研究者詳細 - 橋本　文雄

論文 - 橋本　文雄

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橋本文雄 . 花と健康 . 口腔衛生学会雑誌73 ( 2 ) 90 - 96 2023年

Wang Zitai, Okutsu Kayu, Yoshizaki Yumiko, Futagami Taiki, Tamaki Hisanori, Maruyama Takuro, Toume Kazufumi, Komatsu Katsuko, Hashimoto Fumio, Takamine Kazunori . Massa Medicata Fermentataの酵素活性と揮発性に対する微生物発酵の影響(Effects of microbial fermentation on enzyme activity and volatile properties of Massa Medicata Fermentata) . Traditional & Kampo Medicine9 ( 1 ) 10 - 17 2022年4月

記述言語：英語出版者・発行元：John Wiley & Sons Australia, Ltd

Massa Medicata Fermentata(MMF)はAspergillus属やRhizopus属による微生物発酵でコムギと数種のハーブから調製されるので、微生物発酵の影響について検討した。National Standard for Chinese Patent Drugsに従ってMMFの原材料を混合し、Aspergillus oryzae培養で調製(MMF-A)またはRhizopus oryzae培養で調製(MMF-R)した。MMFの調製により酵素活性は上昇した。MMF-AはMMF-Rよりもα-アミラーゼとリパーゼの活性が高かった。プロテアーゼ活性はMMF-Rがわずかに高かった。テルペノイドは発酵で低下したが、2,3-ブタンジオール、アセトイン、グアヤコールはMMFだけで検出された。1-オクテン-3-オールのC8化合物はMMF-RよりもMMF-Aで高く、4-ビニルグアヤコールとピラジンの芳香族化合物はMMF-Rで高かった。

Wang Z., Okutsu K., Yoshizaki Y., Futagami T., Tamaki H., Maruyama T., Toume K., Komatsu K., Hashimoto F., Takamine K. . Effects of microbial fermentation on enzyme activity and volatile properties of Massa Medicata Fermentata . Traditional and Kampo Medicine9 ( 1 ) 10 - 17 2022年4月

記述言語：日本語出版者・発行元：Traditional and Kampo Medicine

Aim: Massa Medicata Fementata (MMF) is a crude drug used in East Asia to treat anorexia and dyspepsia. It is prepared from wheat and several herbs through microbial fermentation using Aspergillus sp. and Rhizopus sp. There is great difference in the quality of commercial MMF, and the microbes of MMF are suggested to affect its quality. We investigated the effects of microbial fermentation on the quality of MMF. Methods: Raw materials of MMF were mixed according to the ratio listed in the National Standard for Chinese Patent Drugs, and MMF was prepared using pure cultures of Aspergillus oryzae or Rhizopus oryzae. Digestive enzyme activities (α-amylase, protease, and lipase) and volatile compounds were measured using an analytical kit and GC–MS, respectively. Results: Enzyme activity increased in MMF. MMF prepared with A. oryzae (MMF-A) showed higher α-amylase and lipase activities than that prepared with R. oryzae (MMF-R). Protease activity was marginally higher in MMF-R than in MMF-A. GC–MS analysis revealed that terpenoids decreased with fermentation; however, 2,3-butanediol, acetoin, and guaiacol were detected in MMF only. C8 compounds such as 1-octen-3-ol were higher in MMF-A than MMF-R; however, aromatic compounds such as 4-vinylguaiacol and pyrazines were higher in MMF-R than MMF-A. Conclusion: Microbial fermentation contributes to increased enzyme activity and changes in MMF volatiles. These properties of MMF were considerably affected by the microbes used, and it is proposed in this study that it is important to have microbial control in the production of commercial MMF.

DOI： 10.1002/tkm2.1303

Scopus

Takatori Y., Shimizu K., Yauwapaksopon D., Nakamura Y., Oshima H., Hashimoto F. . Flavonoid 3',5'-Hydroxylase (F3'5'H) Gene Polymorphisms Co-segregate with Variation in Anthocyanin Composition in the Flower Petals of Lisianthus [Eustoma grandiflorum (Raf.) Shinn.] . The Horticulture Journal91 ( 2 ) 229 - 239 2022年

記述言語：英語出版者・発行元：一般社団法人　園芸学会

This study investigated genetic polymorphism related to anthocyanin composition variation in lisianthus (Eustoma grandiflorum) flower petals. Three different bands were detected by genomic polymerase chain reaction using specific primers based on the reported flavonoid 3',5'-hydroxylase (F3'5'H) gene sequence. Our genetic study revealed that they were allelic. They were named F3'5'H1-1, F3'5'H1-2, and f3'5'h1-2. F3'5'H1-1 and F3'5'H1-2 differed in the length of the intron. Allele f3'5'h1-2 possessed a retrotransposon insertion in the first exon, but otherwise, its gene sequence was almost identical to that of F3'5'H1-2. This retrotransposon is a Ty1-copia type retrotransposon and was designated as the retrotransposon of Eustoma grandiflorum 1 (rTeg1). The mauve flower line ‘ME’ and red-purple flower line ‘PRP’ were homozygous for F3'5'H1-1 and mostly accumulated cyanidin, with a small amount of delphinidin, in flower petals (the Cy major phenotype). The violet flower line ‘RV’ was homozygous for F3'5'H1-2 and accumulated only delphinidin (the Dp major phenotype). The pink-red flower line ‘AK’ was homozygous for f3'5'h1-2, accumulated pelargonidin, and lacked delphinidin (the Pg major-non Dp phenotype). Segregation analysis of the F2 population from ‘ME’ × ‘RV’ revealed that F3'5'H1-2 was associated with the Dp major phenotype, and the delphinidin major trait was dominant in the Cy major phenotype. All the Cy major phenotype plants in the F2 population possessed homozygous F3'5'H1-1. Genetic analysis of the F2 population from the cross between delphinidin-containing and delphinidin-lacking strains revealed that the homozygous f3'5'h1-2 genotype co-segregated with the Pg major-non Dp phenotype, which was recessive to the delphinidin-containing phenotypes. Expression analysis of the F3'5'H gene demonstrated that an abnormal mRNA was transcribed from the F3'5'H gene in the homozygous f3'5'h1-2 line by the insertion of rTeg1. Therefore, these F3'5'H gene polymorphisms can be used as DNA markers for breeding lisianthus based on flower color.

DOI： 10.2503/hortj.utd-320

Scopus

Zitai Wang, Kayu Okutsu*, Taiki Futagami, Yumiko Yoshizaki, Hisanori Tamaki, Takuro Maruyama, Kazufumi Toume, Katsuko Komatsu, Fumio Hashimoto and Kazunori Takamine. . Microbial Community Structure and Chemical Constituents in Shinkiku, a Fermented Crude Drug Used in Kampo Medicine. . Frontiers in Nutrition115 ( 7 ) 2020年7月査読

濵田延枝, 田浦一成, 野村哲也, 中野八伯, 橋本文雄, 清水圭一, 朴炳宰, 遠城道雄 . トルコギキョウの鹿児島大学オリジナル品種作出をめざした育成系統の生育および切り花品質調査 . 鹿児島大学農場研究報告 2020年3月査読

Md. Abdur Rauf Sarkar, Wakana Otsu, Akihiro Suzuki, Fumio Hashimoto, Toyoaki Anai and Satoshi Watanabe*. . Single-base deletion in GmCHR5 increases the genistein-to-daidzein ratio in soybean seed. . Breeding Science70 265 - 276 2020年3月査読

Atsushi SHIMADA, Kaoru KURAMOTO, Byoung-Jae PARK, Fumio HASHIMOTO, and Masashi YAMAMOTO*. . Relationship between Temperature and Fruit Quality during Ripening Period in Passion Fruit. . Trop. Agr. Develop.64 ( 2 ) 47 - 53 2020年2月査読

Sarkar Md. Abdur Rauf, Otsu Wakana, Suzuki Akihiro, Hashimoto Fumio, Anai Toyoaki, Watanabe Satoshi . Single-base deletion in GmCHR5 increases the genistein-to-daidzein ratio in soybean seed . Ｂｒｅｅｄｉｎｇ　Ｓｃｉｅｎｃｅ70 ( 3 ) 265 - 276 2020年

出版者・発行元：日本育種学会

Novel mutant alleles related to isoflavone content are useful for breeding programs to improve the disease resistance and nutritional content of soybean. However, identification of mutant alleles from high-density mutant libraries is expensive and time-consuming because soybean has a large, complicated genome. Here, we identified the gene responsible for increased genistein-to-daidzein ratio in seed of the mutant line F333ES017D9. For this purpose, we used a time- and cost-effective approach based on selective genotyping of a small number of F2 plants showing the mutant phenotype with nearest-neighboring-nucleotide substitution–high-resolution melting analysis markers, followed by alignment of short reads obtained by next-generation sequencing analysis with the identified locus. In the mutant line, GmCHR5 harbored a single-base deletion that caused a change in the substrate flow in the isoflavone biosynthetic pathway towards genistein. Mutated GmCHR5 was expressed at a lower level during seed development than wild-type GmCHR5. Ectopic overexpression of GmCHR5 increased the production of daidzein derivatives in both the wild-type and mutant plants. The present strategy will be useful for accelerating identification of mutant alleles responsible for traits of interest in agronomically important crops.

DOI： 10.1270/jsbbs.19134

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PubMed

SHIMADA Atsushi, KURAMOTO Kaoru, PARK Byoung-Jae, HASHIMOTO Fumio, YAMAMOTO Masashi . Relationship between Temperature and Fruit Quality during Ripening Period in Passion Fruit . Tropical Agriculture and Development64 ( 2 ) 47 - 53 2020年

出版者・発行元：日本熱帯農業学会

The optimum temperature during fruit ripening period of passion fruit (Passiflora edulis) was elucidated in the present study. 'Summer Queen' (P. edulis × P. edulis f. flavicarpa) and 'Ruby Star' (P. edulis × P. edulis f. flavicarpa) showed a greenish fruit peel and low total soluble solids/titratable acidity (TSS/TA) ratio at 15°C. In 'Summer Queen', a high °Brix, low titratable acidity, and high TSS/TA ratio were observed at 25°C. In 'Ruby Star', the peel coloration was highly favorable at 25°C. In both cultivars, the peel tended to be yellowish and °Brix of the juice was low at 35°C. These results indicate that the optimal temperature for passion fruit ripening was 25°C. In addition, we elucidated the varietal differences in the ripening characteristics of fruit on and off the vine.

DOI： 10.11248/jsta.64.47

Wang Z, Okutsu K, Futagami T, Yoshizaki Y, Tamaki H, Maruyama T, Toume K, Komatsu K, Hashimoto F, Takamine K . Microbial Community Structure and Chemical Constituents in Shinkiku, a Fermented Crude Drug Used in Kampo Medicine. . Frontiers in nutrition7 115 2020年

Md. Abdur Rauf Sarkar, Satoshi Watanabe, Akihiro Suzuki, Fumio Hashimoto, Toyoaki Anai. . Identification of novel MYB transcription factors involved in the isoflavone biosynthetic pathway by using the combination screening system with agroinfiltration and hairy root transformation. . Plant Biotechnology36 241 - 251 2019年3月査読

Sarkar Md. Abdur Rauf, Watanabe Satoshi, Suzuki Akihiro, Hashimoto Fumio, Anai Toyoaki . Identification of novel MYB transcription factors involved in the isoflavone biosynthetic pathway by using the combination screening system with agroinfiltration and hairy root transformation . Ｐｌａｎｔ　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ36 ( 4 ) 241 - 251 2019年

出版者・発行元：日本植物細胞分子生物学会

Soybean isoflavones are functionally important secondary metabolites that are mainly accumulated in seeds. Their biosynthetic processes are regulated coordinately at the transcriptional level; however, screening systems for key transcription factors (TFs) are limited. Here we developed a combination screening system comprising a simple agroinfiltration assay and a robust hairy root transformation assay. First, we screened for candidate MYB TFs that could activate the promoters of the chalcone synthase (CHS) gene GmCHS8 and the isoflavone synthase (IFS) genes GmIFS1 and GmIFS2 in the isoflavone biosynthetic pathway. In the agroinfiltration assay, we co-transformed a LjUbi (Lotus japonicus polyubiquitin gene) promoter-fused MYB gene with target promoter-fused GUS (β-glucuronidase) gene constructs, and identified three genes (GmMYB102, GmMYB280, and GmMYB502) as candidate regulators of isoflavone biosynthesis. We then evaluated the functional regulatory role of identified three MYB genes in isoflavone biosynthesis using hairy roots transformation assay in soybean for the accumulation of isoflavones. Three candidate MYB genes showed an increased accumulation of total isoflavones in hairy root transgenic lines. Accumulation of total isoflavones in the three MYB-overexpressing lines was approximately 2-to 4-folds more than that in the vector control, confirming their possible role to regulate isoflavone biosynthesis. However, the significant accumulation of authentic GmCHS8, GmIFS1, and GmIFS2 transcripts could not be observed except for the GmMYB502-overexpressing line. Therefore, the analysis of isoflavone accumulation in transgenic hairy root was effective for evaluation of transactivation activity of MYB TFs for isoflavone biosynthetic genes. Our results demonstrate a simple and robust system that can potentially identify the function of orphan TFs in diverse plant metabolic pathways.

DOI： 10.5511/plantbiotechnology.19.1025a

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PubMed

Manikharda, Makoto Takahashi, Mika Arakaki, Kaoru Yonamine, Fumio Hashimoto, Kensaku Takara, Koji Wada. . Influence of Fruit Ripening on Color, Organic Acid Contents, Capsaicinoids, Aroma Compounds, and Antioxidant Capacity of Shimatogarashi (Capsicum frutescens). . J Oleo Science67 ( 1 ) 113 - 123 2018年2月査読

Manikharda, Takahashi Makoto, Arakaki Mika, Yonamine Kaoru, Hashimoto Fumio, Takara Kensaku, Wada Koji . Influence of Fruit Ripening on Color, Organic Acid Contents, Capsaicinoids, Aroma Compounds, and Antioxidant Capacity of Shimatogarashi (Capsicum frutescens) . 日本油化学会誌67 ( 1 ) 113 - 123 2018年

出版者・発行元：公益社団法人日本油化学会

Shimatogarashi (Capsicum frutescens) is a typical chili pepper domesticated in southern Japan. Important traits of Shimatogarashi peppers, such as color; proportion of organic acids, capsaicinoids, and aromatic compounds; and antioxidant activity in three stages of maturity (green (immature), orange (turning), and red (mature) stages) were characterized. The results indicated that the concentration of organic acids, including ascorbic, citric, and malic acid, increased during ripening. In addition, the amount of capsaicinoids, which are responsible for the pungent taste of chili peppers, increased as the fruit matured to the orange and red stages. The volatile compound profile of Shimatogarashi was dominated by the presence of esters, which mainly contributed to fruity notes. The total amount of volatile compounds analyzed by gas chromatography-headspace solid-phase microextraction (GC-HS-SPME), especially esters, decreased as the fruit changed in color from green to red. This was in contrast to the amount of terpenoids, especially limonene, which increased at the red stage, denoting a change in flavor from fruity to a more citrus-like aroma. Based on the total phenolic content (TPC), the oxygen radical absorbance capacity (ORAC) and the diphenylpicrylhydrazyl (DPPH) free radical method, the antioxidant capacity of Shimatogarashi showed an increase at the mature red stage. However, while the red stage showed higher pungency and antioxidant capacity as well as an attractive color, the results of aromatic compound analysis revealed that the immature green stage had the advantages of having pleasant fruity smell, making it suitable for use in condiments.

DOI： 10.5650/jos.ess17156

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PubMed

Su Xiaoqin, Zhang Gao-Ju, Ma Yan, Chen Mao, Chen Sheng-Hu, Duan Shuang-Mei, Wan Jin-Qiong, Fumio Hashimoto, Lin Zhi, Li Jia-Hua, Zhao Ming. . Isolation, Identification, and Biotransformation of Teadenol A from Solid State Fermentation of Pu-erh tea and In Vitro Antioxidant Activity. . Applied Sciences6 161 2016年4月査読

髙取由佳, 櫟本裕太郎, 清水圭一, 橋本文雄 . 野生種トルコギキョウを起源とする二重咲き花形の遺伝様式 . 園芸学研究14 ( 4 ) 341 - 348 2015年10月査読

Kayu Okutsu, Yumiko Yoshizaki, Natsumi Ikeda, Tatsuro Kusano, Fumio Hashimoto, Kazunori Takamine . Antioxidants in Heat-Processed Koji and Evaluation of Antioxidant Production Mechanisms. . Food Chem.187 364 - 369 2015年5月査読

Yuka Takatori, Keiichi Shimizu, Jun Ogata, Hiroki Endo, Kanji Ishimaru, Shigehisa Okamoto, Fumio Hashimoto . Cloning of the Flavonoid 3'-Hydroxylase Gene of Eustoma grandiflorum (Raf.) Shinn. (EgF3'H) and Complementation of an F3'H-Deficient Mutant of Ipomoea nil (L.) Roth. by Heterologous Expression of EgF3'H. . The Horticulture J.82 ( 4 ) 131 - 139 2015年4月査読

Phyu Phyu Khine Zar, Satoshi Yano, Kozue Sakao, Fumio Hashimoto, Takayuki Nakano, Makoto Fujii, De-Xing Hou. . In vitro Anticancer Activity of Loquat Tea by Inducing Apoptosis in Human Leukemia Cells. . Biosci. Biotechnol. Biochem.78 ( 10 ) 1731 - 1737 2014年10月査読

Ayami Hisanaga, Hisako Ishida, Kozue Sakao, Takayuki Sogo, Takuma Kumamoto, Fumio Hashimoto and De-Xing Hou. . Anti-inflammatory Activity and Molecular Mechanism of Oolong Tea Theasinensin . Food and Function5 1891 - 1897 2014年8月査読

Katsuyuki Ichitani, Daisuke Yamaguchi, Satoru Taura, Yasuo Fukutoku, Masahira Onoue, Keiichi Shimizu, Fumio Hashimoto, Yusuke Sakata and Muneharu Sato. . Genetic Analysis of Ion-Beam Induced Extremely Late Heading Mutants in Rice. . Breeding Science64 222 - 230 2014年6月査読

城戸麻里、野村哲也、田浦一成、遠城道雄、橋本文雄． . 冬季無加温栽培における種子冷蔵および電照処理がトルコギキョウ（Eustoma grandiflorum (Raf.) Shinn.）の発芽、生育並びに開花に及ぼす影響． . 鹿児島大学農場研究報告（Bull. Exp. Farm Fac. Agr. Kagoshima Univ.）36 7 - 13 2014年3月

Shimizu, K., Hashimoto, F. . The Construction of Two New Activation-Tagging Vectors, pKANAC2H and pKANAC2K. . Bull. Fac. Agr. Kagoshima Univ.64 37 - 43 2014年3月

Phyu Phyu Khine Zar, Akiko Morishita, Fumio Hashimoto, Kozue Sakao, Makoto Fujii, Koji Wada, De-Xing Hou. . Anti-inflammatory Effects and Molecular Mechanisms of Loquat (Eriobotrya japonica) Tea. . Journal of Functional Foods (JFF)6 523 - 533 2014年1月査読

Phyu Phyu Khine Zar, Kozue Sakao, Fumio Hashimoto, Akiko Morishita, Makoto Fujii, Koji Wada, De-Xing Hou. . Antioxidant and Anti-inflammatory Activities of Loquat (Eriobotrya japonica) Tea. . The Journal of Functional Foods in Health and Disease (FFHD)3 447 - 461 2013年11月査読

Shimizu, K., Hashimoto, F. . A New Series of Activation-Tagging Vectors: pKANACB, pKANACK and pKANACH. . Bull. Fac. Agr. Kagoshima Univ.63 39 - 47 2013年3月

Kamizono, T., Ohtsuka, A., Hashimoto, F. Hayashi, K. . Dibutoxybutane Suppresses Protein Degradation and Promotes Growth in Cultured Chicken Muscle Cells . J Poultry Sci.50 37 - 43 2013年1月査読

Li, J.-B., Hashimoto, F., Shimizu, K., Sakata, Y. . Chemical Taxonomy of Red-Flowered Wild Camellia Species Based on Floral Anthocyanins . Phytochemistry85 99 - 106 2013年1月査読

高峯和則, 吉崎由美子，山本優，吉竹一哉，橋本文雄，玉置尚徳，鮫島吉廣 . サツマイモに含まれるモノテルペン配糖体の分布 . 日本醸造学会誌107 782 - 787 2012年10月査読

Chen, J.-H., Qin, S., Xiao, J.-P., Tanigawa, S., Uto, T., Hashimoto, F., Fujii, M., Hou, D.-X. . A Genome-Wide Microarray Highlights the Anti-Inflammatory Genes Targeted by Oolong Tea Theasinensin A in Microphages . Nutrition and Cancer63 ( 7 ) 1064 - 1073 2011年10月査読

Shimizu, K., Onishi, N., Morikawa, N., Ishigami, A., Otake, S., Rabah, I.O., Sakata, S., Hashimoto, F* . A 94-bp Deletion of Anthocyanidin Synthase Gene in Acyanic Flower Lines of Lisianthus [Eustoma grandiflorum (Raf.) Shinn.] . J. Japan. Soc. Hortic. Sci.80 ( 4 ) 434 - 442 2011年10月査読

李家华, 邵宛芳, 张广辉, 坂田祐介, 根角厚司, 橋本文雄 . Hereditary Analysis of Tea Polyphenols in Camellia sinensis F1 Hybrids Based on Principal Component and Cluster Analysis. (基于PCA和聚?分析的茶?F1代茶多???分析) . Molecular Plant Breeding (分子植物育種)(In Chinese with English Abstract)9 ( 4 ) 491 - 497 2011年9月査読

Al-Dabbas, M. M., Al-Ishimail, K., Abu-Taleb, R., Hashimoto, F., Rabah, I.O., Kitahara, K., Fujita, K., Suganuma, T. . Chemistry and Anti-proliferative Activities of 3-Methoxyflavones Isolated from Varthemia iphionoides . Chemistry of Natural Compouds47 ( 1 ) 17 - 21 2011年3月査読

Hou, D.-X., Masuzaki, S., Tanigawa, S., Hashimoto, F., He, X., He, J.-H., Fujii, M. . Oolong Tea Theasinesins Attenuate Cyclooxygenase-2 Expression in Lipopolysaccharide (LPS)-Activated Mouse Macrophages: Structure-Activity Relationship and Molecular Mechanisms. . J. Agr. Food Chem.58 12735 - 12743 2010年12月査読

Li, J.-H., Nesumi, A., Shimizu, K., Sakata, Y., Liang, M.-Z., He, Q.-Y., Zhou, H.-Z., Hashimoto, F. . Chemosystematics of tea trees based on tea leaf polyphenols as phenetic markers. . Phytochemistry71 ( 42320 ) 1342 - 1349 2010年7月査読

Hashimoto, F., Fukuda, S., Maeda, H., Tanaka, M., Shimizu, K., Chishaki, N., Sakata, Y. and Ishiguro, E. . Determination of Flower Coloration in Delphinium spp. by Monitoring Sepal Anthocyanin in Vivo. . Memoir of the Faculty of Agriculture, Kagoshima University60 15 - 27 2010年3月

Li, J.-B., Hashimoto, F., Shimizu, K., Sakata, Y. . A New Acylated Anthocyanin from the Red Flowers of Camellia hongkongensis and Characterization of Anthocyanins in the Section Camellia Species. . Journal of the Integrative and Plant Biology51 ( 6 ) 545 - 552 2009年6月査読

Li, J.-B., Hashimoto, F., Shimizu, K., Sakata, Y. . Anthocyanins from red flowers of Camellia cultivar ‘Dalicha.’ . Phytochemistry69 3166 - 3171 2008年11月査読

李家華、周紅傑、清水圭一、坂田祐介、橋本文雄. . 雲南プーアル茶の発酵過程におけるポリフェノールおよびカフェインの変化. . 農業生産技術管理学会誌15 ( 2 ) 63 - 69 2008年11月査読

Li JB, Hashimoto F, Shimizu K, Sakata Y. . Anthocyanins from the Red Flowers of Camellia saluenensis STAPF EX BEAN. . Journal of the Japanese Society for Horticultural Science77 ( 1 ) 75 - 79 2008年1月査読

李家華、石黒悦爾、根角厚司、石川大太郎、清水圭一、坂田祐介、橋本文雄. . 肥料の違いが茶ポリフェノール類の含量に与える影響. . 農業生産技術管理学会誌14 ( 2 ) 87 - 92 2007年12月査読

Li JB, Hashimoto F, Shimizu K, Sakata Y. . Anthocyanins from Red Flowers of Camellia reticulata LINDL. . Bioscience, Biotechnology and Biochemistry71 ( 11 ) 2833 - 2836 2007年11月査読

Hou DX, Luo D, Tanigawa S, Hashimoto F, Uto T, Masuzaki S, Fujii M, Sakata Y. . Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NFkB pathway. . Biochemical Pharmacology74 742 - 751 2007年9月査読

Hou DX, Masuzaki S, Hashimoto F, Uto T, Tanigawa S, Fujii M, Sakata Y. . Green Tea Proanthocyanidins Inhibit Cyclooxygenase-2 Expression in LPS-Activated Mouse Macrophages: Molecular Mechanisms and Structure-Activity Relationship. . Archives of Biochemistry and Biophysics460 67 - 74 2007年4月査読

Yoshimitsu H, Nishida M, Hashimoto F, Tanaka M, Sakata Y, Okawa M, Nohara T. . Chromone and Flavonol Glycosides from Delphinium hybridum cv. 'Belladonna Casablanca'. . Journal of Natural Medicine61 334 - 338 2007年4月査読

Chi YM, Nakamura M, Zhao XY, Yoshizawa T, Yan WM, Hashimoto F, Chi YC, Kinjo J, Nohara T. . A Novel Macrocyclic Spermine Alkaloid from Incarvillea sinensis. . Journal of Asian Natural Product Research9 ( 2 ) 115 - 118 2007年3月査読

Al-Dabbas MM, Kitahara K, Suganuma T, Hashimoto F, Tadera K. . Antioxidant and a-Amylase Inhibitory Compounds from Aerial Parts of Varthemia iphionoides Boiss. . Bioscience, Biotechnology and Biochemistry70 ( 9 ) 2178 - 2184 2006年9月査読

Chi YM, Nakamura M, Zhao XY, Yoshizawa T, Yan WM, Hashimoto F, Kinjo J, Nohara T, Sakurada S. . Antinociceptive Activities of a-Truxillic Acid and b-Truxillic Acid Derivatives. . Biological and Pharmaceutical Bulletin29 ( 3 ) 580 - 584 2006年3月査読

Chi YM, Nakamura M, Zhao XY, Yoshizawa T, Yan WM, Hashimoto F, Kinjo J, Nohara T, Sakurada S. . Anti-inflamatory Activity of 4,4'-Dihydroxy-a-Truxillic Acid. . Biological and Pharmaceutical Bulletin29 ( 3 ) 489 - 493 2006年3月査読

山本雅史、河野留美子、上野景子、橋本文雄、小橋謙史、松本亮司、吉岡照高、冨永茂人. . ケラジ（Citrus keraji）における果実品質の時期別変化とそれらの相互関係. . 熱帯農業49 ( 4 ) 280 - 287 2005年12月査読

Chi YM, Zhao XY, Yoshizawa T, Nakamura M, Yan WM, Hashimoto F, Chi YC, Kinjo J, Nohara T. . Quantitative Determination of Incarvillateine in Incarvillea sinensis by Solid Phase Extraction and High Performance Liquid Chromatography. . Chemical and Pharmaceutical Bulletin53 ( 11 ) 1472 - 1474 2005年11月査読

Chi YM, Nakamura M, Yoshizawa T, Zhao XY. Yan WM, Hashimoto F, Kinjo J, Nohara T, Sakurada S. . Pharmacological Study on the Novel Antinociceptive Agent, a Novel Monoterpene Alkaloid from Incarvillea sinensis. . Biological and Pharmaceutical Bulletin28 ( 10 ) 1989 - 1991 2005年10月査読

Nakai M, Fukui Y, Asami S, Toyoda-Ono Y, Iwashita T, Shibata H, Mitsunaga T, Hashimoto F, Kiso Y. . Inhibitory Effects of Tea Polyphenols on Pancreatic Lipase in vitro. . Journal of Agricultural and Food Chemistry53 4593 - 4598 2005年9月査読

Chi YM, Nakamura M, Yoshizawa T, Zhao XY, Yan WM, Hashimoto F, Kinjo J, Nohara T, Sakurada S. . Anti-inflammatory Activities of a-Truxillic Acid Derivatives and Their Monomer Component. . Biological and Pharmaceutical Bulletin28 ( 9 ) 1776 - 1778 2005年9月査読

Chi YM, Nakamura M, Zhao XY, Yoshizawa T, Yan WM, Hashimoto F, Kinjo J, Nohara T. . A Monoterpene Alkaloid from Incarvillea sinensis. . Chemical and Pharmaceutical Bulletin53 ( 9 ) 1178 - 1179 2005年9月査読

Shimizu K, Tokumura T, Hashimoto F, Sakata Y. . In vitro Propagation of Sterile Mutant Strains in Japanese Morning Glory by Culture of Embryoid Derived from Immature Embryo. . Journal of the Japanese Society for Horticultural Science74 ( 4 ) 311 - 317 2005年7月査読

Wang JW, Yu YJ, Hashimoto F, Sakata Y, Fujii M, Hou DX. . Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells. . International Journal of Molecular Medicine14 627 - 632 2004年9月査読

Shimizu K, Yogai T, Hashimoto F, Sakata Y. . Plant Regeneration from Suspension Cell Culture of Delphinium. . Journal of the Japanese Society for Horticultural Science73 ( 5 ) 435 - 440 2004年7月査読

Hashimoto F, Uddin AFM J, Shimizu K, Sakata Y. . Multiple Allelism in Flavonoid Hydroxylation in Eustoma grandiflorum (Raf.) Shinn. Flowers. . Journal of the Japanese Society for Horticultural Science73 ( 3 ) 235 - 240 2004年5月査読

Uddin, A. F. M. J., Hashimoto, F., Shimizu, K., Sakata, Y. . Monosaccharides and Chitosan Sensing in Bud Growth and Petal Pigmentation in Eustoma grandiflorum (Raf.) Shinn. . Scientia Horticulturae100 ( 42008 ) 127 - 138 2004年3月査読

Uddin, A. F. M. J., Hashimoto, F., Miwa, T., Shimizu, K., Sakata, Y. . Effect of Plantlux Light on Coloration and Flavonoid Accumulation of Commercial Lisianthus Flowers (in vitro). . Mem. Fac. Agric. Kagoshima. Univ.39 7 - 14 2004年3月査読

Wang, L.-S., Hashimoto, F., Shiraishi, A., Aoki, N., Li, J.-J., Sakata, Y. . Chemical Taxonomy of the Xibei Tree Peony from China by Floral Pigmentation. . J. Plant Res.117 ( 1 ) 47 - 55 2004年3月査読

西本慎一, 橋本文雄, 清水圭一, 坂田祐介. . キンカチャ×ヤブツバキ種間雑種の花色. . 園学雑73 ( 2 ) 189 - 191 2004年3月査読

Uddin, A. F. M. J., Hashimoto, F., Miwa, T., Ohbo, K., Sakata, Y. . Seasonal Variation in Pigmentation and Anthocyanidin Phenetics in Commercial Eustoma Flowers. . Scientia Horticulturae100 ( 42008 ) 103 - 115 2004年1月査読

Shimizu, K., Hashimoto, M., Hashimoto, F., Sakata, Y. . Plant Regeneration from Suspension Culture in Japanese Morning Glory. . J. Jpn. Soc. Hortic. Sci.72 ( 5 ) 409 - 414 2003年9月査読

Oku, N., Matsukawa, M., Yamakawa, S., Asai, T., Yahara, S., Hashimoto, F., Akizawa, T. . Inhibitory Effect of Green Tea Polyphenols on Membrane-Type 1 Matrix Metalloproteinase, MT1-MMP. . Biol. Pharm. Bull.26 ( 9 ) 1235 - 1238 2003年9月査読

西本慎一, 清水圭一, 橋本文雄, 坂田祐介. . 胚珠培養によるツバキ属種間雑種（キンカチャ×ヤブツバキ）の作出. . 園学雑72 ( 3 ) 236 - 242 2003年5月査読

Uddin, A. F. M. J., Hashimoto, F., Sakata, Y. . Mode of Inheritance and Allele Expression of Three Major Anthocyanidins in Eustoma grandiflorum Cultivars. . Acta Horticulturae, XXVIth International Horticultural Congress, Elegant Science in Floriculture (Proceedings) ( 624 ) 51 - 59 2003年3月査読

Hashimoto, F., Ono, M., Masuoka, C., Ito, Y., Sakata, Y., Shimizu, K., Nonaka, G., Nishioka, I., Nohara, T. . Evaluation of the Anti-Oxidative Effect (in vitro) of Tea Polyphenols. . Biosci. Biotechnol. Biochem.67 ( 2 ) 396 - 401 2003年2月査読

Hashimoto, F., Tanaka, M., Maeda, H., Fukuda, S., Shimizu, K., Sakata, Y. . Changes in Flower Coloration and Sepal Anthocyanins of Cyanic Delphinium Cultivars during Flowering. . Biosci. Biotechnol. Biochem.66 ( 8 ) 1652 - 1659 2002年8月査読

王亮生, 橋本文雄, 青木宣明, 劉政安, 清水圭一, 白石綾, 坂田祐介. . 促成栽培がボタンの花色と花弁の色素組成に及ぼす影響. . 農業生産技術管理学会誌9 ( 1 ) 77 - 85 2002年3月査読

Uddin, A. F. M. J., Hashimoto, F., Nishimoto, S., Shimizu, K., Sakata, Y. . Flower Growth, Coloration and Petal Pigmentation in Four Lisianthus Cultivars. . J. Jpn. Soc. Hortic. Sci.71 ( 1 ) 40 - 47 2002年1月査読

Wang, L.-S., Hashimoto, F., Shiraishi, A., Aoki, N., Li, J.-J., Shimizu, K., Sakata, Y. . Phenetics in Tree Peony Species from China by Flower Pigment Cluster Analysis. . J. Plant Res.114 ( 1115 ) 213 - 221 2001年9月査読

Suzuki, K., Yahara, S., Hashimoto, F., Uyeda, M. . Inhibitory Activities of (-)-Epigallocatechin-3-O-gallate against Topoisomerase I and II. . Biol. Pharm. Bull.24 ( 9 ) 1088 - 1090 2001年9月査読

Nakamura, M., Chi, Y.-M., Yan, W.-M., Yonezawa, A., Nakasugi, Y., Yoshizawa, T., Hashimoto, F., Kinjo, J., Nohara, T., Sakurada, S. . Structure-Antinociceptive Activity Studies of Incarvillateine, a Monoterpene Alkaloid from Incarvillea sinensis. . Planta Medica67 ( 2 ) 114 - 117 2001年3月査読

Uddin, A. F. M. J., Hashimoto, F., Kaketani, M., Shimizu, K., Sakata, Y. . Analysis of Light and Sucrose Potencies on Petal Coloration and Pigmentation of Lisianthus Cultivars (in vitro). . Scientia Horticulturae89 ( 1 ) 73 - 82 2001年3月査読

Wang, L.-S., Shiraishi, A., Hashimoto, F., Aoki, N., Shimizu, K., Sakata, Y. . Analysis of Petal Anthocyanins to Investigate Flower Coloration of Zhongyuan (Chinese) and Daikon Island (Japanese) Tree Peony Cultivars. . J. Plant Res.114 ( 1113 ) 33 - 43 2001年1月査読

Hashimoto, F., Tanaka, M., Maeda, H., Shimizu, K., Sakata, Y. . Characterization of Cyanic Flower Color of Delphinium Cultivars. . J. Jpn. Soc. Hortic. Sci.69 ( 4 ) 428 - 434 2000年7月査読

Nakamura, M., Chi, Y. M., Yan, W. M., Nakasugi, Y., Yoshizawa, T., Irino, N., Hashimoto, F., Kinjo, J., Nohara, T., Sakurada, S. . Strong Antinociceptive Effect of Incarvillateine, a Novel Monoterpene Alkaloid from Incarvillea sinensis. . J. Nat. Prod.62 ( 9 ) 1293 - 1294 1999年9月査読

Yoshimitsu, H., Nishida, M., Hashimoto, F., Nohara, T. . Cycloartane-Type Glycosides from Aquilegia flabellata. . Phytochemistry51 ( 3 ) 449 - 452 1999年5月査読

Sugaya, K., Hashimoto, F., Ono, M., Ito, Y., Masuoka, C., Nohara, T. . Anti-Oxidative Constituents from Leonurii Herba (Leonurus japonicus). . Food Sci. Technol. Int. Tokyo4 ( 4 ) 278 - 281 1998年7月査読

Hashimoto, F., Kashiwada, Y., Cosentino, L. M., Chen, C.-H., Garrett, P. E., Lee, K.-H. . Anti-AIDS Agents-XXVII. Synthesis and Anti-HIV Activity of Betulinic Acid and Dihydrobetulinic Acid Derivatives. . Bioorg. Med. Chem.5 ( 12 ) 2133 - 2143 1997年12月査読

Chi, Y. M., Hashimoto, F., Yan, W. M., Nohara, T. . Four Monoterpene Alkaloid Derivatives from Incarvillea sinensis. . Phytochemistry46 ( 4 ) 763 - 769 1997年8月査読

Chi, Y. M., Hashimoto, F., Yan, W. M., Nohara, T. . Five Novel Macrocyclic Spermine Alkaloids from Incarvillea sinensis. . Tetrahedron Lett.38 ( 15 ) 2713 - 2716 1997年5月査読

Chi, Y. M., Hashimoto, F., Yan, W. M., Nohara, T., Yamashita, M., Marubayashi, N. . Monoterpene Alkaloids from Incarvillea sinensis. VI. Absolute Stereochemistry of Incarvilline and Structure of a New Alkaloid, Hydroxyincarvilline. . Chem. Pharm. Bull.45 ( 3 ) 495 - 498 1997年3月査読

田中俊弘, 野呂征男, 川村智子, 池永敏彦, 磯田進, 遠藤豊, 沖和行, 久保成行, 神田博史, 正山征洋, 白井英夫, 菅谷愛子, 谷口抄子, 橋本文雄, 早坂英記, 福井賢, 御影雅幸, 邑田裕子, 柳沢市治, 山下善見, 渡辺高志. . コガネバナの共同栽培試験. . 日本植物園協会誌31 62 - 67 1997年3月査読

Hashimoto, F., Kashiwada, Y., Nonaka, G., Nishioka, I., Nohara, T., Cosentino, L. M., Lee, K. H. . Evaluation of Tea Polyphenols As Anti-HIV Agents. . Bioorg. Med. Chem. Lett.6 ( 6 ) 695 - 700 1996年6月査読

Kashiwada, Y., Hashimoto, F., Cosentino, L. M., Chen, C. H., Garrett, P. E., Lee, K. H. . Betulinic Acid and Dihydrobetulinic Acid Derivatives As Potent Anti-HIV Agents. . J. Med. Chem.39 ( 5 ) 1016 - 1017 1996年5月査読

Nakamura, T., Komori, C., Lee, Y. Y., Hashimoto, F., Yahara, S., Nohara, T., Ejima, A. . Cytotoxic Activities of Solanum Steroidal Glycosides. . Biol. Pharm. Bull.19 ( 4 ) 564 - 566 1996年4月査読

Chi, Y. M., Hashimoto, F., Yan, W. M., Nohara, T. . Incarvine A, A Monoterpene Alkaloid from Incarvillea sinensis. . Phytochemistry40 ( 1 ) 353 - 354 1995年3月査読

Chi, Y. M., Hashimoto, F., Yan, W. M., Nohara, T. . Two Alkaloids from Incarvillea sinensis. . Phytochemistry39 ( 6 ) 1485 - 1487 1995年2月査読

Kinjo, J., Kishida, F., Watanabe, K., Hashimoto, F., Nohara, T. . Five New Triterpene Glycosides from Russell Lupine. . Chem. Pharm. Bull.42 ( 9 ) 1874 - 1878 1994年9月査読

Lee, Y., Hashimoto, F., Yahara, S., Nohara, T., Yoshida, N. . Steroidal Glycosides from Solanum dulcamara. . Chem. Pharm. Bull.42 ( 3 ) 707 - 709 1994年3月査読

Hashimoto, F., Nonaka, G., Nishioka, I. . Tannins and Related Compounds. CXIV. Structures of Novel Fermentation Products, Theogallinin, Theaflavonin and Desgalloyl Theaflavonin from Black Tea, and Changes of Tea Leaf Polyphenols during Fermentation. . Chem. Pharm. Bull.40 ( 6 ) 1383 - 1389 1992年6月査読

Hashimoto, F., Fujii, Y., Toba, M., Okamatsu, H., Kohri, H. . Determination of Absorption and Endogenous Excretion of Iron in Man by Monitoring Fecal Excretion of a Stable Iron Isotope (58Fe). . J. Nutr. Sci. Vitaminol.38 ( 5 ) 435 - 449 1992年5月査読

Kumemura, M., Hashimoto, F., Fujii, C., Matsuo, K., Kimura, H., Miyazoe, R., Okamatsu, H., Inokuchi, T., Ito, H., Oizumi, K., Oku, T. . Effects of Administration of 4G-b-D-Galactosylsucrose on Fecal Microflora, Putrefactive Products, Short-Chain Fatty Acids, Weight, Moisture and pH, and Subjective Sensation of Defecation in the Elderly with Constipation. . J. Clin. Biochem. Nutr.13 ( 3 ) 199 - 210 1992年3月査読

藤井智恵美, 久米村恵, 橋本文雄, 石田晋也, 松尾恵子, 木村弘之, 宮副玲子, 岡松洋, 光岡知足. . 4G-b-D-Galactosylsucrose (ラクトスクロース) のヒト腸内細菌叢に及ぼす影響. . ビフィズス6 ( 1 ) 31 - 41 1992年1月査読

Taniguchi, M., Imamura, H., Shirota, T., Okamatsu, H., Fujii, Y., Toba, M., Hashimoto, F. . Improvement in Iron Defeciency Anemia through Therapy with Ferric Ammonium Citrate and Vitamin C and the Effects of Aerobic Excercise. . J. Nutr. Sci. Vitaminol.37 ( 2 ) 161 - 171 1991年2月査読

Hashimoto, F., Nonaka, G., Nishioka, I. . Tannins and Related Compounds. XC. 8-C-Ascorbyl (-)-Epigallocatechin 3-O-Gallate and Novel Dimeric Flavan-3-ols, Oolonghomobisflavans A and B, from Oolong Tea. (3). . Chem. Pharm. Bull.37 ( 12 ) 3255 - 3263 1989年12月査読

Hashimoto, F., Nonaka, G., Nishioka, I. . Tannins and Related Compounds. LXXVII. Novel Chalcan-flavan Dimers, Assamicains A, B and C, and a New Flavan-3-ol and Proanthocyanidins from the Fresh Leaves of Camellia sinensis L. var. assamica KITAMURA. . Chem. Pharm. Bull.37 ( 1 ) 77 - 85 1989年1月査読

Hashimoto, F., Nonaka, G., Nishioka, I. . Tannins and Related Compounds. LXIX. Isolation and Structure Elucidation of B,B'-Linked Bisflavanoids, Theasinensins D-G and Oolongtheanin from Oolong Tea. (2). . Chem. Pharm. Bull.36 ( 5 ) 1676 - 1684 1988年5月査読

Hashimoto, F., Nonaka, G., Nishioka, I. . Tannins and Related Compounds. LVI. Isolation of Four New Acylated Flavan-3-ols from Oolong Tea. (1). . Chem. Pharm. Bull.35 ( 2 ) 611 - 616 1987年2月査読

Nonaka, G., Hashimoto, F., Nishioka, I. . Tannins and Related Compounds. XXXVI. Isolation and Structures of Theaflagallins, New Red Pigments from Black Tea. . Chem. Pharm. Bull.34 ( 1 ) 61 - 65 1986年1月査読

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