Updated on 2023/08/03

写真a

 
SUZUKI Shinsuke
 
Organization
University Hospital, Medical and Dental Sciences Area University Hospital Clinical Facilities Cancer Center

Degree

  • 博士(医学) ( 2003.3   鹿児島大学 )

Research Interests

  • 白血病幹細胞

  • 癌特異的増殖型アデノウイルス

  • RI標識抗体療法

  • 分子標的治療

  • 成人T細胞白血病

Research Areas

  • Life Science / Hematology and medical oncology

Education

  • Kagoshima University

    - 2003.3

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    Country: Japan

  • Kagoshima University

    1984.4 - 1991.3

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    Country: Japan

Research History

  • Kagoshima University   Medical and Dental Hospital, Medical and Dental Sciences Area Medical and Dental Hospital Clinical Facilities Cancer Center

    2020.4

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Clinical Oncology   Senior Assistant Professor

    2017.4 - 2020.3

  • Kagoshima University   Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Clinical Oncology   Assistant Professor

    2006.4 - 2017.3

Professional Memberships

  • 日本がん治療認定医機構

    2015.10

  • 日本臨床腫瘍学会

    2015.10

  • 日本臨床血液学会

    2015.10

  • 日本血液学会

    2015.10

  • 日本内科学会

    2015.10

Studying abroad experiences

  • 2005.4 - 2006.3   ライプニッツ研究施設 ドイツ微生物・細胞研究所   客員研究員

Qualification acquired

  • Specialist

  • Specialist

  • Specialist

 

Papers

  • Suzuki S, Kofune H, Uozumi K, Yoshimitsu M, Arima N, Ishitsuka K, Ueno SI, Kosai KI. .  A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma .  BMC Cancer19 ( 1 ) 516 - 516   2019.5A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-019-5730-1.

    Other Link: https://doi.org/10.1186/s12885-019-5730-1

  • Suzuki S, Nagel S, Schneider B, Chen S, Kaufmann M, Uozumi K, Arima N, Drexler HG, MacLeod RA. .  A second NOTCH1 chromosome rearrangement: t(9;14)(q34.3;q11.2) in T-cell neoplasia. .  Leukemia23 ( 5 ) 1003 - 1006   2009.5A second NOTCH1 chromosome rearrangement: t(9;14)(q34.3;q11.2) in T-cell neoplasia.Reviewed

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  • Arai A., Yoshimitsu M., Otsuka M., Ito Y., Miyazono T., Nakano N., Obama K., Nakashima H., Hanada S., Owatari S., Nakamura D., Tokunaga M., Kamada Y., Utsunomiya A., Haraguchi K., Hayashida M., Fujino S., Odawara J., Tabuchi T., Suzuki S., Hamada H., Kawamoto Y., Uchida Y., Hachiman M., Ishitsuka K. .  Identification of putative noncanonical driver mutations in patients with essential thrombocythemia .  European Journal of Haematology110 ( 6 ) 639 - 647   2023.6

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    Language:Japanese   Publisher:European Journal of Haematology  

    Essential thrombocythemia (ET) cases without canonical JAK2, CALR, or MPL mutations, that is, triple-negative (TN) ET, have been found in 10%–20% of ET cases. Owing to the limited number of TN ET cases, its clinical significance remains unclear. This study evaluated TN ET's clinical characteristics and identified novel driver mutations. Among 119 patients with ET, 20 (16.8%) had no canonical JAK2/CALR/MPL mutations. Patients with TN ET tended to be younger and had lower white blood cell counts and lactate dehydrogenase values. We identified putative driver mutations in 7 (35%): MPL S204P, MPL L265F, JAK2 R683G, and JAK2 T875N were previously reported as candidate driver mutations in ET. Moreover, we identified a THPO splicing site mutation, MPL*636Wext*12, and MPL E237K. Four of the seven identified driver mutations were germline. Functional studies on MPL*636Wext*12 and MPL E237K revealed that they are gain-of-function mutants that increase MPL signaling and confer thrombopoietin hypersensitivity with very low efficiency. Patients with TN ET tended to be younger, although this was thought to be due to the inclusion of germline mutations, hereditary thrombocytosis. Accumulating the genetic and clinical characteristics of noncanonical mutations may help future clinical interventions in TN ET and hereditary thrombocytosis.

    DOI: 10.1111/ejh.13945

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  • Iwaya H., Tanimoto A., Toyodome K., Kojima I., Hinokuchi M., Tanoue S., Hashimoto S., Kawahira M., Arima S., Kanmura S., Akahane T., Higashi M., Suzuki S., Ueno S., Ohtsuka T., Ido A. .  Next-Generation Sequencing Analysis of Pancreatic Cancer Using Residual Liquid Cytology Specimens from Endoscopic Ultrasound—Guided Fine-Needle Biopsy: A Prospective Comparative Study with Tissue Specimens .  Diagnostics13 ( 6 )   2023.3

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    Language:Japanese   Publisher:Diagnostics  

    This study evaluated the feasibility and clinical utility of liquid-based cytology (LBC) specimens via endoscopic ultrasound–guided fine-needle biopsy (EUS-FNB) for next-generation sequencing (NGS) of pancreatic cancer (PC). We prospectively evaluated the performance of DNA extraction and NGS using EUS-FNB samples obtained from PC. Thirty-three consecutive patients with PC who underwent EUS-FNB at our hospital were enrolled. DNA samples were obtained from 96.8% of the patients. When stratified with a variant allele frequency (VAF) > 10% tumor burden, the NGS success rate was 76.7% (n = 23) in formalin-fixed paraffin-embedded (FFPE), 83.3% (n = 25) in LBC, and 76.7% (n = 23) in frozen samples. The overall NGS success rate was 86.7% (n = 26) using FFPE, LBC, or frozen samples. The detection rates for the main mutated genes were as follows: 86.7% for KRAS, 73.3% for TP53, 66.7% for CDKN2A, 36.7% for SMAD4, and 16.7% for ARID1A. LBC had the highest median value of VAF (23.5%) for KRAS and TP53. PC mutation analysis using NGS was successfully performed using LBC compared with FFPE and frozen samples. This approach provides an alternative and affordable source of molecular testing materials.

    DOI: 10.3390/diagnostics13061078

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  • Suzuki S., Hourai S., Uozumi K., Uchida Y., Yoshimitsu M., Miho H., Arima N., Ueno S.i., Ishitsuka K. .  Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression .  BMC Cancer22 ( 1 ) 1065   2022.12

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    Language:Japanese   Publisher:BMC Cancer  

    Background: Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted agent. NOTCH1 is also expressed in other malignant neoplasms. We aimed to determine the function of NOTCH1 expression and the effects of GSI on adult T-cell leukemia/lymphoma (ATL) caused by long-term human T-cell leukemia virus type I (HTLV-1) infection. Methods: We analyzed the expression of NOTCH1 in six ATL- and HTLV-1-infected cell lines and investigated the influence of activated NOTCH1 (i.e., the cleaved form of NOTCH1) together with GSI on cell proliferation. Results: Activated NOTCH1 found in ATL- and HTLV-1-infected cell lines was undetectable after incubation with GSI, regardless of Tax expression (HTLV-1-coded protein). Whole-exome sequencing revealed that activated NOTCH1 mutations were undetectable in six ATL- and HTLV-1-infected cell lines, regardless of abundant NOTCH1 expression. Moreover, GSI did not suppress the growth of ATL cell lines. Conclusions: These findings suggested that NOTCH1 protein is constitutively activated but is likely a passenger during NOTCH1-mutation-negative ATL cell proliferation.

    DOI: 10.1186/s12885-022-10003-w

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  • Kirishima M., Akahane T., Higa N., Suzuki S., Ueno S., Yonezawa H., Uchida H., Hanaya R., Yoshimoto K., Shimajiri S., Kitazono I., Tanimoto A. .  IDH-mutant astrocytoma with an evolutional progression to CDKN2A/B homozygous deletion and NTRK fusion during recurrence: A case report .  Pathology Research and Practice239   154163   2022.11

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    Language:Japanese   Publisher:Pathology Research and Practice  

    We reported a case of molecularly defined isocitrate dehydrogenase (IDH)-mutant astrocytoma that recurred twice with aggressive behavior and increased anaplastic morphology. Primary and recurrent tumors were analyzed using custom-made DNA-based cancer gene and RNA-based fusion panels for next-generation sequencing (NGS). NGS analyses revealed that recurrent astrocytoma, in addition to IDH1 and tumor protein 53 mutations detected in the primary lesion, harbored cyclin-dependent kinase inhibitor (CDKN) 2 A/B homozygous deletion and neurotrophic tropomyosin receptor kinase 2 (NTRK2) fusion genes that consisted of golgin A1- and cyclin-dependent kinase 5 regulatory subunit associated protein 2-NTRK2 fusions. Anaplasia and necrosis were observed in the recurrent tumors, but not in the primary lesion. Therefore, the integrative diagnosis was primary IDH-mutant astrocytoma grade 2 and recurrent IDH-mutant astrocytoma grade 4 with NTRK2 fusions. This is a worthwhile report describing a case of IDH-mutant astrocytoma that showed genomic evolution during tumor recurrence. Our report suggests that NTRK fusion and CDKN2A/B homozygous deletion promote high-grade transformation and indicate an unfavorable prognosis of IDH-mutant astrocytoma.

    DOI: 10.1016/j.prp.2022.154163

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  • Kawahira M., Kanmura S., Mizuno K., Machida K., Ohtsuka T., Sato M., Enokida H., Yamashita M., Kanekura T., Arima S., Nakamura N., Sugiura T., Yoshimoto K., Kobayashi H., Ishitsuka K., Suzuki S., Ueno S., Ido A. .  Effects of immune checkpoint inhibitor therapy resumption in patients with malignant tumors after moderate-to-severe immune-related adverse events .  PLoS ONE17 ( 4 April ) e0267572   2022.4

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    Language:Japanese   Publisher:PLoS ONE  

    Background and aims Immune checkpoint inhibitors (ICIs) are used to treat several cancers, but they sometimes induce immune-related adverse events (irAEs). Patients with irAEs often have improved antitumor responses, but discontinuation of ICIs after irAEs is considered necessary. Resuming the use of ICIs after irAEs is preferable, but few studies have investigated the safety of ICI resumption after irAEs. Therefore, we evaluated the factors associated with the recurrence of irAEs after ICI resumption to investigate the safety of this approach. Methods In this observational study, we enrolled patients treated with ICIs from September 2014 to March 2020 at our institution. Patient characteristics, ICIs, grades of irAEs, ICI discontinuation or resumption rates, and recurrence rates of irAEs after ICI therapy were analysed. Results Two-hundred eighty-seven patients were included in the present study, and 76 patients experienced grade 2 or higher irAEs. Forty-two patients underwent ICI resumption after recovering from irAEs, and 13 of them had a recurrence of irAEs. Among those 13 patients, six had a recurrence of the same irAE, and seven experienced other irAEs. Ten of the 13 patients had grade ≥2 irAEs, and none had fatal irAEs. In the grade 2 or higher irAE group, more patients had irAEs associated with multiple organs and of initial grade ≥2 than those in the grade 1 and no recurrent irAEs group. Conclusions Patients with initial multisystemic irAEs and irAEs of grade ≥2 were more likely to experience relapse or develop new grade ≥2 irAEs after ICI resumption.

    DOI: 10.1371/journal.pone.0267572

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  • Kawada H, Yoshimitsu M, Nakamura D, Arai A, Hayashida M, Kamada Y, Maekawa K, Fujino S, Arima M, Arima N, Tabuchi T, Inoue H, Hamda H, Suzuki S, Matsushita K, Arima N. .  A Retrospective Analysis of Treatment Outcomes in Adult T Cell Leukemia/Lymphoma Patients with Aggressive Disease Treated with or without Allogeneic Stem Cell Transplantation: A Single-Center Experience. .  Biol Blood Marrow Transplant21 ( 4 ) 696 - 700   2015.4A Retrospective Analysis of Treatment Outcomes in Adult T Cell Leukemia/Lymphoma Patients with Aggressive Disease Treated with or without Allogeneic Stem Cell Transplantation: A Single-Center Experience.Reviewed

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  • White Y, Yoshimitsu M, Kozako T, Matsushita K, Koriyama C, Uozumi K, Suzuki S, Kofune H, Arima N. .  Effects of exogenous interleukin-7 on CD8(+) T-cell survival and function in human T-cell lymphotropic virus type 1 infection. .  Leukemia & lymphoma54 ( 10 ) 2243 - 2250   2013.10Effects of exogenous interleukin-7 on CD8(+) T-cell survival and function in human T-cell lymphotropic virus type 1 infection.Reviewed

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  • Nakamura D, Yoshimitsu M, Kawada H, Inoue H, Kuroki T, Kaieda T, Fujino S, Hamada H, Suzuki S, Matsushita K, Uozumi K, Arima N. .  Recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome post allogeneic hematopoietic SCT. .  Bone Marrow Transplant.47 ( 3 ) 463 - 464   2012.3Recombinant human soluble thrombomodulin for the treatment of hepatic sinusoidal obstructive syndrome post allogeneic hematopoietic SCT.Reviewed

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  • Nakamura T, Hashiguchi A, Suzuki S, Uozumi K, Tokunaga S, Takashima H. .  Vincristine exacerbates asymptomatic Charcot-Marie-tooth disease with a novel EGR2 mutation. .  Neurogenetics.13 ( 1 ) 77 - 82   2012.2Vincristine exacerbates asymptomatic Charcot-Marie-tooth disease with a novel EGR2 mutation.Reviewed

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  • Maekawa K, Yoshimitsu M, Fujiwara H, Matsushita K, Kawada H, Hamada H, Suzuki S, Uozumi K, Ohtsuka M, Hanada S, Yabe M, Yabe H, Arima N. .  Successful allo-HSCT with a minimal myeloablative conditioning regimen in an adult patient with Fanconi's anemia. .  Bone Marrow Transplantation 47 ( 1 ) 159 - 160   2012.1Successful allo-HSCT with a minimal myeloablative conditioning regimen in an adult patient with Fanconi's anemia.Reviewed

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  • White Y, Hamada T, Yoshimitsu M, Nakashima M, Hachiman M, Kozako T, Matsushita K, Uozumi K, Suzuki S, Kofune H, Furukawa T, Arima N. .  Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance. .  Anticancer Res.31 ( 12 ) 4251 - 4257   2011.12Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance.Reviewed

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  • Yoshioka T, Harada M, Umekita Y, Taguchi S, Higashi M, Nakamura D, Suzuki S, Tanimoto A. .  Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. .  Pathol Int.60 ( 4 ) 326 - 329   2010.4Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature.Reviewed

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  • Owatari S, Otsuka M, Takeshita T, Mizukami K, Suzuki S, Uozumi K, Tashiro Y, Arima N, Hanada S. .  Uncommon cases of immature-type CD56+ natural killer (NK)-cell neoplasms, characterized by expression of myeloid antigen of blastic NK-cell lymphoma. .  Int J Haematol89 ( 2 ) 188 - 194   2009.3Uncommon cases of immature-type CD56+ natural killer (NK)-cell neoplasms, characterized by expression of myeloid antigen of blastic NK-cell lymphoma.Reviewed

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  • Kozako T, Yoshimitsu M, Fujiwara H, Masamoto I, Horai S, White Y, Akimoto M, Suzuki S, Matsushita K, Uozumi K, Tei C, Arima N. .  PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients. .  Leukemia23 ( 2 ) 375 - 382   2009.2PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients.Reviewed

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  • Suzuki S, Uozumi K, Utsunomiya A, Ishitsuka K, Masamoto I, Owatari S, Makino T, White Y, Arima N. .  Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome. .  Eur J Haematology 81 ( 3 ) 236 - 241   2008.9Aggressive NK cell leukaemia after splenectomy: association with CD95-resistant memory T-cell proliferation and recalcitrant clinical course of haemophagocytic syndrome.Reviewed

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  • 麓由紀子, 大納伸人, 川口博明, 前田拓郎, 山下恵里香, 西田知夏, 徳永公紀, 阪本卓爾, 曽我部篤史, 鈴木紳介, 魚住公治, 野崎 剛, 坪内博仁 .  腎浸潤による急性腎不全をきたした血液透析を必要とした成人T細胞性白血病の1例 .  透析会誌40 ( 10 ) 865 - 869   2007.7腎浸潤による急性腎不全をきたした血液透析を必要とした成人T細胞性白血病の1例Reviewed

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  • Satsuki Owataria, Kimiharu Uozumi, Kouichi Haraguchi, Nobuhito Ohno, Masahito Tokunaga, Mayumi Tokunaga, Shinsuke Suzuki, Shuichi Hanada and Naomichi Arima .  A new cytogenetic abnormality, t(2;7)(q33;q36), in acute promyelocytic leukemia. .  Cancer Genetics and Cytogenetics173 ( 1 ) 71 - 74   2007.2A new cytogenetic abnormality, t(2;7)(q33;q36), in acute promyelocytic leukemia.Reviewed

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  • Noriaki Kawano, Kazuya Shimoda, Fumihiko Ishikawa, Akinobu Taketomi , Tomoharu Yoshizumi, Shinji Shimoda, Shuro Yoshida, Kimiharu Uozumi, Shinsuke Suzuki, Yoshihiko Maehara, Mine Harada .  Adult T-cell Leukemia Development From a Human T-cell Leukemia Virus Type I Carrier After a Living-Donor Liver Transplantation. .  Transplantation82 ( 6 ) 840 - 843   2006.9Adult T-cell Leukemia Development From a Human T-cell Leukemia Virus Type I Carrier After a Living-Donor Liver Transplantation.Reviewed

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  • Shinsuke Suzuki, Kimiharu Uozum, Masahiko Maeda, Yoshiko Yamasuji, Shin-ichi Hashimoto, Yasuji Komorizono, Satsuki Owatari, Masahito Tokunaga, Kouichi Haraguchi and Naomichi Arima .  Adult T-cell leukemia in a liver transplant recipient who did not progress after onset of graft rejection. .  International Journal of Hematology83 ( 5 ) 429 - 432   2006.6Adult T-cell leukemia in a liver transplant recipient who did not progress after onset of graft rejection. Reviewed

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  • Satsuki Owataria, Kimiharu Uozumi, Kouichi Haraguchi, Masahito Tokunaga, Mayumi Tokunaga, Shinsuke Suzuki, Naomichi Arima .  Adult T-cell leukemia/lymphoma in a 21-year-old man. .  Clinical and laboratory haematology28 ( 2 ) 141 - 144   2006.4Adult T-cell leukemia/lymphoma in a 21-year-old man.Reviewed

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  • 呉 建、魚住公治、菊池 晃、大渡五月、辻 隆宏、原口浩一、徳永雅仁、徳永真弓、鈴木紳介、有馬暉勝 日本内科学会誌93:774-776, 2004 .  Cyclophosphamide・Prednisolone 内服の後、CHOP療法を施行したLymphomatoid Granulomatosis の一例 .  日本内科学会雑誌93 ( 4 ) 774 - 776   2004.4Cyclophosphamide・Prednisolone 内服の後、CHOP療法を施行したLymphomatoid Granulomatosis の一例Reviewed

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  • Suzuki S, Uozumi K, Hanada S, Lin XY, Ohno N, Takatsuka Y, Takeuchi S, Owatari S, Takeshita T, Arima T. .  A novel c-kit positive biphenotypic acute leukemia cell line, TMBL-1, carrying a p53 point mutation. .  Leuk Lymphoma44 ( 5 ) 849 - 857   2003.5A novel c-kit positive biphenotypic acute leukemia cell line, TMBL-1, carrying a p53 point mutation.Reviewed

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  • Ishitsuka K, Ikeda R, Utsunomiya A, Uozumi K, Hanada S, Suzuki S, Takeuchi S, Takatsuka Y, Takeshita T, Ohno N, Arima T. .  Arsenic trioxide induces apoptosis in HTLV-I infected T-cell lines and fresh adult T-cell leukemia cells through CD95 or tumor necrosis factor alpha receptor independent caspase activation. .  Leuk Lymphoma43 ( 2 ) 343 - 349   2002.5Arsenic trioxide induces apoptosis in HTLV-I infected T-cell lines and fresh adult T-cell leukemia cells through CD95 or tumor necrosis factor alpha receptor independent caspase activation.Reviewed

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  • Lin XY, Hanada S, Uozumi K, Utsunomiya A, Suzuki S, Shimotakahara S, Takeuchi S, Takatsuka Y, Arima T. .  Serum levels of endogenous thrombopoietin and granulocyte-colony stimulating factor in patients with acute or lymphoma type adult T-cell leukemia during multicycle chemotherapy. .  Leuk Lymphoma43 ( 2 ) 1107 - 1114   2002.5Serum levels of endogenous thrombopoietin and granulocyte-colony stimulating factor in patients with acute or lymphoma type adult T-cell leukemia during multicycle chemotherapy.Reviewed

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  • Suzuki S, Takeshita T, Hanada S .  A case of delirium caused by interferon-alpha for chronic myelogenous leukemia .  Iryo55 ( 6 ) 296 - 299   2001.6A case of delirium caused by interferon-alpha for chronic myelogenous leukemiaReviewed

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  • Uozumi K, Ohno N, Shimotakahara S, Suzuki S, Takeuchi S, Hanada S, Arima T. .  Trisomy 8 in essential thrombocythemia in leukemic transformation. .  Cancer Genet Cytogenet.116 ( 1 ) 84 - 86   2000.1Trisomy 8 in essential thrombocythemia in leukemic transformation.Reviewed

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  • Uozumi K, Otsuka M, Ohno N, Moriyama T, Suzuki S, Shimotakahara S, Matsumura I, Hanada S, Arima T. .  Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles. .  Leukemia14 ( 1 ) 142 - 152   2000.1Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles.Reviewed

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  • Ishitsuka K, Hanada S, Suzuki S, Utsunomiya A, Chyuman Y, Takeuchi S, Takeshita T, Shimotakahara S, Uozumi K, Makino T, Arima T. .  Arsenic trioxide inhibits growth of human T-cell leukaemia virus type I infected T-cell lines more effectively than retinoic acids. .  Br J Haematol.103 ( 3 ) 721 - 728   1998.12Arsenic trioxide inhibits growth of human T-cell leukaemia virus type I infected T-cell lines more effectively than retinoic acids.Reviewed

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  • Hanada S, Utsunomiya A, Suzuki S, Uozumi K, Makino T, Arima T. .  Treatment for adult T-cell leukemia. .  Cancer Chemother Pharmacol. 40   S47 - 50   1997.12Treatment for adult T-cell leukemia.Reviewed

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  • Makino T, Utsunomiya A, Suzuki S, Ishizuka K, Nakahara K, Takeshita T, Daino N, Chuma Y, Otsuka M, Uozumi K .  Double cancer in patients with adult T cell leukemia .  Rinsho Ketsueki36 ( 8 ) 792 - 794   1995.8Double cancer in patients with adult T cell leukemiaReviewed

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MISC

  • 亜急性連合性脊髄変性症

    鈴木紳介、魚住公治、有馬直道

    別冊日本臨床 血液症候群(第2版)(I)ーその他の血液疾患を含めてー・日本臨床社   123 - 126   2013.1

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  • 慢性炎症に伴うび慢性大細胞型B細胞リンパ腫

    蓮井和久、鈴木紳介、松下格司

    WHO血液腫瘍分類~WHO分類2008をうまく利用するために~   389 - 392   2010.2

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  • 白血病における免疫回避の機序.

    花田修一, 鈴木紳介.

    Bio Clinica   17 ( 4 )   328 - 333   2002.4

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Presentations

  • Shinsuke Suzuki*, Kimiharu Uozumi, Yohan White, Makoto Yoshimitsu, Hideaki kawada, Hei-ichiro Hamada, Akihiko Arai, Daisuke Nakamura, Naosuke Arima, Mamiko Shiraishi, Kakushi Matsushita and Naomichi Arima.   Achieving clear status of recalcitrant psoriasis during low-dose dasatinib in a patient with CML  

    日本血液学会  日本血液学会

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    Event date: 2012.10

    Language:Japanese  

    Venue:京都  

    国内学会

  • Shinsuke Suzuki, Hiroki Kofune, Kimiharu Uozumi , Yohann White, Makoto Yoshimitsu, Tomohiro Kozako, Kakushi Matsushita, Hideaki kawad, Hei-ichiro Hamada , Hirosaka Inoue, Daisuke Nakamura, Maiko Hyashida, Ken-ichiro Kosai and Naomichi Arima.   Induction of cell death in Adult T-cell leukemia cell lines by survivin-responsive conditionally replicating adenoviruses.  

    日本血液学会  日本血液学会

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    Event date: 2011.10

    Language:Japanese  

    Venue:名古屋  

    国内学会

  • Hiroki Kofune, Shinsuke Suzuki, Kimiharu Uozumi, Yohann White, Makoto Yoshimitsu, Tomohiro Kozako, Ken-ichiro Kosai and Naomichi Arima.   Induction of cell death in Adult T-cell leukemia cell lines by survivin-responsive conditionally replicating adenoviruses.   International conference

    15th Congress of European hematology Association  15th Congress of European hematology Association

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    Event date: 2010.6

    Language:English  

    Venue:スペイン王国  

    国際学会

  • 鈴木紳介、魚住公治、松下格司、小浜浩介、川田英明、濱田平一郎、吉満誠、井上大栄、有馬直道   成人T細胞白血病・リンパ腫のNOTCH1蛋白発現に関する研究  

    日本血液学会  日本血液学会

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    Event date: 2008.10

    Language:Japanese  

    Venue:京都  

    国内学会

  • 鈴木紳介、魚住公治、川田英明、濱田平一郎、吉満誠、松下格司、有馬直道   新しいNOTCH1変異、t(9;14)を持つ白血病細胞とgamma-secretase inhibitor感受性の解析  

    日本血液学会  日本血液学会

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    Event date: 2007.9

    Language:Japanese  

    Venue:横浜  

    国内学会

  • Shinsuke Suzuki, Stefan Nagel, Bjorn Schneider, Maren Kaufmann, Dorothea Anders, Hirohito Tsubouchi, Kimiharu Uozumi, Naomichi Arima, Hans G. Drexler and Roderick A.F. MacLeod   Characterization of T-cell acute lymphoblastic leukemia cell lines with a novel t(9;14)(q34;q11.2) rearrangement: Does gamma-secretase inhibitor sensitivity depend on intragenic NOTCH1 breakpoint ?   International conference

    American Society of Hematology  American Society of Hematology

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    Event date: 2006.12

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • Shinsuke Suzuki, Shuichi Hanada, Kenji Ishitsuka, Kimiharu Uozumi, Atae Utsunomiya, Nobuhito Ohno, Yoshifusa Takatsuka, Syogo Takeuchi, Terukatsu Arima, Hiroshi Takahashi   Peripheral blood lymphocytes from patients with adult T-cell leukemia in remission induce apoptosis to HTLV-1 infected T-cell line by activation with chimeric SF-25 monoclonal antibody   International conference

    American Society of Hematology  American Society of Hematology

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    Event date: 1999.12

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • Shinsuke Suzuki, Shuichi Hanada, Kenji Ishitsuka, Kimiharu Uozumi, Atae Utsunomiya, Syogo Takeuchi, Terukatsu Arima, Hiroshi Takahashi   Human lymphocytes activated by chimeric SF-25 monoclonal antibody induce apoptosis of HTLV-1 infected T-cell line.   International conference

    American Society of Hematology  American Society of Hematology

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    Event date: 1998.12

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

  • Shinsuke Suzuki, Shuichi Hanada, Kenji Ishitsuka, Syogo Takeuchi, Yoshifusa Takatsuka, Satoko Nakano, Nobuhito Ohno, Shigemi Shimotakahara, Yoshiko Cyuman, Maki Ohtsuka, Torahiko Makino, Kimiharu Uozumi, Atae Utsunomiya, Terukatsu Arima, Hiroshi Takahashi   Chimeric SF-25 monoclonal antibody-mediated apoptosis of adult T-cell leukemia cells by human blood lymphocytes   International conference

    American Society of Hematology  American Society of Hematology

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    Event date: 1997.12

    Language:English  

    Venue:アメリカ合衆国  

    国際学会

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Research Projects

  • 生体内ゲノム編集を利用したHTLV-1を標的にする新規抗ウイルス療法

    2019.4

    科学研究費助成事業 

    鈴木 紳介

  • 発がんウィルスであるHTLV-1を標的にした遺伝子組み替えウィルス療法

    2015.4 - 2017.3

    科学研究費補助金  基盤研究(C)

  • 成人T細胞白血病幹細胞の遺伝子治療

    2011.4 - 2013.3

    科学研究費補助金  基盤研究(C)

  • 白血病幹細胞を標的とした成人T細胞白血病の新規化学療法の開発

    2010.4 - 2012.3

    科学研究費補助金  基盤研究(C)