研究者詳細 - 三好　宣彰

論文 - 三好　宣彰

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Md. Mahfuzur Rahman, Yu-Chang Lai, Al Asmaul Husna, Hui-wen Chen, Yuiko Tanaka , Hiroaki Kawaguchi, Noriaki Miyoshi, Takayuki Nakagawa, Ryuji Fukushima, Naoki Miura. . Micro RNA Transcriptome Profile in Canine Oral Melanoma . International Journal of Molecular Sciences20 ( 19 ) 4832 2019年9月査読

記述言語：英語掲載種別：研究論文（学術雑誌）

Abstract: MicroRNAs (miRNAs) dysregulation contribute the cancer pathogenesis. However, the miRNA profile of canine oral melanoma (COM), one of the frequent malignant melanoma in dogs is still unrevealed. The aim of this study is to reveal the miRNA profile in canine oral melanoma. MiRNAs profile of oral tissues from normal healthy dogs and COM patients were compared by next-generation sequencing. Along with tumour suppressor miRNAs, we report 30 oncogenic miRNAs in COM. The expressions of miRNAs were further confirmed by quantitative real-time PCR (qPCR). Pathway analysis showed that deregulated miRNAs impact on cancer and signalling pathways. Three oncogenic miRNAs targets (miR-450b, 301a, and 223) from human study also were down-regulated in COM and had a significant negative correlation with their respective miRNA. Furthermore, we found that miR-450b expression is higher in metastatic cells and regulated MMP9 expression through a PAX9-BMP4-MMP9 axis. In silico analysis indicated that miR-126, miR-20b, and miR-106a regulated the highest numbers of differentially expressed transcription factors with respect to human melanoma. Chromosomal enrichment analysis revealed the X chromosome was enriched with oncogenic miRNAs. We comprehensively analyzed the miRNA’s profile in COM which will be a useful resource for developing therapeutic interventions in both species.

DOI： doi:10.3390/ijms20194832

Norio Ushio, Md Mahfuzur Rahman, Tadashi Maemura, Yu-Chang Lai, Tomoko Iwanaga, Hiroaki Kawaguchi, Noriaki Miyoshi, Yasuyuki Momoi, Naoki Miura . Identification of dysregulated microRNAs in canine malignant melanoma. . Oncology Letter17 ( 1 ) 1080 - 1088 2019年1月査読

Kido N, Tanaka S, Omiya T, Shoji Y, Senzaki M, Hanzawa S, Ando M, Osaki T, Hatai H, Miyoshi N, Hifumi T, Suzuki N, Kawakami S. . Novel treatment for chronic pododermatitis in an Indian elephant (Elephas maximus indicus) with Mohs' paste. . Journal of Veterinary Medical Science80 ( 12 ) 1834 - 1838 2018年12月査読

Y-C Lai, N Ushio, M M Rahman, Y Katanoda, K Ogiharn, Y Naya, A Moriyama, T Iwanaga, Y Saitoh, T Sogawa, T Sunaga, Y Momoi, H Izumi, N Miyoshi, Y Endo, M Fujiki, H Kawaguchi, N Miura . Aberrant expression of microRNAs and the miR-1/MET pathway in canine hepatocellular carcinoma . Veterinary and Comparative Oncology16 ( 2 ) 288 - 296 2018年6月査読

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Veterinary and Comparative Oncology

Canine hepatocellular carcinoma (HCC) is the most common primary hepatic tumour in dogs. MicroRNA (miRNA) dysregulation has been reported in human HCC and shown to have diagnostic and prognostic value; however, there are no data on miRNA expression in canine HCC. The aim of the present study was to investigate differentially expressed miRNAs in canine HCC. Analysis of miRNA expression in canine HCC tissues and cell lines by quantitative reverse transcription PCR showed that miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC. MET is one of the target genes of miR-1. MET was upregulated in canine HCC at the gene and protein levels, and a significant correlation between the concomitant downregulation of miR-1 and upregulation of MET was observed. Fast/intermediate-proliferating canine HCC cell lines had higher MET gene and protein expression levels than the slow-proliferating cell line. These findings suggest that miRNAs are differentially expressed in canine HCC, and that the miR-1/MET pathway may be associated with canine HCC cell proliferation.

DOI： 10.1111/vco.12379

Scopus

Mariko Sawa, Akira Yabuki, Moeko Kohyama, Noriaki Miyoshi, Osamu Yamato . Rapid multiple immunofluorescent staining for the simultaneous detection of cytokeratin and vimentin in the cytology of canine tumors. . Veterinary Clinical Pathology47 ( 2 ) 326 - 332 2018年6月査読

OTOMARU Konosuke, ONO Keisuke, WATAYA Kenta, AKIOKA Kohei, ANDO Takaaki, YABUKI Akira, KUBOTA Chikara, MIYOSHI Noriaki, KAWASAKI Yasuaki . Hydromyelia in a Japanese Black calf . The Jounal of Veterinary Science79 ( 12 ) 1983 - 1985 2017年12月査読

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：公益社団法人日本獣医学会

<p>A Japanese Black calf, manifested by clinical signs of inability to stand and extending hind limbs after birth, was investigated clinically and pathologically. In the neurological inspection, gastrocnemius reflex and patellar tendon reflex of the right hind limb were hyperactive, and gastrocnemius reflex and crossed extension reflex of the left hind limb were also hyperactive. Magnetic resonance imaging (MRI) examination showed a cavity in the cord at the area of the third and fourth lumbar vertebrae in T2-weighted imaging. After the calf was euthanized, necropsy confirmed the swelling of the spinal cord at the third and fourth lumbar vertebrae. The histopathological examination confirmed that the central canal remained open, and the inner surface of central canal was lined with ependymal cells. Therefore, this calf was diagnosed to have hydromyelia of the lumbar cord. This study indicated that MRI was useful for diagnosing myelodysplasia such as hydoromyelia. This is the first report of hydoromyelia in Japanese Black calf.</p>

DOI： 10.1292/jvms.17-0371

Scopus

PubMed

Md. Zahorul Islam, Hiroaki Kawaguchi, Naoki Miura, Noriaki Miyoshi, Emi Yamazaki-Himeno, Mitsuya Shiraishi, Atsushi Miyamoto, Akihide Tanimoto . Hypertension alters the endothelial-dependent biphasic response of bradykinin in isolated Microminipig basilar artery. . Microvascular Research114 52 - 57 2017年11月査読

Mohammad E.H. Kayesh, Sayeh Ezzikouri, Haiying Chi, Khadija Rebbani, Bouchra Kitab, Aya Matsuu, Noriaki Miyoshi, Michinori Kohara, Kyoko Tsukiyama-Kohara . Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri.Tupaia belangeri . Scientific Reports7 9848 2017年8月査読

Mohammad Enamul Hoque Kayesh, Sayeh Ezzikouri, Haiying Chi, Takahiro Sanada, Naoki Yamamoto, Bouchra Kitab, Takumi Haraguchi, Rika Matsuyama, Chimene Nze Nkogue, Hitoshi Hatai, Noriaki Miyoshi, Shuko Murakami, Yasuhito Tanaka, Jun-ichiro Takano, Yumiko Shigama, Yasuhiro Yasutomi, Michinori Kohara, Kyoko Tsukiyama-Kohara . Interferon-β response is imparied by hepatitis B virus infection in Tupaia belangeri. . Virus Research237 47 - 57 2017年5月査読

Sawa M, Inoue M, Yabuki A, Kohyama M, Miyoshi N, Setoguchi A, Yamato O. . Rapid immunocytochemistry for the detection of cytokeratin and vimentin: assessment of its diagnostic value in neoplastic diseases of dogs. . Veterinary Clinical Pathology46 ( 1 ) 172 - 178 2017年5月査読

西　洋志，松永　文，上村　利也，三好　宣彰 . 若齢猫の両側性腎周囲偽嚢胞の１例 . 鹿児島県獣医師会会報58 20 - 21 2016年12月

本川　裕介，五位塚　勝利，藤川　拓郎，齋藤　靖生，畑井　仁，乙丸　孝之介，安藤　貴朗，三浦　直樹，三好　宣彰，窪田　力 . 黒毛和種子牛の腹部体表にみられたメラノサイトーマの一例 . 鹿児島県獣医師会会報58 9 - 10 2016年12月

GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-breed Dog. . 51 ( 6 ) 396 - 400 2015年11月査読

Murata D, Tokunaga S, Tamura T, Kawaguchi H, Miyoshi N, Fujiki M, Nakayama K, Misumi K. . A preliminary study of osteochondral regeneration using a scaffold-free three-dimensional construct of porcine adipose tissue-derived mesenchymal stem cells. . J Orthop Surg Res10 35 2015年3月査読

松永　文，三好宣彰，齋藤靖生，三浦直樹，德永　暁， . 雄性仮性半陰陽のミニチュアダックスフントの１例 . 鹿児島県獣医師会会報55 ( 1 ) 21 - 23 2015年3月

Yasuo Fushimi, Mitsuhiro Takagi, Hiroaki Kawaguchi, Noriaki Miyoshi, Takeshi Tsuka, Eisaburo Deguchi . Three cases of idiopathic eosinophilic enteritis with chronic obstinate diarrhea in Japanese Black fattening cattle. . J. Vet. Med. Sci.77 ( 3 ) 337 - 340 2015年3月査読

Kohei Matsushita, Yuji Ishii, Shinji Takasu, Ken Kuroda, Aki Kijima, Takuma Tsuchiya, Hiroaki Kawaguchi, Noriaki Miyoshi, Takehiko Nohmi, Kumiko Ogawa, Akiyoshi Nishikawa, Takashi Umemura . A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action. . Exp. Toxicol. Pathol.67 ( 1 ) 31 - 39 2015年1月査読

一二三達郎、真下忠久、原崎裕介、阿野直子、野村耕二、安田準、川口博明、三好宣彰 . 犬の胸腔内異所性肝の１例 . 日獣会誌68 ( 1 ) 64 - 67 2015年1月査読

Miura N, Kucho K, Noguchi M, Miyoshi N, Uchiumi T, Kawaguchi H, Tanimoto A. . Comparison of the genomic sequence of the microminipig, a novel breed of swine, with the genomic database for conventional pig. . In Vivo28 ( 6 ) 1107 - 1111 2014年11月査読

Kohei Matsushita, Ken Kuroda, Yuji Ishii, Shinji Takasu, Aki Kijima, Hiroaki Kawaguchi, Noriaki Miyoshi, Takehiko Nohmi, Kumiko Ogawa, Akiyoshi Nishikawa, Takashi Umemura . Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action. . Exp. Toxicol. Pathol.66 ( 7 ) 313 - 321 2014年9月査読

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