Updated on 2023/05/10

写真a

 
YAMANAKA Atsushi
 
Organization
Research Field in Dentistry, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Advanced Therapeutics Course Neurology Associate Professor
Title
Associate Professor

Degree

  • 博士(理学) ( 2002.5   京都大学 )

Research Interests

  • tooth

  • mammals

  • development

  • evolution

  • morphology

Research Areas

  • Life Science / Oral biological science

  • Life Science / Physical anthropology

Research History

  • Kagoshima University   Associate Professor

    2010.7

  • Kagoshima University   Lecturer

    2008.1 - 2010.6

  • Kagoshima University   Research Assistant

    2001.4 - 2007.12

Professional Memberships

  • Japanese Association for Oral Biology

  • The Japanese Association of Anatomists

  • The Anthropological Society of Nippon

  • Society of Evolutionary Studies, Japan

 

Papers

  • Atsushi Yamanaka .  Evolution and development of the mammalian multicuspid teeth. .  Journal of oral biosciences64 ( 2 ) 165 - 175   2022.6Invited Reviewed International journal

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Mammalian premolars and molars (cheek teeth) are teeth with multiple cusps, which are important characteristics of mammals. Endothermic mammals have high basal metabolic rates and must take in much energy by efficient mastication of food using their multicuspid cheek teeth. From the phylogenetic (evolutionary) perspective, the mammalian multicuspid teeth are derived from the reptilian unicuspid teeth with a single cone by adding new cusps around the original cone. Nearly 100 million years of long geological time were required for the unicuspid tooth to transform into a tribosphenic molar, which is the prototype of all molars in modern mammals. From the ontogenetic (developmental) perspective, the shape of the tooth germ becomes complex by adding the secondary enamel knots repeatedly in a short embryonic period. The secondary enamel knots are signaling centers that determine the future cusp positions. HIGHLIGHT: Here we first reviewed the evolutionary process of the tribosphenic molar in the Mesozoic Era (the age of dinosaurs), and cusp homologies in the fossil record. Next, we reviewed the developmental mechanisms controlling the patterning of secondary enamel knots, which determine the final cusp patterns of molars in modern mammals. Finally, we discussed the possible relationship between the two processes from the extremely different time scales. CONCLUSION: A parallel relationship between ontogeny and phylogeny of the mammalian multicuspid teeth was expected.

    DOI: 10.1016/j.job.2022.03.007

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    PubMed

  • Eriko Kuramoto, Ayano Kitawaki, Takakazu Yagi, Hiroshi Kono, Shin-Ei Matsumoto, Hiromitsu Hara, Yasumasa Ohyagi, Haruki Iwai, Atsushi Yamanaka, Tetsuya Goto .  Development of a system to analyze oral frailty associated with Alzheimer's disease using a mouse model. .  Frontiers in aging neuroscience14   935033 - 935033   2022International journal

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    Language:English   Publishing type:Research paper (scientific journal)  

    The rapid aging of the population makes the detection and prevention of frailty increasingly important. Oral frailty has been proposed as a novel frailty phenotype and is defined as a decrease in oral function coexisting with a decline in cognitive and physical functions. Oral frailty has received particular attention in relation to Alzheimer's disease (AD). However, the pathomechanisms of oral frailty related to AD remain unknown. It is assumed that the mesencephalic trigeminal nucleus (Vmes), which controls mastication, is affected by AD pathology, and as a result, masticatory function may be impaired. To investigate this possibility, we included male 3 × Tg-AD mice and their non-transgenic counterpart (NonTg) of 3-4 months of age in the present study. Immunohistochemistry revealed amyloid-β deposition and excessive tau phosphorylation in the Vmes of 3 × Tg-AD mice. Furthermore, vesicular glutamate transporter 1-immunopositive axon varicosities, which are derived from Vmes neurons, were significantly reduced in the trigeminal motor nucleus of 3 × Tg-AD mice. To investigate whether the AD pathology observed in the Vmes affects masticatory function, we analyzed electromyography of the masseter muscle during feeding. The 3 × Tg-AD mice showed a significant delay in masticatory rhythm compared to NonTg mice. Furthermore, we developed a system to simultaneously record bite force and electromyography of masseter, and devised a new method to estimate bite force during food chewing in mice. Since the muscle activity of the masseter showed a high correlation with bite force, it could be accurately estimated from the muscle activity. The estimated bite force of 3 × Tg-AD mice eating sunflower seeds was predominantly smaller than that of NonTg mice. However, there was no difference in masseter weight or muscle fiber cross-sectional area between the two groups, suggesting that the decreased bite force and delayed mastication rhythm observed in 3 × Tg-AD mice were not due to abnormality of the masseter. In conclusion, the decreased masticatory function observed in 3 × Tg-AD mice was most likely caused by AD pathology in the Vmes. Thus, novel quantitative analyses of masticatory function using the mouse model of AD enabled a comprehensive understanding of oral frailty pathogenesis.

    DOI: 10.3389/fnagi.2022.935033

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    PubMed

  • Haruki Iwai, Koji Ataka, Hajime Suzuki, Ashis Dhar, Eriko Kuramoto, Atsushi Yamanaka, Tetsuya Goto .  Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury. .  Journal of neuroinflammation18 ( 1 ) 227 - 227   2021.12International journal

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Macrophages in the peripheral nervous system are key players in the repair of nerve tissue and the development of neuropathic pain due to peripheral nerve injury. However, there is a lack of information on the origin and morphological features of macrophages in sensory ganglia after peripheral nerve injury, unlike those in the brain and spinal cord. We analyzed the origin and morphological features of sensory ganglionic macrophages after nerve ligation or transection using wild-type mice and mice with bone-marrow cell transplants. METHODS: After protecting the head of C57BL/6J mice with lead caps, they were irradiated and transplanted with bone-marrow-derived cells from GFP transgenic mice. The infraorbital nerve of a branch of the trigeminal nerve of wild-type mice was ligated or the infraorbital nerve of GFP-positive bone-marrow-cell-transplanted mice was transected. After immunostaining the trigeminal ganglion, the structures of the ganglionic macrophages, neurons, and satellite glial cells were analyzed using two-dimensional or three-dimensional images. RESULTS: The number of damaged neurons in the trigeminal ganglion increased from day 1 after infraorbital nerve ligation. Ganglionic macrophages proliferated from days 3 to 5. Furthermore, the numbers of macrophages increased from days 3 to 15. Bone-marrow-derived macrophages increased on day 7 after the infraorbital nerve was transected in the trigeminal ganglion of GFP-positive bone-marrow-cell-transplanted mice but most of the ganglionic macrophages were composed of tissue-resident cells. On day 7 after infraorbital nerve ligation, ganglionic macrophages increased in volume, extended their processes between the neurons and satellite glial cells, and contacted these neurons. Most of the ganglionic macrophages showed an M2 phenotype when contact was observed, and little neuronal cell death occurred. CONCLUSION: Most of the macrophages that appear after a nerve injury are tissue-resident, and these make direct contact with damaged neurons that act in a tissue-protective manner in the M2 phenotype. These results imply that tissue-resident macrophages signal to neurons directly through physical contact.

    DOI: 10.1186/s12974-021-02283-z

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    PubMed

  • Dhar Ashis, Kuramoto Eriko, Fukushima Makoto, Iwai Haruki, Yamanaka Atsushi, Goto Tetsuya .  The Periodontium Damage Induces Neuronal Cell Death in the Trigeminal Mesencephalic Nucleus and Neurodegeneration in the Trigeminal Motor Nucleus in C57BL/6J Mice .  Acta Histochemica et Cytochemica54 ( 1 ) 11 - 19   2021

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY  

    <p>Proprioception from masticatory apparatus and periodontal ligaments comes through the trigeminal mesencephalic nucleus (Vmes). We evaluated the effects of tooth loss on neurodegeneration of the Vmes and trigeminal motor nucleus (Vmo). Bilateral maxillary molars of 2-month-old C57BL/6J mice were extracted under anesthesia. Neural projections of the Vmes to the periodontium were confirmed by injecting Fluoro-Gold (FG) retrogradely into the extraction sockets, and for the anterograde labeling adeno-associated virus encoding green fluorescent protein (AAV-GFP) was applied. For immunohistochemistry, Piezo2, ATF3, Caspase 3, ChAT and TDP-43 antibodies were used. At 1 month after tooth extraction, the number of Piezo2-immunoreactive (IR) Vmes neurons were decreased significantly. ATF3-IR neurons were detected on day 5 after tooth extraction. Dead cleaved caspase-3-IR neurons were found among Vmes neurons on days 7 and 12. In the Vmo, neuronal cytoplasmic inclusions (NCIs) formation type of TDP-43 increased at 1 and 2 months after extraction. These indicate the existence of neural projections from the Vmes to the periodontium in mice and that tooth loss induces the death of Vmes neurons followed by TDP-43 pathology in the Vmo. Therefore, tooth loss induces Vmes neuronal cell death, causing Vmo neuro­degeneration and presumably affecting masticatory function.</p>

    DOI: 10.1267/ahc.20-00036

    PubMed

  • Goto T. .  Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice .  Journal of Alzheimer's Disease76 ( 4 ) 1443 - 1459   2020

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    Language:Japanese   Publisher:Journal of Alzheimer's Disease  

    DOI: 10.3233/JAD-200257

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  • Yamanaka A, Iwai H, Kuramoto E, Goto T .  Three-dimensional gene expression pattern reconstructed from serial section in situ hybridization .  鹿児島大学歯学部紀要35   87 - 92   2015.3Three-dimensional gene expression pattern reconstructed from serial section in situ hybridizationReviewed

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  • Yamanaka A, Iwai H, Uemura M, Goto T .  Patterning of mammalian heterodont dentition within the upper and lower jaws .  Evolution & Development17 ( 2 ) 127 - 138   2015.3Patterning of mammalian heterodont dentition within the upper and lower jawsReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Yamanaka A, Yasui K, Sonomura T, Iwai H, Uemura M .  Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus) .  Arch Oral Biol55 ( 4 ) 279 - 287   2010.4Development of deciduous and permanent dentitions in the upper jaw of the house shrew (Suncus murinus)Reviewed

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  • Yamanaka A, Yasui K, Sonomura T, Uemura M .  Development of heterodont dentition in house shrew (Suncus murinus) .  Eur J Oral Sci115 ( 6 ) 433 - 440   2007.12Development of heterodont dentition in house shrew (Suncus murinus)Reviewed

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  • Yamanaka A, Gunji H, Ishida H .  Curvature, length, and cross-sectional geometry of the femur and humerus in anthropoid primates .  Am J Phys Anthropol127 ( 1 ) 46 - 57   2005.5Curvature, length, and cross-sectional geometry of the femur and humerus in anthropoid primatesReviewed

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Atsushi Yamanaka .  Biomechanical Investigation of Anthropoid Limb Bone Morphology in Terms of Bending Strength .      2002.5Biomechanical Investigation of Anthropoid Limb Bone Morphology in Terms of Bending Strength

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    Language:English   Publishing type:Doctoral thesis  

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Books

  • Comparison of limb structural properties in free-ranging chimpanzees from Kibale, Bombe, Mahale, and Tai communities.

    Carlson KJ, Wrangham RW, Muller MN, Sumner DR, Morbeck ME, Nishida T, Yamanaka A, Boesch C( Role: Joint author)

    Springer  2012 

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    Language:English Book type:Scholarly book

  • 歯の新知見

    山中淳之, 花村肇( Role: Joint author)

    スンクスの生物学, 東京: 学会出版センター  2011.2 

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    Language:Japanese Book type:Scholarly book

  • 立体組織像構築によるジャコウネズミの歯の発生様式の研究

    山中淳之, 植村正憲( Role: Joint author)

    自然人類学研究, 京都: 金星舎  2004.1 

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    Language:Japanese Book type:Scholarly book

MISC

  • 哺乳類の歯列の異形歯性と二生歯性の発生メカニズム Reviewed

    山中淳之

    鹿児島大学歯学部紀要   31   71 - 80   2011.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • The house shrew, Suncus murinus, as a model organism to investigate mammalian basal condition of tooth development Reviewed

    Yamanaka A, Uemura M

    J Oral Biosci   52 ( 3 )   215 - 224   2010.8

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Presentations

  • 山中淳之   実験動物スンクスを使った歯の発生と進化の研究   Invited

    第124回日本解剖学会  スンクス研究会

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟市  

  • 山中淳之, 岩井治樹, 倉本恵梨子, Ashis Dhar, 後藤哲哉   非筋ミオシンIIによる上皮細胞内張力は歯胚上皮の陥入、形態形成に必要である  

    第124回日本解剖学会  2019.3 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Poster presentation  

  • 山中淳之, 岩井治樹, 倉本恵梨子, Ashis Dhar, 後藤哲哉   歯胚上皮の陥入および形態形成過程における非筋ミオシンIIの役割  

    第60回歯科基礎医学会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Poster presentation  

  • Developmental process of the modern shrew's molar replays evolution of the tribosphenic molar in Mesozoic mammals  

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  • 山中淳之, Jimmy Hu, 後藤哲哉, Ophir Klein   マウス切歯の形態形成における非筋ミオシンIIの役割  

    第58回歯科基礎医学会 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (general)  

  • Atsushi Yamanaka, Eriko Kuramoto, Haruki Iwai,Tetsuya Goto   Developmental process of modern shrew’s molar replays evolution of the tribosphenic molar in Mesozoic mammals   International conference

    TMD2016 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

    Venue:Porvoo, Finland  

  • 山中淳之, 安井金也, 岩井治樹, 倉本恵梨子, 後藤哲哉   トガリネズミの双波歯型臼歯における咬頭形成順序  

    第68回日本人類学会  第68回日本人類学会

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    Event date: 2014.11

    Language:Japanese  

    Venue:静岡  

    国内学会

  • 山中淳之, 岩井治樹, 後藤哲哉   トガリネズミの上顎および下顎第1大臼歯の咬頭形成  

    第56回歯科基礎医学会  第56回歯科基礎医学会

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    Event date: 2014.9

    Language:Japanese  

    Venue:福岡  

    国内学会

  • 山中淳之, 岩井治樹, 安井金也   トガリネズミの上顎臼歯の咬頭形成順序  

    第55回歯科基礎医学会  第55回歯科基礎医学会

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    Event date: 2013.9

    Language:Japanese  

    Venue:岡山  

    国内学会

  • 山中淳之, 安井金也, 薗村貴弘, 岩井治樹, 植村正憲   トガリネズミのトリボスフェニック型臼歯の咬頭形成  

    第118回日本解剖学会  第118回日本解剖学会

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    Event date: 2013.3

    Language:Japanese  

    Venue:高松  

    国内学会

  • 山中淳之, 薗村貴弘, 岩井治樹, 植村正憲   歯胚の遺伝子発現パターンの歯種間の相違  

    第53回歯科基礎医学会  第53回歯科基礎医学会

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    Event date: 2011.10

    Language:Japanese  

    Venue:岐阜  

    国内学会

  • Yamanaka A, Yasui K, Uemura M   Patterning of the heterodont dentition in the house shrew (Suncus murinus)   International conference

    10th Tooth Morphogenesis and Differentiation  10th Tooth Morphogenesis and Differentiation

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    Event date: 2010.9

    Language:English  

    Venue:ドイツ  

    国際学会

  • 山中淳之, 薗村貴弘, 岩井治樹, 植村正憲   ジャコウネズミの歯列形成過程における歯胚の発生順序  

    第51回歯科基礎医学会  第51回歯科基礎医学会

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    Event date: 2009.9

    Language:Japanese  

    Venue:新潟  

    国内学会

  • 山中淳之, 植村正憲   哺乳類の歯列の異形歯性と二生歯性に関する分子発生学的研究  

    第114回日本解剖学会  第114回日本解剖学会

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    Event date: 2009.3

    Language:Japanese  

    Venue:岡山  

    国内学会

  • 山中淳之, 薗村貴弘, 岩井治樹, 植村正憲   食虫類ジャコウネズミにおける上顎歯列の形成と切歯縫合の関係  

    第50回歯科基礎医学会  第50回歯科基礎医学会

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    Event date: 2008.9

    Language:Japanese  

    Venue:東京  

    国内学会

  • 山中淳之, 安井金也, 薗村貴弘, 岩井治樹, 植村正憲   食虫類ジャコウネズミにおける乳歯歯胚と代生歯胚の関係  

    第113回日本解剖学会  第113回日本解剖学会

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    Event date: 2008.3

    Language:Japanese  

    Venue:大分  

    国内学会

  • 山中淳之, 薗村貴弘, 岩井治樹, 植村正憲   ジャコウネズミにおける乳歯歯胚と永久歯歯胚の関係  

    第49回歯科基礎医学会  第49回歯科基礎医学会

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    Event date: 2007.8

    Language:Japanese  

    Venue:北海道  

    国内学会

  • 山中淳之, 植村正憲, 安井金也   食虫類ジャコウネズミの異形歯性歯列の発生と前顎骨の形成  

    第60回日本人類学会  第60回日本人類学会

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    Event date: 2006.11

    Language:Japanese  

    Venue:高知  

    国内学会

  • 山中淳之, 薗村貴弘, 田畑純, 植村正憲   食虫類ジャコウネズミにおける歯列の発生と前顎骨の形成  

    第48回歯科基礎医学会  第48回歯科基礎医学会

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    Event date: 2006.9

    Language:Japanese  

    Venue:神奈川  

    国内学会

  • 山中淳之, 薗村貴弘, 田畑純, 植村正憲   食虫類スンクスにおける歯種決定に関与する遺伝子の発現パターン  

    第47回歯科基礎医学会  第47回歯科基礎医学会

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    Event date: 2005.9

    Language:Japanese  

    Venue:宮城  

    国内学会

  • 山中淳之, 安井金也, 薗村貴弘, 田畑純, 植村正憲   食虫類スンクスにおける歯隙のない歯列の発生様式  

    第110回日本解剖学会  第110回日本解剖学会

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    Event date: 2005.3

    Language:Japanese  

    Venue:富山  

    国内学会

  • 山中淳之, 植村正憲, 安井金也   食虫類スンクスにおける歯隙のない歯列の発生様式  

    第58回日本人類学会  第58回日本人類学会

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    Event date: 2004.11

    Language:Japanese  

    Venue:長崎  

    国内学会

  • 山中淳之, 安井金也, 薗村貴弘, 田畑純, 植村正憲   スンクスの歯の発生過程におけるPax9の発現パターンの解析  

    第46回歯科基礎医学会  第46回歯科基礎医学会

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    Event date: 2004.9

    Language:Japanese  

    Venue:広島  

    国内学会

  • 山中淳之, 田畑純, 薗村貴弘, 植村正憲   立体組織像構築によるスンクスの歯の発生様式の研究  

    第45回歯科基礎医学会  第45回歯科基礎医学会

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    Event date: 2003.9

    Language:Japanese  

    Venue:岩手  

    国内学会

  • Atsushi Yamanaka, Yasin Haider, Urara Taguchi, Eriko Kuramoto, Haruki Iwai, Tetsuya Goto   Developmental sequence of cusp formation in the modern shrew’s molar: an implication for the evolution of tribosphenic molar in Mesozoic mammals  

    2021.3 

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    Language:English   Presentation type:Poster presentation  

  • 山中淳之, Yasin Haider, 森田航, 岩井治樹, 倉本恵梨子, 後藤 哲哉   歯冠の発生メカニズムに基づいた「小臼歯相似説」の検証  

    第75回日本人類学会  2022.10 

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    Venue:東京都  

  • 山中淳之, Haider Y   現生トガリネズミ科の臼歯の形態形成過程:哺乳類の多咬頭歯の進化発生学的考察  

    第76回日本人類学会大会・第38回日本霊長類学会大会連合大会  2022.9 

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    Presentation type:Symposium, workshop panel (public)  

  • 山中淳之   現生トガリネズミ科の臼歯の発生過程:歯の発生と進化の並行性に関する考察   Invited

    日本哺乳類学会2022年度大会  2022.8 

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    Presentation type:Symposium, workshop panel (nominated)  

    Venue:津   Country:Japan  

  • Yamanaka A, Morita W, Haider Y, Goto T   Developmental assessment of cusp formation in the modern shrew’s molar: an implication for the evolution of the tribosphenic molar in Mesozoic mammals   International conference

    Tooth Morphogenesis and Differentiation (TMD)  2022.6 

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    Country:Czech Republic  

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Research Projects

  • Tracing the origin of morphological change in tooth class during human evolution ~ QTL analysis with Suncus murinus ~

    Grant number:22K06416  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  • 味蕾基底細胞の再定義:「細胞型分化の解明」と「味蕾オルガノイド評価系の確立」

    Grant number:20K09892  2020.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    三浦 裕仁, 小柳 江梨子, 原田 秀逸, 山中 淳之

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    味蕾のI、II、III型細胞は味受容機能が異なり、五基本味のうち甘味・うま味・苦味はII型細胞、酸味はIII型細胞が受容する。塩味は濃度によって受容細胞が異なり、低濃度の塩味はI型細胞の一部、高濃度の塩味はII型とIII型細胞の一部が受容するとされている。各味蕾内の細胞型の構成比は、I型が全細胞の約半数程度と最も多く、次いでII型が多く、III型細胞は最も少ないとされる。この比率には味蕾が存在する口腔内の部位ごとに差があり、III型細胞の割合は有郭乳頭で最も高く、軟口蓋、茸状乳頭の順に少ないとされている。味蕾幹細胞を培養して形成されるオルガノイド内には、幹細胞を採取する口腔内部位に対応した割合で各細胞型が分化するという報告がある。しかし、実際は、生体における個々の味蕾の細胞構成は充分には検討されていない。また細胞型の分類に使用される分子マーカーにも、検討が不十分な分子がある。
    本研究では、味蕾の形態を維持したままホールマウント免疫染色を行い、個々の味蕾の II型とIII型の細胞構成を詳細に解析した。その結果、1) 抗3型イノシトール三リン酸受容体 (IP3R3) 抗体で検出されるII型細胞と抗4型炭酸脱水酵素 (CA4)抗体で検出されるIII型細胞は、完全に独立しており、これらの分子の細胞型マーカーとしての信頼性が確認された。2) 一方、これらの分子マーカーで検出されるII型とIII型細胞の数は、味蕾間で大きくばらついており、特に茸状乳頭と軟口蓋の味蕾では従来提唱されてきた相関関係は検出されなかった。さらに、III型細胞マーカーとされているNCAMを加えて解析したところ、CA4を発現する細胞はすべてNCAMを発現すること、また、軟口蓋と茸状乳頭の味蕾では、CA4を発現しないNCAM発現細胞の中にII型細胞マーカーであるIP3R3を発現する細胞が存在することが、明らかになった。

  • Shhシグナルによるアクトミオシン細胞内張力を介した歯の形態形成の新たな制御機構

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

  • A new function of Shh signaling to control epithelial actomyosin contractility during tooth morphogenesis

    Grant number:19K10047  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

  • 非筋型ミオシンIIが歯の幹細胞ニッチの形成とエナメル芽細胞の移動に果たす役割

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)