Updated on 2024/10/16

写真a

 
HORIUCHI Masahisa
 
Organization
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Graduate School of Medical and Dental Sciences Health Research Course Human and Environmental Science Professor
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine
Title
Professor

Degree

  • 博士（医学） ( 1994.3   鹿児島大学 )

Research Interests

  • 脳と栄養

  • カルニチン

  • 医科栄養学

  • 産業保健

  • 健康科学

Research History

  • Kagoshima University   Professor

    2013.1

  • Kagoshima University

    2013.1

Professional Memberships

  • 日本ビタミン学会

    2015.10

  • 日本生化学会

    2015.10

  • 日本産業衛生学会（代議員）

    2015.10

  • 日本衛生学会（評議員）

    2015.10

 

Papers

  • Arimura E., Maruguti Y., Nakao Y., Ushikai M., Yotsueda K., Kajiya S., Nishio Y., Horiuchi M. .  Nutritional Risk Factors in Albuminuria and Retinopathy in Patients Newly Diagnosed With Type 2 Diabetes: A Cross-sectional Case Series Study .  In Vivo38 ( 5 ) 2506 - 2514   2024.9

    　More details

    Language：Japanese   Publisher：In Vivo  

    Background/Aim: Although nutritional risk factors for developing complications in type 2 diabetes mellitus (T2DM) have been examined, the effect of protein intake on nephropathy is debated, and there is little research on retinopathy. This cross-sectional case-series study aimed to examine the risk factors, including nutritional status, for complications in patients newly diagnosed with T2DM. Patients and Methods: Fifty-four patients were recruited, based on the results of examinations of blood glucose and/or glycated hemoglobin level for T2DM. To evaluate nutritional status, blood and urine examinations were performed and the Food Frequency Questionnaire was administered. Two-way analysis of variance, Fisher’s exact test and logistic regression analyses were performed. Results: The patients were categorized into four groups: 24 without albuminuria and without retinopathy, four without albuminuria with retinopathy, 21 with albuminuria without retinopathy, and five with albuminuria with retinopathy. Logistic analysis of albuminuria revealed that estimated sodium intake was significantly independent as the explanatory factors of age, sex, and body mass index. Patients with retinopathy had significantly higher blood urea nitrogen, and significantly lower plasma total protein levels than patients without retinopathy, suggesting that retinopathy is related to a higher catabolic state. Through a questionnaire on food intake, patients with retinopathy had a significantly lower intake of fat and monounsaturated fatty acids and a significantly higher intake of iodine based on intake of seaweed, corrected for energy intake, than patients without retinopathy. Conclusion: The present study may lead to planning a large cohort study for examining nutritional risk factors related to complications in patients newly diagnosed with T2DM in Japan.

    DOI： 10.21873/invivo.13722

    Scopus

    PubMed

  • ARIMURA Yoichi, JIN'O Yusuke, KAWAHARA Naruto, SHIMAUCHI Yuichiro, NAKAHOGI Naoki, HORIUCHI Masahisa .  The insurance pharmacy pharmacist as a key component of chemical management in the community .  Annual Meeting of the Japanese Society of Toxicology51.1 ( 0 ) S12-4   2024The insurance pharmacy pharmacist as a key component of chemical management in the community

    　More details

    Language：Japanese   Publisher：The Japanese Society of Toxicology  

    <p> Regulations are being comprehensively reviewed to ensure that chemical substances are managed autonomously and effectively at business sites. For chemical substances with known hazardous and toxic properties, it is necessary to conduct risk assessment and risk reduction/measures in line with the site. Chemical substance management is expected to vary depending on the type and scale of business. In rural areas, the percentage of small and medium-sized enterprises is large, and it is feared that inadequate implementation due to lack of manpower or insufficient measures due to lack of experience may lead to health hazards.</p><p> We pharmacists systematically study chemistry at university, and in clinical practice, we evaluate the pharmacokinetics of chemical substances in the body and provide drug administration guidance. We believe that pharmacists who understand the GHS, read and understand SDSs, and are able to assess not only the hazards of chemical substances but also the acute and chronic toxicity will become a new profession as "(commissioned) industrial pharmacists" supporting occupational health in rural areas. Insurance pharmacies in the community can be used as a place for direct contact and consultation with individual workers. In local cities, the distance between the place of residence and the workplace is close, and the provision of health services that can be completed within one municipality can be considered. Pharmacists' testing centers are already involved in the measurement of food and environmental substances, and their required role may also increase with the current revision of the law, which expands the range of substances to be controlled. In any case, pharmacists must take advantage of the revision of the law to deepen their knowledge by conducting awareness activities and training sessions, as this is an area of occupational health that they have not been involved in to date. Kagoshima is already conducting training sessions on industrial health, including chemical substance management, starting in 2019. The number of pharmacists who are certified as hygienic engineering hygiene managers and working environment measurement specialists is increasing, and activities are gradually becoming more widespread. In this presentation, we would like to let people know about our efforts in Kagoshima and provide topics on the possibilities of (commissioned) industrial pharmacists.</p>

    DOI： 10.14869/toxpt.51.1.0_s12-4

  • Fushuku S., Ushikai M., Arimura E., Komaki Y., Horiuchi M. .  Acute repeated cage exchange stress modifies urinary stress and plasma metabolic profiles in male mice .  PLoS ONE18 ( 10 October ) e0292649   2023.10

    　More details

    Language：Japanese   Publisher：PLoS ONE  

    Exposure to a novel environment is psychologically and physically stressful for humans and animals. The response has been reported to involve enhanced sympathetic nervous system activity, but changes in nutrient levels under stress are not fully understood. As a form of exposure to a novel environment, repeated cage exchange (CE, four times at 2-h intervals for 8 h from 08:00 h) during the light phase with no restraint on movement was applied to A/J mice, a strain particularly prone to stress. Body temperature was measured with a temperature-sensing microchip implanted in the interscapular region. The stress conditions and anxiety level were evaluated by measuring urinary catecholamines and corticosterone and by performing an anxiety-like behavior test, respectively. Major nutrients such as glucose, fatty acids, and amino acids in the plasma were also examined. CE mice showed a significant increase in body temperature with each CE. They also showed a significantly greater reduction of body weight change, more water intake, and higher levels of urinary catecholamines and corticosterone and anxiety-like behavior score than control mice. The model revealed a significantly lower plasma glucose level and higher levels of several essential amino acids, such as branched-chain amino acids and phenylalanine, than those of control mice. Meanwhile, free fatty acids and several amino acids such as arginine, aspartic acid, proline, threonine, and tryptophan in both sets of mice were significantly decreased from the corresponding levels at 08:00 h, while similar plasma levels were exhibited between mice with and without CE. In conclusion, repeated CE stress was associated with changes in glucose and amino acids in plasma. Although further study is needed to clarify how these changes are specifically linked to anxiety-like behavior, this study suggests the potential for nutritional intervention to counter stress in humans exposed to novel environments.

    DOI： 10.1371/journal.pone.0292649

    Scopus

    PubMed

  • Komaki Y., Ushikai M., Kanmura S., Horiuchi M. .  Survey of Smokers Among Workers at One Facility: A Cross-sectional Study With Propensity Score Matching .  In Vivo37 ( 4 ) 1873 - 1879   2023.7

    　More details

    Language：Japanese   Publisher：In Vivo  

    Background/Aim: Smoking has been reported to be a risk factor for a variety of diseases. In Japan, the Brief Job Stress Questionnaire (BJSQ) has been administered by the Ministry of Health, Labour and Welfare since December 2015, but few reports have focused on its relationship with smoking. We investigated the current situation of smokers among staff of Kagoshima University who underwent a medical check-up. Patients and Methods: Of 2,478 people who underwent a medical check-up in May and June 2021, we targeted 2,237 workers who reported whether they smoked. We examined results of the medical check-up and BJSQ and the background of smokers (n=139, 6.2%). We compared smokers and non-smokers (n=2,098) using propensity score matching (PSM) for sex, age, drinking habits, medication for dyslipidaemia, and overtime working hours at a 1:1 ratio. Results: The results showed that white blood cell count (p=0.044), platelet count (p<0.001), glutamyl transferase (p=0.023), and triglyceride (p=0.027) were significantly higher among current smokers in comparison with current non-smokers. Smokers reported significantly more stress than non-smokers in terms of social support (p=0.027). Conclusion: As a result of PSM, several blood test items related to non-communicable diseases (lifestyle-related diseases) showed high values in current smokers, and these individuals reported significantly more stress than non-smokers. According to the emphasis on group analysis in the Total Health Promotion Plan revised in 2020, our findings can be helpful in enhancing smoking cessation programs in the workplace.

    DOI： 10.21873/invivo.13279

    Scopus

    PubMed

  • Komaki Y., Kanmura S., Yutsudo K., Kuwazuru K., Komaki F., Tanaka A., Maeda H., Arima S., Tanoue S., Sasaki F., Hashimoto S., Horiuchi M., Ido A. .  Clinical features of obscure gastrointestinal bleeding undergoing capsule endoscopy: A retrospective cohort study .  PLoS ONE17 ( 3 March ) e0265903   2022.3

    　More details

    Language：Japanese   Publisher：PLoS ONE  

    Background Capsule endoscopy has been widely used to investigate obscure gastrointestinal bleeding (OGIB) in the small intestine since its approval in 2001. However, the clinical features of OGIB remain unclear. Aim We retrospectively examined the clinical features and risk factors of OGIB in patients who underwent capsule endoscopy in our hospital. Methods We included 420 of the 431 patients who underwent capsule endoscopy from June 2014 to May 2021, in whom the small intestine could be observed. We retrospectively compared the clinical features and treatment of OGIB cases, with or without active small bowel bleeding (n = 173), with other cases (n = 247). Patient sex, age, diabetes mellitus, and heart failure histories were matched for the analysis. Results The male/female ratio was 247/173 and the average age was 51.54 years. In multivariate analysis, the use of direct oral anticoagulants was significant (P = 0.016), and vascular lesions (P = 0.018) were observed in OGIB cases. When OGIB cases with and without active small bowel bleeding were compared, serum albumin level was lower in cases with active bleeding (P = 0.031). When treatment of OGIB cases were compared, those without vascular lesions could be treated conservatively (P = 0.0047). In the 1:1 propensity score matching analysis, serum creatinine level was elevated in cases of active bleeding (P = 0.029), and cases without vascular lesions were treated conservatively (P = 0.010). Conclusions Use of direct oral anticoagulants is frequently associated with OGIB. OGIB patients without vascular lesions may be treated conservatively.

    DOI： 10.1371/journal.pone.0265903

    Scopus

    PubMed

  • Ikeda K, Abe M, Masamoto I, Ishii C, Arimura E, Ushikai M, Oketani K, Hashiguchi T, Horiuchi M .  Comparison of dipstick and quantitative tests for proteinuria and hematuria in middle-aged, male Japanese employees: A single-center study. .  Health science reports4 ( 2 ) e267   2021.6

    　More details

    Language：Japanese   Publisher：Health Science Reports  

    Background and Aims: The early and reliable detection of chronic kidney disease is important. In the present study, we aimed to compare the diagnostic results for proteinuria and hematuria between the dipstick test used in primary occupational health examinations and the quantitative tests used in more thorough examinations in clinics. Methods: We conducted a single-center observational study of male staff (N = 573) at Kagoshima University who underwent a health examination in 2017. Both dipsticks and biochemical methods were used to assess proteinuria and hematuria. Results: For the dipstick test, the sensitivity, specificity, and positive predictive value were 55.6%, 92.4% and 10.4% for proteinuria, and 64.3%, 98.3% and 66.7% for hematuria, respectively. Four participants for whom false-negative results were obtained using dipsticks for proteinuria, and two of these had 3+ urinary glucose. Conclusion: Qualitative tests for proteinuria and hematuria had low sensitivities and positive predictive values. Therefore, for the early and reliable detection of chronic kidney disease, the use of quantitative urine tests should be considered during occupational health examinations.

    DOI： 10.1002/hsr2.267

    Scopus

    PubMed

  • Arimura E., Ushikai M., Horiuchi M. .  Higher branched-chain amino acids and lower serine exist in the plasma of nondiabetic mice: A comparison between high- And low-protein diet conditions .  In Vivo35 ( 3 ) 1555 - 1560   2021.5

    　More details

    Language：Japanese   Publisher：In Vivo  

    Background/aim: The effects of dietary protein and carbohydrate content on the plasma amino acid profile of patients with diabetes are not fully understood. Therefore, we examined whether there are effects of diets with differing proportions of protein and carbohydrate on the plasma amino acid concentrations of control (CT) mice and mice with type 2 diabetes (db). Materials and Methods: We used db mice as an animal model of type 2 diabetes which are genetically deficient in leptin receptor. Diets with differing proportions of protein and carbohydrates (L diet: low protein/carbohydrate ratio, H diet: high protein/carbohydrate ratio) were supplied. db Mice were fed with a restriction on the basis of the consumption by CT-L mice, such that equivalent amounts of energy and fat were consumed. In CT mice fed the L or H diets, there was no significant difference in ad libitum food intake. Results: There were significant interactions between diet and genotype with respect to water intake, urine volume, urinary glucose concentration, and plasma isoleucine, leucine, valine, branched-chain amino acids, and serine concentrations. db-H mice showed significantly higher water intake, urine volume, and urinary glucose than db-L mice. db Mice fed the L or H diets had similar plasma amino acid profiles, except for valine. In contrast, CT-H mice showed significantly higher valine and branched-chain amino acids and lower serine concentrations than CT-L mice. Thus, the CT-H mice were more similar to db mice fed either of the diets. Conclusion: There were different effects of the dietary protein or carbohydrate content on the plasma amino acid profiles between nondiabetic and diabetic mice. In particular, the profiles in nondiabetic conditions were different between the low- and high-protein diet conditions.

    DOI： 10.21873/invivo.12410

    Scopus

    PubMed

  • Kodama D. .  Inhibition of abl1 tyrosine kinase reduces htlv-1 proviral loads in peripheral blood mononuclear cells from patients with htlv-1-associated myelopathy/tropical spastic paraparesis .  PLoS Neglected Tropical Diseases14 ( 7 ) 1 - 21   2020.7

    　More details

    Publisher：PLoS Neglected Tropical Diseases  

    DOI： 10.1371/journal.pntd.0008361

    Scopus

    PubMed

  • Saheki T. .  Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model .  Scientific Reports9 ( 1 ) 4179   2019.12

    　More details

    Publisher：Scientific Reports  

    DOI： 10.1038/s41598-019-39627-y

    Scopus

    PubMed

  • Kure T. .  Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity: A cross-sectional study .  Medicine98 ( 46 ) e17879   2019.11

    　More details

  • Namino F. .  Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation .  Clinical and Applied Thrombosis/Hemostasis25   1076029619851570   2019.5

    　More details

    Publisher：Clinical and Applied Thrombosis/Hemostasis  

    DOI： 10.1177/1076029619851570

    Scopus

    PubMed

  • 有村 恵美, 大山 律子, 町田 美由紀, 日高 宏実, 阿部 正治, 中熊 美和, 堀内 正久, 鹿児島市CKD予防ネットワークプロジェクト会議 .  食塩摂取状況アンケートおよび食塩味覚感受性評価の報告　鹿児島市CKD啓発イベント参加者を対象として .  日本栄養士会雑誌62 ( 2 ) 89 - 95   2019.2食塩摂取状況アンケートおよび食塩味覚感受性評価の報告　鹿児島市CKD啓発イベント参加者を対象として

    　More details

    Publisher：(公社)日本栄養士会  

    慢性腎臓病(CKD)啓発イベント「世界腎臓デーinかごしま」にて、食塩摂取状況アンケートと食塩味覚感受性評価(ソルセイブ検査)を実施した。対象者は、自主的に参加された172人(男性59人:平均年齢55.5±14.8歳、女性113人:平均年齢50.8±19.3歳)であった。単変量解析では、食塩感受性低値者は、高値者に比べて男性割合・年齢・薬剤服用者割合・漬物摂取頻度が有意に高かった。多変量解析(ロジスティック回帰分析)では、食塩味覚感受性と関連する因子として性別、年齢が認められた。食塩味覚感受性と性別、年齢との関係は知られており、本検討によって、試験そのものの有用性が確認できたと示唆された。体験型のソルセイブ検査により、食塩味覚感受性が低いと分かった方は、その結果を踏まえて今後の食生活に注意を払うことが可能となることは有意義であると思われた。このようなCKD啓発イベントを通じて、参加者に質の高い情報や経験を与えることは、食塩味覚感受性保持と減塩への関心を高めることにつながる可能性が考えられた。(著者抄録)

  • Arimura Emi, Oyama Ritsuko, Machida Miyuki, Hidaka Hiromi, Abe Masaharu, Nakakuma Miwa, Horiuchi Masahisa .  Salt intake questionnaire and salt taste sensitivity test for the volunteers participating in a CKD enlightenment event in Kagoshima city .  Journal of the Japan Dietetic Association62 ( 2 ) 89 - 95   2019

    　More details

    Publisher：The Japan Dietetic Association  

    <p>We performed a questionnaire survey regarding salt intake and a salt taste sensitivity test using a sheet of salt-impregnated paper (Salsave test) among voluntary participants in the chronic kidney disease (CKD) awareness-raising event "World Kidney Day in Kagoshima". Then, we analyzed the relationship between salt taste sensitivity and characteristics of the participants or the questionnaire answers. The 172 participants for the analysis were 59 men (55.5 ± 14.8 years old) and 113 women (50.8 ± 19.3 years old). In univariate analyses, the subjects with lower salt taste sensitivity tended to be male, older, and had a higher rate of taking medicine than the subjects with higher salt taste sensitivity. There were significant differences between participants with high and low salt taste sensitivity in terms of frequency pickle consumption. Finally, multivariate logistic regression analysis showed that sex and age were significant factors related to salt taste sensitivity. Because the relationship of sex and age to salt taste sensitivity has been reported, the Salsave test examined in the event worked well. In the event, the participants not only obtained knowledge, but with practices such as the Salsave test, they might pay an attention on maintenance of their own salt taste sensitivity and reduction of dietary salt.</p>

    DOI： 10.11379/jjda.62.89

  • Pulong WP, Ushikai M, Arimura E, Abe M, Kawaguchi H, Horiuchi M. .  Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation. .  J Diabetes Res   2018.12Food Intake and Core Body Temperature of Pups and Adults in a db Mouse Line Deficient in the Long Form of the Leptin Receptor without Misty Mutation.Reviewed

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • Abe M. .  Diurnal variation of melatonin concentration in the cerebrospinal fluid of unanesthetized microminipig .  In Vivo32 ( 3 ) 583 - 590   2018.5

    　More details

    Publisher：In Vivo  

    DOI： 10.21873/invivo.11279

    Scopus

    PubMed

  • MASAHARU ABE, HIROAKI KAWAGUCHI, NAOKI MIURA, KOHEI AKIOKA, MIHARU USHIKAI, S AYUMI OI, AIRO YUKAWA, TETSUYA YOSHIKAWA, HIROYUKI IZUMI, MASAHISA HORIUCHI .  Diurnal Variation of Melatonin Concentration in the Cerebrospinal Fluid of Unanesthetized Microminipig. .  in vivo   2018.3Diurnal Variation of Melatonin Concentration in the Cerebrospinal Fluid of Unanesthetized Microminipig.Reviewed

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

  • Takeishi K. .  Effects of dietary and lighting conditions on diurnal locomotor activity and body temperature in microminipigs .  In Vivo32 ( 1 ) 55 - 62   2018.1

    　More details

    Publisher：In Vivo  

    DOI： 10.21873/invivo.11204

    Scopus

    PubMed

  • Pulong W.P. .  Food intake and core body temperature of pups and adults in a db mouse line deficient in the long form of the leptin receptor without misty mutation .  Journal of Diabetes Research2018   9670871   2018

    　More details

    Publisher：Journal of Diabetes Research  

    DOI： 10.1155/2018/9670871

    Scopus

    PubMed

  • Arimura E. .  Effects of diets with different proportions of protein/ carbohydrate on retinal manifestations in db mice .  In Vivo32 ( 2 ) 265 - 272   2018

    　More details

    Publisher：In Vivo  

    DOI： 10.21873/invivo.11233

    Scopus

    PubMed

  • 牛飼 美晴, 川口 博明, 阿部 正治, 堀内 正久 .  エタノールの糖尿病病態への影響　レプチン受容体欠損マウスを用いた検討 .  鹿児島大学医学雑誌69 ( 1-3 ) 1 - 8   2017.12エタノールの糖尿病病態への影響　レプチン受容体欠損マウスを用いた検討

    　More details

    Publisher：鹿児島大学医学会  

    雄性2型糖尿病モデルマウス(dbマウス)とヘテロ接合体マウス(対照マウス)を用いた。対照水群・対照エタノール群・db水群・dbエタノール群の4群に分けた。脳重量は、対照マウスに比べてdbマウスは軽く、エタノール群でさらに軽くなる傾向を示した。心臓重量は、db水群は軽く、dbエタノール詳で重くなる傾向にあった。肝臓重量は、対照マウスでは、2群間(水・エタノール)に差は認めなかった。dbマウスは、2群間(水・エタノール)とも対照マウスに比べて有意に重く、dbエタノール群は、db水群に比べて有意に重かった。腎臓重量は、db群では有意に重く、エタノール群では水群に比べて軽い傾向であった。膵臓重量は、db水群が対照水群に比べて重くなる傾向を示し、dbエタノール群ではdb水群と比べて軽くなる傾向を示した。白色脂肪重量は、dbマウスは、対照マウスよりも有意に重かった。筋肉重量は、db水群に比べてdbエタノール群は重い傾向を示した。エタノールによって、dbマウスの血糖コントロールの悪化がないことが示唆された。肝臓組織1gあたりの中性脂肪、コレステロールは、どちらも対照マウスよりもdbマウスが高かった。

  • Okita Shinobu, Daitoku Satoshi, Abe Masaharu, Arimura Emi, Setoyama Hitoshi, Koriyama Chihaya, Ushikai Miharu, Kawaguchi Hiroaki, Horiuchi Masahisa .  日本人新人看護師における職業性ストレス感受性の予測因子　予備的研究(Potential predictors of susceptibility to occupational stress in Japanese novice nurses: a pilot study) .  Environmental Health and Preventive Medicine22 ( April ) 1 - 11   2017.4日本人新人看護師における職業性ストレス感受性の予測因子　予備的研究(Potential predictors of susceptibility to occupational stress in Japanese novice nurses: a pilot study)

    　More details

    Publisher：(一社)日本衛生学会  

    当大学病院の女性新人看護師を対象に、職業性ストレスに対する感受性の潜在的な予測因子を評価した。看護師62名にBrief Job Stress Questionnaireを行い、最終的に42名(年齢21〜24歳)を解析対象とした。全員に健康診断と泌尿器検査を行い、就職時に生活習慣に関する質問票調査を行った。登録から5ヵ月の時点で三つのストレス状態スコアが全て有意に低下し、職業性ストレス状態であることが示唆された。収縮期血圧(r=-0.324、p<0.05)と尿中ナトリウム(r=-0.313、p<0.05)は登録から5ヵ月後のBJSQスコアと有意に負の相関があった。登録後のストレス状態スコアは、1年間の体重変化が±3kg以下および夕食から就寝までが2時間以下の看護師では有意に低かった。尿中ナトリウム、1年間の体重変化、夕食から就寝までの時間は職業性ストレス感受性の予測因子として有望であることが示唆された。

  • Arimura E. .  Deteriorated glucose metabolism with a high-protein, low-carbohydrate diet in db mice, an animal model of type 2 diabetes, might be caused by insufficient insulin secretion .  European Journal of Nutrition56 ( 1 ) 237 - 246   2017.2

    　More details

    Publisher：European Journal of Nutrition  

    DOI： 10.1007/s00394-015-1075-y

    Scopus

    PubMed

  • Okita S. .  Potential predictors of susceptibility to occupational stress in Japanese novice nurses - A pilot study .  Environmental Health and Preventive Medicine22 ( 1 ) 20   2017

    　More details

    Publisher：Environmental Health and Preventive Medicine  

    DOI： 10.1186/s12199-017-0641-8

    Scopus

    PubMed

  • Daitoku S, Yuasa T, Tsunenari H, Maenohara S, Mine K, Tamatsu Y, Shimada K, Koriyama C, Ohishi M, Horiuchi M. .  Angle between the common and internal carotid arteries detected by ultrasound is related to intima-media thickness among those with atherosclerotic disease. .  Environ Health Prev Med.   2015.3Angle between the common and internal carotid arteries detected by ultrasound is related to intima-media thickness among those with atherosclerotic disease.Reviewed

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Marchianti AC, Arimura E, Ushikai M, Horiuchi M. .  Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetes. .  Environ Health Prev Med. 19 ( 5 ) 339 - 347   2014.1Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetes.Reviewed

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Arimura E, Horiuchi M, Kawaguchi H, Miyoshi N, Aoyama K, Takeuchi T .  Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice. .  Eur. J. Nutr52   813 - 824   2013.3Low-protein diet improves blood and urinary glucose levels and renal manifestations of diabetes in C57BLKS-db/db mice.Reviewed

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • 堀内正久(Horiuchi Masahisa),中河志朗(NakagawaShiro),口岩聡(Kuchiiwa Satoshi),飯島幹雄(IIJIMA Mikio),小林圭子(Kobayashi Keiko) .  Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice .  Neuroscience Research55 ( 1 ) 78 - 86   2006.5Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient miceReviewed

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • 堀内正久(HoriuchiMasahisa) .  Cellular localization and subcellular distribution of unc-33-like protein 6, a brain-specific protein of the collapsin response mediator protein family that interacts with the neuronal glycine transporter 2 .  J Neurochem94 ( ※ ) 307 - 315   2005.1Cellular localization and subcellular distribution of unc-33-like protein 6, a brain-specific protein of the collapsin response mediator protein family that interacts with the neuronal glycine transporter 2Reviewed

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

▼display all

MISC

  • メンタルヘルスケアに資する栄養学的観点

    堀内 正久, 沖田 信夫, 牛飼 美晴, 有村 恵美, 小牧 祐雅

    産業医学レビュー   32 ( 3 )   181 - 190   2020.1

    　More details

    Publisher：(公財)産業医学振興財団  

    就寝前の食事摂取習慣、長い絶食を伴う不規則な食事など、食事摂取パターンとメンタルヘルス不調との関係について述べた。次いで、ω3系脂肪酸と鉄・ナトリウム、葉酸代謝関連化合物、亜鉛、脂質といった栄養素の摂取量が低下や増加した際のメンタルヘルス悪化状況について概説した。さらに、メンタルヘルス不調の予測指標としての体重変化について述べた。

Presentations

  • 佐伯 英二, 上村 寛和, 眞川 昌大, 石川 祥子, 堀内 正久   鹿児島市慢性腎臓病(CKD)予防ネットワーク事業を通じた当院の取り組み  

    日本腎臓学会誌  2020.7  (一社)日本腎臓学会

  • 有村 恵美, 大山 律子, 町田 美由紀, 日高 宏実, 阿部 正治, 中熊 美和, 堀内 正久, 鹿児島市CKDネットワークプロジェクト会議   食塩摂取状況アンケート及び食塩味覚感受性評価の報告　鹿児島市CKD啓発イベント参加者を対象として  

    日本病態栄養学会誌  2020.1  (一社)日本病態栄養学会

  • 有村 恵美, 岡谷 秀明, 荒木 智陽, 川口 博明, 中熊 美和, 阿部 正治, 牛飼 美晴, 和泉 博之, 堀内 正久   食事蛋白質量が2型糖尿病網膜症に及ぼす影響　レプチン受容体欠損マウスを用いた検討  

    糖尿病  2017.2  (一社)日本糖尿病学会

  • 伊瀬 知良, 陳尾 祐介, 内田 光祐, 宇都宮 さおり, 牛飼 美晴, 川口 博明, 堀内 正久   薬局薬剤師の産業保健活動への関わりを考える  

    産業衛生学雑誌  2019.9  (公社)日本産業衛生学会

  • 牛飼 美晴, 松元 菜奈, 堀内 正久   脂肪酸代謝異常時の心臓糖取り込み促進について　カルニチン欠乏マウスの新規病態解析  

    日本衛生学雑誌  2019.2  (一社)日本衛生学会

  • 牛飼 美晴, 松元 菜奈, 川口 博明, 阿部 正治, 堀内 正久   脂肪酸代謝異常における心臓糖取り込み促進機構の解析  

    日本衛生学雑誌  2018.3  (一社)日本衛生学会

  • 牛飼 美晴, 松元 菜奈, 川口 博明, 阿部 正治, 堀内 正久   脂肪酸代謝異常における心臓糖取り込み促進機序の解析  

    日本生化学会大会プログラム・講演要旨集  2018.9  (公社)日本生化学会

  • 堀内 正久, 桶谷 薫, 瀬戸山 仁, 阿部 正治   職場健診の胸部レントゲン異常症例からの学び　画像診断情報の取り扱いについて  

    産業衛生学雑誌  2019.1  (公社)日本産業衛生学会

  • 阿部 正治, 池田 加奈子, 政元 いずみ, 石井 千佳子, 有村 恵美, 桶谷 薫, 橋口 照人, 堀内 正久   職域健診における尿蛋白検査の検討  

    日本腎臓学会誌  2018.8  (一社)日本腎臓学会

  • 阿部 正治, 川口 博明, 牛飼 美晴, 大井 紗弓, 柚川 藍色, 吉川 哲也, 和泉 博之, 谷本 昭英, 堀内 正久   昼行性動物ミニブタにおける無麻酔下経時的脳脊髄液採取法の確立  

    日本衛生学雑誌  2018.3  (一社)日本衛生学会

  • 川口 博明, 阿部 正治, 牛飼 美晴, 大井 紗弓, 柚川 藍色, 吉川 哲也, 和泉 博之, 谷本 昭英, 堀内 正久   昼行性動物マイクロミニピッグにおける無麻酔下経時的脳脊髄液採取法の確立  

    日本毒性病理学会講演要旨集  2018.1  日本毒性病理学会

  • 今村 也寸志, 屋 万栄, 馬渡 誠一, 平峯 靖也, 宮原 広典, 堀内 正久, 井戸 章雄   日本における食生活の変容と健診データ  

    日本病態栄養学会誌  2019.1  (一社)日本病態栄養学会

  • 波野 史典, 山口 宗一, 前之園 隆一, 入來 泰久, 二宮 雄一, 市來 仁志, 政元 いずみ, 大石 充, 堀内 正久, 橋口 照人, 丸山 征郎   心房細動アブレーション治療における可溶性トロンボモジュリンと循環miRNAの動態  

    臨床病理  2019.10  (一社)日本臨床検査医学会

  • 舟橋 亞希, 佐伯 武頼, 黒田 英志, 安田 いづみ, 瀬戸川 芳子, 高 青華, 牛飼 美晴, 堀内 正久   安定同位体を用いたシトリン欠損症モデルマウスのin vivo尿素合成速度の測定  

    日本先天代謝異常学会雑誌  2019.9  日本先天代謝異常学会

  • 堀内 正久, 池田 加奈子, 牛飼 美晴, 阿部 正治, 川口 博明, 橋元 浩幸   一事業所における雇入時健康診断対応からの学び  

    産業衛生学雑誌  2018.1  (公社)日本産業衛生学会

  • 牛飼 美晴, プロンウイジャン・パラランピタ , 阿部 正治, 川口 博明, 有村 恵美, 中熊 美和, 堀内 正久   レプチン受容体欠損マウスを用いた時期特異的レプチンシグナル動態の解析  

    日本衛生学雑誌  2017.3  (一社)日本衛生学会

  • Pralampita Wijang Pulong, Ushikai Miharu, Arimura Emi, Abe Masaharu, Kawaguchi Hiroaki, Horiuchi Masahisa   レプチン受容体欠損マウスにおける加齢依存的なレプチン情報伝達の変化の分析(Analysis of age-dependent leptin-signaling in the leptin receptor deficient mice)  

    糖尿病  2017.4  (一社)日本糖尿病学会

  • 竹下 温子, 伊達 美里, 新井 千智, 堀内 正久   ライフスタイルを考慮した運動パターンが腸内細菌叢に及ぼす影響  

    日本衛生学雑誌  2019.2  (一社)日本衛生学会

  • 佐伯 武頼, 黒田 英志, 舟橋 亞希, 安田 いづみ, 瀬戸川 芳子, 古川 龍彦, 堀内 正久, 森山 光章   モデルマウスを用いるシトリン欠損症の研究　高アンモニア血症マウスの作製  

    日本先天代謝異常学会雑誌  2017.9  日本先天代謝異常学会

  • 佐伯 武頼, 黒田 英志, 舟橋 亞希, 安田 いづみ, 瀬戸川 芳子, 古川 龍彦, 堀内 正久, 森山 光章   モデルマウスを用いるシトリン欠損症の研究　高い治療効果を持つアミノ酸の探索  

    日本先天代謝異常学会雑誌  2017.9  日本先天代謝異常学会

  • 阿部 正治, 牛飼 美晴, 川口 博明, 堀内 正久   メンタルヘルスケアを志向したミニブタ生体リズムへのミネラルの影響  

    産業衛生学雑誌  2018.1  (公社)日本産業衛生学会

  • 川口 博明, 武石 嘉一朗, 阿部 正治, 有村 恵美, 牛飼 美晴, 堀内 正久   ミニブタを用いた食事・光による生体リズムへの影響解析  

    日本衛生学雑誌  2017.3  (一社)日本衛生学会

  • Miyahara Emiko, Nishikawa Takuro, Ikawa Kazuro, Ushikai Miharu, Kawaguchi Hiroaki, Okamoto Yasuhiro, Morikawa Norifumi, Horiuchi Masahisa, Kawano Yoshifumi   マウスにおける大量シクロホスファミドの薬物動態及び毒性の評価(Pharmacokinetics and toxicological evaluation of high-dose cyclophosphamide in mice)  

    臨床血液  2017.9  (一社)日本血液学会-東京事務局

  • 堀内 正久, 阿部 正治, 川口 博明, 牛飼 美晴   ストレス脆弱性に関与する栄養関連因子のミニブタを用いた解析  

    日本衛生学雑誌  2019.2  (一社)日本衛生学会

  • 森山 光章, 黒田 英志, 舟橋 亞希, 安田 いづみ, 高 青華, 瀬戸川 芳子, 牛飼 美晴, 堀内 正久, 佐伯 武頼   シトリン欠損症モデルマウス灌流肝を用いたアンモニアからの尿素生成に対する中鎖脂肪酸の効果  

    日本先天代謝異常学会雑誌  2019.9  日本先天代謝異常学会

  • 寺師 睦美, 黒田 英志, 舟橋 亞希, 瀬戸川 芳子, 安田 いづみ, 高 青華, 牛飼 美晴, 堀内 正久, 佐伯 武頼   シトリン欠損症における高脂肪食は脂質代謝異常症発症を促進するか　モデルマウスを用いた検討  

    日本病態栄養学会誌  2020.1  (一社)日本病態栄養学会

  • 佐伯 武頼, 舟橋 亞希, 黒田 英志, 安田 いづみ, 高 青華, 瀬戸川 芳子, 牛飼 美晴, 堀内 正久, 森山 光章   シトリン欠損症における高アンモニア血症に対するMCTの作用点  

    日本先天代謝異常学会雑誌  2019.9  日本先天代謝異常学会

  • 牛飼 美晴, 小迫 恵美子, 川口 博明, 阿部 正治, 堀内 正久   エタノールの糖尿病病態への影響　レプチン受容体欠損マウスを用いた検討  

    日本衛生学雑誌  2020.3  (一社)日本衛生学会

  • 牛飼 美晴, Pralampita Pulong, 阿部 正治, 川口 博明, 堀内 正久   Dock7変異遺伝子(misty)を有しないレプチン受容体欠損マウスラインを用いた時期特異的レプチンシグナル動態の解析  

    生命科学系学会合同年次大会  2017.12  生命科学系学会合同年次大会運営事務局

  • 佐伯 武頼, 舟橋 亞希, 黒田 英志, 安田 いづみ, 瀬戸川 芳子, 高 青華, 濱野 桃子, 牛飼 美晴, 堀内 正久, 森山 光章   Citrin-KOマウスは肝細胞質高NADH条件下で高アンモニア血症を呈する  

    日本先天代謝異常学会雑誌  2018.9  日本先天代謝異常学会

  • 松山 吏香, Bakri Saekhol, Nandakumar Athira, 堀内 正久, 郡山 千早   鹿児島大学医療従事者を対象とした新型コロナウイルス血清抗体の分布  

    Journal of Epidemiology  2022.1  (一社)日本疫学会

    　More details

    Language：Japanese  

  • 堀内 正久   食と健康、動物モデルからの学びと健康を守る社会の仕組みづくり  

    日本衛生学雑誌  2023.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 冨宿 小百合, 牛飼 美晴, 小牧 祐雅, 堀内 正久   頻回の新規環境負荷に対するマウスの応答性について  

    日本衛生学雑誌  2022.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 牛飼 美晴, 小牧 祐雅, 吉田 剛一郎, 堀内 正久   脂肪酸代謝障害におけるストレス脆弱性の解析  

    日本生化学会大会プログラム・講演要旨集  2021.11  (公社)日本生化学会

    　More details

    Language：Japanese  

  • 牛飼 美晴, 小牧 祐雅, 堀内 正久   脂肪酸代謝異常症におけるストレス脆弱性の解析  

    日本衛生学雑誌  2022.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 有村 恵美, 丸口 由紀子, 中尾 矢央子, 四枝 晧二, 加治屋 昌子, 西尾 善彦, 堀内 正久   糖尿病腎症・網膜症発症に関連する栄養因子の検討  

    糖尿病  2023.4  (一社)日本糖尿病学会

    　More details

    Language：Japanese  

  • 堀内 正久, 中甫木 直樹   化学物質管理における薬剤師の関わり  

    産業衛生学雑誌  2023.1  (公社)日本産業衛生学会

    　More details

    Language：Japanese  

  • 小牧 祐雅, 牛飼 美晴, 堀内 正久   勤労世代における便回数と健康指標　1事業所での検討  

    産業衛生学雑誌  2023.4  (公社)日本産業衛生学会

    　More details

    Language：Japanese  

  • 有村 恵美, 丸口 由紀子, 中尾 矢央子, 牛飼 美晴, 四枝 晧二, 加治屋 昌子, 西尾 善彦, 堀内 正久   初診糖尿病患者における腎症・網膜症発症に関連する栄養因子の検討  

    日本衛生学雑誌  2024.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 堀内 正久   健康管理と体質について考える  

    日本衛生学雑誌  2023.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 小牧 祐雅, 牛飼 美晴, 堀内 正久   一事業所の、勤労世代における喫煙者に関する現状  

    産業衛生学雑誌  2022.5  (公社)日本産業衛生学会

    　More details

    Language：Japanese  

  • 岩倉 瑞季, 堀内 正久, 竹下 温子   ライフタイルを考慮した運動パターンが腸内細菌叢に及ぼす影響  

    日本衛生学雑誌  2021.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 竹下 温子, 片桐 奈保, 藤雄 まどか, 堀内 正久   ヒトのライフスタイルを考慮した運動パターンがマウスの生体に及ぼす影響  

    日本衛生学雑誌  2022.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 堀内 正久, 有村 恵美, 牛飼 美晴   たんぱく質摂取量の血中アミノ酸への影響　野生型と2型糖尿病モデルマウスでの比較  

    日本衛生学雑誌  2021.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

  • 堀内 正久   "連携"をキーワードにした衛生学研究の展開　栄養学・ビタミン学研究における連携  

    日本衛生学雑誌  2021.3  (一社)日本衛生学会

    　More details

    Language：Japanese  

▼display all