Updated on 2021/03/23
博士（医学） ( 1992.3 鹿児島大学 )
CRISPR/Cas9システムを用いた誘導性遺伝子欠失マウス作製
Life Science / Molecular biology
Life Science / Cell biology
Kagoshima University
1989.4 - 1992.3
Country： Japan
Kagoshima University Associate Professor
2003.4
日本分子生物学会
2005.10
日本癌学会
1990.4
日本生化学会
1985.10
1997.4 - 2000.3 Sanford Burnham Prebys medical discovery institute
Haraguchi M, Fukushige T, Kanekura T, Ozawa M . E-cadherin loss in RMG-1 cells inhibits cell migration and its regulation by Rho GTPases. . Biochem Biophys Rep18 100650 2019.5E-cadherin loss in RMG-1 cells inhibits cell migration and its regulation by Rho GTPases.Reviewed
Haraguchi M, Sato M, Ozawa M. . 1. CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells . PLoS One 2015.71. CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) CellsReviewed
Haraguchi M, Indo HP, Iwasaki Y, Iwashita Y, Fukushige T, Majima HJ, Izumo K, Horiuchi M, Kanekura T, Furukawa T, Ozawa M. . Snail modulates cell metabolism in MDCK cells. . Biochem Biophys Res Commun.432 ( 4 ) 618 - 625 2013.3Snail modulates cell metabolism in MDCK cells. Reviewed
Shimokawa M, Haraguchi M, Kobayashi W, Higashi Y, Matsushita S, Kawai K, Kanekura T, Ozawa M. . The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. . Biochem Biophys Res Commun.430 ( 3 ) 1078 - 1082 2013.1The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2.Reviewed
Kume K, Haraguchi M, Hijioka H, Ishida T, Miyawaki A, Nakamura N, Ozawa M. . The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells. . Biochem Biophys Res Commun.430 ( 3 ) 889 - 894 2013.1The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein 2 in oral squamous cell carcinoma cells. Reviewed
Zhao HY, Ooyama A, Yamamoto M, Ikeda R. Haraguchi M, Tabata S, Furukawa T, Che XF, Iwashita K, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M, Akiyama S. . Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells. . Cancer Lett. 270 ( 1 ) 156 - 163 2008.10Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.Reviewed
Zhao HY, Ooyama A, Yamamoto M, Ikeda R, Haraguchi M, Tabata S, Furukawa T, Che XF, Zhang S, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M, Akiyama S. . Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. . Cancer Res. 68 ( 17 ) 7035 - 7041 2008.9Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil.Reviewed
Haraguchi M, Okubo T, Miyashita Y, Miyamoto Y, Hayashi M, Crotti TN, McHugh KP, Ozawa M 2008;283(35):23514-23 . Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. . J Biol Chem.283 ( 35 ) 23514 - 23523 2008.8Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins. Reviewed
Tachiwada T, Chen ZS, Che XF, Matsumoto M, Haraguchi M, Gotanda T, Sumizawa T, Furukawa T, Nishiyama K, Seki N, Yamamoto M, Nakagawa M, Akiyama S. . Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells. . Oncol Rep. 18 ( 3 ) 721 - 727 2007.9Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells. Reviewed
Uto T.,Wang X.,Sato K.,Haraguchi M., Akagi T.,Akashi M.,馬場昌範(BABAMASANORI) . Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity . The Journal of Immunology178 ( 5 ) 2979 - 2986 2007.3Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunityReviewed
Nakajima Y, Haraguchi M, Furukawa T, Yamamoto M, Nakanishi H, Tatematsu M, Akiyama S. . 2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9. . Int J Cancer.119 ( 7 ) 1710 - 1716 2006.102-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9.Reviewed
Zhang Y, Yasumoto Y, Ikeda T, Takenouchi S, Sogabe A, Nosaki T, Che X, Zheng C, Haraguchi M, Akiyama S, Tsubouchi H. . Apolipoprotein E regulates primary cultured human mesangial cell proliferation. 2 . Nephron Exp Nephrol102 ( 2 ) 62 - 70 2006.9Apolipoprotein E regulates primary cultured human mesangial cell proliferation. 2Reviewed
Gotanda T, *Haraguchi M, Tachiwada T, Shinkura R, Koriyama C, Akiba S, Kawahara M, Nishiyama K, Sumizawa T, Furukawa T, Mimata H, Nomura Y, Akiyama S, Nakagawa M. . Molecular basis for the involvement of thymidine phosphorylase in cancer invasion. . Int J Mol Med. 17 ( 6 ) 1085 - 1091 2006.6Molecular basis for the involvement of thymidine phosphorylase in cancer invasion. Reviewed
Che XF, Zheng CL, Owatari S, Mutoh M, Gotanda T, Jeung HC, Furukawa T, Ikeda R, Yamamoto M, Haraguchi M, Arima N, Akiyama S. . Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines. . Blood105 ( 12 ) 4880 - 4887 2006.6Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines.Reviewed
Shimamoto Y, Sumizawa T, Haraguchi M, Gotanda T, Jueng HC, Furukawa T, Sakata R, Akiyama S. . Direct activation of the human major vault protein gene by DNA-damaging agents. 2006 15(3):645-52有り . Oncol Rep. 15 ( 3 ) 645 - 652 2006.3Direct activation of the human major vault protein gene by DNA-damaging agents. 2006 15(3):645-52有りReviewed
Ikeda R, Che XF, Ushiyama M, Yamaguchi T, Okumura H, Nakajima Y, Takeda Y, Shibayama Y, Furukawa T, Yamamoto M, Haraguchi M, Sumizawa T, Yamada K, Akiyama S. . 2-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK. . Biochem Biophys Res Commun.342 ( 1 ) 280 - 285 2006.32-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK. Reviewed
Jeung HC, Che XF, Haraguchi M*, Zhao HY, Furukawa T, Gotanda T, Zheng CL, Tsuneyoshi K, Sumizawa T, Roh JK, Akiyama S. . Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase . FEBS Lett.580 ( 5 ) 1294 - 1302 2006.2Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase Reviewed
Tsuneyoshi K, *Haraguchi M, Hongye Z, Gotanda T, Tachiwada T, Sumizawa T, Furukawa T, Baba M, Akiyama SI, Nakagawa M. . Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity. . Cancer Lett. 244 ( 2 ) 239 - 246 2006.2Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity. Reviewed
Noguchi T, Ren XQ, Aoki S, Igarashi Y, Che XF, Nakajima Y, Takahashi H, Mitsuo R, Tsujikawa K, Sumizawa T, Haraguchi M, Kobayashi M, Goto S, Kanehisa M, Aikou T, Akiyama S, Furukawa T. . MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 o . Biochem.Pharmacol.70 ( 7 ) 1056 - 1065 2005.10MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 oReviewed
Jeung HC, Che XF, Haraguchi M, Furukawa T, Zheng CL, Sumizawa T, Rha SY, Roh JK, Akiyama S. . Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents. . Biochem Pharmacol.70 ( 1 ) 13 - 21 2005.7Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents.Reviewed
Ikeda R, Che XF, Yamaguchi T, Ushiyama M, Zheng CL, Okumura H, Takeda Y, Shibayama Y, Nakamura K, Jeung HC, Furukawa T, Sumizawa T, Haraguchi M, Akiyama S, Yamada K. . Cepharanthine has potent enhancement of the sensitivity of anticancer agents in K562 cells. . Cancer Sci.96 ( 6 ) 372 - 376 2005.6Cepharanthine has potent enhancement of the sensitivity of anticancer agents in K562 cells.Reviewed
GSH inhibits trypsinization of the C-terminal half of human MRP1.Ren XQ, Furukawa T, Nakajima Y, Takahashi H, Aoki S, Sumizawa T, Haraguchi M, Kobayashi M, Chijiiwa K, Akiyama S. . GSH suppresses a tryptic site in the C-terminal half human MRP1. . J. Biol. Chem280 ( 7 ) 6231 - 6237 2005.2GSH suppresses a tryptic site in the C-terminal half human MRP1.Reviewed
Zheng CL, Sumizawa T, Che XF, Tsuyama S, Furukawa T, Haraguchi M, Gao H, Gotanda T, Jueng HC, Murata F, Akiyama S. . Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes. . Biochem. Biophys. Res. Commun. 326 ( 1 ) 100 - 107 2005.1Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes.Reviewed
Ren X.Q., Furukawa T., Haraguchi M., Sumizawa T., Aoki S., Kobayashi M., Akiyama S. . Function of the ABC signature sequences in the human multidrug resistance protein 1. . Mol. Pharmacol65 ( 6 ) 1536 - 1542 2004.6Function of the ABC signature sequences in the human multidrug resistance protein 1.Reviewed
Mitsuo M, NoguchiT, Nakajima Y, Aoki S, Ren XO, Sumizawa T, Haraguchi M, Kobayashi M, Baba M, Nagata Y, Akiyama S, Furukawa T . P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A. . Oncol Res14 39 - 48 2003P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A.
Ichikawa M, Yoshimura A, Sumizawa T, Shudo N, Kuwazuru Y, Furukawa T, Akiyama S. . Interaction of organic chemicals with P-glycoprotein in the adrenal gland, kidney, and a multidrug-resistant KB cell. . JOurnal of Biological Chemistry992 ( 3 ) 307 - 314 1992.3 Interaction of organic chemicals with P-glycoprotein in the adrenal gland, kidney, and a multidrug-resistant KB cell. Reviewed
The role of the transcriptional regulator snail in cell detachment, reattachment and migration. Reviewed
Haraguchi,M
Cell Adh Migr. 3 ( 3 ) 259 - 263 2009.7
αカテニンとカドヘリン 細胞骨格と接着
原口みさ子、小沢政之
蛋白質核酸酵素 51 ( 6 ) 636 - 641 2006.5
チミジンホスホリラーゼ がん分子標的治療 2005, 3(2), 32-39
原口みさ子、中島融一、池田龍二、古川龍彦、住澤知之、秋山伸一
メデイカルビュー社 3 ( 2 ) 32 - 39 2005.4
The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression. Reviewed
Akiyama S, Furukawa T, Sumizawa T, Takebayashi Y, Nakajima Y, Shimaoka S, Haraguchi M.
Cancer Sci. 95 ( 11 ) 851 - 857 2004.11
原口みさ子、小沢政之 CRISPR/Cas9システムを用いたsnail欠失細胞の作製、および細胞内代謝における変化解析
日本生化学会 日本生化学会
原口みさ子、小澤政之 Snail, slug発現誘導による細胞内代謝変化
日本分子生物学会 日本分子生物学会
原口 みさ子、小澤政之 2012
日本生化学会 日本生化学会
Misako Haraguchi, Masayuki Ozawa Snail reduces oxydative phosphorylation in MDCK cells International conference
Keystone symposium Keystone symposium
原口みさ子 小沢政之 snailによる細胞内代謝調節機構
日本生化学会 日本生化学会
原口みさ子 小沢政之 Snail regulates cell Metabolism
日本生化学会 日本生化学会
原口みさ子 小沢政之 Snail modulates cell metabolism in MDCK cells
日本癌学会 日本癌学会
原口みさ子 小沢政之 Regulation of MDCK cell metabolism by transcription factor snail
日本生化学会 日本生化学会
原口みさ子 小沢政之 Snail regulates cell-matrix adhesion by regulation of the expression of integrins and basement membrane proteins
日本癌学会 日本癌学会
原口みさ子、大久保議、宮下矢誉衣、小澤政之 転写因子スネイルはインテグリンや細胞外マトリックスタンパクの発現を調節することにより細胞と基質間の接着を制御する。
日本生化学会 日本生化学会
原口みさ子 チミジンホスホリラーゼ遺伝子の一塩基多型 (SNPs)とその酵素活性との関連日本癌学会総会
日本癌学会総会 日本癌学会総会
原口みさ子 チミジンホスホリラーゼの血管新生活性機構
がん分子標的治療研究会 がん分子標的治療研究会
