cheng, Haruka Amitani, Akio Inui, Akihiro Asakawa .  Antagonism for NPY signaling reverses cognitive behavior defects induced by activity-based anorexia in mice .  Psychoneuroendocrinology126   105133 - 105133   2021.4Reviewed International journal

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Patients with AN often express psychological symptoms such as body image distortion, cognitive biases, abnormal facial recognition, and deficits in working memory. However, the molecular mechanisms underlying the impairment of cognitive behaviors in AN remain unknown. In the present study, we measured cognitive behavior using novel object recognition (NOR) tasks and mRNA expressions in hypothalamic neuropeptides in female C57BL/6J mice with activity-based anorexia (ABA). Additionally, we evaluated the effects of antagonists with intracerebroventricular (icv) administration on the impairment of cognitive behavior in NOR tasks. Our results showed that NOR indices were lowered, subsequently increasing mRNA levels of agouti-related peptide (AgRP) and neuropeptide Y (NPY), and c-Fos- and AgRP- or NPY-positive cells in the hypothalamic arcuate nucleus in ABA mice. We also observed that icv administration of anti-NPY antiserum (2 µl), anti-AgRP antibody (0.1 μg), and Y5 receptor antagonist CPG71683 (15 nmol) significantly reversed the decreased NOR indices. Therefore, our results suggest that increased NPY and AgRP signaling in the brain might contribute to the impairment of cognitive behavior in AN.

    DOI: 10.1016/j.psyneuen.2021.105133

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  • Dhar Ashis, Kuramoto Eriko, Fukushima Makoto, Iwai Haruki, Yamanaka Atsushi, Goto Tetsuya .  The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice .  ACTA HISTOCHEMICA ET CYTOCHEMICA54 ( 1 ) 11 - 19   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY  

    <p>Proprioception from masticatory apparatus and periodontal ligaments comes through the trigeminal mesencephalic nucleus (Vmes). We evaluated the effects of tooth loss on neurodegeneration of the Vmes and trigeminal motor nucleus (Vmo). Bilateral maxillary molars of 2-month-old C57BL/6J mice were extracted under anesthesia. Neural projections of the Vmes to the periodontium were confirmed by injecting Fluoro-Gold (FG) retrogradely into the extraction sockets, and for the anterograde labeling adeno-associated virus encoding green fluorescent protein (AAV-GFP) was applied. For immunohistochemistry, Piezo2, ATF3, Caspase 3, ChAT and TDP-43 antibodies were used. At 1 month after tooth extraction, the number of Piezo2-immunoreactive (IR) Vmes neurons were decreased significantly. ATF3-IR neurons were detected on day 5 after tooth extraction. Dead cleaved caspase-3-IR neurons were found among Vmes neurons on days 7 and 12. In the Vmo, neuronal cytoplasmic inclusions (NCIs) formation type of TDP-43 increased at 1 and 2 months after extraction. These indicate the existence of neural projections from the Vmes to the periodontium in mice and that tooth loss induces the death of Vmes neurons followed by TDP-43 pathology in the Vmo. Therefore, tooth loss induces Vmes neuronal cell death, causing Vmo neuro­degeneration and presumably affecting masticatory function.</p>

    DOI: 10.1267/ahc.20-00036

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  • Ashis Dhar, Eriko Kuramoto, Makoto Fukushima, Haruki Iwai, Atsushi Yamanaka, Tetsuya Goto .  The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice. .  Acta histochemica et cytochemica54 ( 1 ) 11 - 19   2021.2The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice.Reviewed International journal

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  • Tetsuya Goto, Eriko Kuramoto, Ashis Dhar, Rachel Pei-Hsuan Wang, Haruka Seki, Haruki Iwai, Atsushi Yamanaka, Shin-Ei Matsumoto, Hiromitsu Hara, Makoto Michikawa, Yasumasa Ohyagi, Wai Keung Leung, Raymond Chuen-Chung Chang .  Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice .  Journal of Alzheimer's disease76 ( 4 ) 1443 - 1459   2020.8Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model MiceReviewed International journal

  • Kazuhiro Shiozaki , Momoko Kawabe , Kiwako Karasuyama , Takayoshi Kurachi , Akito Hayashi , Koji Ataka , Haruki Iwai , Hinako Takeno , Oki Hayasaka , Tomonari Kotani , Masaharu Komatsu , Akio Inui .  Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio). .  Scientific reports10 ( 1 ) 5913 - 5913   2020.4Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio). Reviewed International journal

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  • Hajime Suzuki, Koji Ataka, Akihiro Asakawa, Kai-Chun Cheng, Miharu Ushikai, Haruki Iwai, Takakazu Yagi, Takeshi Arai, Kinnosuke Yahiro, Katsuhiro Yamamoto, Yoshito Yokoyama, Masayasu Kojima, Toshihiko Yada, Toshiya Hirayama, Norifumi Nakamura, Akio Inui .  Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice. .  Scientific reports9 ( 1 ) 6011 - 6011   2019.4Reviewed International journal

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    Helicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalamic urocortin1 (Ucn1). VacA was detected in the hypothalamus after peripheral administration and increased Ucn1 mRNA expression and c-Fos-positive cells in the hypothalamus but not in the nucleus tractus solitarius. c-Fos and Ucn1-double positive cells were detected. CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively. VacA activated single paraventricular nucleus neurons and A7r5 cells; this activation was inhibited by phospholipase C (PLC) and protein kinase C (PKC) inhibitors. VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis.

    DOI: 10.1038/s41598-019-42163-4

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  • Furukawa M, Tsukahara T, Tomita K, Iwai H, Sonomura T, Miyawaki S, Sato T .  Neonatal maternal separation delays the GABA excitatory-to-inhibitory functional switch by inhibiting KCC2 expression .  Biochemical and Biophysical Research Communications493 ( 3 ) 1243 - 1249   2017.11Neonatal maternal separation delays the GABA excitatory-to-inhibitory functional switch by inhibiting KCC2 expressionReviewed International journal

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  • Goto T, Iwai H, Kuramoto E, Yamanaka A .  Neuropeptides and ATP signaling in the trigeminal ganglion .  Jpn Dent Sci Rev53 ( 4 ) 117 - 124   2017.11Neuropeptides and ATP signaling in the trigeminal ganglionReviewed International journal

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  • Kuramoto E, Iwai H, Yamanaka A, Ohno S, Seki H, Tanaka YR, Furuta T, Hioki H, Goto T .  Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors .  J Comp Neurol525 ( 1 ) 166 - 185   2017.8Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectorsReviewed International journal

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  • Kuramoto E, Pan S, Furuta T, Tanaka YR, Iwai H, Yamanaka A, Ohno S, Kaneko T, Goto T, Hioki H .  Individual mediodorsal thalamic neurons project to multiple areas of the rat prefrontal cortex: A single neuron-tracing study using virus vectors .  J comp neurol525   166 - 185   2017.1Individual mediodorsal thalamic neurons project to multiple areas of the rat prefrontal cortex: A single neuron-tracing study using virus vectorsReviewed International journal

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  • Tsukahara T, Masuhara M, Iwai H, Sonomura T, Sato T .  The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice .  Data in Brief6   521 - 525   2016.3Reviewed International journal

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    DOI: doi:10.1016/j.dib.2015.12.041

  • Tsukahara T, Masuhara M, Iwai H, Sonomura T, Sato T .  Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female mice .  Biochemical and Biophysical Research Communications17 ( 2 ) 127 - 138   2015.8Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female miceReviewed International journal

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  • Yamanaka A, Iwai H, Uemura M, Goto T .  Patterning of mammalian heterodont dentition within the upper and lower jaws .  Evolution and Development17 ( 2 ) 127 - 138   2015.3Patterning of mammalian heterodont dentition within the upper and lower jawsReviewed International journal

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  • Uemura M, Sonomura T, Iwai H, Yamanaka A .  Localization of masticatory motoneurons in the trigeminal motor nucleus of shrew and pig, with emphasis on the innervation ratio in the shrew .  Journal of Oral Biosciences55 ( 2 ) 101 - 107   2013.4Localization of masticatory motoneurons in the trigeminal motor nucleus of shrew and pig, with emphasis on the innervation ratio in the shrewReviewed International journal

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  • Sonomura T, Furuta T, Nakatani I, Yamamoto Y, Unzai T, Matsuda W, Iwai H, Yamanaka A, Uemura M, Kaneko T .  Correlative Analysis of Immunoreactivity in Confocal Laser-Scanning Microscopy and Scanning Electron Microscopy with Focused Ion Beam Milling .  Frontiers in Neural Circuits7 ( Article 26 )   2013.3Correlative Analysis of Immunoreactivity in Confocal Laser-Scanning Microscopy and Scanning Electron Microscopy with Focused Ion Beam MillingReviewed International journal

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  • Yamanaka A., Yasui K., Sonomura T., Iwai H., Uemura M. .  Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus) .  Arch Oral Biol.55 ( 4 ) 279 - 287   2010.4Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus)Reviewed International journal

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Books

  • Pro Tips & Techniques for Drawing Animals

    Author: Michiyo Miyanaga (Haruki Iwai, Role: Provides skeletal drawings)

    Tuttle Pub  2023.8  ( ISBN:0804856117

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    Total pages:185  

    ASIN

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  • レイの美術解剖学 躍動する人体を描くための実践的なアプローチ

    岩井 治樹( Role: Joint translator ,  PART2 解剖学の応用)

    マール社  2022.11  ( ISBN:4837306918

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  • 動物デッサンの基本とコツ : ゼロから学ぶプロの技法 : 驚くほどリアルに描ける!完成度が上がる!

    著者: 宮永 美知代 (岩井 治樹, 担当: 動物骨格デッサンの提供)

    ソーテック社  2020.8  ( ISBN:9784800730220

  • モーションを描くための美術解剖学

    岩井 治樹( Role: Joint translator ,  第12章: リズミカルな動き、第13章: 連続する動き)

    マール社  2018.5 

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    Language:Japanese Book type:Scholarly book

  • 顔の百科事典

    岩井 治樹( Role: Joint author ,  肖像画の顔)

    丸善出版  2015.9 

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    Language:Japanese Book type:Scholarly book

  • 動物デッサンの基本 : 美術解剖学を基礎にした : 骨格・生態・動作をとらえて生き生きとリアルに描ける

    著者: 宮永 美知代 (岩井 治樹, 担当: 動物骨格デッサンの提供)

    ナツメ社  2013.10  ( ISBN:9784816351662

  • アーティストのための美術解剖学

    岩井 治樹( Role: Joint translator ,  第1章:解剖学用語)

    マール社  2013.4 

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    Language:Japanese Book type:Scholarly book

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MISC

  • 消化管ペプチド・骨髄由来細胞による情動行動の調節 Invited

    岩井治樹, 和田みどり, 浅川明弘

    日本心療内科学会誌   26 ( 3 )   50 - 54   2022.10

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  • 患者参加型医療における味覚BMIの可能性

    薗村貴弘, 岩井治樹

    Precision Medicine   2 ( 11 )   88 - 91   2019.10

  • 結合腕傍核を起点とする線条体腹側部の機能形態学:摂食行動と味覚/内臓感覚とを結びつける神経回路 Invited

    岩井治樹

    自律神経   56 ( 1 )   7 - 13   2019.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

  • QOL維持・向上のための味覚BMIに対するニーズと可能性.

    薗村貴弘, 岩井治樹

    地域ケアリング   21 ( 2 )   99 - 102   2019.1

  • 味覚BMIの現在地と今後の展望

    薗村貴弘, 岩井治樹

    BIO Clinica   33 ( 14 )   90 - 92   2018.11

  • 人工の舌「味覚BMI」~美味しさをいつまでも感じ続けるために~

    薗村 貴弘, 岩井 治樹

    地域ケアリング   19 ( 13 )   112 - 115   2017.10

  • 味覚BMI開発の現状と未来

    薗村 貴弘, 岩井 治樹

    Medical Science Digest   43 ( 10 )   22 - 24   2017.9

  • 食物の好き嫌いを生み出す脳のメカニズム Invited

    岩井治樹, 倉本恵梨子, 山中淳之, 後藤哲哉

    鹿歯会報 TEETHful   131 ( 710 )   9 - 11   2017.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • 連続切片のin situハイブリダイゼーションを利用した遺伝子発現の3次元再構築法

    山中 淳之, 岩井 治樹, 倉本 恵梨子, 後藤 哲哉

    鹿児島大学歯学部紀要   35   87 - 92   2015.3

  • 顎顔面の運動神経細胞の脳内分布,および味覚の神経回路

    植村 正憲, 薗村 貴弘, 岩井 治樹, 山中 淳之

    鹿児島大学歯学部紀要   33   3 - 17   2013.3

  • 表情筋は咀嚼にいかにかかわるか Invited

    田松 裕一, 岩井 治樹, 島田 和幸

    歯科臨床研究   3 ( 2 )   52 - 60   2006.7

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Presentations

  • 岩井 治樹、アシス ダール、倉本 恵梨子、後藤 哲哉   三叉神経節の組織常在性マクロファージ様細胞は神経損傷によって一次神経細胞に接触する  

    第12回三叉神経領域の感覚‐運動統合機構研究会 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Haruki Iwai, Eriko Kuramoto, Ashis Dhar, Atsushi Yamanaka, Tetsuya Goto   Peripheral nerve injury induces the proliferation and activation of M2 resident macrophage-like cells in the mouse trigeminal ganglion  

    第60回歯科基礎医学会学術大会 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

  • 岩井 治樹,倉本恵梨子,山中 淳之,Dhar Ashis,後藤 哲哉   マウス三叉神経節のマクロファージ様細胞は神経傷害によって増殖・活性化する  

    第59回歯科基礎医学会学術大会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Haruki Iwai   Functional morphology of the ventral part of the caudate putamen originating from the parabrachial nucleus: Neural circuits connecting between feeding behavior and gustatory and visceral senses   Invited International conference

    ISAN/JSNR 2017 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (general)  

  • 岩井 治樹、倉本 恵梨子、山中 淳之、後藤 哲哉   ラット三叉神経節における神経細胞?衛星細胞?マクロファージ様細胞間の細胞外ATPによる情報伝達機構  

    第122回日本解剖学会総会全国学術集会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 岩井治樹、倉本恵梨子、山中淳之、後藤哲哉   ラット三叉神経節における VNUT を介した神経細胞、衛星細胞、およびミクログリア様細胞間の細胞外 ATP 情報伝達  

    第58回歯科基礎医学会学術大会  

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

  • Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka, Tetsuya Goto   Neuron-satellite glia-microglia signaling in the rat trigeminal ganglion  

    第39回日本神経科学大会 

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    Event date: 2016.7

    Language:English   Presentation type:Poster presentation  

  • Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka, Tetsuya Goto   ATP mediates neuron-satellite glia-microglia signaling in the rat trigeminal ganglion   International conference

    IADR 2016 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

  • 岩井 治樹、倉本 恵梨子、後藤 哲哉   ラット三叉神経節における神経細胞および衛星細胞の小胞型ヌクレオチドトランスポーターの発現と分布  

    第121回日本解剖学会総会全国学術集会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Poster presentation  

  • 岩井 治樹、倉本 恵梨子、後藤 哲哉   三叉神経節における神経節細胞および衛星細胞の小胞型ヌクレオチドトランスポーターの発現と分布  

    第9回三叉神経領域の感覚‐運動統合機構研究会 

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    Event date: 2015.12

    Language:English   Presentation type:Oral presentation (general)  

  • 岩井治樹, 倉本恵梨子, 山中淳之, 後藤哲哉   味覚神経回路と摂食行動の神経回路は、視床髄板内核群尾腹側部を介して結合する  

    第71回解剖学会九州支部学術集会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Iwai H, Kuramoto E, Yamanaka A, Goto T   Projection pattern of the ventrocaudal part of the intralaminar thalamic nucleus to the caudate putamen in the rat brain   International conference

    Neuroscience 2015 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

  • 岩井治樹, 倉本恵梨子, 山中淳之, 後藤哲哉   摂食行動と内臓感覚とを結びつける新たな神経回路  

    第57回 歯科基礎医学会学術大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Iwai H, Kuramoto E, Yamanaka A, Goto T   Ascending parabrahio-thalamo-striatal pathways in the rat brain  

    第38回 日本神経科学大会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Poster presentation  

  • Iwai H, Kuramoto E, Yamanaka A, Goto T   Gustatory pathways from the parabrachial nuclei to the ventral part of the caudate putamen via the caudal part of the intralaminar thalamic nuclei in rat brain  

    第120回 日本解剖学会総会・全国学術大会  第120回 日本解剖学会総会・全国学術大会

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    Event date: 2015.3

    Language:Japanese  

    Venue:兵庫  

    国内学会

  • 岩井治樹, 山中淳之, 後藤哲哉   ラットにおける視床髄板内核群から線条体腹側部への味覚投射  

    第56回 歯科基礎医学会学術大会  第56回 歯科基礎医学会学術大会

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    Event date: 2014.9

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 岩井治樹, 山中淳之   ラットにおける結合腕傍核-視床-線条体味覚路  

    第119回 日本解剖学会総会・全国学術大会  第119回 日本解剖学会総会・全国学術大会

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    Event date: 2014.3

    Language:Japanese  

    Venue:栃木  

    国内学会

  • 岩井治樹, 薗村貴弘, 山中淳之, 植村正憲   ラットにおける結合腕傍核・視床ニューロンと視床・線条体ニューロンの神経連絡  

    第117回 日本解剖学会総会・全国学術大会  第117回 日本解剖学会総会・全国学術大会

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    Event date: 2012.3

    Language:Japanese  

    Venue:山梨  

    国内学会

  • 岩井治樹, 薗村貴弘, 山中淳之, 植村正憲   ラット結合腕傍核から視床への味覚投射  

    第52回 歯科基礎医学会学術大会  第52回 歯科基礎医学会学術大会

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    Event date: 2010.9

    Language:Japanese  

    Venue:東京  

    国内学会

  • Iwai H., Sonomura T., Yamanaka A., Uemura M.   Territory of gustatory area in the rat thalamus  

    第33回 日本神経科学大会  第33回 日本神経科学大会

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    Event date: 2010.9

    Language:Japanese  

    Venue:兵庫  

    国内学会

  • 岩井治樹, 薗村貴弘, 山中淳之, 植村正憲   ラット後内側腹側核小細胞部から扁桃体中心核および線条体への投射  

    第115回 日本解剖学会総会・全国学術大会  第115回 日本解剖学会総会・全国学術大会

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    Event date: 2010.3

    Language:Japanese  

    Venue:岩手  

    国内学会

  • Iwai H., Sonomura T., Yamanaka A., Uemura M   Neural connections among the thalamic gustatory area, amygdaloid complex and bed nucleus of the stria terminalis in the rat  

    第32回 日本神経科学大会  第32回 日本神経科学大会

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    Event date: 2009.9

    Language:Japanese  

    Venue:愛知  

    国内学会

  • 岩井治樹, 薗村貴弘, 山中淳之, 植村正憲   ラット扁桃体中心核から分界条床核への投射  

    第114回 日本解剖学会総会・全国学術大会  第114回 日本解剖学会総会・全国学術大会

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    Event date: 2009.3

    Language:Japanese  

    Venue:岡山  

    国内学会

  • 岩井治樹,島田和幸   眼輪筋の外側における小頬骨筋の形態  

    第111回 日本解剖学会総会・全国学術集会  第111回 日本解剖学会総会・全国学術集会

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    Event date: 2006.3

    Language:Japanese  

    Venue:神奈川  

    国内学会

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Awards

  • 令和3年度ベストリサーチャー賞

    2022.12   鹿児島大学歯学部  

    岩井 治樹

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  • 平成28年度ベストリサーチャー賞

    2016.9   鹿児島大学歯学部  

    岩井 治樹

  • 平成27年度 奨励賞

    2015.10   鹿児島大学歯学部同窓会  

    岩井 治樹

  • 第2回 芸術科学会 (DiVA) 展 奨励賞

    2004.4   芸術科学会  

    岩井治樹, 中村恭子, 大石真依子, 坂井れいしう, 銅金裕司

Research Projects

  • 自閉スペクトラム症モデル動物の口腔感覚異常は、栄養、発育、行動異常に影響するか?

    Grant number:24K14774  2024.4 - 2028.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    岩井 治樹, 八坂 敏一, 鈴木 甫

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • 自閉スペクトラム症における口腔感覚異常の改善は、心身の発育・ 発達を促進できるか?

    2023.9 - 2024.3

    鹿児島大学  若手研究者研究支援事業 

    岩井 治樹

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  • Morphological exploration of cognitive neurocircuits for the gustatory brain-machine interface

    Grant number:23K10461  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

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  • 植物由来セスキテルペン類によるがんおよびがん性疼痛の予防・治療効果の実証

    2023.4 - 2024.3

    公益財団法人サンケイ科学振興財団  科学研究助成 

    岩井 治樹

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  • 終末期の病態解明と新規治療法開発ー骨髄‐脳‐筋相関と運動からのアプローチー

    Grant number:22K07423  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    浅川 明弘, 岩井 治樹, 安宅 弘司, 加藤 郁夫, 網谷 東方

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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  • 痛みと痒みのラベルドライン神経回路における脊髄後角モジュールの同定

    Grant number:21K07303  2021.4 - 2024.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    八坂 敏一, 岩井 治樹

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    本来痛みや痒みは、有害な刺激から身体を守るために重要な役割を持つが、慢性化した病態では、本来の役割は失われ、耐え難い痛みや痒みに長時間晒され、QOLの著しい低下をもたらす。特に既存の治療が奏効しないケースが問題であり、より良い治療のためには発症メカニズムの解明が必要不可欠である。近年、痛みと痒みは異なった知覚神経と脊髄後角局所神経回路で処理されることが明らかになってきた。
    脊髄後角には様々なインターニューロンが存在する。機能的な分類では、情報伝達を促進する興奮性細胞と、反対に情報伝達を遮断する抑制性細胞がある。また、形態学的分類では4種類の細胞(vertical, islet, radial, central)が認識されている。代表的な興奮性細胞であるvertical cellは、最初痛みの伝達に重要な細胞と報告された。しかし、近年の痒み研究の著しい発展により、痒みの伝達にもvertical cellが関与することが報告された。おそらく、脊髄後角における痛みの伝達にも痒みの伝達にもvertical cellの形態を持つ神経が関わると考えられる。痛みに関わると考えられてきた脊髄後角神経回路の基本モジュールが報告されている。本研究では、この基本モジュールを基に考え、痛みと痒みの基本モジュールはどれほど類似し、何が違うのかについて明らかにすることを目的とする。
    研究代表者は、現職に2020年度より赴任し、コロナ禍の影響もあり、実験環境の構築が不十分であったため、本年度は、実験環境の構築に必要な備品を購入し、セットアップを行った。

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  • Investigation of the cause of mental illnesses using model mice with early-life and adolescent stress

    Grant number:21K07343  2021.4 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

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  • 高次味覚BMI開発のための美味しさを認識する脳内味覚地図の解析

    Grant number:20K11195  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    薗村 貴弘, 岩井 治樹, 古田 貴寛, 大平 耕司, 松田 和郎

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    Authorship:Coinvestigator(s) 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    近年のBMIの進歩はめざましく、自分の脳で思い描いた通りに自由に動く義手や、聾者の聴覚を回復させる人工内耳の開発も盛んに行われている。しかし舌癌などで味覚を喪失してしまった人に対する味覚BMIの試みは未だ行われていない。口腔の主な機能は栄養の摂取であるが人生の最後まで美味しくかつ安心安全にものを食することや口から味を感じながら生活することはQOLの向上に極めて重要である。そこで本研究では脳内味覚回路がヒトに近似している霊長類の中でも我が国で積極的に使われているコモン・マーモセットを対象に最新の細胞外記録法として注目されているjuxtacellular recording法を用いることにより脳内の味覚地図を解明し味覚BMIの開発に向けた基礎的データを供給すること目指している。脳内の味覚回路には、安全な食べ物か危険な食べ物か、必要とされる食べ物や飲み物かなどを判断する比較的原始的な生存のための摂食行動を引き起こす味覚と、より嗜好性の高い脳の高次機能としての美味しさを感じる味覚が存在しこれらは脳内の途中で分岐し異なる経路を形成している。しかしその分岐点とされる一次味覚野や島皮質以降の味覚脳内回路はあまり解明されておらず、美味しさを感じる味覚地図は未だほとんど空白のままである。そこで、現在、高次認知と情動とを統合する役割を持つ島皮質に注目しその前後の解析を進めている。しかし、新たな研究環境の再起ち上げによる機材や試料の管理などの関係で研究遂行はやや停滞しており、島皮質に至るまでのより末梢の神経回路や他の研究試料での味覚神経回路への対象領域の拡大を含め幅広く解析を進めている。

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  • 神経節マクロファージとニューロンとのコンタクトは神経因性疼痛のスイッチとなるか?

    Grant number:20K09881  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    岩井 治樹, 鈴木 甫, 八坂 敏一, 安宅 弘司

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    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    本研究の目的は、口腔や顔面の神経因性疼痛時、「血管浸潤性あるいは組織常在性マクロファージが神経節ニューロンにコンタクトすることで、このニューロン の遺伝子発現が誘導され、ここから産生された因子が中枢に放出、二次ニューロンの活動を促進し、神経因性疼痛が惹起される」という仮説を証明することである。
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    これまでに、血管浸潤性あるいは組織常在性マクロファージを同定する目的で、キメラマウスを作製し、三叉神経 (上顎神経) を切断、潅流固定後、免疫組織染色した。その結果、神経損傷7日後、三叉神経節では、GFP 陽性・Iba1 陽性の血管浸潤性マクロファージおよび GFP 陰性・Iba1 陽性の組織常在性マクロファージ両方の細胞数の増加が認められた。血管浸潤性マクロファージと組織常在性マクロファージを比較したところ、神経節に存在するマクロファージの大部分は組織常在性であることが明らかとなった。さらに、Iba1陽性マクロファージ、NeuroTrace 陽性神経節ニューロン、およびグルタミン合成酵素陽性衛星細胞の三次元再構築像を構成したところ、多数のマクロファージが神経節ニューロンと衛星細胞との間に入り込み、さらにマクロファージとニューロンとの間でコンタクト様構造を示すことが明らかとなった。
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    本年度は、このコンタクト様構造が実際に接触しているかどうか電子顕微鏡を用いて形態解析を行った。その結果、電子密度の高い脂質体とリソソームを持つマクロファージがニューロンと直接接触していることが明らかとなった。さらにこのマクロファージの機能を同定する目的で、M1型 炎症性マクロファージのマーカーである CD86 および M2型 組織修復性マクロファージのマーカーである CD206 による解析を行った。その結果、神経損傷7日目では、ほとんどのマクロファージは、CD206 陽性の組織修復性マクロファージであった。

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  • 自閉スペクトラム症 (ASD) における社会的行動障害および感覚刺激に対する反応異常の発症機構の解明

    2019.11 - 2021.3

    鹿児島大学  異分野融合研究プロジェクト創出研究助成 事業 (K-ips 研究助成事業) 

    岩井 治樹, 塩崎 一弘, 鈴木 甫, 八坂 敏一, 富原 一哉, 浅川 明弘, 安宅 弘司

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    Authorship:Principal investigator 

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  • マクロファージ様細胞と神経細胞とのコンタクトは神経因性疼痛の スイッチとなるか?

    2019.11 - 2020.3

    鹿児島大学  若手研究者研究支援事業 

    岩井 治樹

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  • 口腔顔面痛の病態解明に向けた三叉神経節における神経と免疫のクロストークの探索

    2018.9 - 2019.3

    鹿児島大学  若手研究者研究支援事業 

    岩井 治樹

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    Authorship:Principal investigator  Grant type:Competitive

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  • 美術解剖学教育の交流と展開 ー独、UK、USA、NZの教育・研究の比較を通してー

    2018.4 - 2023.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • The interaction and develipment of artistic anatomy education -Through the comparison with the education in Germany, UK, USA and NZ-

    Grant number:18K00227  2018.4 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • Effects of brain-gut peptides on the amelioration of stress-induced abnormalities of maxillofacial function.

    Grant number:18K09838  2018.4 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Yagi Takakazu

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    Authorship:Coinvestigator(s) 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    The purpose of this study was to elucidate some of the mechanisms of the development of bruxism-like movements induced by intracerebroventricular administration of corticosteroid releasing factor (CRF), a stressor, or by physical restraints, focusing on the relationship between stress and the trigeminal nervous system. The parabrachial nucleus of the connecting arm and the locus coeruleus in the region of the trigeminal mesencephalic tract nucleus were positive for anti-c-Fos antibodies. In restraint stress, immunopositive cells were observed around the trigeminal motor nucleus and in the lateral nucleus of the hypothalamus, and double-labeled cells of c-Fos and orexin were observed. These results suggest that the connecting arm antinuclear nucleus, locus coeruleus, and orexin cells may be potentially contributing to bruxism-like behavior.

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  • 脳腸ペプチドによるストレス起因性顎口腔機能異常の改善に対する効果の検証

    2018.4 - 2020.3

    科学研究費補助金  科学研究費補助金   基盤研究(C)

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    Authorship:Coinvestigator(s) 

  • 食行動の基本原理の解明:単一味覚ニューロン標識法による大脳皮質味覚マッピング

    2014.4 - 2017.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  • 単一ニューロン記録法・標識法を用いた食行動を呼び起こす味覚神経回路の解析

    2012.4 - 2014.3

    科学研究費補助金  若手研究(B)

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  • 味覚神経回路と報酬系神経回路との相互線維連絡の形態学的解析

    2010.4 - 2012.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

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Other research activities

  • 学芸員資格

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  • 教育職員免許状 高等学校教諭 第一種 (美術・工芸)

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  • 教育職員免許状 中学校教諭 第一種 (美術)

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Teaching Experience

  • 運動器疾患

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  • 美術解剖学-人とかたち-

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  • 解剖生理学

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  • 美術解剖学

    Institution:名古屋造形大学

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  • 組織学

    Institution:鹿児島大学

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  • 神経解剖学

    Institution:鹿児島大学

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  • 口腔組織学

    Institution:鹿児島大学

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  • 生物学

    Institution:長岡造形大学

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  • 教員免許更新講習 食育と味覚の基礎

    Institution:鹿児島大学

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  • 研究実践

    Institution:鹿児島大学

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