Updated on 2023/12/12

写真a

 
IDO Akio
 
Organization
President, Executive Director
Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area Faculty of Medicine

Degree

  • 博士(医学) ( 1995.10   長崎大学 )

Research Interests

  • トランスレーショナルリサーチ

  • 肝癌

  • 肝再生

  • 劇症肝炎

  • 肝不全

Research Areas

  • Others / Others  / 特に肝臓病学

  • Others / Others  / 消化器病学

Education

  • Nagasaki University

    - 1984.3

      More details

    Country: Japan

Research History

  • Kagoshima University   Professor

    2014.1

  • Kagoshima University

    2014.1

Professional Memberships

  • 日本消化器内視鏡学会(専門医・指導医・評議員、九州支部幹事)

    2015.10

  • 日本肝臓学会(専門医・指導医、評議員)

    2015.10

  • 日本消化器病学会(専門医・指導医、評議員、九州支部長)

    2015.10

  • 日本内科学会(認定内科医・指導医)

    2015.10

Studying abroad experiences

  • 1990.9 - 1993.8   Calgary University   Research fellow

 

Papers

  • Nakazawa J, Kawahira M, Kawahira M, Kodama T, Arima S, Iwashita Y, Mawatari S, Hashimoto S, Kanmura S, Hori T, Tsubouchi H, Ido A .  Analysis of factors affecting progression-free survival of first-line chemotherapy in older patients with advanced gastrointestinal cancer. .  Journal of geriatric oncology   2021.5Analysis of factors affecting progression-free survival of first-line chemotherapy in older patients with advanced gastrointestinal cancer.

  • Yoshimine H, Tanoue S, Ibi Y, Minami M, Nakahara M, Tokunaga K, Kanmura S, Ido A .  Hepatocyte growth factor ameliorates methylglyoxal-induced peritoneal inflammation and fibrosis in mouse model. .  Clinical and experimental nephrology   2021.4Hepatocyte growth factor ameliorates methylglyoxal-induced peritoneal inflammation and fibrosis in mouse model.

  • Kanmura S, Morinaga Y, Tanaka A, Komaki Y, Iwaya H, Kumagai K, Mawatari S, Sasaki F, Tanoue S, Hashimoto S, Sameshima Y, Ono Y, Ohi H, Ido A .  Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis. .  Clinical and translational gastroenterology12 ( 4 ) e00331   2021.4Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis.

  • Hisanaga T, Hidaka I, Sakaida I, Nakayama N, Ido A, Kato N, Takikawa Y, Inoue K, Shimizu M, Genda T, Terai S, Tsubouchi H, Takikawa H, Mochida S, Intractable Hepato-Biliary Disease Study Group Of Japan .  Analysis of the safety of pretransplant corticosteroid therapy in patients with acute liver failure and late-onset hepatic failure in Japan. .  JGH open : an open access journal of gastroenterology and hepatology5 ( 4 ) 428 - 433   2021.4Analysis of the safety of pretransplant corticosteroid therapy in patients with acute liver failure and late-onset hepatic failure in Japan.

     More details

  • Hiramine Y, Uto H, Mawatari S, Kanmura S, Imamura Y, Hiwaki T, Saishoji A, Kakihara A, Maenohara S, Tokushige K, Ido A .  Efficacy of rifaximin, a poorly absorbed rifamycin antimicrobial agent, for hepatic encephalopathy in Japanese patients. .  Hepatology research : the official journal of the Japan Society of Hepatology51 ( 4 ) 445 - 460   2021.4Efficacy of rifaximin, a poorly absorbed rifamycin antimicrobial agent, for hepatic encephalopathy in Japanese patients.

     More details

  • Hashiguchi M, Tamai T, Kiyama K, Ooi T, Yamauchi T, Kamikihara Y, Kodama T, Kawahira M, Nakamura Y, Yano H, Nakazawa J, Iwashita Y, Nasu Y, Hori T, Tsubouchi H, Ido A .  Two cases of liver cirrhosis with hyperammonemic encephalopathy caused by urease-producing bacteria in the urinary tract. .  Clinical journal of gastroenterology14 ( 2 ) 650 - 655   2021.4Two cases of liver cirrhosis with hyperammonemic encephalopathy caused by urease-producing bacteria in the urinary tract.

  • Hashimoto S, Iwaya H, Tanoue S, Fujino Y, Hinokuchi M, Arima S, Ido A .  Salvage endoscopic ultrasound-guided rendezvous technique for disconnected pancreatic duct syndrome in a patient with severe acute pancreatitis. .  Endoscopy53 ( 4 ) 450 - 451   2021.4Salvage endoscopic ultrasound-guided rendezvous technique for disconnected pancreatic duct syndrome in a patient with severe acute pancreatitis.

     More details

  • Ito S, Nishiguchi A, Sasaki F, Maeda H, Kabayama M, Ido A, Taguchi T .  Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing. .  Materials science & engineering. C, Materials for biological applications123   111993   2021.4Robust closure of post-endoscopic submucosal dissection perforation by microparticle-based wound dressing.

  • Iwaya H, Fukukura Y, Hashimoto S, Tanoue S, Kawahira M, Hinokuchi M, Fujita T, Komaki Y, Arima S, Sasaki F, Kanmura S, Higashi M, Tamada K, Ido A .  Prognostic significance of extracellular volume fraction with equilibrium contrast-enhanced computed tomography for pancreatic neuroendocrine neoplasms. .  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   2021.3Prognostic significance of extracellular volume fraction with equilibrium contrast-enhanced computed tomography for pancreatic neuroendocrine neoplasms.

  • Matsukubo M, Yano K, Kaji T, Sugita K, Onishi S, Harumatsu T, Nagano A, Matsui M, Murakami M, Yamada K, Yamada W, Muto M, Kumagai K, Ido A, Ieiri S .  The administration of hepatocyte growth factor prevents total parenteral nutrition-induced hepatocellular injury in a rat model. .  Pediatric surgery international37 ( 3 ) 353 - 361   2021.3The administration of hepatocyte growth factor prevents total parenteral nutrition-induced hepatocellular injury in a rat model.

  • Komaki Y, Kanmura S, Yutsudo K, Kuwazuru K, Komaki F, Tanaka A, Nishimata N, Sameshima Y, Sasaki F, Ohi H, Nakamura Y, Tokushige K, Sameshima Y, Ido A .  Infliximab therapy intensification based on endoscopic activity is related to suppress treatment discontinuation in patients with Crohn disease: A retrospective cohort study. .  Medicine100 ( 6 ) e24731   2021.2Infliximab therapy intensification based on endoscopic activity is related to suppress treatment discontinuation in patients with Crohn disease: A retrospective cohort study.

  • Minami M, Mizuma E, Nakahara M, Oda Y, Yoshimine H, Tokunaga K, Mitsuke A, Yamada Y, Enokida H, Masutani K, Goto N, Ido A .  A case of latent heterozygous Fabry disease in a female living kidney donor candidate. .  CEN case reports10 ( 1 ) 30 - 34   2021.2A case of latent heterozygous Fabry disease in a female living kidney donor candidate.

  • Takikawa Y, Kakisaka K, Suzuki Y, Ido A, Shimamura T, Nishida O, Oda S, Shimosegawa T .  Multicenter study on the consciousness-regaining effect of a newly developed artificial liver support system in acute liver failure: An on-line continuous hemodiafiltration system. .  Hepatology research : the official journal of the Japan Society of Hepatology51 ( 2 ) 216 - 226   2021.2Multicenter study on the consciousness-regaining effect of a newly developed artificial liver support system in acute liver failure: An on-line continuous hemodiafiltration system.

     More details

  • Enomoto H, Ueno Y, Hiasa Y, Nishikawa H, Hige S, Takikawa Y, Taniai M, Ishikawa T, Yasui K, Takaki A, Takaguchi K, Ido A, Kurosaki M, Kanto T, Nishiguchi S, Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH. .  The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan. .  Journal of gastroenterology56 ( 2 ) 158 - 167   2021.2The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan.

  • Komaki Y, Komaki F, Yamada A, Micic D, Ido A, Sakuraba A .  Risk of Cancers in Patients with Pediatric Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis. .  The Journal of pediatrics229   102 - 117.e36   2021.2Risk of Cancers in Patients with Pediatric Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis.

  • Hiramine Y, Uto H, Mawatari S, Kanmura S, Imamura Y, Hiwaki T, Saishoji A, Oku M, Tokushige K, Maenohara S, Ido A .  Impact of acute kidney injury on prognosis and the effect of tolvaptan in patients with hepatic ascites. .  Journal of gastroenterology56 ( 1 ) 54 - 66   2021.1Impact of acute kidney injury on prognosis and the effect of tolvaptan in patients with hepatic ascites.

  • Tahata Y, Hikita H, Mochida S, Kawada N, Enomoto N, Ido A, Yoshiji H, Miki D, Hiasa Y, Takikawa Y, Sakamori R, Kurosaki M, Yatsuhashi H, Tateishi R, Ueno Y, Itoh Y, Yamashita T, Kanto T, Suda G, Nakamoto Y, Kato N, Asahina Y, Matsuura K, Terai S, Nakao K, Shimizu M, Takami T, Akuta N, Yamada R, Kodama T, Tatsumi T, Yamada T, Takehara T .  Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study. .  Journal of gastroenterology56 ( 1 ) 67 - 77   2021.1Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: a Japanese real-world multicenter study.

  • Maeda H, Sasaki F, Morinaga Y, Kabayama M, Iwaya H, Komaki Y, Arima S, Nasu Y, Tanoue S, Hashimoto S, Kanmura S, Nishiguchi A, Taguchi T, Ido A .  Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis. .  Digestion102 ( 3 ) 415 - 427   2021Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis.

     More details

  • Sasaki F, Kanmura S, Oda K, Maeda H, Kabayama M, Iwaya H, Komaki Y, Arima S, Tanoue S, Hashimoto S, Fujita H, Ido A .  Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma. .  PloS one16 ( 5 ) e0251457   2021Acetaldehyde breath test as a cancer risk marker in patients with esophageal and hypopharyngeal squamous cell carcinoma.

  • Hashiguchi M, Tamai T, Nakazawa J, Iwashita Y, Nasu Y, Funakawa K, Hori T, Sueyoshi K, Tsubouchi H, Ido A .  [Pulse steroid therapy to treat liver injury with risk of liver failure due to immune-related adverse events:a case report]. .  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology118 ( 2 ) 175 - 182   2021[Pulse steroid therapy to treat liver injury with risk of liver failure due to immune-related adverse events:a case report].

  • Kudo M, Morimoto M, Moriguchi M, Izumi N, Takayama T, Yoshiji H, Hino K, Oikawa T, Chiba T, Motomura K, Kato J, Yasuchika K, Ido A, Sato T, Nakashima D, Ueshima K, Ikeda M, Okusaka T, Tamura K, Furuse J .  A randomized, double-blind, placebo-controlled, phase 3 study of tivantinib in Japanese patients with MET-high hepatocellular carcinoma. .  Cancer science111 ( 10 ) 3759 - 3769   2020.10A randomized, double-blind, placebo-controlled, phase 3 study of tivantinib in Japanese patients with MET-high hepatocellular carcinoma.

     More details

  • 矢野 弘樹, 橋元 慎一, 田口 宏樹, 田ノ上 史郎, 岩屋 博道, 有馬 志穂, 佐々木 文郷, 上村 修司, 東 美智代, 井戸 章雄 .  膵体部癌との鑑別に難渋し、切除標本により診断し得た2型自己免疫性膵炎の1例 .  膵臓35 ( 5 ) 447 - 454   2020.10膵体部癌との鑑別に難渋し、切除標本により診断し得た2型自己免疫性膵炎の1例

     More details

    Publisher:(一社)日本膵臓学会  

    症例は46歳女性.心窩部痛,嘔気を主訴に受診した.膵酵素の上昇を認め,急性膵炎の診断で保存的に加療された.画像所見で膵体尾部実質の不均一な造影効果と尾側膵管の拡張を認め,膵腫瘍が疑われた.EUS-FNAにおける組織診断で確定診断が得られなかったが,膵体部癌の可能性が否定できず,手術治療を行った.切除標本にて特徴的な組織所見を示し,2型自己免疫性膵炎の診断に至った.(著者抄録)

  • Hashimoto S, Tanoue S, Fujino Y, Hinokuchi M, Iwaya H, Arima S, Ido A .  Endoscopic ultrasonography-guided hybrid rendezvous technique for pancreatic stenting in a patient with pancreatoduodenectomy. .  Endoscopy   2020.9Endoscopic ultrasonography-guided hybrid rendezvous technique for pancreatic stenting in a patient with pancreatoduodenectomy.

     More details

  • 前田 英仁, 佐々木 文郷, 小吉 尚裕, 福迫 哲史, 藤田 浩, 菰原 義弘, 井戸 章雄 .  高齢化の進む地域中核病院における85歳以上の超高齢者の胃内視鏡的粘膜下層剥離術の現状と問題点 .  日本消化管学会雑誌4 ( 1 ) 25 - 30   2020.9高齢化の進む地域中核病院における85歳以上の超高齢者の胃内視鏡的粘膜下層剥離術の現状と問題点

     More details

    Publisher:(一社)日本消化管学会  

    【目的】85歳以上の超高齢者に対する胃内視鏡的粘膜下層剥離術(ESD)の安全性、有効性を検討した。【対象と方法】2012年4月から2019年12月に当院でESDを施行した早期胃癌病変149例165病変を対象とした。85歳以上の21症例の超高齢者群と84歳以下の非超高齢者群に分けて治療成績、ESD後の経過観察、3年生存率を検討した。【結果】治療成績は両群間で有意差は認めなかった。超高齢者群は、3年以内に通院の自己中断例が有意に多く、経過が追えた8症例の3年生存率は100%であった。【結語】85歳以上の超高齢者への胃ESDは比較的安全に施行できた。しかし、通院の自己中断に留意する必要がある。(著者抄録)

  • Tanaka A, Kanmura S, Sakiyama T, Ido A .  Huge gastric lesion disappears in a day. .  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   2020.8Huge gastric lesion disappears in a day.

  • Kudo M, Ueshima K, Ikeda M, Torimura T, Tanabe N, Aikata H, Izumi N, Yamasaki T, Nojiri S, Hino K, Tsumura H, Kuzuya T, Isoda N, Yasui K, Aino H, Ido A, Kawabe N, Nakao K, Wada Y, Yokosuka O, Yoshimura K, Okusaka T, Furuse J, Kokudo N, Okita K, Johnson PJ, Arai Y, TACTICS study group. .  Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial. .  Gut69 ( 8 ) 1492 - 1501   2020.8Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial.

  • Tanaka A, Sasaki F, Kanmura S, Ido A .  Magnified endoscopic imaging of a Peutz-Jeghers-type polyp in the jejunum. .  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver   2020.6Magnified endoscopic imaging of a Peutz-Jeghers-type polyp in the jejunum.

  • Fukuzako S, Maeda H, Koyoshi N, Fujita H, Kuroki H, Uemura S, Hanada N, Urakado T, Ido A .  Perirectal abscess with dysuria. .  JGH open : an open access journal of gastroenterology and hepatology4 ( 3 ) 548 - 549   2020.6Perirectal abscess with dysuria.

     More details

  • Maeda-Iino A, Fukushima M, Sakoguchi Y, Omure H, Oishi A, Oga Y, Furukawa-Sainoki M, Kanmura S, Ido A, Miyawaki S .  Effects of intra-oesophageal acid infusion and a stress task on masseter muscle activity and autonomic nervous activity in wakefulness. .  Journal of oral rehabilitation47 ( 5 ) 567 - 576   2020.5Effects of intra-oesophageal acid infusion and a stress task on masseter muscle activity and autonomic nervous activity in wakefulness.

     More details

  • Hinokuchi M, Iwaya H, Ido A .  Endoscopic ultrasound-guided hepaticogastrostomy for intraductal papillary neoplasm of bile duct with obstructive jaundice and cholangitis due to mucus overproduction. .  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society32 ( 4 ) e80 - e81   2020.5Endoscopic ultrasound-guided hepaticogastrostomy for intraductal papillary neoplasm of bile duct with obstructive jaundice and cholangitis due to mucus overproduction.

     More details

  • Mawatari S, Oda K, Kumagai K, Tabu K, Ijuin S, Fujisaki K, Inada Y, Uto H, Saisyoji A, Hiramine Y, Hori T, Taniyama O, Toyodome A, Sakae H, Hashiguchi M, Kure T, Sakurai K, Tamai T, Moriuchi A, Ido A .  Viral and host factors are associated with retreatment failure in hepatitis C patients receiving all-oral direct antiviral therapy. .  Hepatology research : the official journal of the Japan Society of Hepatology50 ( 4 ) 453 - 465   2020.4Viral and host factors are associated with retreatment failure in hepatitis C patients receiving all-oral direct antiviral therapy.

     More details

  • 笠井 亜衣, 橋元 慎一, 恒吉 研吾, 樺山 雅之, 岩屋 博道, 有馬 志穂, 田口 宏樹, 上村 修司, 東 美智代, 井戸 章雄 .  膵臓の腫瘤性病変に対するEUS-FNAで診断に至ったB細胞リンパ腫の3例 .  膵臓35 ( 2 ) 213 - 221   2020.4膵臓の腫瘤性病変に対するEUS-FNAで診断に至ったB細胞リンパ腫の3例

     More details

    Publisher:(一社)日本膵臓学会  

    膵原発の悪性リンパ腫は,節外性悪性リンパ腫の2%以下,膵悪性腫瘍の0.5%未満と稀である.画像所見のみでは鑑別が難しく,病理組織学的評価による正確な診断が重要である.今回,膵腫瘤に対し超音波内視鏡下穿刺吸引法(EUS-FNA)でB細胞リンパ腫と診断した3例を経験し,うち2例は化学放射線療法で改善した.EUS-FNAは,リンパ腫の病型診断および治療方針決定に有用と考えられた.(著者抄録)

  • Tanaka A, Kanmura S, Komaki Y, Ido A .  A case of papilloma-like lesions of the esophagus in Cronkhite-Canada syndrome. .  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver52 ( 3 ) 352   2020.3A case of papilloma-like lesions of the esophagus in Cronkhite-Canada syndrome.

  • Tanaka A, Kanmura S, Morinaga Y, Kawabata K, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Takeshita M, Takeda S, Ido A .  Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response. .  Molecular medicine reports21 ( 3 ) 1181 - 1191   2020.3Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response.

     More details

  • Enomoto H, Ueno Y, Hiasa Y, Nishikawa H, Hige S, Takikawa Y, Taniai M, Ishikawa T, Yasui K, Takaki A, Takaguchi K, Ido A, Kurosaki M, Kanto T, Nishiguchi S, Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH. .  Transition in the etiology of liver cirrhosis in Japan: a nationwide survey. .  Journal of gastroenterology55 ( 3 ) 353 - 362   2020.3Transition in the etiology of liver cirrhosis in Japan: a nationwide survey.

  • Kosedo I, Tokushige A, Takumi T, Yoshikawa A, Teraguchi K, Takenouchi K, Shiraishi K, Ikeda D, Imamura M, Sonoda T, Kanda D, Ikeda Y, Ido A, Ohishi M .  Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: Insight from the kids registry. .  European journal of internal medicine72   79 - 87   2020.2Use of proton pump inhibitors is associated with an increase in adverse cardiovascular events in patients with hemodialysis: Insight from the kids registry.

  • Kamikihara Y, Tanoue S, Kawahira M, Iwaya H, Arima S, Sasaki F, Nasu Y, Hashimoto S, Kanmura S, Higashi M, Gejima K, Ido A .  A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy. .  Oncology letters19 ( 1 ) 247 - 254   2020.1A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy.

     More details

  • Kumagai K, Mawatari S, Ido A .  [Pathophysiology of acute liver failure from onset to liver regeneration]. .  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology117 ( 9 ) 750 - 755   2020[Pathophysiology of acute liver failure from onset to liver regeneration].

  • Nishikoba N, Kumagai K, Kanmura S, Nakamura Y, Ono M, Eguchi H, Kamibayashiyama T, Oda K, Mawatari S, Tanoue S, Hashimoto S, Tsubouchi H, Ido A .  HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression. .  Frontiers in immunology11   2135   2020HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression.

  • Kanmura S, Tanaka A, Yutsudou K, Kuwazuru K, Komaki F, Komaki Y, Iwaya H, Arima S, Sasaki F, Tanoue S, Hashimoto S, Ido A .  Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis. .  Gastroenterology research and practice2020   3108690   2020Significance of Linked Color Imaging for Predicting the Risk of Clinical Relapse in Ulcerative Colitis.

     More details

  • Tabu K, Mawatari S, Oda K, Kumagai K, Inada Y, Uto H, Saisyoji A, Hiramine Y, Hashiguchi M, Tamai T, Hori T, Fujisaki K, Imanaka D, Kure T, Taniyama O, Toyodome A, Ijuin S, Sakae H, Sakurai K, Moriuchi A, Kanmura S, Ido A .  Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals. .  PloS one15 ( 8 ) e0237475   2020Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals.

  • Hiraishi N, Kanmura S, Oda K, Arima S, Kumagai K, Mawatari S, Tanoue S, Sasaki F, Hashimoto S, Ido A .  Extract of <i>Lactobacillus plantarum</i> strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells. .  Biochemistry and biophysics reports20   100691   2019.12Extract of <i>Lactobacillus plantarum</i> strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells.

  • Kure T, Mawatari S, Imamura Y, Oda K, Kumagai K, Hiramine Y, Miyahara H, Kanmura S, Moriuchi A, Uto H, Horiuchi M, Ido A .  Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity: A cross-sectional study. .  Medicine98 ( 46 ) e17879   2019.11Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity: A cross-sectional study.

  • 山下 芳恵, 下川原 尚人, 宮田 尚幸, 田淵 雅裕, 鉾之原 基, 中武 信純, 美園 俊明, 山口 淳正, 清水 健, 井戸 章雄 .  十二指腸病変として発症したメトトレキセート関連リンパ増殖性疾患の1例 .  Gastroenterological Endoscopy61 ( 11 ) 2466 - 2472   2019.11十二指腸病変として発症したメトトレキセート関連リンパ増殖性疾患の1例

     More details

    Publisher:(一社)日本消化器内視鏡学会  

    症例は76歳女性。心窩部痛と黒色便の精査で当科紹介となった。慢性関節リウマチ(RA)で41歳時よりメトトレキセート(MTX)で加療されていた。上部消化管内視鏡検査で十二指腸下行脚に潰瘍性病変を認め、生検結果でびまん性大細胞型B細胞性リンパ腫(diffuse large B-cell lymphoma:DLBCL)の診断となった。CTで全身のリンパ節腫大を認め、可溶性IL-2レセプター(sIL-2R)は高値であり、メトトレキセート関連リンパ増殖性疾患(methotrexate-associated lymphoproliferative disorders:MTX-LPD)と判断しMTXを中止とした。十二指腸下行脚の潰瘍性病変は、MTX中止1ヵ月後より縮小改善傾向であり、リンパ節は縮小増大様々であった。MTX中止で経過観察していたがリンパ節病変が寛解に至らず、MTX中止から9ヵ月後にリツキシマブを投与し、リンパ節の縮小、sIL-2Rの低下を認め、十二指腸病変は瘢痕化していた。MTX-LPDの十二指腸病変は非常に稀である。MTX内服中のRA患者の消化管病変を認めた場合、MTX-LPDも鑑別すべき疾患であると考えられた。(著者抄録)

  • Iwaya H, Hijioka S, Mizuno N, Kuwahara T, Okuno N, Tajika M, Tanaka T, Ishihara M, Hirayama Y, Onishi S, Ito A, Kuraoka N, Matsumoto S, Polmanee P, Shimizu Y, Yatabe Y, Niwa Y, Tamada K, Ido A, Hara K .  Usefulness of septal thickness measurement on endoscopic ultrasound as a predictor of malignancy of branched-duct and mixed-type intraductal papillary mucinous neoplasm of the pancreas. .  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society31 ( 6 ) 672 - 681   2019.11Usefulness of septal thickness measurement on endoscopic ultrasound as a predictor of malignancy of branched-duct and mixed-type intraductal papillary mucinous neoplasm of the pancreas.

     More details

  • Komaki Y, Kanmura S, Tanaka A, Nakashima M, Komaki F, Iwaya H, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Ido A .  Cola Dissolution Therapy via Ileus Tube Was Effective for Ileus Secondary to Small Bowel Obstruction Induced by an Enterolith. .  Internal medicine (Tokyo, Japan)58 ( 17 ) 2473 - 2478   2019.9Cola Dissolution Therapy via Ileus Tube Was Effective for Ileus Secondary to Small Bowel Obstruction Induced by an Enterolith.

  • Iwaya H, Hashimoto S, Ido A .  Laparo-endoscopic rendezvous using a single balloon endoscope for cholecysto-choledocholithiasis in a patient with roux-en Y. .  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society31 ( 5 ) e101 - e102   2019.9Laparo-endoscopic rendezvous using a single balloon endoscope for cholecysto-choledocholithiasis in a patient with roux-en Y.

     More details

  • Kim JD, Cho EJ, Ahn C, Park SK, Choi JY, Lee HC, Kim DY, Choi MS, Wang HJ, Kim IH, Yeon JE, Seo YS, Tak WY, Kim MY, Lee HJ, Kim YS, Jun DW, Sohn JH, Kwon SY, Park SH, Heo J, Jeong SH, Lee JH, Nakayama N, Mochida S, Ido A, Tsubouchi H, Takikawa H, Shalimar, Acharya SK, Bernal W, O'Grady J, Kim YJ .  A Model to Predict 1-Month Risk of Transplant or Death in Hepatitis A-Related Acute Liver Failure. .  Hepatology (Baltimore, Md.)70 ( 2 ) 621 - 629   2019.8A Model to Predict 1-Month Risk of Transplant or Death in Hepatitis A-Related Acute Liver Failure.

     More details

  • Kanmura S, Hamamoto H, Tanaka A, Arima S, Sasaki F, Tanoue S, Nasu Y, Hashimoto S, Higashi M, Ido A .  Diagnostic utility of linked color imaging in the evaluation of colonic mucosal inflammation in ulcerative colitis: a pilot study. .  Endoscopy international open7 ( 8 ) E937 - E943   2019.8Diagnostic utility of linked color imaging in the evaluation of colonic mucosal inflammation in ulcerative colitis: a pilot study.

     More details

  • Nakao M, Nakayama N, Uchida Y, Tomiya T, Oketani M, Ido A, Tsubouchi H, Takikawa H, Mochida S .  Deteriorated outcome of recent patients with acute liver failure and late-onset hepatic failure caused by infection with hepatitis A virus: A subanalysis of patients seen between 1998 and 2015 and enrolled in nationwide surveys in Japan. .  Hepatology research : the official journal of the Japan Society of Hepatology49 ( 8 ) 844 - 852   2019.8Deteriorated outcome of recent patients with acute liver failure and late-onset hepatic failure caused by infection with hepatitis A virus: A subanalysis of patients seen between 1998 and 2015 and enrolled in nationwide surveys in Japan.

     More details

  • Nishiguchi A, Sasaki F, Maeda H, Kabayama M, Ido A, Taguchi T .  Multifunctional Hydrophobized Microparticles for Accelerated Wound Healing after Endoscopic Submucosal Dissection. .  Small (Weinheim an der Bergstrasse, Germany)15 ( 35 ) e1901566   2019.8Multifunctional Hydrophobized Microparticles for Accelerated Wound Healing after Endoscopic Submucosal Dissection.

     More details

  • Kanmura S, Tanaka A, Komaki Y, Ido A .  A case of screening colonoscopy using linked-color imaging to detect ulcerative colitis-associated colorectal cancer. .  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver51 ( 7 ) 1061   2019.7A case of screening colonoscopy using linked-color imaging to detect ulcerative colitis-associated colorectal cancer.

  • Hiramine Y, Uto H, Mawatari S, Kanmura S, Imamura Y, Hiwaki T, Saishoji A, Yada T, Inada Y, Sakamoto H, Higashi H, Kubozono O, Maenohara S, Ido A .  Effect of tolvaptan on the prognosis of patients with hepatic ascites. .  Hepatology research : the official journal of the Japan Society of Hepatology49 ( 7 ) 765 - 777   2019.7Effect of tolvaptan on the prognosis of patients with hepatic ascites.

     More details

  • Komaki Y, Komaki F, Micic D, Ido A, Sakuraba A .  Risk of Fractures in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis. .  Journal of clinical gastroenterology53 ( 6 ) 441 - 448   2019.7Risk of Fractures in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis.

  • 上床 美紀, 大保 玲衣, 大塚 彰行, 阿部 正治, 吉嶺 陽造, 屋 万栄, 吉嶺 陽仁, 曾我部 篤史, 内田 義男, 野崎 剛, 徳永 公紀, 井戸 章雄 .  腎代替療法導入の選択およびバスキュラーアクセス作製に難渋した強皮症腎クリーゼの1例 .  日本透析医学会雑誌52 ( 6 ) 363 - 368   2019.6腎代替療法導入の選択およびバスキュラーアクセス作製に難渋した強皮症腎クリーゼの1例

     More details

    Publisher:(一社)日本透析医学会  

    症例は44歳、女性。全身性強皮症の診断の約2年後に強皮症腎クリーゼを発症し、末期腎不全へと至ったために腎代替療法が必要となった。移植希望はなく、透析を導入する予定となった。血液透析を行ううえでは、皮膚硬化・血管病変の存在によりバスキュラーアクセスの作製・維持が困難と考えられた。腹膜透析に関しては、手指の皮膚硬化にて機械操作が困難であり、ステロイド長期内服による易感染状態から腹膜透析カテーテル感染も懸念された。最終的に血液透析を選択したが、血管の伸展不良・皮膚硬化から内シャント作製は難渋し、穿刺可能となるまでの血管の成長に長期間を要した。強皮症は多臓器障害をきたすという問題点の他にも、特有の皮膚、血管病変を有すること、また血管病変のため腹膜機能が低下している可能性があることから、腎代替療法の選択においては熟考を要する。個々の症例で慎重な検討が必要であり、症例の蓄積が望まれると考え報告する。(著者抄録)

  • Nepal P, Mori S, Kita Y, Tanabe K, Baba K, Sasaki F, Nasu Y, Ido A, Uchikado Y, Kurahara H, Arigami T, Sakoda M, Maemura K, Natsugoe S .  Combined endoscopic submucosal dissection and transanal minimally invasive surgery for the management of lower rectal adenoma extending above the dentate line: A case report. .  Medicine98 ( 19 ) e15289   2019.5Combined endoscopic submucosal dissection and transanal minimally invasive surgery for the management of lower rectal adenoma extending above the dentate line: A case report.

  • Ide T, Koga H, Nakano M, Hashimoto S, Yatsuhashi H, Higuchi N, Nakamuta M, Oeda S, Eguchi Y, Shakado S, Sakisaka S, Yoshimaru Y, Sasaki Y, Honma Y, Harada M, Seike M, Maeshiro T, Miuma S, Nakao K, Mawatari S, Ido A, Nagata K, Matsumoto S, Takami Y, Sohda T, Kakuma T, Torimura T .  Direct-acting antiviral agents do not increase the incidence of hepatocellular carcinoma development: a prospective, multicenter study. .  Hepatology international13 ( 3 ) 293 - 301   2019.5Direct-acting antiviral agents do not increase the incidence of hepatocellular carcinoma development: a prospective, multicenter study.

  • Hashimoto S, Fujita T, Ido A .  Emergent endoscopic ultrasonography-guided antegrade treatment for acute biliary pancreatitis in a patient with altered gastrointestinal anatomy. .  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society31 ( 3 ) e58 - e59   2019.5Emergent endoscopic ultrasonography-guided antegrade treatment for acute biliary pancreatitis in a patient with altered gastrointestinal anatomy.

     More details

  • Nakano M, Koga H, Ide T, Kuromatsu R, Hashimoto S, Yatsuhashi H, Seike M, Higuchi N, Nakamuta M, Shakado S, Sakisaka S, Miuma S, Nakao K, Yoshimaru Y, Sasaki Y, Oeda S, Eguchi Y, Honma Y, Harada M, Nagata K, Mawatari S, Ido A, Maeshiro T, Matsumoto S, Takami Y, Sohda T, Torimura T .  Predictors of hepatocellular carcinoma recurrence associated with the use of direct-acting antiviral agent therapy for hepatitis C virus after curative treatment: A prospective multicenter cohort study. .  Cancer medicine8 ( 5 ) 2646 - 2653   2019.5Predictors of hepatocellular carcinoma recurrence associated with the use of direct-acting antiviral agent therapy for hepatitis C virus after curative treatment: A prospective multicenter cohort study.

     More details

  • Motoi S, Toyoda H, Obara T, Ohta E, Arita Y, Negishi K, Moriya K, Kuboi Y, Soejima M, Imai T, Ido A, Tsubouchi H, Kawano T .  Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time. .  International journal of molecular sciences20 ( 8 )   2019.4Anti-Apoptotic Effects of Recombinant Human Hepatocyte Growth Factor on Hepatocytes Were Associated with Intrahepatic Hemorrhage Suppression Indicated by the Preservation of Prothrombin Time.

     More details

  • Kawabata K, Kanmura S, Morinaga Y, Tanaka A, Makino T, Fujita T, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Ido A .  A high‑fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium‑induced colitis. .  International journal of molecular medicine43 ( 3 ) 1487 - 1496   2019.3A high‑fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium‑induced colitis.

     More details

  • Taniyama O, Mawatari S, Oda K, Tabu K, Ijuin S, Kumagai K, Kasai A, Tashima S, Tamai T, Moriuchi A, Ido A .  Sustained virologic response after eight weeks of treatment with sofosbuvir, ledipasvir, and ribavirin in a decompensated cirrhotic patient with hepatitis C virus genotype 1b. .  Hepatology research : the official journal of the Japan Society of Hepatology49 ( 2 ) 239 - 243   2019.2Sustained virologic response after eight weeks of treatment with sofosbuvir, ledipasvir, and ribavirin in a decompensated cirrhotic patient with hepatitis C virus genotype 1b.

     More details

  • Fujita T, Hashimoto S, Tanoue S, Tsuneyoshi K, Nakamura Y, Hinokuchi M, Iwaya H, Arima S, Iwashita Y, Sasaki F, Taguchi H, Kanmura S, Ido A .  Factors Associated with the Technical Success of Bilateral Endoscopic Metallic Stenting with Partial Stent-In-Stent Placement in Patients with Malignant Hilar Biliary Obstruction. .  Gastroenterology research and practice2019   5928040   2019Factors Associated with the Technical Success of Bilateral Endoscopic Metallic Stenting with Partial Stent-In-Stent Placement in Patients with Malignant Hilar Biliary Obstruction.

     More details

  • Komaki Y, Kanmura S, Sasaki F, Maeda H, Oda K, Arima S, Tanoue S, Nasu Y, Hashimoto S, Mawatari S, Tsubouchi H, Ido A .  Hepatocyte Growth Factor Facilitates Esophageal Mucosal Repair and Inhibits the Submucosal Fibrosis in a Rat Model of Esophageal Ulcer. .  Digestion99 ( 3 ) 227 - 238   2019Hepatocyte Growth Factor Facilitates Esophageal Mucosal Repair and Inhibits the Submucosal Fibrosis in a Rat Model of Esophageal Ulcer.

     More details

  • Mukaino A, Minami H, Isomoto H, Hamamoto H, Ihara E, Maeda Y, Higuchi O, Okanishi T, Kokudo Y, Deguchi K, Sasaki F, Ueki T, Murata KY, Yoshida T, Kinjo M, Ogawa Y, Ido A, Matsuo H, Nakao K, Nakane S .  Anti-ganglionic AChR antibodies in Japanese patients with motility disorders. .  Journal of gastroenterology53 ( 12 ) 1227 - 1240   2018.12Anti-ganglionic AChR antibodies in Japanese patients with motility disorders.

  • Komaki Y, Komaki F, Micic D, Ido A, Sakuraba A .  Risk of Colorectal Cancer in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. .  Journal of clinical gastroenterology52 ( 9 ) 796 - 804   2018.10Risk of Colorectal Cancer in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

  • Akuta N, Toyota J, Karino Y, Ikeda F, Ido A, Tanaka K, Takaguchi K, Naganuma A, Tomita E, Chayama K, Fujiyama S, Inada Y, Yoshiji H, Watanabe H, Ishikawa H, McPhee F, Noviello S, Kumada H .  Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection. .  Journal of gastroenterology53 ( 9 ) 1089 - 1097   2018.9Potent viral suppression and improvements in alpha-fetoprotein and measures of fibrosis in Japanese patients receiving a daclatasvir/asunaprevir/beclabuvir fixed-dose combination for the treatment of HCV genotype-1 infection.

  • Hamamoto H, Hashimoto S, Taguchi H, Kojima I, Kasai A, Tsuneyoshi K, Kuwazuru K, Arima S, Kanmura S, Ido A .  Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall. .  Internal medicine (Tokyo, Japan)57 ( 13 ) 1841 - 1847   2018.7Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall.

  • Mawatari S, Moriuchi A, Ohba F, Kawano T, Oda K, Takikawa Y, Takikawa H, Ido A, Tsubouchi H .  The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury. .  Journal of gastroenterology53 ( 7 ) 861 - 872   2018.7The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury.

  • Nakao M, Nakayama N, Uchida Y, Tomiya T, Ido A, Sakaida I, Yokosuka O, Takikawa Y, Inoue K, Genda T, Shimizu M, Terai S, Tsubouchi H, Takikawa H, Mochida S .  Nationwide survey for acute liver failure and late-onset hepatic failure in Japan. .  Journal of gastroenterology53 ( 6 ) 752 - 769   2018.6Nationwide survey for acute liver failure and late-onset hepatic failure in Japan.

  • 上床 美紀, 吉嶺 陽仁, 阿部 正治, 水間 英美子, 山下 和, 潤田 心, 久保 拓也, 濱田 富志夫, 徳永 公紀, 井戸 章雄 .  施設入所中に短時間の圧迫にてcrush症候群を発症した高齢女性の1例 .  日本透析医学会雑誌51 ( 6 ) 401 - 408   2018.6施設入所中に短時間の圧迫にてcrush症候群を発症した高齢女性の1例

     More details

    Publisher:(一社)日本透析医学会  

    症例はうつ病・認知症のため施設入所中の77歳女性。職員訪室の1時間後、ベッドから上半身が柵を乗り越えるかたちで頭から床へ転落しているところを発見された。下腹部が柵に押し付けられ、下半身はベッド上にある状態であった。救出後に下肢運動消失を認め、翌日には腎機能障害、高K血症が出現したため当院へ搬送された。受傷機転・諸データよりcrush症候群による急性腎障害・DICと診断した。大量補液を行うも無尿状態であり、同日より血液透析を施行。透析は3回で離脱し、その後DIC・下肢運動機能も改善した。Crush症候群は震災・事故時の発生が注目されやすいが、長時間の圧迫という状況があれば日常でも生じうる病態であり、痩身や高齢者においては短時間での発症も報告されている。その発症の可能性が念頭に置かれていない場合にはしばしば生命を脅かす事態に至る深刻な病態であり、診断には受傷機転の聴取が重要である。(著者抄録)

  • Kumada H, Watanabe T, Suzuki F, Ikeda K, Sato K, Toyoda H, Atsukawa M, Ido A, Takaki A, Enomoto N, Kato K, Alves K, Burroughs M, Redman R, Pugatch D, Pilot-Matias TJ, Krishnan P, Oberoi RK, Xie W, Chayama K .  Correction to: Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection. .  Journal of gastroenterology53 ( 5 ) 689   2018.5Correction to: Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection.

  • Tamai T, Taniyama O, Oda K, Kasai A, Ijyuin S, Sakae H, Onishi H, Tabu K, Kumagai K, Mawatari S, Moriuchi A, Uto H, Ido A .  Reduction effect of the quantity of radiation exposure and contrast media by image support system in transarterial chemoembolization for the treatment of hepatocellular carcinoma. .  Journal of gastroenterology and hepatology33 ( 5 ) 1115 - 1122   2018.5Reduction effect of the quantity of radiation exposure and contrast media by image support system in transarterial chemoembolization for the treatment of hepatocellular carcinoma.

     More details

  • Kumada H, Watanabe T, Suzuki F, Ikeda K, Sato K, Toyoda H, Atsukawa M, Ido A, Takaki A, Enomoto N, Kato K, Alves K, Burroughs M, Redman R, Pugatch D, Pilot-Matias TJ, Krishnan P, Oberoi RK, Xie W, Chayama K .  Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection. .  Journal of gastroenterology53 ( 4 ) 566 - 575   2018.4Efficacy and safety of glecaprevir/pibrentasvir in HCV-infected Japanese patients with prior DAA experience, severe renal impairment, or genotype 3 infection.

  • 樺山 雅之, 佐々木 文郷, 前田 英仁, 有馬 志穂, 田ノ上 史郎, 那須 雄一郎, 橋元 慎一, 上村 修司, 門野 潤, 井戸 章雄 .  審査腹腔鏡が診断に有用であった胃癌術後再発による二次性アカラシアの1例 .  日本消化器病学会雑誌115 ( 4 ) 394 - 400   2018.4審査腹腔鏡が診断に有用であった胃癌術後再発による二次性アカラシアの1例

     More details

    Publisher:(一財)日本消化器病学会  

    65歳男性。進行胃癌術後3年目に、嘔吐、体重減少が出現した。各種検査で食道アカラシア様の所見を認めた。(1)壮年層の発症、(2)短い有症状期間、(3)著明な体重減少を三徴とするTucker's criteriaを満たし、二次性アカラシアを疑った。原因として胃癌術後再発を疑い、審査腹腔鏡にて確定診断に至った。二次性アカラシアの診断には、Tucker's criteriaが有用であると考えられた。(著者抄録)

  • Nakayama N, Uemura H, Uchida Y, Tomiya T, Ido A, Inoue K, Genda T, Takikawa Y, Sakaida I, Terai S, Yokosuka O, Shimizu M, Takikawa H, Mochida S .  A multicenter pilot survey to clarify the clinical features of patients with acute-on-chronic liver failure in Japan. .  Hepatology research : the official journal of the Japan Society of Hepatology48 ( 4 ) 303 - 312   2018.3A multicenter pilot survey to clarify the clinical features of patients with acute-on-chronic liver failure in Japan.

     More details

  • Mochida S, Nakayama N, Ido A, Inoue K, Genda T, Takikawa Y, Sakaida I, Terai S, Yokosuka O, Shimizu M, Takikawa H .  Proposed diagnostic criteria for acute-on-chronic liver failure in Japan. .  Hepatology research : the official journal of the Japan Society of Hepatology48 ( 4 ) 219 - 224   2018.3Proposed diagnostic criteria for acute-on-chronic liver failure in Japan.

     More details

  • Tominaga H, Oku M, Arishima Y, Ikeda T, Ishidou Y, Nagano S, Minami M, Ido A, Komiya S, Setoguchi T .  Association between bone mineral density, muscle volume, walking ability, and geriatric nutritional risk index in hemodialysis patients. .  Asia Pacific journal of clinical nutrition27 ( 5 ) 1062 - 1066   2018Association between bone mineral density, muscle volume, walking ability, and geriatric nutritional risk index in hemodialysis patients.

     More details

  • Kabayama M, Sasaki F, Maeda H, Arima S, Tanoue S, Nasu Y, Hashimoto S, Kanmura S, Kadono J, Ido A .  [A case of postoperative recurrent gastric cancer resembling esophageal achalasia diagnosed by staging laparoscopy]. .  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology115 ( 4 ) 394 - 400   2018[A case of postoperative recurrent gastric cancer resembling esophageal achalasia diagnosed by staging laparoscopy].

  • Mawatari S, Oda K, Tabu K, Ijuin S, Kumagai K, Fujisaki K, Hashiguchi M, Inada Y, Uto H, Hiramine Y, Kure T, Hori T, Taniyama O, Kasai A, Tamai T, Moriuchi A, Ido A .  The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir. .  PloS one13 ( 6 ) e0198642   2018The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir.

  • Tamai T, Kumagai K, Sakae H, Onishi H, Tabu K, Tabu E, Muromachi K, Saishoji A, Oda K, Mawatari S, Moriuchi A, Sakurai K, Ido A .  Early sorafenib induction after transarterial chemoembolization for unresectable hepatocellular carcinoma: Can sorafenib after TACE improve loco-regional control? .  Molecular and clinical oncology7 ( 6 ) 1135 - 1141   2017.12Early sorafenib induction after transarterial chemoembolization for unresectable hepatocellular carcinoma: Can sorafenib after TACE improve loco-regional control?

     More details

  • Taguchi H, Kanmura S, Maeda T, Iwaya H, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Ido A .  Helicobacter pylori eradication improves the quality of life regardless of the treatment outcome: A multicenter prospective cohort study. .  Medicine96 ( 52 ) e9507   2017.12Helicobacter pylori eradication improves the quality of life regardless of the treatment outcome: A multicenter prospective cohort study.

  • 橋口 正史, 玉井 努, 山崎 成博, 長谷川 将, 藤崎 邦夫, 井戸 章雄 .  肝動脈化学塞栓療法時のhydrationによる体液貯留予防にTolvaptanが有効であった肝硬変合併肝細胞癌の4例 .  肝臓58 ( 10 ) 582 - 588   2017.10肝動脈化学塞栓療法時のhydrationによる体液貯留予防にTolvaptanが有効であった肝硬変合併肝細胞癌の4例

     More details

    Publisher:(一社)日本肝臓学会  

    肝細胞癌症例の多くは肝硬変が背景にあり、肝動脈化学塞栓療法(transcatheter arterial chemoembolization;TACE)後に胸腹水の貯留や浮腫をきたすことがある。また、TACEの際に使用する造影剤、抗癌剤等の薬剤は腎障害のリスクがあり、特にシスプラチンは腎毒性が強く、腎障害の予防としてhydrationが確立しているが、肝硬変症例では大量輸液は体液貯留につながる可能性がある。Tolvaptan(TLV)は選択的V2受容体拮抗薬で、腎機能悪化やNaの低下を起こしにくいとされる。体液貯留のリスクがある肝硬変合併肝細胞癌症例のTACE直後にTLVを投与したところ、術後尿量が増加し、体液貯留を抑制し、eGFRの維持が可能であった。TVLは、腎保護や体液貯留予防として、TACE時のhydrationにおける有効な利尿薬となりうる可能性が示唆された。(著者抄録)

  • Tamai T, Oshige A, Tabu K, Tabu E, Ijyuin S, Sakae H, Onishi H, Muromachi K, Saisyoji A, Oda K, Kumagai K, Mawatari S, Moriuchi A, Sakurai K, Hori T, Ido A .  Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma. .  Oncology letters14 ( 3 ) 3199 - 3206   2017.9Utility of percutaneous radiofrequency ablation alone or combined with transarterial chemoembolization for early hepatocellular carcinoma.

     More details

  • 猪俣 美穂, 福元 まゆみ, 曽我部 篤史, 内田 義男, 梅原 藤雄, 徳永 公紀, 井戸 章雄 .  吃逆・食欲不振に続き、両側視神経炎を呈したNMO spectrum disorderに対して血漿交換が著効した1例 .  日本透析医学会雑誌50 ( 9 ) 555 - 559   2017.9吃逆・食欲不振に続き、両側視神経炎を呈したNMO spectrum disorderに対して血漿交換が著効した1例

     More details

    Publisher:(一社)日本透析医学会  

    症例は80歳代女性。湿性咳嗽および食欲不振を認め、近医にて抗生剤治療されるも、食欲不振が持続し、第5病日頃から吃逆および嘔気が増悪し、当院消化器内科に入院となった。柿蒂湯内服後吃逆は消失し自宅退院となった。退院1週間後、急に視覚異常出現・光覚喪失し緊急入院となった。意識清明、両眼とも光覚喪失、対光反射消失、ほかの神経学的異常は認めなかった。頭部MRI検査で両側視神経の腫大およびGd造影効果を認め、嘔吐および難治性吃逆を前駆症状とした急激な視力低下という一連の経過より、視神経脊髄炎を疑い、メチルプレドニゾロンパルス療法を施行した。視力回復が乏しく、血漿交換療法(plasma exchange therapy:PE)6回施行後、視力は徐々に改善した。その後血清抗アクアポイン4抗体陽性が判明し、視神経脊髄炎関連疾患(neuromyelitis optica spectrum disorder:NMOSD)と診断した。NMOSDは不可逆的な経過を呈することがあり、ステロイド治療抵抗性の症例には早期のPEが効果的であると考えられた。(著者抄録)

  • Hashimoto S, Taguchi H, Higashi M, Hatanaka K, Fujita T, Iwaya H, Nakazawa J, Arima S, Iwashita Y, Sasaki F, Nasu Y, Kanmura S, Ido A .  Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis. .  Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society29 ( 5 ) 608 - 616   2017.7Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis.

     More details

  • Mawatari S, Oda K, Tabu K, Ijuin S, Kumagai K, Inada Y, Uto H, Hiramine Y, Kure T, Fujisaki K, Hashiguchi M, Hori T, Oshige A, Imanaka D, Saishoji A, Taniyama O, Sakae H, Tamai T, Moriuchi A, Ido A .  New resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir. .  Journal of gastroenterology52 ( 7 ) 855 - 867   2017.7New resistance-associated substitutions and failure of dual oral therapy with daclatasvir and asunaprevir.

  • Hashimoto Shinichi, Taguchi Hiroki, Higashi Michiyo, Hatanaka Kazuhito, Fujita Toshihiro, Iwaya Hiromichi, Nakazawa Junichi, Arima Shiho, Iwashita Yuji, Sasaki Fumisato, Nasu Yuichiro, Kanmura Shuji, Ido Akio .  超音波内視鏡下穿刺吸引法で採取した膵腫瘤性病変検体に対するliquid-based cytologyの診断的有効性 傾向スコアマッチング解析(Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis) .  Digestive Endoscopy29 ( 5 ) 608 - 616   2017.7超音波内視鏡下穿刺吸引法で採取した膵腫瘤性病変検体に対するliquid-based cytologyの診断的有効性 傾向スコアマッチング解析(Diagnostic efficacy of liquid-based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound-guided fine-needle aspiration: Propensity score-matched analysis)

     More details

    Publisher:John Wiley & Sons Australia, Ltd  

    超音波内視鏡下穿刺吸引法(EUS-FNA)で採取した膵腫瘤性病変検体に対するliquid-based cytology(LBC)法とconventional Papanicolaou smear(CPS)法の診断的有効性を比較するため後向き研究を実施した。対象は2009年1月〜2014年8月に当院で腫瘤性病変に対して初回EUS-FNAを施行した患者126例で、このうち63例は2012年5月迄にCPSによる細胞診を施行し、その後63例にLBCによる細胞診を施行した。悪性腫瘍の全発生率は86%であった。LBCはCPSと比較して感度および正診率が高かった。LBCは膵頭部病変の診断において感度が高かった。膵管腺癌(PDAC)の感度もLBCが高かった。多変量解析により、PDAC以外の悪性腫瘍と20mm以下の病変は全参加者においてLBCによる誤診の危険因子であることが明らかになった。以上から、膵腫瘤性病変に対するEUS-FNAにおいてLBCは悪性腫瘍の診断に有用であるが、PDAC以外の悪性腫瘍と小型腫瘍の場合はEUS-FNAとLBCの診断は困難であることが示された。

  • Komaki Y, Komaki F, Micic D, Ido A, Sakuraba A .  Risk of colorectal cancer in chronic liver diseases: a systematic review and meta-analysis. .  Gastrointestinal endoscopy86 ( 1 ) 93 - 104.e5   2017.7Risk of colorectal cancer in chronic liver diseases: a systematic review and meta-analysis.

  • Hiramine Y, Uto H, Imamura Y, Hiwaki T, Kure T, Ijuin S, Oda K, Mawatari S, Kumagai K, Tokunaga K, Higashi H, Kanetsuki I, Kubozono O, Maenohara S, Ido A .  Efficacy of vasopressin V2 receptor antagonist tolvaptan in treatment of hepatic edema. .  Hepatology research : the official journal of the Japan Society of Hepatology47 ( 6 ) 542 - 557   2017.5Efficacy of vasopressin V2 receptor antagonist tolvaptan in treatment of hepatic edema.

     More details

  • Komaki Y, Yamada A, Komaki F, Kudaravalli P, Micic D, Ido A, Sakuraba A .  Efficacy, safety and pharmacokinetics of biosimilars of anti-tumor necrosis factor-α agents in rheumatic diseases; A systematic review and meta-analysis. .  Journal of autoimmunity79   4 - 16   2017.5Efficacy, safety and pharmacokinetics of biosimilars of anti-tumor necrosis factor-α agents in rheumatic diseases; A systematic review and meta-analysis.

  • Ono Y, Kanmura S, Morinaga Y, Oda K, Kawabata K, Arima S, Sasaki F, Nasu Y, Tanoue S, Hashimoto S, Taguchi H, Uto H, Tsubouchi H, Ido A .  The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn's disease. .  BMC gastroenterology17 ( 1 ) 40   2017.3The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn's disease.

  • Toyota J, Karino Y, Suzuki F, Ikeda F, Ido A, Tanaka K, Takaguchi K, Naganuma A, Tomita E, Chayama K, Fujiyama S, Inada Y, Yoshiji H, Watanabe H, Ishikawa H, Hu W, McPhee F, Linaberry M, Yin PD, Swenson ES, Kumada H .  Daclatasvir/asunaprevir/beclabuvir fixed-dose combination in Japanese patients with HCV genotype 1 infection. .  Journal of gastroenterology52 ( 3 ) 385 - 395   2017.3Daclatasvir/asunaprevir/beclabuvir fixed-dose combination in Japanese patients with HCV genotype 1 infection.

  • Kanmura S, Moriuchi A, Hamamoto H, Ido A .  Hepatitis B virus reactivation in inflammatory bowel diseases. .  Nihon rinsho. Japanese journal of clinical medicine75 ( 3 ) 461 - 465   2017.3Hepatitis B virus reactivation in inflammatory bowel diseases.

     More details

  • 橋口 正史, 玉井 努, 那須 雄一郎, 佐々木 文郷, 東 美智代, 肱黒 薫, 二渡 久智, 重田 浩一朗, 長谷川 将, 井戸 章雄 .  内視鏡的粘膜下層剥離術(endoscopic submucosal dissection)の1年10ヵ月後に異時性肝転移をきたした胃神経内分泌癌(neuroendocrine carcinoma)の1例 .  日本消化器病学会雑誌114 ( 2 ) 238 - 247   2017.2内視鏡的粘膜下層剥離術(endoscopic submucosal dissection)の1年10ヵ月後に異時性肝転移をきたした胃神経内分泌癌(neuroendocrine carcinoma)の1例

     More details

    Publisher:(一財)日本消化器病学会  

    症例は77歳男性。胃噴門部O-IIc病変にESDを施行、病理診断は深達度SMの分化型優位混在癌、垂直断端(±)のため追加外科切除を施行した。1年10ヵ月後、肝腫瘍を認め肝部分切除を施行、NECと診断された。ESD病変は病理再検討により、胃NECと診断した。Stage IAのR0手術であったが、肝転移再発をきたした。肝切後の補助療法はS-1投与が有効で、1年4ヵ月無再発生存中である。(著者抄録)

  • Tokunaga M, Uto H, Takeuchi S, Nakano N, Kubota A, Tokunaga M, Takatsuka Y, Seto M, Ido A, Utsunomiya A .  Newly identified poor prognostic factors for adult T-cell leukemia-lymphoma treated with allogeneic hematopoietic stem cell transplantation. .  Leukemia & lymphoma58 ( 1 ) 37 - 44   2017.1Newly identified poor prognostic factors for adult T-cell leukemia-lymphoma treated with allogeneic hematopoietic stem cell transplantation.

  • Taida T, Arai M, Kanda T, Hige S, Ueno Y, Imazeki F, Izumi N, Tanaka E, Shinkai N, Yoshioka K, Nakamoto Y, Nishiguchi S, Tsuge M, Abe M, Sata M, Yatsuhashi H, Ido A, Kita K, Azemoto R, Kitsukawa Y, Goto N, Yokosuka O .  The prognosis of hepatitis B inactive carriers in Japan: a multicenter prospective study. .  Journal of gastroenterology52 ( 1 ) 113 - 122   2017.1The prognosis of hepatitis B inactive carriers in Japan: a multicenter prospective study.

  • Komaki F, Komaki Y, Micic D, Ido A, Sakuraba A .  Outcome of pregnancy and neonatal complications with anti-tumor necrosis factor-α use in females with immune mediated diseases; a systematic review and meta-analysis. .  Journal of autoimmunity76   38 - 52   2017.1Outcome of pregnancy and neonatal complications with anti-tumor necrosis factor-α use in females with immune mediated diseases; a systematic review and meta-analysis.

  • Hashiguchi M, Tamai T, Nasu Y, Sasaki F, Higashi M, Hijikuro K, Futawatari H, Shigeta K, Hasegawa S, Ido A .  A case of metachronous liver metastasis from neuroendocrine carcinoma of the stomach at 1 year and 10 months after endoscopic submucosal dissection. .  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology114 ( 2 ) 238 - 247   2017A case of metachronous liver metastasis from neuroendocrine carcinoma of the stomach at 1 year and 10 months after endoscopic submucosal dissection.

  • Ibusuki R, Uto H, Oda K, Ohshige A, Tabu K, Mawatari S, Kumagai K, Kanmura S, Tamai T, Moriuchi A, Tsubouchi H, Ido A .  Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis. .  PloS one12 ( 4 ) e0174913   2017Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis.

  • Kumagai K, Tabu K, Sasaki F, Takami Y, Morinaga Y, Mawatari S, Hashimoto S, Tanoue S, Kanmura S, Tamai T, Moriuchi A, Uto H, Tsubouchi H, Ido A. .  Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice .  PLoS One10 ( 11 ) e0143413   2015.11Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in MiceReviewed

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND AND AIMS: Glycoprotein nonmetastatic melanoma B (Gpnmb), atransmembrane glycoprotein that is expressed in macrophages, negatively regulates inflammation. We have reported that Gpnmb is strongly expressed in the livers of rats fed a choline-deficient, L-amino acid-defined (CDAA) diet. However, the role of macrophage-expressed Gpnmb in liver injury is still unknown. This study aimed to clarify the characteristics of infiltrating macrophages that express Gpnmb, and the involvement of Gpnmb in the repair process in response to liver injury.
    METHODS: C57BL/6J, DBA/2J [DBA] and DBA/2J-Gpnmb+ [DBA-g+] mice were treated with a single intraperitoneal injection of carbon tetrachloride (CCl4) at a dose of 1.0 mL/kg body weight. Mice were sacrificed at predetermined time points, followed by measurement of serum alanine aminotransferase (ALT) levels and histological examination. Expression of Gpnmb, pro-/anti-inflammatory cytokines,
    and profibrotic/antifibrotic factors were examined by quantitative RT-PCR and/or Western blotting. Immunohistochemistry, fluorescent immunostaining and flow cytometry were used to determine the expression of Gpnmb, CD68, CD11b and α-SMA, phagocytic activity, and the presence of apoptotic bodies. We used quantitative RT-PCR and ELISA to examine TGF-β and MMP-13 expression and the concentrations and supernatants of isolated infiltrating hepatic macrophages transfected with siGpnmb.
    RESULTS: In C57BL/6J mice, serum ALT levels increased at two days after CCl4 injection and decreased at four days. Gpnmb expression in the liver was stimulated four days after CCl4 injection. Histological examination and flow cytometry showed that Gpnmb-positive cells were almost positive for CD68-positive macrophages, contained engulfed apoptotic bodies and exhibited enhanced phagocytic activity. Isolated infiltrating hepatic macrophages transfected with siGpnmb showed high MMP-13 secretion. There was no significant difference in the magnitude of CCl4-induced liver injury between DBA-g+ and DBA mice. However,
    hepatic MMP-13 expression, as well as α-SMA expression and collagen production, increased significantly in DBA-g+ compared with DBA mice.
    CONCLUSIONS: Gpnmb-positive macrophages infiltrate the liver during the recovery phase of CCl4-induced acute liver injury and contribute to the balance between fibrosis and fibrolysis in the repair process following acute liver injury.

    DOI: doi: 10.1371

    PubMed

  • Ido A, Nakata K, Kato K, Nakao K, Murata K, Fujita M, Ishii N, Tamaoki T, Shiku H, Nagataki S .  Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter .  Cancer Research55   3105 - 3109   1995.10Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoterReviewed

     More details

    Language:English   Publishing type:Doctoral thesis  

▼display all

MISC

  • 【急性肝不全up to date】急性肝不全 病態解明 発症機序から肝再生まで

    熊谷 公太郎, 馬渡 誠一, 井戸 章雄

    日本消化器病学会雑誌   117 ( 9 )   750 - 755   2020.9

     More details

    Publisher:(一財)日本消化器病学会  

    急性肝不全は致死的な疾患であり,肝移植以外に有効な治療法がない.急性肝不全の発症機序を知ることは新たな治療法を開発するためには不可欠である.今回われわれは急性肝不全の発症から肝再生まで中心的な役割を果たす単球,マクロファージに着目し,機序について概説する.発症から肝再生・修復までの過程は,肝細胞死の誘導,クッパー細胞の活性化,単球の肝組織への遊走・分化・増殖,炎症性マクロファージから抗炎症性マクロファージへの機能的リプログラミング,肝細胞増殖という経過で説明できる.またその過程にはさまざまな分子が関わっており,その発症機序に基づいた新規治療法が近年報告されており,今後の展開が期待される.(著者抄録)

  • On-line HDFを急性肝不全の患者に施行する際の診療ガイド

    井上 和明, 織田 成人, 安部 隆三, 滝川 康裕, 中山 伸朗, 加藤 直也, 藤原 慶一, 安井 伸, 寺井 崇二, 井戸 章雄, 坂井田 功, 玄田 拓哉, 清水 雅仁, 持田 智, 滝川 一

    肝臓   61 ( 2 )   47 - 60   2020.2

     More details

    Publisher:(一社)日本肝臓学会  

  • 【指定難病ペディア 2019】個別の指定難病 代謝・内分泌系 肝型糖原病[指定難病257]

    馬渡 誠一, 井戸 章雄

    日本医師会雑誌   148 ( 特別1 )   S273 - S273   2019.6

     More details

    Publisher:(公社)日本医師会  

  • 術後再建腸管患者における急性胆道性膵炎に対する、緊急超音波内視鏡ガイド下順方向治療(Emergent endoscopic ultrasonography-guided antegrade treatment for acute biliary pancreatitis in a patient with altered gastrointestinal anatomy)

    Hashimoto Shinichi, Fujita Toshihiro, Ido Akio

    Digestive Endoscopy   31 ( 3 )   e58 - e59   2019.5

     More details

    Publisher:John Wiley & Sons Australia, Ltd  

  • 報告 自己免疫性膵炎臨床診断基準2018 自己免疫性膵炎臨床診断基準2011改訂版

    竹山 宜典, 岡崎 和一, 新倉 則和, 池浦 司, 糸井 隆夫, 伊藤 鉄英, 乾 和郎, 井上 大, 入江 裕之, 入澤 篤志, 岩崎 栄典, 植木 敏晴, 上原 剛, 内田 一茂, 大原 弘隆, 神澤 輝実, 川 茂幸, 菅野 敦, 窪田 賢輔, 洪 繁, 児玉 裕三, 阪上 順一, 清水 京子, 全 陽, 多田 稔, 中沢 貴宏, 西野 隆義, 能登原 憲司, 浜野 英明, 平野 賢二, 廣岡 芳樹, 正宗 淳, 増田 充弘, 水野 伸匡, 吉田 仁, 井戸 章雄, 下瀬川 徹, 妹尾 浩, 滝川 一, 千葉 勉, 仲瀬 裕志, 伊佐山 浩通, 伊藤 哲也, 梅村 武司, 太田 正穂, 鎌田 研, 河邉 顕, 菅野 敦, 木村 理, 栗山 勝利, 小山 貴, 塩川 雅広, 田妻 進, 田中 篤, 玉木 長良, 露口 利夫, 内藤 格, 仲野 俊成, 濱田 晋, 藤永 康成, 村木 崇, 本谷 雅代, 渡邉 貴之, 渡邉 智裕, 日本膵臓学会・厚生労働科学研究費補助金(難治性疾患等政策研究事業)「IgG4関連疾患の診断基準並びに治療指針の確立を目指す研究」班, 自己免疫性膵炎臨床診断基準2011改訂合同委員会, 日本膵臓学会膵炎調査研究委員会

    膵臓   33 ( 6 )   902 - 913   2018.12

     More details

    Publisher:(一社)日本膵臓学会  

    自己免疫性膵炎臨床診断基準2011では、限局性膵腫大例の診断にはendoscopic retrograde pancreatography(ERP)は必須である。ERPは昨今施行されることが少なくなり、限局性膵腫大例をmagnetic resonance cholangiopancreatography所見や超音波内視鏡下穿刺吸引法による癌の否定所見などにより、ERPなしでも診断できるプロセスを策定することが、厚生労働科学研究費補助金(難治性疾患等政策研究事業)「IgG4関連疾患の診断基準並びに治療指針の確立を目指す研究」班より提案された。同消化器疾患分科会で自己免疫性膵炎臨床診断基準2011改訂案を作成し、日本膵臓学会自己免疫性膵炎分科会との合同会議、公聴会にて審議し、決定された最終案に対してパブリックコメントを求めた後、合同会議最終版を自己免疫性膵炎臨床診断基準2018公表版とした。(著者抄録)

  • 我が国におけるAcute-On-Chronic Liver Failure(ACLF)の診断基準(案)

    持田 智, 中山 伸朗, 井戸 章雄, 井上 和明, 玄田 拓哉, 滝川 康裕, 坂井田 功, 寺井 崇二, 横須賀 収, 清水 雅仁, 滝川 一

    肝臓   59 ( 3 )   155 - 161   2018.3

     More details

    Publisher:(一社)日本肝臓学会  

    厚生労働省「難治性の肝・胆道疾患に関する調査研究」班の劇症肝炎分科会は、acute-on-chronic liver failure(ACLF)の診断基準を確立する目的で予備調査を実施し、わが国の症例にはアジア太平洋肝臓学会(APASL)の診断基準が適合しているが、その重症度分類にはヨーロッパ肝臓学会の慢性肝不全(EASL-Clif)コンソーシアムの基準が有用であることを明らかにした。そこで、わが国の診断基準はAPASL基準に準拠して、「Child-Pughスコアが5〜9点の代償性ないし非代償性肝硬変に、アルコール多飲、感染症、消化管出血、原疾患増悪などの増悪要因が加わって、28日以内に高度の肝機能異常に基づいて、プロトロンビン時間INRが1.5以上ないし同活性が40%以下で、総ビリルビン濃度が5.0mg/dL以上を示す肝障害」と定義することになった。APASL基準とは異なって、非肝硬変症例は対象から除外し、一方、増悪要因に消化管出血を加えている。また、その重症度はEASL-Clifコンソーシアム基準に準拠して、肝、腎、脳、血液凝固系、循環器、呼吸器の障害の程度に応じて4段階に分類することとなった。同診断基準の有用性は、今後、全国規模で前向き調査を実施し、評価する予定である。(著者抄録)

  • 【急性肝不全】急性肝不全治療薬HGFの臨床開発

    井戸 章雄, 森内 昭博, 小田 耕平, 馬渡 誠一, 玉井 努, 坪内 博仁

    ICUとCCU   41 ( 10 )   631 - 636   2017.10

     More details

    Publisher:医学図書出版(株)  

    肝細胞増殖因子(HGF)は肝再生を強力に促進する増殖因子で、抗アポトーシス、抗繊維化作用などの多彩な作用を併せ持っている。われわれは長年、組換えヒトHGFの医薬品化に取り組み、2005年に劇症肝炎を対象とした第I/II相臨床試験を医師主導治験の枠組みで実施した。本臨床試験では劇症肝炎患者4例に組換えヒトHGFを反復静脈内投与したが、重篤な有害事象はみられなかった。その後、製薬企業の協力を得てJST研究成果最適展開支援プログラムA-STEP本格研究開発ステージ実用化挑戦タイプ「組換えヒト肝細胞増殖因子を用いた急性肝不全の治療」に採択され、新たに製造した組換えヒトHGFを用いて臨床開発を推進している。(著者抄録)

▼display all

Presentations

  • 平峯 靖也, 宇都 浩文, 井戸 章雄   肝硬変の予後改善を目指した治療戦略 肝性腹水患者の予後に及ぼす急性腎障害の影響とトルバプタンの効果  

    肝臓  2020.4  (一社)日本肝臓学会